Clinical trials
High blood pressure clinical trials
Persistently raised blood pressure, a major risk factor for heart disease and stroke. We’re tracking 990 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04624490RecruitingPhase 1
Lung function MRI using a special gas in volunteers
This Phase 1 study tests a lung scan that uses a special gas and MRI to measure how well your lungs work. It includes healthy volunteers and people with lung disease to see how well the scan works and how safe it is.
Kansas City, KansasAges 3 years+ - NCT04633356RecruitingPhase 1/Phase 2
Measuring pressure in the liver using an endoscopy device
This early-phase study tests a technique to measure blood pressure changes in people with cirrhosis (scarring of the liver). It may help doctors better understand liver circulation problems and guide safer treatment decisions.
Hong Kong, Hong KongAges 18–75 - NCT04647292RecruitingPhase 2
Intensive blood pressure lowering after stroke
This Phase 2 study tests whether aiming for a lower blood pressure targets after a stroke reduces the risk of future problems. You may be asked to measure your blood pressure at home and follow the study’s treatment plan.
DublinAges 40 years+ - NCT04669548Recruiting
Accuryn monitoring study for people having heart surgery
This registry collects information from patients who are monitored with the Accuryn system during heart surgery and their ICU stay. It helps researchers learn from the system’s signals to better understand patient care around cardiac procedures.
Los Angeles, CaliforniaAges 18 years+ - NCT04715568RecruitingPhase 4
Testing how smoke exposure affects heart health
This study looks at whether being exposed to secondhand tobacco smoke at work affects heart and blood vessel health. It may help researchers understand which people are at higher risk and how the body responds to that exposure.
San Francisco, CaliforniaAges 40 years+ - NCT04755153Recruiting
Community health program to lower heart disease risk
This trial tests a community-based health intervention in Chicago to help reduce the risk of cardiovascular (heart and blood vessel) disease. It may help people by offering structured support through local clinics or churches.
Chicago, IllinoisAges 18–89 - NCT04766866Recruiting
Check two blood markers to help prevent preeclampsia
This trial tests whether measuring two pregnancy blood markers (sFlt1 and PlGF) and planning delivery timing can help prevent preeclampsia as you reach term. It may help reduce risk for mother and baby by guiding when to deliver based on test results.
LiègeAges 18 years+ - NCT04832009RecruitingEarly Phase 1
Test a way to improve blood vessel function with lifestyle
This early-phase study looks at whether a treatment can help reverse problems in blood vessels caused by high glucose (sugar) and blood fat signals. It may be a fit if you are generally healthy, have normal insulin and sugar levels, and have a stable weight.
Kansas City, KansasAges 18–79 - NCT04835857Recruiting
Testing a cuff-less wrist monitor versus a regular blood pressure cuff
This study compares a cuff-less wrist blood pressure device to the usual arm cuff. You may be able to help test whether the wrist device reads blood pressure accurately and safely.
Newton, MassachusettsAges 18–90 - NCT04901884Recruiting
PET/MR scans before and after radiation for heart-lung effects
This study uses special PET/MR imaging before and after radiation treatment to better understand how radiation may affect the heart and lungs. It may help researchers find ways to predict and monitor these side effects using imaging and blood tests.
Toronto, OntarioAges 18 years+ - NCT04911491Recruiting
Breathing muscle training for people with kidney disease
This study tests whether training your breathing muscles can improve health in people with chronic kidney disease (stage 3–4). It may help how your body handles daily activity and circulation-related measurements, compared with usual care.
Aurora, ColoradoAges 50 years+ - NCT04943926Recruiting
Diet changes to help put type 2 diabetes into remission
This study tests whether specific dietary strategies can help people with type 2 diabetes reach remission (better blood sugar without ongoing high medication needs). You may be a good candidate if your diabetes is relatively recent, your weight is above a certain threshold, and your heart and other health conditions are stable.
Bergen, VestlandAges 24–70 - NCT04957329RecruitingPhase 4
Latanoprost eye drops: with or without preservative
This study compares two versions of latanoprost eye drops—one that contains a preservative and one that is preservative-free. It aims to see how each version affects the eye’s “goblet cells,” which help keep the eye surface healthy.
