Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 922 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06690320Enrolling by invitation
Education program for women at high risk of breast cancer
This trial tests whether a planned education program can improve health beliefs and reduce fatalism in women who are at high risk for breast cancer. If you are 30 or older and have a high breast cancer risk score, this study may help you feel more in control of your health.
Bornova, İzmirAges 30 years+ - NCT07537400RecruitingPhase 2
Naxitamab plus standard therapy for newly diagnosed high-risk neuroblastoma
This study tests adding two medications (naxitamab and GM-CSF) to standard chemotherapy for children and young adults with newly diagnosed high-risk neuroblastoma, a cancer of nerve cells. The goal is to help the body's immune system fight the cancer more effectively.
JerusalemAges 1–21 - NCT03630991RecruitingPhase 1
Calcium chelator medicine for AML or MDS during chemotherapy
This Phase 1 study tests whether edetate calcium disodium (also called succimer) can be safely given to people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) while they are on chemotherapy. The goal is to learn the safest dose and whether it has signs of helping the blood cancer respond to treatment.
Houston, TexasAges 1 year+ - NCT00801489RecruitingPhase 2
New treatment for AML or high-risk MDS using combination chemo
This trial tests a combination treatment (chemo drugs plus a growth-factor medicine) for people newly diagnosed with acute myeloid leukemia (AML) or certain high-risk myelodysplastic syndromes (MDS). It may help by targeting cancer cells in the blood and bone marrow and improving remission chances.
Houston, TexasAges 18 years+ - NCT04394663Recruiting
High-dose omeprazole by mouth for serious ulcer bleeding
This trial tests whether taking a high dose of omeprazole by mouth can help control bleeding from a peptic ulcer that looks high-risk on endoscopy. It may be aimed at lowering the chance of bleeding again after your procedure.
Pathum Wan, BangkokAges 18 years+ - NCT07596147Recruiting
Early Movement Training for At-Risk Infants
This trial tests an early intervention program called SAFE for babies aged 3–12 months who had complications at birth or were born prematurely. The goal is to help their brain and movement development through specialized therapy.
Ankara, AnkaraAges 3 months–1 year - NCT06607692RecruitingPhase 1/Phase 2
LuPARPed: Targeted radiation plus olaparib for certain childhood cancers
This trial tests a combination of a radioactive drug (Lutathera) and a targeted pill (olaparib) for children and teens whose solid tumors have come back or not responded to treatment and show high levels of a specific receptor (SSTR) on scans. The goal is to see if this two-drug approach can shrink tumors or stop them from growing.
Boadilla del Monte, MadridAges 3 years+ - NCT07844850Recruiting
Blood tests to predict silent strokes after heart procedures
This study looks at whether certain blood tests can help predict if small, silent strokes occur in the brain during heart or blood vessel procedures that carry a higher risk of clots. The goal is to better identify who might need extra protection during these procedures.
ThessalonikiAges 18 years+ - NCT03417336Recruiting
Radiation for prostate cancer using smaller, targeted doses
This trial studies a specific radiation schedule for prostate cancer (with an extra “boost” dose) and checks whether it works well and is tolerable. It may help people with higher-risk, localized prostate cancer by aiming at the cancer while limiting side effects to surrounding tissues.
DijonAges 18–85 - NCT05408897Recruiting
Blood test to predict risk after surgery for high-risk GIST
This study uses a “liquid biopsy” blood test to look for leftover cancer signals after surgery. It aims to predict how well treatment will work and how likely the cancer is to come back in people with high-risk GIST.
Beijing, Beijing MunicipalityAges Any age - NCT07801664RecruitingPhase 2
Short course hormone therapy for prostate cancer
This trial tests a short course of hormone therapy (androgen deprivation therapy) for men with a certain type of prostate cancer that is considered high-risk. The goal is to see if a shorter treatment period can still control the cancer while reducing side effects.
New York, New YorkAges 18 years+ - NCT06685289RecruitingPhase 2
Donafenib and capecitabine after surgery for biliary cancer with high risk of return
This trial tests whether taking donafenib and capecitabine pills after surgery can help prevent biliary cancer from coming back in people who have a high risk of recurrence. It is for patients whose cancer was completely removed but had certain features that make recurrence more likely.
