Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 922 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07214571RecruitingPhase 2
Study of S-337395 for RSV in high-risk adults
This trial tests an experimental drug called S-337395 for adults with RSV who are not in the hospital but are at high risk for severe illness. It aims to see if the drug can help prevent symptoms from getting worse.
Los Angeles, CaliforniaAges 18 years+ - NCT07217899RecruitingPhase 2
Calcium to reduce bleeding after C-section
This trial tests if giving calcium through an IV before a C-section can help reduce blood loss in women at higher risk for heavy bleeding due to the uterus not contracting well.
Ann Arbor, MichiganAges 18 years+ - NCT07220993RecruitingPhase 1
Modified immune cells for aggressive T-cell cancers
This trial tests a new treatment using specially engineered immune cells (CAR T cells) from a past stem cell donor to attack cancer cells in people with certain types of T-cell cancers that have returned after a stem cell transplant. The goal is to see if this treatment can lead to remission so a second stem cell transplant can be done.
Houston, TexasAges Up to 75 years - NCT07219303Recruiting
Adaptive radiation therapy for intermediate- or high-risk prostate cancer
This trial tests a type of radiation that adjusts to changes in your prostate during treatment. It aims to improve accuracy and reduce side effects for men with intermediate- or high-risk prostate cancer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06547892RecruitingPhase 2
Vasopressin to prevent kidney injury in the ICU
This trial tests if a drug called vasopressin can help prevent acute kidney injury in patients at high risk. It's for adults in the ICU who have a predicted risk score of 5 or higher based on their lab and health data.
São Paulo, São PauloAges 18 years+ - NCT06140966RecruitingPhase 2
Daratumumab and Carfilzomib combo for high-risk multiple myeloma
This trial tests a combination of the drugs daratumumab, carfilzomib, lenalidomide, and dexamethasone given before and after a stem cell transplant for people with ultra high-risk multiple myeloma. The goal is to see if this regimen is safe and more effective than standard treatments.
Wuhan, HubeiAges 18–70 - NCT07207824RecruitingPhase 3
Study of a new drug for high-risk bladder cancer
This trial tests a combination of a drug (DV) and BCG immunotherapy for people with high-risk, early-stage bladder cancer that has not spread into the muscle. The cancer must show a specific protein called HER2 on its cells.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07208240RecruitingPhase 1/Phase 2
PSMA-targeted radiation before prostate removal for advanced cancer
This trial tests giving a radioactive drug (PSMA-targeted) before surgery for prostate cancer that has spread locally but not to other parts of the body. The goal is to see if it helps lower the risk of the cancer coming back.
Petah TikvaAges 18 years+ - NCT05288777RecruitingPhase 2/Phase 3
Testing follow-up chemo and radiation for high-risk breast cancer
This trial studies a standard follow-up treatment plan that combines chemotherapy and radiation after surgery, and it looks for blood/tissue “biomarkers” that predict who benefits most. If you have high-risk breast cancer that didn’t fully disappear after initial (neoadjuvant) chemo, you may be eligible to help guide better future treatment choices.
Charlottesville, VirginiaAges 18 years+ - NCT06923345RecruitingPhase 2
Modified long-course radiation and chemo with immunotherapy for rectal cancer
This trial tests a treatment plan involving radiation, chemotherapy, and an immunotherapy drug (a PD-1 inhibitor) for people with a specific type of high-risk rectal cancer. The goal is to see if this combination helps shrink the tumor before surgery.
Guangzhou, GuangdongAges 18–75 - NCT06542640Recruiting
Understanding brain changes in youth at risk for psychosis
This research study looks at how the brain changes in young people who are at high risk for developing psychosis. It aims to find better ways to predict and prevent psychosis by using brain imaging and thinking tests.
Shanghai, Shanghai MunicipalityAges 15–35 - NCT06817239Recruiting
Low-dose esketamine for preventing confusion after surgery in older adults
This study tests whether a low dose of the medicine esketamine can help prevent confusion after surgery in older adults at higher risk. You may qualify if you are 65 or older, planning a major non-cardiac surgery, and have certain health conditions like high blood pressure or diabetes.
