Clinical trials
High Risk clinical trials
Below are recruiting high risk clinical trials, each written for real people, not researchers. We’re tracking 923 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07358715Recruiting
Liquid biopsy to improve lung cancer screening
This study tests whether a simple blood test (liquid biopsy) can help find lung cancer earlier in people at high risk. It also includes people already diagnosed with lung cancer to refine the test.
SingaporeAges 21–75 - NCT06681363Recruiting
Leukemia and MDS biobank study at Nantes Hospital
This trial creates a biobank of blood or bone marrow samples from patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or high-risk myelodysplastic syndrome (MDS). It aims to collect samples for future research, which may help develop better treatments.
NantesAges 18 years+ - NCT07146074Recruiting
Early radiation vs. observation for high-risk bone metastases
This trial tests whether giving radiation therapy early to high-risk but pain-free or nearly pain-free bone metastases can prevent future problems, compared to waiting and monitoring them. It is for people whose cancer has spread to multiple bones and who have certain risky features in those spots.
Wilrijk, AntwerpAges 18 years+ - NCT06518265Recruiting
Locked nail surgery for high-risk ankle fractures
This study looks at how well a special locking nail works for ankle fractures in patients with skin problems or injuries that make standard surgery risky. It aims to find out who benefits most from this less invasive method.
La TroncheAges 18–100 - NCT06758882RecruitingPhase 2
Surgery with or without apalutamide for high-risk prostate cancer that has spread a little
This trial tests whether adding the drug apalutamide before and after surgery helps men with high-risk prostate cancer that has spread to a few spots (seen on a special PET scan). You would also receive standard hormone therapy.
Torino, ToAges 18–80 - NCT06762782RecruitingPhase 2
Lenvatinib after liver cancer surgery to prevent recurrence
This trial tests whether taking lenvatinib after liver cancer surgery can lower the chance of the cancer coming back. It is for people who have a high risk of recurrence and have recently had their liver tumor completely removed.
Nanjing, JiangsuAges 18–80 - NCT03500133RecruitingPhase 4
Low-dose chemotherapy and less radiation for childhood Hodgkin lymphoma
This trial studies a treatment plan for children with classical Hodgkin lymphoma that uses lower total doses of chemotherapy and reduced radiation. The goal is to help control the lymphoma while lowering long-term side effects.
Buenos Aires, Buenos Aires F.D.Ages 2–18 - NCT06279663Recruiting
Comparing bypass surgery vs stenting for high-risk heart attacks
This study compares two common treatments (bypass surgery vs. stenting) for people having a high-risk heart attack that involves blockages in multiple arteries. It aims to find which approach leads to better long-term outcomes.
Novosibirsk, Novosibirsk OblAges 18 years+ - NCT07120633Recruiting
CAR-T cell therapy plus BTK inhibitor for high-risk CLL/SLL
This trial tests a new approach for people newly diagnosed with high-risk CLL or SLL. It combines your own immune cells (CAR-T cells) with a targeted pill (BTK inhibitor) to try to attack the cancer more effectively. It may be an option if you have certain high-risk genetic features and haven't had prior chemotherapy.
Xuzhou, JiangsuAges 18 years+ - NCT06636682RecruitingPhase 2
Vaccine for men with high-risk prostate cancer after surgery
This trial tests a personalized vaccine (FK-PC101) given after prostate removal surgery for men with high-risk prostate cancer. It aims to see if the vaccine can help prevent the cancer from coming back without the need for additional hormone therapy or radiation.
Chicago, IllinoisAges Any age - NCT06997913Enrolling by invitation
Immunotherapy and chemoradiation after bile duct cancer surgery
This trial tests whether combining immunotherapy with chemotherapy and radiation after surgery can help prevent bile duct cancer from coming back in people who have a high risk of recurrence.
XiAn, ShanxiAges 18–70 - NCT07109323RecruitingPhase 1/Phase 2
Stem cell transplant plus CAR-T for aggressive myeloma
This trial tests combining a stem cell transplant with a special immune cell therapy (BCMA CAR-T) to treat very aggressive multiple myeloma. The goal is to see if this powerful one-two punch can help people whose myeloma is hard to control.
