Clinical trials
Hypofractionation clinical trials
Below are recruiting hypofractionation clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03646617RecruitingPhase 2
Testing immunotherapy with or without targeted radiation for melanoma
This trial studies whether combining two immunotherapy medicines (ipilimumab and nivolumab) works better with targeted radiation for metastatic melanoma that has specific treatable spots. It may help shrink tumors and improve control of the disease, depending on your individual situation.
Lancaster, PennsylvaniaAges 18 years+ - NCT03742687Recruiting
Testing a shorter, stronger radiation schedule for lung cancer
This trial studies a different way to deliver radiation to people with locally advanced, non-operable non-small cell lung cancer. It may help by aiming to treat the tumor effectively with a different radiation timing and dose pattern.
AarhusAges 18 years+ - NCT03829553RecruitingPhase 3
Radiation to breast lymph nodes versus standard breast cancer care
This Phase 3 trial tests whether a shorter, more focused radiation treatment to the regional lymph nodes works as well as the current standard approach for certain breast cancers. It may help patients by potentially improving treatment efficiency while keeping cancer control effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT03856372Recruiting
Shorter radiation schedule after mastectomy for high-risk breast cancer
This trial compares a shorter radiation plan to a standard longer plan after mastectomy for people considered high risk. It may help reduce treatment time while still trying to prevent breast-cancer recurrence.
Suzhou, JiangsuAges 18–75 - NCT03920033Recruiting
Radiation schedule for prostate cancer PSA relapse after surgery
This trial compares two different radiation schedules to treat prostate cancer that returned based on rising PSA blood tests after prostatectomy (prostate removal). If you qualify, it may help you and your team choose a radiation approach with the goal of controlling PSA relapse.
SeoulAges 20 years+ - NCT04025164Recruiting
Shorter vs standard breast radiation after lumpectomy
This study compares a shorter course of radiation to a standard longer course after breast-conserving surgery (lumpectomy). It’s meant to see which schedule works just as well while focusing on safety and cancer control.
Guiyang, GuizhouAges 18–70 - NCT04083937Recruiting
Radiation after prostate surgery for men with prostate cancer
This study looks at different radiation approaches after prostate surgery to see which strategy works best. You may be able to join if your cancer is at a stage where radiation to the prostate bed is planned, and you have not had prior radiation.
HeidelbergAges 18 years+ - NCT04278118Recruiting
Proton radiation study for non-cancer brain tumor types
This trial tests a radiation plan that gives treatment in fewer, larger “fractions” using proton beams (or sometimes photon beams) for certain non-cancer brain tumor types. It aims to see how well this approach works while keeping side effects manageable.
Atlanta, GeorgiaAges 18 years+ - NCT04430452RecruitingPhase 2
Durvalumab with or without tremelimumab after liver radiation
This study tests whether the immunotherapy drugs durvalumab (with or without tremelimumab) can help control hepatocellular carcinoma (liver cancer) after you receive palliative, targeted radiation. It especially focuses on people whose cancer continued to grow after, or without, certain prior immune therapies.
San Francisco, CaliforniaAges 18 years+ - NCT04472845Recruiting
Shorter or longer breast radiation after surgery for high-risk cancer
This trial compares two schedules of radiation after breast surgery in people with high-risk, node-positive breast cancer. The goal is to see whether giving radiation in 1 week or 2 weeks works well and is safe after standard treatments.
ChandigarhAges 18 years+ - NCT04636008RecruitingPhase 1/Phase 2
Immunotherapy with radiation for MSI-H or dMMR rectal cancer
This trial tests the drug sintilimab combined with a specific radiation schedule to treat rectal cancer that is MSI-H or dMMR (tumor DNA repair/instability markers). It may help shrink the tumor and improve outcomes when standard options are limited or not yet started.
Chengdu, SichuanAges 18 years+ - NCT04642027RecruitingPhase 3
PSMA scan-guided salvage radiation after prostate surgery
This trial tests whether using a specialized PSMA PET scan to guide radiation can better treat prostate cancer that returns after prostate surgery. It targets the “prostate bed” area with a shorter, stronger radiation schedule (hypofractionated) to control rising PSA levels.