Fuzhou, FujianAges 65–90 - NCT07188025RecruitingPhase 3
Cancer DNA test to guide chemo after rectal cancer surgery
This trial tests whether checking for tumor DNA in your blood after surgery can help decide if you need additional chemotherapy. If the test finds cancer DNA, you may get chemo to lower the risk of the cancer coming back.
's-HertogenboschAges 18 years+ - NCT07186933Recruiting
Ventilator settings to protect lungs during high-risk surgery
This study compares two ways of setting the ventilator during surgery to reduce lung complications. Researchers will test whether using a lower 'driving pressure' (a setting on the breathing machine) helps protect the lungs better than usual care. It is for adults having high-risk surgeries under general anesthesia with a breathing tube.
PátraiAges 18 years+ - NCT06935513Recruiting
Wearable devices for stroke prevention
This trial tests if using a smart wearable device can help people at high risk for stroke stay active and reduce their risk. You may be able to join if you have certain health conditions or habits that increase your stroke risk.
Nantong, JiangsuAges 30 years+ - NCT07158970Recruiting
Home ultrasound for gestational diabetes in high-risk pregnancy
This study tests whether using a small ultrasound device at home can help monitor high-risk pregnancies in people with gestational diabetes. You would perform quick scans and share them with your doctor remotely.
H̱olon, Central DistrictAges 18–51 - NCT07149714Recruiting
Heart pump support for high-risk angioplasty
This trial tests the iVAC 2L device, a temporary heart pump placed in the main artery, to help patients who need a high-risk angioplasty (PCI) because of a very narrowed or blocked coronary artery. The goal is to prevent the heart from failing during the procedure.
MoscowAges 18 years+ - NCT07148154Recruiting
Non-invasive test for endometrial cancer screening
This study tests a simple, non-invasive method to detect endometrial cancer in women after menopause who have abnormal bleeding. It aims to find cancer early in those at higher risk, such as women with certain genetic conditions or risk factors.
L'Hospitalet de Llobregat, BarcelonaAges 40 years+ - NCT07151885Recruiting
Using ultrasound and blood tests to predict varices risk in cirrhosis
This trial tests if a special ultrasound technique combined with liver stiffness and platelet count can predict which patients with cirrhosis have high-risk varices in the esophagus or stomach, potentially reducing the need for repeated endoscopy.
Changchun, JilinAges 18 years+ - NCT07151911Recruiting
Study of drugs for high-risk early breast cancer
This study looks at the effectiveness of the drugs abemaciclib and olaparib plus hormone therapy for people with high-risk, hormone receptor-positive, HER2-negative early breast cancer. It aims to understand how well these treatments work in real-world settings.
Modena, ModenaAges 18 years+ - NCT06686108RecruitingPhase 2
Medication combo to prevent lymphoma relapse after transplant
This trial tests a combination of two drugs (a demethylating agent and venetoclax) to help prevent high-risk T-cell lymphoma or leukemia from coming back after a stem cell transplant. It is for patients who have certain risk factors for relapse.
ShanghaiAges 14–55 - NCT07139951Enrolling by invitationPhase 2
Heated Chemotherapy for Stomach Cancer at High Risk of Recurrence
This trial tests a special type of chemotherapy that is heated and delivered directly into the belly during surgery (called HIPEC). It uses two drugs, cisplatin and paclitaxel, and is for people with stomach cancer who are at high risk of the cancer returning in the lining of the belly.
Rochester, MinnesotaAges 18–80 - NCT05845333Recruiting
Study brain changes in women with recent stimulant use
This trial looks at neurocognitive (thinking and brain function) differences in high-risk women who have used stimulant drugs recently. It may help researchers understand how stimulant use affects the brain and which brain changes are linked to thinking and behavior.
Albuquerque, New MexicoAges 18–70 - NCT07130578Recruiting
Urine DNA test to guide second bladder cancer surgery
This trial is testing whether a urine test for tumor DNA/RNA can help guide the decision for a second surgery in people with high-risk, non-muscle-invasive bladder cancer. It aims to see if the urine test can predict who needs the second surgery, potentially avoiding unnecessary procedures.
TianjinAges 18 years+
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 922 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.