Clinical trials
Hypofractionation clinical trials
Below are recruiting hypofractionation clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05774678RecruitingPhase 3
Pre-surgery radiation options for invasive breast cancer
This trial compares two schedules of radiation given before mastectomy to see which works better for invasive breast cancer, followed by immediate breast reconstruction. It also studies tiny “biomarker” signals in tissue to learn why one radiation approach may help more.
Houston, TexasAges 18 years+ - NCT05794035Recruiting
Shorter radiation after skin cancer surgery for older adults
This study looks at whether giving a shorter course of radiation after surgery can help prevent skin cancer from coming back in people age 70 and older. It focuses on higher-risk skin cancers and checks how well the treatment works and what side effects occur.
CréteilAges 70 years+ - NCT05857631Recruiting
After-surgery radiation schedule for cervical or uterine cancers
This trial studies a shorter, focused radiation schedule given after surgery for certain higher-risk cervical or endometrial (uterine) cancers. It may help reduce cancer recurrence while checking side effects in the bladder and bowel area.
Navi Mumbai, MaharahstraAges 18–80 - NCT05861245Recruiting
Proton radiation in 5 or 25 treatments for skull-base tumors
This trial tests a radiation plan using protons given in either 5 or 25 sessions for chordoma or chondrosarcoma at the skull base. The goal is to shrink or control the tumor while protecting nearby critical nerves and brain structures.
Madrid, MadridAges 18 years+ - NCT05917301Recruiting
Pre-surgery proton radiation for soft tissue sarcoma
This trial studies a shorter-course proton radiation plan given before surgery for certain soft tissue sarcomas. The goal is to treat the tumor locally while helping surgery be safer or more effective.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06022159RecruitingPhase 2
Short radiation therapy for older adults with sarcoma
This trial tests a shorter, more convenient radiation schedule (hypofractionated) for older or fragile adults with soft tissue sarcoma in a limb or trunk. It aims to see if this approach is safe and effective before surgery.
BordeauxAges 65 years+ - NCT06160206RecruitingPhase 2
Study of retifanlimab, bevacizumab, and radiation for recurrent glioblastoma
This trial tests a combination of immunotherapy (retifanlimab), a targeted drug (bevacizumab), and low-dose radiation for people whose glioblastoma has come back. The goal is to see if this treatment can help shrink or slow the tumor.
Scottsdale, ArizonaAges 18 years+ - NCT06205316RecruitingPhase 3
Radiation therapy for returning or limited-spread prostate cancer
This trial compares two types of radiation therapy for prostate cancer that has come back or spread to a few places after surgery. The goal is to see which radiation schedule works better with fewer side effects.
Scottsdale, ArizonaAges 18 years+ - NCT06321653Recruiting
Lymphedema after radiation for early breast cancer with 1-2 positive nodes
This trial aims to see if a shorter course of radiation after breast-conserving surgery affects arm swelling (lymphedema) in people with early breast cancer that has spread to 1 or 2 nearby lymph nodes. The goal is to learn if this approach is safe and effective.
MilanAges 18 years+ - NCT06331013Recruiting
CyberKnife Radiation for Prostate Cancer
This trial tests a high-precision radiation treatment (CyberKnife SBRT) for prostate cancer that is still within the prostate. It aims to see if a very short course of radiation works well with fewer side effects.
MilanAges 18–80 - NCT06349044Recruiting
Radiation and immunotherapy with or without probiotics for advanced digestive cancers
This trial tests if adding a probiotic (Lactobacillus rhamnosus M9) to standard radiation and immunotherapy can help people with advanced digestive system cancers. It aims to see if the combination is more effective and safer than the standard approach alone.
Hangzhou, ZhejiangAges 18–75 - NCT06389422RecruitingPhase 2
Radiation plus Keytruda for liver cancer with vein clots
This trial tests a combination of moderate-dose radiation therapy and the immunotherapy drug pembrolizumab (Keytruda) for liver cancer that has spread into the main veins of the liver. It aims to see if this combination can shrink tumors and improve survival.