Arnhem, GelderlandAges 18–80 - NCT04669873Recruiting
Partial breast radiation vs whole breast radiation after lumpectomy
This trial studies whether treating only part of the breast with radiation works as well as treating the whole breast in people with early breast cancer after lumpectomy. It may help reduce radiation exposure to healthy tissue, while still controlling the cancer.
São Paulo, São PauloAges 50–90 - NCT04683653RecruitingPhase 1/Phase 2
Pelvic radiation test for uterine or cervical cancer
This trial studies a specific radiation schedule aimed at the pelvis (lower belly area) for uterine or cervical cancer. It looks at whether this “hypofractionated” approach can control cancer while limiting side effects, especially in patients whose disease has not spread to distant organs.
Atlanta, GeorgiaAges 18 years+ - NCT04699773Recruiting
Laser treatment then focused radiation for new brain gliomas
This trial studies a two-step treatment for newly diagnosed high-grade glioma: first laser treatment (LITT) to target the tumor, followed by a shorter, more focused course of radiation. It may help shrink or control the tumor while limiting treatment time.
Baltimore, MarylandAges 18 years+ - NCT04805255Recruiting
Study brain-targeted radiation for limited brain metastases
This study looks at people with a small number of brain metastases who are treated with a focused, staged form of radiation after surgery or to treat the cancer. It may help doctors better understand how well this approach works and who benefits most.
TaoyuanAges 18–84 - NCT05038332RecruitingPhase 2
Testing two types of radiation after prostate surgery
This Phase 2 study compares two schedules of radiation treatment after prostate surgery in men whose PSA starts rising again. It aims to see which radiation approach works well while tracking quality of life and safety.
Ann Arbor, MichiganAges 18 years+ - NCT05102747Recruiting
Surgery-like brain radiation for up to 5 metastases
This trial compares two ways of giving focused radiation to the brain for people with a limited number of brain metastases. It aims to see which schedule works best (and is likely best for costs and quality of life).
BordeauxAges 18 years+ - NCT05313815Recruiting
Test a stronger prostate radiation boost for high-risk prostate cancer
This trial studies whether giving a moderate “boost” dose of radiation to the prostate—along with radiation to the pelvic area—can better control high-risk localized prostate cancer. You may benefit if you have high-risk disease and can safely receive radiation.
Toronto, OntarioAges 18 years+ - NCT05370144Recruiting
Pre-surgery chemotherapy and radiation for esophagus cancer
This study tests a new pre-surgery treatment plan that combines chemotherapy with focused, shorter-course radiation for esophagus or stomach-where-it-meets-the-esophagus (GEJ) adenocarcinoma. The goal is to shrink the tumor before surgery and improve treatment outcomes.
Calgary, AlbertaAges 18–80 - NCT05439278RecruitingPhase 3
Radiation schedules plus temozolomide for elderly glioblastoma
This study compares a standard radiation schedule versus a shorter, higher-dose radiation schedule, both with the chemotherapy medicine temozolomide, in older adults with newly diagnosed glioblastoma. It aims to see which approach works better and is practical for people age 70 and older.
SeoulAges 70 years+ - NCT05491395Recruiting
Radiation after mastectomy with breast implant reconstruction
This trial studies a radiation schedule given after breast cancer surgery when your breast was rebuilt right away with a prosthesis (implant or similar). It aims to see whether this “hypofractionated” (fewer, larger treatment sessions) radiation approach is appropriate for patients who need additional (adjuvant) radiation to reduce recurrence risk.
Barretos, São PauloAges 18 years+ - NCT05545007Recruiting
Pre-op vs post-op focused radiation for large brain metastases
This study compares giving focused, high-dose radiation before surgery versus after surgery for people with large brain metastases. The goal is to see which timing works best to control the tumors and help neurological outcomes.
Brescia, BresciaAges 18 years+ - NCT05692674RecruitingPhase 2
Proton radiation after breast surgery with implant reconstruction
This trial studies a type of radiation made with proton beams given after mastectomy and implant reconstruction to lower breast cancer coming back. It’s for people who need additional (adjuvant) radiation and have not had prior radiation to the chest or breast.
Shanghai, Shanghai MunicipalityAges 18–80
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Common questions
- Are there clinical trials for hypofractionation?
- Yes. Clin2 currently lists 181 recruiting hypofractionation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypofractionation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypofractionation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.