Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 923 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04184505RecruitingPhase 3
Testing stem cell transplant in higher-risk myelodysplastic syndrome
This Phase 3 trial tests whether doing an “allogeneic” stem cell transplant works best for people newly diagnosed with higher-risk MDS (a bone marrow disorder). It’s mainly for patients who are healthy enough to receive a transplant and haven’t started MDS treatment yet.
AlessandriaAges 18–70 - NCT05968560Recruiting
Online therapy to help youth at risk for psychosis
This trial tests a telehealth (video/phone) version of cognitive behavioral therapy to help young people who are at risk for developing psychosis. It may help by teaching skills to reduce symptoms and improve coping, with support from a key family or close person.
New York, New YorkAges 14–25 - NCT04402151RecruitingPhase 2
PSMA scan–guided targeted radiation for higher-risk prostate cancer
This trial uses a special PET/MR scan to help doctors aim stereotactic radiation more precisely for certain higher-risk or unfavorable intermediate prostate cancers. It studies whether this targeted approach can safely treat the prostate (and specific areas needing extra treatment) without spreading to the body.
New York, New YorkAges 21–90 - NCT06449781RecruitingPhase 2
177Lu-PSMA after surgery or radiation for high-risk prostate cancer
This study tests a new treatment called 177Lu-PSMA given after standard therapy (surgery or radiation) to see if it can prevent prostate cancer from coming back. It is for patients with high or very high-risk prostate cancer that hasn't spread yet.
GliwiceAges 18 years+ - NCT07028463Recruiting
Awareness and resources for fall risk in older ED patients
This study tests a program in the emergency department that helps older adults at risk for falls get connected to resources and support after they go home.
Aurora, ColoradoAges 65 years+ - NCT06608576Enrolling by invitation
Video support for babies at risk of delays
This study tests whether extra support through video calls and texts can help babies at risk for developmental delays. If your baby is 3 to 12 months old and you have a smartphone with WhatsApp, you may be able to join and get guidance from a physical therapist without leaving home.
Granada, GranadaAges 3 months–1 year - NCT06506630Recruiting
Coenzyme Q10 for metabolic syndrome risk
This trial tests whether taking Coenzyme Q10, a natural supplement, can improve heart health markers in people who have or are at high risk for metabolic syndrome. Metabolic syndrome is a group of conditions like high blood sugar, high blood pressure, and belly fat that raise your risk for heart disease and diabetes.
ShenzhenAges 30–90 - NCT06946732Recruiting
Acostream for high-risk and intermediate-risk pulmonary embolism
This trial is testing a device (called the Acostream) to break up blood clots in the lungs for people with serious pulmonary embolism who cannot receive standard clot-busting drugs or surgery. It may be an option if you have high-risk or intermediate-risk PE and are between 18 and 85.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07614958RecruitingPhase 3
Testing a new cholesterol medicine against bempedoic acid
This study compares two new medicines—obicetrapib and bempedoic acid—to see which one better lowers cholesterol in people whose cholesterol remains high despite taking standard medications. If your cholesterol isn't controlled well enough with current drugs, this trial may help you access an experimental treatment.
Stockton-on-TeesAges 18 years+ - NCT07464730Recruiting
High-flow nasal oxygen after high-risk surgery for frail adults
This trial tests whether using high-flow nasal oxygen after surgery helps frail patients recover better and avoid breathing problems. It includes people having long abdominal, vascular, or chest surgeries who have several health risks like older age, low oxygen levels, or heart or lung conditions.
StockholmAges 18 years+ - NCT05920252Recruiting
Phone-based suicide risk support for teens in DBT
This trial tests whether a smartphone tool can help reduce suicide risk for teens who are already in an intensive therapy program (DBT). It may help you or your family recognize risk earlier and use skills more consistently between sessions.