Tianjin, Tianjin MunicipalityAges 18–70 - NCT06990737RecruitingPhase 2
Sentinel node biopsy for high-risk skin cancer of the head and neck
This trial is testing whether a procedure called sentinel lymph node biopsy (SLNB) can help manage high-risk skin cancer on the head and neck that has not spread to lymph nodes. It is for people whose skin cancer is considered high-risk due to features like size, depth, or location, and who are able to have surgery.
Sacramento, CaliforniaAges 18 years+ - NCT06690320Enrolling by invitation
Education program for women at high risk of breast cancer
This trial tests whether a planned education program can improve health beliefs and reduce fatalism in women who are at high risk for breast cancer. If you are 30 or older and have a high breast cancer risk score, this study may help you feel more in control of your health.
Bornova, İzmirAges 30 years+ - NCT03630991RecruitingPhase 1
Calcium chelator medicine for AML or MDS during chemotherapy
This Phase 1 study tests whether edetate calcium disodium (also called succimer) can be safely given to people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) while they are on chemotherapy. The goal is to learn the safest dose and whether it has signs of helping the blood cancer respond to treatment.
Houston, TexasAges 1 year+ - NCT00801489RecruitingPhase 2
New treatment for AML or high-risk MDS using combination chemo
This trial tests a combination treatment (chemo drugs plus a growth-factor medicine) for people newly diagnosed with acute myeloid leukemia (AML) or certain high-risk myelodysplastic syndromes (MDS). It may help by targeting cancer cells in the blood and bone marrow and improving remission chances.
Houston, TexasAges 18 years+ - NCT04394663Recruiting
High-dose omeprazole by mouth for serious ulcer bleeding
This trial tests whether taking a high dose of omeprazole by mouth can help control bleeding from a peptic ulcer that looks high-risk on endoscopy. It may be aimed at lowering the chance of bleeding again after your procedure.
Pathum Wan, BangkokAges 18 years+ - NCT06607692RecruitingPhase 1/Phase 2
LuPARPed: Targeted radiation plus olaparib for certain childhood cancers
This trial tests a combination of a radioactive drug (Lutathera) and a targeted pill (olaparib) for children and teens whose solid tumors have come back or not responded to treatment and show high levels of a specific receptor (SSTR) on scans. The goal is to see if this two-drug approach can shrink tumors or stop them from growing.
Boadilla del Monte, MadridAges 3 years+ - NCT07596147Recruiting
Early Movement Training for At-Risk Infants
This trial tests an early intervention program called SAFE for babies aged 3–12 months who had complications at birth or were born prematurely. The goal is to help their brain and movement development through specialized therapy.
Ankara, AnkaraAges 3 months–1 year - NCT03417336Recruiting
Radiation for prostate cancer using smaller, targeted doses
This trial studies a specific radiation schedule for prostate cancer (with an extra “boost” dose) and checks whether it works well and is tolerable. It may help people with higher-risk, localized prostate cancer by aiming at the cancer while limiting side effects to surrounding tissues.
DijonAges 18–85 - NCT06685289RecruitingPhase 2
Donafenib and capecitabine after surgery for biliary cancer with high risk of return
This trial tests whether taking donafenib and capecitabine pills after surgery can help prevent biliary cancer from coming back in people who have a high risk of recurrence. It is for patients whose cancer was completely removed but had certain features that make recurrence more likely.
Nanjing, JiangsuAges 18–75 - NCT05408897Recruiting
Blood test to predict risk after surgery for high-risk GIST
This study uses a “liquid biopsy” blood test to look for leftover cancer signals after surgery. It aims to predict how well treatment will work and how likely the cancer is to come back in people with high-risk GIST.
Beijing, Beijing MunicipalityAges Any age - NCT07030881Recruiting
Spacer use in older adults with COPD or asthma on triple therapy
This trial tests whether using a spacer with your inhaler can lower the risk of serious flare-ups for people over 65 who have COPD or asthma and are already on triple therapy.
Hefei, AnhuiAges 65 years+ - NCT07393867RecruitingPhase 2
PSMA-guided radiation boost for prostate cancer
This trial tests a special type of radiation therapy (SBRT) that delivers a higher dose directly to the main tumor in your prostate, guided by a PSMA PET scan. It aims to improve cancer control while limiting side effects.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for high risk?
- Yes. Clin2 currently lists 923 recruiting high risk studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high risk trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high risk trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.