Beijing, Beijing MunicipalityAges 18–90 - NCT06435260RecruitingPhase 2
Short radiation, chemo, and immunotherapy before pancreas cancer surgery
This trial tests a short course of radiation combined with chemo and the immunotherapy drug camrelizumab before surgery for pancreatic cancer. It aims to shrink tumor to make removal easier and improve outcomes.
Shijiazhuang, HebeiAges 18–75 - NCT06509724RecruitingPhase 3
Comparing standard vs. shorter radiation after hysterectomy for cervical cancer
This trial tests two different radiation schedules for women with high-risk cervical cancer after surgery. The goal is to see if a shorter course of radiation works as well as or better than the standard longer course, while possibly being more convenient.
Seoul, Gangnam-guAges 20–75 - NCT06527898RecruitingPhase 1/Phase 2
Short-course radiation plus immunotherapy for limited-stage small-cell lung cancer
This study tests using a shorter course of radiation (hypofractionated radiotherapy) combined with immunotherapy for people with limited-stage small-cell lung cancer. The goal is to see if this approach works better at controlling the cancer and may cause fewer side effects.
Hefei, AnhuiAges 18–70 - NCT06557512Recruiting
Targeted radiation after surgery for aggressive or recurring meningioma
This trial tests a precise, low-dose radiation treatment (hypofractionated stereotactic radiosurgery) given after surgery for certain high-risk or returning meningiomas. It aims to lower the chance of the tumor coming back with fewer side effects.
San Francisco, CaliforniaAges 18 years+ - NCT06568705RecruitingPhase 2
Shorter adaptive radiation for early breast cancer
This trial tests a shorter, more targeted course of daily radiation for early-stage breast cancer. The radiation plan is adjusted each day to better fit your body, which may reduce side effects.
BeijingAges 35–70 - NCT06591819RecruitingPhase 2
Shorter pelvic radiation with HDR boost for prostate cancer
This trial tests a shorter course of radiation therapy (hypofractionated whole-pelvis radiation) combined with a high-dose-rate (HDR) brachytherapy boost for men with high-risk or unfavorable intermediate-risk prostate cancer. The goal is to see if this approach controls cancer while possibly reducing side effects.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06635980RecruitingPhase 2
Radiation before or after breast cancer surgery
This trial compares two ways of giving radiation for breast cancer that has not spread: before or after surgery. It aims to see if giving radiation first might work as well or better.
Scottsdale, ArizonaAges 18 years+ - NCT06641635RecruitingPhase 3
Shorter radiation schedule with adaptive planning for cervical cancer
This trial tests a shorter, personalized radiation schedule for cervical cancer. It uses daily CT scans to adjust the radiation beam for better targeting. It may mean fewer hospital visits and less damage to healthy tissue.
BeijingAges 18–75 - NCT06692062Recruiting
Hypofractionated radiation for thymoma and thymic carcinoma
This trial tests a shorter course of radiation (hypofractionated radiotherapy) for people with thymoma or thymic carcinoma. It aims to see if fewer, larger doses of radiation are safe and effective for treating these tumors.
Changsha, HunanAges 18–75 - NCT06740955Recruiting
Shorter radiation course for newly diagnosed glioblastoma
This trial tests a shorter, more intense course of radiation therapy (hypofractionated radiotherapy) for people with newly diagnosed glioblastoma who have had surgery. The goal is to see if this approach is safe and works well for treating the tumor.
Changchun, JilinAges 18–70 - NCT06796270Recruiting
Short-course radiation for nasopharyngeal cancer
This trial tests a shorter course of radiation therapy for people with nasopharyngeal cancer, a type of head and neck cancer. The goal is to see if a hypofractionated (fewer, larger doses) approach is safe and effective.
Haikou, HainanAges 18–75 - NCT06830083Recruiting
Shorter radiation schedule after mastectomy with implant reconstruction
This trial is testing a shorter, higher-dose radiation schedule (hypofractionation) for women who have had a mastectomy and immediate breast reconstruction with implants. The goal is to see if this approach works as well as standard radiation while possibly being more convenient and causing fewer side effects.
Nanjing, JiangsuAges 18–65
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Common questions
- Are there clinical trials for hypofractionation?
- Yes. Clin2 currently lists 181 recruiting hypofractionation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypofractionation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypofractionation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.