Hypofractionation clinical trials

Compare short radiation courses for node-positive breast cancer

This study compares two shorter courses of radiation therapy for women with node-positive breast cancer. It aims to see if an ultra-short course is as safe and effective as the slightly longer short course.

Comparing two proton radiation schedules for early breast cancer after lumpectomy

This study compares two types of proton radiation after lumpectomy for early breast cancer. It tests whether a shorter, stronger course (ultra-hypofractionated) works as well as a slightly longer moderate course.

Faster vs. Standard Radiation After Breast Cancer Surgery

This study compares two radiation schedules for breast cancer patients at high risk of cancer returning in lymph nodes. Both use modern radiation therapy, but one delivers treatment faster (ultra-hypofractionated) while the other uses a more moderate schedule. The goal is to see which approach works better with fewer side effects.

Shorter radiation therapy for head and neck cancer in older adults

This trial tests a shorter course of radiation therapy for patients aged 65 and older with head and neck cancer who cannot have surgery or standard radiation. The goal is to find an effective and more convenient treatment option.

Short radiation plus chemotheapy and immunotherapy before surgery for junction cancer

This trial tests a combination of shortened radiation therapy, immunotherapy, and chemotherapy given before surgery for cancer at the junction of the esophagus and stomach. The goal is to see if this approach is safe and improves outcomes.

Radiation plus chemoimmunotherapy for gastroesophageal junction cancer

This trial tests a shorter course of radiation combined with chemotherapy and immunotherapy to shrink gastroesophageal junction cancer before surgery. It aims to make the tumor removable and improve outcomes.

Radiation before surgery for retroperitoneal soft-tissue sarcoma

This trial tests giving a shorter, lower-dose radiation treatment before surgery for a retroperitoneal (deep belly/back space) soft-tissue sarcoma. The goal is to shrink or control the tumor and make surgery more effective and safe.

Shorter radiation after breast surgery for certain node-positive cancer

This trial compares a shorter, more concentrated radiation schedule versus a standard shorter schedule after breast-conserving surgery. It looks at whether the treatment works well and is safe, especially for women whose lymph nodes also need radiation.

Shorter radiation after surgery for high-risk endometrial cancer

This trial studies a new type of radiation therapy (called online adaptive radiotherapy) given in shorter, higher daily doses after surgery for high-risk endometrial cancer. The goal is to see if this approach is safe and effective for reducing side effects while still controlling the cancer.

Comparing two radiation schedules for rising PSA after prostate surgery

This trial is testing two types of radiation therapy for men whose PSA level rises after prostate removal, but without clear signs of cancer spread on a PSMA PET scan. The goal is to see which radiation schedule works better to control the cancer.

Pelvic Ultra-Hypofractionated Adjuvant Radiotherapy for Endometrial Cancer (PURE-cohort)

Adjuvant treatment for elderly or unfit patients with stage III lung cancer

This trial tests whether adding an immunotherapy drug called cemiplimab to chemotherapy, followed by radiation, can help older or less fit patients with stage III lung cancer. The goal is to see if this combination improves outcomes compared to usual care.

Combination therapy for newly diagnosed brain lymphoma

This trial tests a combination of radiation, immune-boosting drugs, and a targeted antibody for people newly diagnosed with primary central nervous system diffuse large B-cell lymphoma (a type of brain lymphoma). The goal is to see if this approach is safe and effective.

Shorter Radiation Plus Immunotherapy for Recurrent Rectal Cancer

This trial tests whether a shorter, higher-dose radiation course (hypofractionated) combined with immunotherapy works better than standard radiation for locally recurrent rectal cancer that hasn't spread elsewhere. It's for people who haven't had chemotherapy or recent pelvic radiation.

Shorter radiation for localized prostate cancer

This trial tests a shorter, more intense course of radiation (hypofractionated radiotherapy) for men with localized prostate cancer that hasn't spread. It aims to see if this treatment is safe and effective and may reduce the number of hospital visits.

Pre-surgery radiation and chemo for esophageal cancer

This trial tests a shorter course of radiation combined with chemotherapy (FOLFOX) before surgery for esophageal or stomach-junction cancer. It aims to reduce side effects and still improve outcomes.

Shorter radiation for early breast cancer after breast surgery

This trial studies giving whole-breast radiation in a shorter, more concentrated way after breast-conserving surgery. It aims to see if this “ultra-short” schedule is effective and safe for people with early breast cancer.

Pembrolizumab plus radiation for resected mucosal melanoma

This trial studies whether giving pembrolizumab (an immunotherapy) together with a targeted form of radiation can help after surgery for mucosal melanoma. It aims to lower the chance of the cancer coming back and improve outcomes in people whose tumor was removed.

Fast-Track Radiation and Chemotherapy for Esophageal Cancer

This study tests a shorter course of combined radiation therapy and chemotherapy (using drugs called paclitaxel and carboplatin) to treat esophageal cancer with the goal of curing it. The faster treatment schedule may help patients finish therapy sooner while still being effective.

Shorter Chemo-Radiation Plus Immunotherapy for Stage III Lung Cancer

This trial tests a new schedule of chemo-radiation (fewer, stronger sessions) followed by an immunotherapy drug called tislelizumab. The goal is to see if this approach works better than the standard longer schedule for people with stage III lung cancer that can't be surgically removed.

Short radiation course after prostate surgery for rising PSA

This trial tests a shorter, stronger course of radiation (hypofractionated radiotherapy) given after prostate removal surgery. It may help people whose PSA levels rise again after surgery, aiming to reduce side effects and improve outcomes.

Shorter radiation therapy after surgery for cervical cancer

This trial tests a shorter course of radiation therapy (fewer sessions) after hysterectomy for cervical cancer. It aims to see if it's safe and effective for patients who meet certain criteria based on their tumor type and recovery.

Drug and radiation combo for recurrent pelvic endometrial cancer

This study tests a combination of two drugs (lenvatinib and pembrolizumab) plus focused radiation to the pelvis for a specific type of endometrial cancer that has returned or cannot be surgically removed. The goal is to see if this treatment is safe and effective for tumors that are pMMR and limited to the pelvic area.

Radiation before surgery for limb or trunk wall sarcoma

This trial tests a shorter course of radiation given before surgery for soft tissue sarcoma in the arms, legs, or trunk wall. It aims to see if this approach works well long-term and may help you keep your limb.