Clinical trials
Hypofractionation clinical trials
Below are recruiting hypofractionation clinical trials, each written for real people, not researchers. We’re tracking 175 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07527689Recruiting
Faster vs. Standard Radiation After Breast Cancer Surgery
This study compares two radiation schedules for breast cancer patients at high risk of cancer returning in lymph nodes. Both use modern radiation therapy, but one delivers treatment faster (ultra-hypofractionated) while the other uses a more moderate schedule. The goal is to see which approach works better with fewer side effects.
ShanghaiAges 18 years+ - NCT07135661Recruiting
Comparing two proton radiation schedules for early breast cancer after lumpectomy
This study compares two types of proton radiation after lumpectomy for early breast cancer. It tests whether a shorter, stronger course (ultra-hypofractionated) works as well as a slightly longer moderate course.
ShanghaiAges 40 years+ - NCT06559540RecruitingPhase 2
Compare short radiation courses for node-positive breast cancer
This study compares two shorter courses of radiation therapy for women with node-positive breast cancer. It aims to see if an ultra-short course is as safe and effective as the slightly longer short course.
St Louis, MissouriAges 18 years+ - NCT05665920Recruiting
Shorter radiation after breast surgery for certain node-positive cancer
This trial compares a shorter, more concentrated radiation schedule versus a standard shorter schedule after breast-conserving surgery. It looks at whether the treatment works well and is safe, especially for women whose lymph nodes also need radiation.
São Paulo, São PauloAges 18 years+ - NCT07500701RecruitingPhase 3
Comparing two radiation schedules for rising PSA after prostate surgery
This trial is testing two types of radiation therapy for men whose PSA level rises after prostate removal, but without clear signs of cancer spread on a PSMA PET scan. The goal is to see which radiation schedule works better to control the cancer.
Seoul, Gangnam-guAges 20 years+ - NCT07182565RecruitingPhase 1/Phase 2
Short radiation plus chemotheapy and immunotherapy before surgery for junction cancer
This trial tests a combination of shortened radiation therapy, immunotherapy, and chemotherapy given before surgery for cancer at the junction of the esophagus and stomach. The goal is to see if this approach is safe and improves outcomes.
Xiamen, FujianAges 18 years+ - NCT07116213Recruiting
Shorter radiation after surgery for high-risk endometrial cancer
This trial studies a new type of radiation therapy (called online adaptive radiotherapy) given in shorter, higher daily doses after surgery for high-risk endometrial cancer. The goal is to see if this approach is safe and effective for reducing side effects while still controlling the cancer.
Beijing, Beijing MunicipalityAges 18–70 - NCT07072351RecruitingPhase 1/Phase 2
Radiation plus chemoimmunotherapy for gastroesophageal junction cancer
This trial tests a shorter course of radiation combined with chemotherapy and immunotherapy to shrink gastroesophageal junction cancer before surgery. It aims to make the tumor removable and improve outcomes.
Xiamen, FujianAges 18 years+ - NCT06768125Enrolling by invitation
Shorter radiation therapy for head and neck cancer in older adults
This trial tests a shorter course of radiation therapy for patients aged 65 and older with head and neck cancer who cannot have surgery or standard radiation. The goal is to find an effective and more convenient treatment option.
Beijing, Beijing MunicipalityAges 65 years+ - NCT05224934Recruiting
Radiation before surgery for retroperitoneal soft-tissue sarcoma
This trial tests giving a shorter, lower-dose radiation treatment before surgery for a retroperitoneal (deep belly/back space) soft-tissue sarcoma. The goal is to shrink or control the tumor and make surgery more effective and safe.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04025164Recruiting
Shorter vs standard breast radiation after lumpectomy
This study compares a shorter course of radiation to a standard longer course after breast-conserving surgery (lumpectomy). It’s meant to see which schedule works just as well while focusing on safety and cancer control.
Guiyang, GuizhouAges 18–70 - NCT03920033Recruiting
Radiation schedule for prostate cancer PSA relapse after surgery
This trial compares two different radiation schedules to treat prostate cancer that returned based on rising PSA blood tests after prostatectomy (prostate removal). If you qualify, it may help you and your team choose a radiation approach with the goal of controlling PSA relapse.
