Clinical trials
High-Risk Cancer clinical trials
Below are recruiting high-risk cancer clinical trials, each written for real people, not researchers. We’re tracking 396 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06952803RecruitingPhase 3
Testing a new drug for men with BRCA-related prostate cancer
This trial tests whether adding a new drug (saruparib) to standard radiation and hormone therapy can help prevent prostate cancer from spreading to other parts of the body. It is for men with high-risk prostate cancer that has a BRCA gene mutation.
Phoenix, ArizonaAges 18 years+ - NCT06943781Recruiting
Gastric cancer screening using high-risk gene detection
This trial is testing a new way to identify people at higher risk for stomach cancer using a gene test for Helicobacter pylori. It may help detect cancer early in people aged 40 and older.
TonglingAges 40 years+ - NCT06949254Recruiting
Study of radiation and hormone therapy for high-risk prostate cancer
This study looks at combining stereotactic body radiation therapy (a precise type of radiation) with hormone therapy for men with high-risk prostate cancer that hasn't spread. The goal is to see how well this treatment works with fewer side effects.
Bergamo, BergamoAges 18 years+ - NCT06907095Recruiting
Early cancer detection study for high-risk individuals
This study tests if a simple blood or fluid test can find cancer early in people with a higher-than-average risk. If you have certain genetic mutations, a strong family history of cancer, or other high-risk conditions, you may be able to join.
VillejuifAges 18 years+ - NCT04221035RecruitingPhase 3
Trial for children with high-risk neuroblastoma testing next steps
This Phase 3 study tests treatment strategies for children with high-risk neuroblastoma, aiming to improve how well the cancer responds and how long patients can stay in control. It compares different intensities and add-ons at key treatment steps depending on your child’s response and health.
Sydney, RandwickAges Up to 21 years - NCT06888102RecruitingEarly Phase 1
Epigenetic therapy before prostate surgery
This trial tests a short course of 'epigenetic therapy' (drugs that change how genes work) given before prostate removal surgery. The goal is to see if it can improve treatment effects and help shrink or control the tumor.
Los Angeles, CaliforniaAges 18 years+ - NCT06831552Recruiting
Supporting families of children with high-risk neuroblastoma
This study tests a resource intervention to help families with low income who have a child with high-risk neuroblastoma. It aims to reduce financial stress and improve care during treatment.
Hartford, ConnecticutAges Up to 17 years - NCT06816121Recruiting
Blood test for early lung cancer in high-risk smokers
This study is evaluating a blood-based test that might detect lung cancer early, before symptoms appear. Researchers are looking for heavy smokers who have no signs of cancer, as well as those with suspicious lung nodules or confirmed lung cancer, to see if a simple blood draw could help identify cancer sooner.
Oklahoma City, OklahomaAges 30–80 - NCT06803875RecruitingPhase 1/Phase 2
CAR T cells for relapsed high-risk neuroblastoma
This trial is testing a new type of immunotherapy called hALK.CAR T cells for children and young adults with high-risk neuroblastoma that has come back or not responded to standard treatment. The goal is to see if these specially engineered cells can find and destroy the cancer cells.
Boston, MassachusettsAges 1–29 - NCT06791161Enrolling by invitation
Adjuvant therapy study for BRCA1/2 positive breast cancer
This study tests if additional treatment after surgery helps prevent breast cancer from returning. It is for people with hormone receptor-positive, HER2-negative breast cancer who have a BRCA1 or BRCA2 gene mutation and a high risk of recurrence.
Beijing, Beijing MunicipalityAges 18–75 - NCT06732388RecruitingPhase 2
Itraconazole with ablation to prevent esophageal cancer in Barrett's esophagus
This trial tests if adding the antifungal drug itraconazole to standard ablation therapy can help prevent esophageal cancer in people with high-risk Barrett's esophagus. You must have a confirmed diagnosis of Barrett's esophagus with low- or high-grade dysplasia or early-stage cancer, and be planning to have ablation treatment.
