Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 922 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06857539Recruiting
Assessing thinking and movement in high-risk infants
This study looks at how high-risk infants (especially those born early or with brain concerns) develop their thinking and movement skills over time, comparing them to healthy babies. The goal is to better understand and support their development.
CorkAges birth–4 months - NCT07723703RecruitingPhase 1
Study of a new drug for acute myeloid leukemia and related blood cancer
This trial is testing a new medicine called AMX-883 for people with a type of blood cancer called acute myeloid leukemia (AML) or a high-risk blood disorder called myelodysplastic syndrome (MDS) that has come back or not responded to other treatments. The study hopes to see if the drug is safe and works, either alone or combined with another drug.
Fairfax, VirginiaAges 18 years+ - NCT03541928RecruitingPhase 2
Gene therapy with standard treatment for high-risk prostate cancer
This trial combines gene therapy with hormone therapy, radiation, and possibly surgery to treat high-risk prostate cancer. It aims to improve outcomes by adding gene therapy to standard treatments and will require additional biopsies.
Houston, TexasAges 18 years+ - NCT06378242RecruitingPhase 1/Phase 2
Testing a bladder cancer drug for high-risk NMIBC patients
This trial tests a drug called Disitamab Vedotin, given directly into the bladder, for a type of early bladder cancer (high-risk NMIBC) that has a protein called HER2. It aims to see if this treatment can help avoid more radical surgery.
Guangzhou, GuangdongAges 18–75 - NCT07669220RecruitingPhase 2
Short radiation, immunotherapy, and chemo for advanced rectal cancer
This trial compares a new treatment approach—short-course radiation followed by an immunotherapy drug (PD-1 inhibitor) and chemotherapy (FOLFOX)—to the standard long-course chemoradiation for people with a specific type of advanced rectal cancer that is pMMR/MSS. The goal is to see if the shorter treatment works as well or better.
GuangzhouAges 18–75 - NCT06409702RecruitingPhase 4
Treating high-risk multiple myeloma with MRD testing
This trial tests a treatment plan for people with newly diagnosed high-risk multiple myeloma. It uses a special test called minimal residual disease (MRD) detection to see how well the treatment is working and guide next steps.
Suzhou, JiangsuAges 18 years+ - NCT06279793RecruitingPhase 2
Fish oil for recovery after high-risk heart surgery
This trial tests if giving fish oil through a vein before and after heart surgery can help patients recover faster. It is for people who have a high risk of complications during surgery.
AugsburgAges 18 years+ - NCT07358715Recruiting
Liquid biopsy to improve lung cancer screening
This study tests whether a simple blood test (liquid biopsy) can help find lung cancer earlier in people at high risk. It also includes people already diagnosed with lung cancer to refine the test.
SingaporeAges 21–75 - NCT06275568Recruiting
Healthy food support for high-risk pregnant women
This trial tests a program that helps pregnant women at high risk get healthy food. It uses a special card from a partner (About Fresh) to make it easier to eat well during pregnancy.
Houston, TexasAges 18 years+ - NCT04891068RecruitingPhase 2
Pre-surgery low-dose azacitidine for high-risk early breast cancer
This trial studies whether giving a low dose of azacitidine before surgery can shrink or control high-risk early breast cancer. It’s meant for adults whose cancer has not yet spread to distant organs.
Chicago, IllinoisAges 18 years+ - NCT07559071Recruiting
Emotional Freedom and Music Therapy for High-Risk Pregnancy
This study tests whether emotional freedom technique (a tapping-based stress-relief method) and music therapy can help reduce anxiety in pregnant women diagnosed with preterm premature rupture of membranes (PPROM)—a condition where the amniotic sac breaks early. The goal is to see if these therapies improve emotional well-being during a stressful pregnancy situation.
Konya, KonyaAges 18 years+ - NCT06681363Recruiting
Leukemia and MDS biobank study at Nantes Hospital
This trial creates a biobank of blood or bone marrow samples from patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or high-risk myelodysplastic syndrome (MDS). It aims to collect samples for future research, which may help develop better treatments.
NantesAges 18 years+ - NCT07146074Recruiting
Early radiation vs. observation for high-risk bone metastases
This trial tests whether giving radiation therapy early to high-risk but pain-free or nearly pain-free bone metastases can prevent future problems, compared to waiting and monitoring them. It is for people whose cancer has spread to multiple bones and who have certain risky features in those spots.