SeoulAges 20 years+ - NCT04669873Recruiting
Partial breast radiation vs whole breast radiation after lumpectomy
This trial studies whether treating only part of the breast with radiation works as well as treating the whole breast in people with early breast cancer after lumpectomy. It may help reduce radiation exposure to healthy tissue, while still controlling the cancer.
São Paulo, São PauloAges 50–90 - NCT03829553RecruitingPhase 3
Radiation to breast lymph nodes versus standard breast cancer care
This Phase 3 trial tests whether a shorter, more focused radiation treatment to the regional lymph nodes works as well as the current standard approach for certain breast cancers. It may help patients by potentially improving treatment efficiency while keeping cancer control effective.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05491395Recruiting
Radiation after mastectomy with breast implant reconstruction
This trial studies a radiation schedule given after breast cancer surgery when your breast was rebuilt right away with a prosthesis (implant or similar). It aims to see whether this “hypofractionated” (fewer, larger treatment sessions) radiation approach is appropriate for patients who need additional (adjuvant) radiation to reduce recurrence risk.
Barretos, São PauloAges 18 years+ - NCT04472845Recruiting
Shorter or longer breast radiation after surgery for high-risk cancer
This trial compares two schedules of radiation after breast surgery in people with high-risk, node-positive breast cancer. The goal is to see whether giving radiation in 1 week or 2 weeks works well and is safe after standard treatments.
ChandigarhAges 18 years+ - NCT05692674RecruitingPhase 2
Proton radiation after breast surgery with implant reconstruction
This trial studies a type of radiation made with proton beams given after mastectomy and implant reconstruction to lower breast cancer coming back. It’s for people who need additional (adjuvant) radiation and have not had prior radiation to the chest or breast.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT04805255Recruiting
Study brain-targeted radiation for limited brain metastases
This study looks at people with a small number of brain metastases who are treated with a focused, staged form of radiation after surgery or to treat the cancer. It may help doctors better understand how well this approach works and who benefits most.
TaoyuanAges 18–84 - NCT03742687Recruiting
Testing a shorter, stronger radiation schedule for lung cancer
This trial studies a different way to deliver radiation to people with locally advanced, non-operable non-small cell lung cancer. It may help by aiming to treat the tumor effectively with a different radiation timing and dose pattern.
AarhusAges 18 years+ - NCT05794035Recruiting
Shorter radiation after skin cancer surgery for older adults
This study looks at whether giving a shorter course of radiation after surgery can help prevent skin cancer from coming back in people age 70 and older. It focuses on higher-risk skin cancers and checks how well the treatment works and what side effects occur.
CréteilAges 70 years+ - NCT04642027RecruitingPhase 3
PSMA scan-guided salvage radiation after prostate surgery
This trial tests whether using a specialized PSMA PET scan to guide radiation can better treat prostate cancer that returns after prostate surgery. It targets the “prostate bed” area with a shorter, stronger radiation schedule (hypofractionated) to control rising PSA levels.
Arnhem, GelderlandAges 18–80 - NCT06321653Recruiting
Lymphedema after radiation for early breast cancer with 1-2 positive nodes
This trial aims to see if a shorter course of radiation after breast-conserving surgery affects arm swelling (lymphedema) in people with early breast cancer that has spread to 1 or 2 nearby lymph nodes. The goal is to learn if this approach is safe and effective.
MilanAges 18 years+ - NCT06389422RecruitingPhase 2
Radiation plus Keytruda for liver cancer with vein clots
This trial tests a combination of moderate-dose radiation therapy and the immunotherapy drug pembrolizumab (Keytruda) for liver cancer that has spread into the main veins of the liver. It aims to see if this combination can shrink tumors and improve survival.
Beijing, Beijing MunicipalityAges 18–90 - NCT06509724RecruitingPhase 3
Comparing standard vs. shorter radiation after hysterectomy for cervical cancer
This trial tests two different radiation schedules for women with high-risk cervical cancer after surgery. The goal is to see if a shorter course of radiation works as well as or better than the standard longer course, while possibly being more convenient.
Seoul, Gangnam-guAges 20–75
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Common questions
- Are there clinical trials for hypofractionation?
- Yes. Clin2 currently lists 175 recruiting hypofractionation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypofractionation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypofractionation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.