New York, New YorkAges 13–18 - NCT07062016Recruiting
Studying high-risk endometrial cancer with blood and tissue tests
This trial studies tumor DNA in blood and tissue from people with aggressive endometrial cancer to better understand the disease. You donate samples during surgery and follow-up visits.
Rochester, MinnesotaAges 18 years+ - NCT07420465Recruiting
Heart and metabolic risks in pregnancy and after birth
This study looks at heart and metabolic health during late pregnancy and after delivery, tracking both healthy women and those with complications like high blood pressure or diabetes in pregnancy. The goal is to understand how these risks change and what can be done to improve long-term health.
AccraAges 18–45 - NCT05287451Recruiting
Tube removal now, ovaries later for high cancer-risk women
This study looks at the safety of removing your fallopian tubes first (RRS) and delaying ovary removal (oophorectomy) to lower cancer risk. It focuses on women who carry certain inherited gene changes, and may help avoid earlier menopause for some people.
Boston, MassachusettsAges 18 years+ - NCT07366424Recruiting
Testing new shoes to prevent falls in seniors
This trial is testing if special shoes called 'CHUT OTONOM®' can improve walking and reduce fall risk in older adults who have fallen before. It may help you find better balance and confidence.
LilleAges 65 years+ - NCT05454280RecruitingPhase 3
Manage surgical risk after high-risk cancer operations
This study looks at a “risk-based plan” to help guide care after major cancer surgery, aiming to improve recovery and outcomes. You may be in the study when you’re about to have elective (planned) high-risk cancer surgery and then again just before hospital discharge.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06408220Recruiting
Stomach cancer risk check for minority groups
This study checks if you are at high risk for stomach cancer. You will give blood samples and have a stomach exam (endoscopy) to look for early signs.
Duarte, CaliforniaAges 40–80 - NCT06204315RecruitingPhase 2
Spine radiosurgery for spinal cord compression
This trial tests a precise radiation technique for people whose spinal tumors are very close to the spinal cord or nerves. It aims to safely give higher radiation doses while limiting damage to the cord.
Houston, TexasAges 18 years+ - NCT06529042Enrolling by invitation
Sickle Cell Risk in Pregnancy Tool Study
This study is developing a risk assessment tool to help predict complications in pregnant women with sickle cell disease. It reviews medical records from women who have received prenatal care and given birth at participating hospitals.
Baltimore, MarylandAges 16–60 - NCT06166329Recruiting
Chair lift test for pulmonary embolism prognosis
This study checks if a simple chair lift test can help predict recovery in patients with a blood clot in the lung (pulmonary embolism) who are not critically ill. It aims to find out if this test can help doctors decide on the best follow-up care.
RouenAges 18 years+ - NCT00291096Recruiting
Clinic program for women at high risk of breast cancer
This trial enrolls women who are at higher-than-usual risk of developing breast cancer to help guide prevention and monitoring. You may be asked to get a recent mammogram, have blood tests, and follow medication/supplement changes.
Kansas City, KansasAges 30–65 - NCT05384535Recruiting
Test a special MRI to screen high-risk prostate cancer
This study checks whether a detailed MRI method can help find prostate cancer earlier in people considered high risk. You may be asked to get an MRI and help the team see if it works well as a screening test.
Lake Success, New YorkAges 40–55 - NCT06026267Recruiting
Comparing two doses of albumin for cirrhosis patients with SBP
This trial tests whether a lower dose of albumin works as well as the standard dose for people with cirrhosis and a type of infection called spontaneous bacterial peritonitis (SBP). It aims to see if the low dose can protect kidney function while reducing side effects and costs.
New Delhi, National Capital Territory of DelhiAges 18–75 - NCT05463796Recruiting
Prevention and early detection for people at high cancer risk
This study looks at surveillance (watching closely), prevention, and early “interception” steps to lower the chance that cancer will develop or be found later. It is for people with genetic risk, past cancer treatment exposures, strong family history, or certain early pre-cancer or high-risk conditions.
Boston, MassachusettsAges Any age
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 923 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.