Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 922 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05859048Recruiting
Care plan to help high-risk people spot heart failure early
This trial tests a multidisciplinary care approach aimed at helping people with high risk for heart failure get diagnosed earlier. It may help you catch heart failure sooner if it starts, so treatment can begin earlier.
Vancouver, British ColumbiaAges 40 years+ - NCT04243785RecruitingPhase 1
Testing BTX-A51 for hard-to-treat AML or high-risk MDS
This Phase 1 study tests BTX-A51 in adults with relapsed or refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). It’s designed to see if the treatment can be given safely and to learn how it works in people whose standard treatments have not helped or are no longer an option.
Duarte, CaliforniaAges 18 years+ - NCT06327568Recruiting
Screening for anal cancer and precancer with a new HPV test
This study tests how well a special HPV test (called BD Onclarity™) can find anal cancer or precancer. It is for people at high risk or with known anal abnormalities, and aims to improve early detection.
MilanAges 18 years+ - NCT06280508RecruitingPhase 2
Perioperative chemo plus immunotherapy for bile duct cancer
This trial tests a combination of chemotherapy, immunotherapy (adebrelimab), and a targeted therapy (apatinib) before and after surgery for bile duct cancer that can be removed and has a high risk of coming back. It aims to see if this approach can lower the chance of recurrence.
Guangzhou, China/GuangdongAges 18 years+ - NCT06385717Recruiting
ESD plus chemoradiotherapy for early esophageal cancer
This study tests whether combining radiation and chemotherapy after endoscopic removal of early-stage esophageal cancer can effectively treat the cancer without needing surgery. It may be an option for people whose cancer was removed with ESD but who want to avoid additional surgery.
Hangzhou, ZhejiangAges 18–75 - NCT06404697RecruitingPhase 2
Extra radiation to lymph nodes above collarbone for high-risk breast cancer
This trial tests giving a focused, higher dose of radiation to the lymph nodes above the collarbone after breast cancer treatment. It is for patients whose cancer did not fully disappear from those nodes after pre-surgery chemotherapy, to see if extra radiation can help prevent recurrence.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06414655Recruiting
Twin pregnancy study: tracking mothers and babies
This study follows mothers expecting twins from early pregnancy through delivery. It helps doctors learn more about caring for twin pregnancies and their babies in China.
Hefei, AnhuiAges 18–45 - NCT05326919Recruiting
Study biobank for people newly diagnosed with certain blood cancers
This study follows people who are newly diagnosed (and haven’t been fully treated yet) with specific leukemia or related blood disorders to help researchers learn which treatments may work best. It may help by connecting you to a larger “precision medicine” patient group for future research.
BobignyAges Any age - NCT06441110RecruitingPhase 3
BCG instillation for medium- to high-risk bladder cancer
This trial tests whether a specific schedule of BCG (a weakened germ that boosts the immune system) placed directly into the bladder is safe and effective for medium- to high-risk bladder cancer that hasn't grown into the muscle. It aims to see if adjusting the standard BCG course can work better for people with a PD-L1-positive tumor.
Fuzhou, FujianAges 18–75 - NCT04005508Recruiting
Study sleep apnea and heart outcomes in high-risk atrial fibrillation
This trial looks at how obstructive sleep apnea (OSA, a breathing problem during sleep) relates to heart outcomes in people with atrial fibrillation (AF). It may help doctors better predict risk and choose safer care for people who are high cardiovascular risk.
SingaporeAges 22–99 - NCT06407947RecruitingEarly Phase 1
CT071 for high-risk newly diagnosed multiple myeloma
This trial tests an experimental therapy called CT071 for people with newly diagnosed, high-risk multiple myeloma. It aims to see if this treatment can help control the disease in people who have certain aggressive features.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT04240834RecruitingPhase 4
Low-dose ticagrelor vs aspirin after heart stent placement
This study compares ticagrelor taken at a lower dose versus regular aspirin to help prevent future heart attacks in people who recently had a stent placed after acute coronary syndrome. You may qualify if you’re considered “high risk” for new blockages or clots and can take dual anti-platelet therapy for 12 months.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06455124RecruitingPhase 2
Short radiation and chemo-immunotherapy for early rectal cancer after local surgery
This trial tests a combination of short-course radiation, chemotherapy (CapeOx), and an immunotherapy drug (PD-1 inhibitor) for people with early-stage rectal cancer who have had a local excision but are at high risk of the cancer coming back. The goal is to avoid more extensive surgery while still effectively treating the cancer.