Wilrijk, AntwerpAges 18 years+ - NCT07468851RecruitingPhase 1/Phase 2
Study of HS-10566 for high-risk bladder cancer that hasn't spread into muscle
This study tests a new treatment called HS-10566 for people with a type of bladder cancer that has not reached the muscle layer and is considered high-risk, where the usual treatments have not worked or were not an option. It aims to control the cancer and avoid the need for removing the bladder.
BeijingAges 18 years+ - NCT06758882RecruitingPhase 2
Surgery with or without apalutamide for high-risk prostate cancer that has spread a little
This trial tests whether adding the drug apalutamide before and after surgery helps men with high-risk prostate cancer that has spread to a few spots (seen on a special PET scan). You would also receive standard hormone therapy.
Torino, ToAges 18–80 - NCT06746714Recruiting
Preventing low blood sugar in high-risk type 2 diabetes
This study tests a program to help people with type 2 diabetes who are at high risk for low blood sugar (hypoglycemia) avoid dangerous drops. It may help you better manage your blood sugar and reduce worrying episodes.
Pleasanton, CaliforniaAges 18 years+ - NCT06762782RecruitingPhase 2
Lenvatinib after liver cancer surgery to prevent recurrence
This trial tests whether taking lenvatinib after liver cancer surgery can lower the chance of the cancer coming back. It is for people who have a high risk of recurrence and have recently had their liver tumor completely removed.
Nanjing, JiangsuAges 18–80 - NCT03500133RecruitingPhase 4
Low-dose chemotherapy and less radiation for childhood Hodgkin lymphoma
This trial studies a treatment plan for children with classical Hodgkin lymphoma that uses lower total doses of chemotherapy and reduced radiation. The goal is to help control the lymphoma while lowering long-term side effects.
Buenos Aires, Buenos Aires F.D.Ages 2–18 - NCT06279663Recruiting
Comparing bypass surgery vs stenting for high-risk heart attacks
This study compares two common treatments (bypass surgery vs. stenting) for people having a high-risk heart attack that involves blockages in multiple arteries. It aims to find which approach leads to better long-term outcomes.
Novosibirsk, Novosibirsk OblAges 18 years+ - NCT07071961RecruitingPhase 2
Treatment for colorectal cancer with signs of remaining disease after therapy
This trial tests a combination of two drugs, regorafenib and lorigerlimab, for people with colorectal cancer that has a positive blood test for cancer DNA after they have finished standard treatments. The goal is to see if this treatment can delay or prevent the cancer from coming back.
Houston, TexasAges 18 years+ - NCT06636682RecruitingPhase 2
Vaccine for men with high-risk prostate cancer after surgery
This trial tests a personalized vaccine (FK-PC101) given after prostate removal surgery for men with high-risk prostate cancer. It aims to see if the vaccine can help prevent the cancer from coming back without the need for additional hormone therapy or radiation.
Chicago, IllinoisAges Any age - NCT07120633Recruiting
CAR-T cell therapy plus BTK inhibitor for high-risk CLL/SLL
This trial tests a new approach for people newly diagnosed with high-risk CLL or SLL. It combines your own immune cells (CAR-T cells) with a targeted pill (BTK inhibitor) to try to attack the cancer more effectively. It may be an option if you have certain high-risk genetic features and haven't had prior chemotherapy.
Xuzhou, JiangsuAges 18 years+ - NCT06997913Enrolling by invitation
Immunotherapy and chemoradiation after bile duct cancer surgery
This trial tests whether combining immunotherapy with chemotherapy and radiation after surgery can help prevent bile duct cancer from coming back in people who have a high risk of recurrence.
XiAn, ShanxiAges 18–70 - NCT07109323RecruitingPhase 1/Phase 2
Stem cell transplant plus CAR-T for aggressive myeloma
This trial tests combining a stem cell transplant with a special immune cell therapy (BCMA CAR-T) to treat very aggressive multiple myeloma. The goal is to see if this powerful one-two punch can help people whose myeloma is hard to control.
Tianjin, Tianjin MunicipalityAges 18–70
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 922 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.