Kansas City, KansasAges 18 years+ - NCT05123625Recruiting
Testing lymph node removal during bladder cancer surgery
This study looks at whether removing nearby lymph nodes during radical cystectomy (bladder removal) improves outcomes for people with high-risk non–muscle-invasive bladder cancer. It may help doctors choose the best surgical approach to reduce the chance of cancer coming back.
Nanjing, JiangsuAges 18–75 - NCT06726642Recruiting
Blood test study for people with inherited cancer risk
This study looks for DNA fragments in blood of people with certain inherited cancer syndromes. It may help find cancer earlier or guide better monitoring. You would give blood samples every 4 months (if in the experimental group).
Vancouver, British ColumbiaAges Up to 90 years - NCT06687421Recruiting
Precision medicine for high-risk prostate cancer
This study aims to use precision medicine (tailored treatment based on your specific cancer) for men at high risk of prostate cancer. It may help doctors choose the best treatment for you.
UmeåAges 18 years+ - NCT06628570Recruiting
Screening methods for anal cancer in high-risk adults
This study is looking at ways to screen for anal cancer in people who are at higher risk, such as those with weakened immune systems or a history of abnormal cells in the lower genital tract. It aims to find better methods for early detection.
Miami, FloridaAges 30–80 - NCT06623110RecruitingPhase 2
RP2 vaccine to prevent mouth cancer in high-risk pre-cancer
This trial tests an injected virus therapy (RP2) to stop pre-cancerous mouth lesions from turning into cancer. It is for people with high-risk oral pre-cancer or a history of early-stage head and neck cancer with certain worrisome features.
Boston, MassachusettsAges 18 years+ - NCT06625970RecruitingPhase 3
Darolutamide and high-dose radiation for high-risk prostate cancer
This trial tests a combination of a hormone therapy pill (darolutamide) and a high-dose, precise form of radiation for men with localized prostate cancer that has high-risk features of coming back. The goal is to see if this approach is more effective than standard treatment.
BrestAges 18–80 - NCT06567743RecruitingPhase 2
Study of a new virus therapy for high-risk bladder cancer
This trial tests a new virus-based medicine, cretostimogene grenadenorepvec, given directly into the bladder for people with high-risk non-muscle-invasive bladder cancer. It may help prevent the cancer from coming back, especially for those who have not had BCG treatment or whose cancer did not respond to BCG.
Gilbert, ArizonaAges 18 years+ - NCT06522256Recruiting
HPV and anal cancer risk 10 years later
This study looks at HPV (the virus that can cause anal cancer) and checks if certain types of high-risk HPV are linked to abnormal cells or cancer in the anus, 10 years after joining the IPERGAY trial. It helps researchers understand long-term risks.
LyonAges 18 years+ - NCT06525571RecruitingPhase 3
Blue light surgery for high-risk bladder cancer
This trial tests if using blue light during surgery helps remove all cancer in people with high-risk non-muscle invasive bladder cancer. It may lower the chance of the cancer coming back.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06523868Recruiting
Multi-cancer early detection test for military veterans
This trial is testing a blood test that looks for early signs of multiple types of cancer. It is designed for current or former military members who are at least 45 years old and have used VA healthcare. If the test finds something, you would need to be willing to travel to Boston for follow-up.
Boston, MassachusettsAges 45 years+ - NCT06488482RecruitingPhase 3
Short immunotherapy after melanoma surgery
This trial tests whether giving a shorter course of immunotherapy after surgery can help prevent melanoma from coming back. It is for people with high-risk melanoma who have had the cancer fully removed.
HelsinkiAges 18 years+ - NCT06482073Recruiting
Genetic testing for suspected lung cancer
This study looks at genetic changes in people with suspected or high-risk lung cancer. It aims to use those results to guide more personalized treatment decisions.
Rochester, MinnesotaAges 18 years+ - NCT05557487Recruiting
Real-world low-dose CT screening for people at high lung risk
This study looks at how people at high risk for lung cancer use low-dose CT scans in real life, and what outcomes happen over time. It may help confirm which groups benefit most from regular screening and support safer screening decisions.
Taichung, TaiwanAges 20–80
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Common questions
- Are there clinical trials for high-risk cancer?
- Yes. Clin2 currently lists 396 recruiting high-risk cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high-risk cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high-risk cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.