ShanghaiAges 18–75 - NCT07837739Recruiting
EGFR-targeted pill after surgery for early lung cancer
This trial tests whether taking an EGFR-targeted pill after lung cancer surgery can lower the chance of the cancer coming back. It is for people with early-stage non-small cell lung cancer that has a specific EGFR mutation.
Wuhan, HubeiAges 18–75 - NCT07838207Recruiting
Molecular markers and outcomes in early-stage endometrial cancer
This study looks at women with certain high-risk types of endometrial cancer that have not spread into the muscle wall of the uterus. It aims to understand how these cancers behave and whether lymph node testing is needed, which could help guide treatment decisions.
Barcelona, BarcelonaAges 18 years+ - NCT07829484Recruiting
Exercise and olive oil for fall prevention in older adults
This study tests whether a home exercise program combined with daily extra virgin olive oil can reduce the risk of falls in older adults who are frail or at high risk of falling. It may help improve strength, balance, and overall health.
Pamplona, NavarreAges 75 years+ - NCT04790305RecruitingPhase 4
Huaier granules with standard therapy for early triple-negative breast cancer
This trial looks at whether adding Huaier granules to usual after-surgery treatment can improve outcomes for people with high-risk early-stage triple-negative breast cancer. It focuses on whether the added supplement is safe and helpful after standard care.
Hefei, AnhuiAges 18–70 - NCT07820423Recruiting
AI tool predicts high-risk lung cancer linked to air-filled spaces
This study uses artificial intelligence to examine CT scans and predict whether lung cancer containing air-filled spaces is aggressive. It may help doctors tailor treatment after surgery.
Changsha, HunanAges 18 years+ - NCT07822737Recruiting
Using CT scans to find high-risk heart plaque
This study uses a special CT scan to look at the inside of your heart arteries and find any high-risk fatty deposits (plaque) that might cause problems later. It aims to see if this scan can predict future heart events, so you and your doctor can make better treatment choices.
Beijing, ChinaAges 18 years+ - NCT06482684RecruitingPhase 2
CAR-T cell therapy for new, high-risk mantle cell lymphoma
This study tests a type of immunotherapy called CAR-T cells (modified immune cells) for people with untreated, high-risk mantle cell lymphoma. It aims to see if this therapy can help control the disease early on.
MainzAges 18–75 - NCT06486233Recruiting
Early invasive treatment for elderly heart attack patients
This trial tests whether early invasive treatment (like stenting) is safe and effective for patients 60 or older who have a certain type of heart attack called high-risk non-ST-segment elevation acute coronary syndrome. The goal is to see if this approach improves outcomes for older adults.
Ho Chi Minh CityAges 60 years+ - NCT06487052Recruiting
Catheter-based clot-dissolving drug for intermediate-high risk pulmonary embolism
This trial tests whether a standard procedure using a catheter to deliver clot-dissolving medicine directly into the lung artery works well for people with a serious but not immediately life-threatening blood clot in the lungs (pulmonary embolism). It aims to improve heart function and reduce long-term complications.
Saint PetersburgAges 18 years+ - NCT06319846RecruitingPhase 3
Tirofiban for recent mild stroke or TIA with narrowed brain artery
This trial tests the drug tirofiban (a blood thinner) to prevent another stroke in people who have had a mild stroke or high-risk TIA and have a narrowed artery in the brain. It must be started within 24 hours of symptoms.
Harbin, HeilongjiangAges 40 years+ - NCT06498622RecruitingPhase 2
Liver cancer relapse prevention after surgery
This trial tests a combination of two drugs (Donafenib and Envafolimab) after surgery to lower the risk of liver cancer coming back in people who have high-risk features. It may help if you qualify based on your tumor(s) and overall health.
Fuyang, AnhuiAges 18–80
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 922 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.