Glostrup Municipality, DanmarkAges 18 years+ - NCT04967989RecruitingPhase 3
Laser eye treatment timing for certain glaucoma or eye pressure
This Phase 3 study tests how best to use a laser treatment (SLT) for people with high eye pressure or mild-to-moderate primary open-angle glaucoma. It aims to find the best way to lower eye pressure and protect vision while comparing treatment approaches.
Laguna Hills, CaliforniaAges 18 years+ - NCT04971720RecruitingPhase 2/Phase 3
Personalized blood pressure timing therapy for some adults
This trial tests whether timing blood pressure medications (based on your natural daily body rhythms) can improve blood pressure control. It’s designed for adults with moderately high blood pressure and focuses on who may benefit from a more precise schedule.
Birmingham, AlabamaAges 18 years+ - NCT04993612Recruiting
Blood test during heart procedure from a wedge position
This study checks whether measuring blood gases from a specific heart “wedge” position during a right heart catheter test gives useful information. It may help doctors understand how blood and oxygen are doing in certain heart and lung conditions.
AachenAges 18–99 - NCT05000515Recruiting
Breathing muscle training to lower blood pressure in postmenopause
This study compares a breathing-based exercise program with regular aerobic exercise to help lower blood pressure and improve blood vessel function in postmenopausal women. It’s mainly for people with mildly elevated resting blood pressure who are not already doing very intense workouts.
Boulder, ColoradoAges 50 years+ - NCT05000996Recruiting
Gut microbiome study for people having metabolic surgery
This study looks at your gut bacteria (your “microbiome”) around the time of metabolic surgery. It may help researchers understand how surgery affects gut health and related conditions like diabetes, blood pressure, and cholesterol.
Nashville, TennesseeAges 21–65 - NCT05009433Recruiting
Exercise plans in pregnancy and afterward for mom and baby health
This study compares two types of exercise—short, intense intervals versus moderate steady activity—during pregnancy and looks at effects on mothers and children. It also checks how participants do on health, fitness, and well-being tests before, during, and after pregnancy.
Gdansk, Pomeranian VoivodeshipAges 18–45 - NCT05027685Recruiting
Registry for people getting renal nerve ultrasound treatment
This registry follows people who may receive—or recently received—renal denervation using the Paradise ultrasound system. It collects real-world information to help understand safety and effectiveness over time.
ViennaAges 18 years+ - NCT05030545RecruitingPhase 4
PET/CT study of spironolactone or eplerenone in primary aldosteronism
This study looks at how primary aldosteronism affects the heart and blood vessels, and whether blocking its hormone signal (with spironolactone or eplerenone) changes those findings on imaging tests. It is small and focuses on people with confirmed or suspected primary aldosteronism who are being followed for heart health.
Boston, MassachusettsAges 18–85 - NCT05030987Recruiting
Renal denervation for heart failure with preserved heart strength
This trial studies whether a procedure that calms overactive kidney nerves (renal denervation) can improve symptoms and heart function in people with heart failure with preserved ejection fraction. It also checks that the kidney arteries are suitable and that your blood pressure and heart pressure measurements meet the study targets.
Halle, Saxony-AnhaltAges 18–80 - NCT05050864Recruiting
Stent versus brain-surgery options for idiopathic pressure
This study compares two treatment approaches for idiopathic intracranial hypertension (high pressure in the brain) that has not improved with usual medical treatment. It may help doctors learn which option works better and is safer for people with specific scan and eye findings.
Paris, ParisAges 18 years+ - NCT05067231Recruiting
UAB heart research biobank for adults 18 and older
This study builds a heart-focused research database by enrolling adults who are willing to provide information and/or samples for future cardiovascular research. It may help researchers study heart disease and develop better treatments over time.
Birmingham, AlabamaAges 18 years+
Hear when a new High blood pressure trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for high blood pressure?
- Yes. Clin2 currently lists 990 recruiting high blood pressure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high blood pressure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.