Nanjing, JiangsuAges 18–75 - NCT07393867RecruitingPhase 2
PSMA-guided radiation boost for prostate cancer
This trial tests a special type of radiation therapy (SBRT) that delivers a higher dose directly to the main tumor in your prostate, guided by a PSMA PET scan. It aims to improve cancer control while limiting side effects.
Boston, MassachusettsAges 18 years+ - NCT07030881Recruiting
Spacer use in older adults with COPD or asthma on triple therapy
This trial tests whether using a spacer with your inhaler can lower the risk of serious flare-ups for people over 65 who have COPD or asthma and are already on triple therapy.
Hefei, AnhuiAges 65 years+ - NCT07575438RecruitingPhase 2
Fish oil types for reducing diabetes risk
This study tests whether different types of fish oil can improve blood sugar and cholesterol levels in people at high risk for type 2 diabetes. The goal is to see if one type of fish oil is better at reducing diabetes risk.
Montreal, QuebecAges 40–70 - NCT06449781RecruitingPhase 2
177Lu-PSMA after surgery or radiation for high-risk prostate cancer
This study tests a new treatment called 177Lu-PSMA given after standard therapy (surgery or radiation) to see if it can prevent prostate cancer from coming back. It is for patients with high or very high-risk prostate cancer that hasn't spread yet.
GliwiceAges 18 years+ - NCT04184505RecruitingPhase 3
Testing stem cell transplant in higher-risk myelodysplastic syndrome
This Phase 3 trial tests whether doing an “allogeneic” stem cell transplant works best for people newly diagnosed with higher-risk MDS (a bone marrow disorder). It’s mainly for patients who are healthy enough to receive a transplant and haven’t started MDS treatment yet.
AlessandriaAges 18–70 - NCT05968560Recruiting
Online therapy to help youth at risk for psychosis
This trial tests a telehealth (video/phone) version of cognitive behavioral therapy to help young people who are at risk for developing psychosis. It may help by teaching skills to reduce symptoms and improve coping, with support from a key family or close person.
New York, New YorkAges 14–25 - NCT04402151RecruitingPhase 2
PSMA scan–guided targeted radiation for higher-risk prostate cancer
This trial uses a special PET/MR scan to help doctors aim stereotactic radiation more precisely for certain higher-risk or unfavorable intermediate prostate cancers. It studies whether this targeted approach can safely treat the prostate (and specific areas needing extra treatment) without spreading to the body.
New York, New YorkAges 21–90 - NCT07028463Recruiting
Awareness and resources for fall risk in older ED patients
This study tests a program in the emergency department that helps older adults at risk for falls get connected to resources and support after they go home.
Aurora, ColoradoAges 65 years+ - NCT06946732Recruiting
Acostream for high-risk and intermediate-risk pulmonary embolism
This trial is testing a device (called the Acostream) to break up blood clots in the lungs for people with serious pulmonary embolism who cannot receive standard clot-busting drugs or surgery. It may be an option if you have high-risk or intermediate-risk PE and are between 18 and 85.
Shanghai, Shanghai MunicipalityAges 18–85 - NCT07804420Recruiting
Personalized blood pressure prevention for high-risk adults
This study tests a program that uses a health app to estimate your risk of developing high blood pressure and then gives personalized advice to help lower that risk. You must live in Shunyi District, be between 35 and 65, and not have high blood pressure currently.
Beijing, Beijing MunicipalityAges 35–65 - NCT07783061Recruiting
Study on alcohol reduction to improve heart health
This study tests whether reducing alcohol intake can help lower blood pressure and reduce heart risks in adults who drink above recommended limits. Participants will receive support to cut back on drinking and will be monitored for changes in blood pressure and heart health.
Arlington, TexasAges 26–49 - NCT07614958RecruitingPhase 3
Testing a new cholesterol medicine against bempedoic acid
This study compares two new medicines—obicetrapib and bempedoic acid—to see which one better lowers cholesterol in people whose cholesterol remains high despite taking standard medications. If your cholesterol isn't controlled well enough with current drugs, this trial may help you access an experimental treatment.
Stockton-on-TeesAges 18 years+
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 922 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.