Clinical trials
Ketamine clinical trials
Below are recruiting ketamine clinical trials, each written for real people, not researchers. We’re tracking 147 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06951802RecruitingPhase 4
Low-dose ketamine for pain during endometriosis surgery
This study tests whether giving a low dose of ketamine during endometriosis surgery can help reduce pain. If you qualify, you'll receive ketamine or a placebo during your procedure, and the team will check your pain levels afterward.
BernAges 18 years+ - NCT06140927RecruitingPhase 3
Ketamine's effect on spinal monitoring during back surgery
This study tests if giving ketamine during certain back surgeries affects how well doctors can monitor your spinal nerves during the operation. It's for adults having a posterior spinal fusion.
San Francisco, CaliforniaAges 18–100 - NCT07120763RecruitingPhase 3
Better pain control for kids with broken wrists
This trial compares different ways to manage pain for children who come to the emergency room with a broken wrist that needs to be reset. The goal is to find which pain medicine or numbing method works best and is safest for kids.
Buffalo, New YorkAges 3–17 - NCT07095842RecruitingPhase 2/Phase 3
Early ketamine for kids with seizure emergencies
This trial tests if giving ketamine early, before reaching the hospital, can stop prolonged seizures in children with epilepsy. It is for kids who have had at least one seizure emergency in the past year.
SohagAges 2–16 - NCT07088380RecruitingPhase 3
Ketamine combined with ECT for hard-to-treat depression
This trial tests whether adding ketamine to electroconvulsive therapy (ECT) works better than ECT alone for people with depression that hasn't improved with at least two different antidepressants. It may offer a new option for those who have not found relief from standard treatments.
MilanAges 18–70 - NCT06981494Recruiting
Study of two medicines for relaxing blood pressure during ear and nose surgery
This trial tests if adding a second medicine, ketamine, to dexmedetomidine helps control blood pressure better during ear or nose surgery. It may lead to safer and smoother anesthesia for patients needing controlled low blood pressure.
SohagAges 18–60 - NCT07056582Recruiting
Pain relief before nasal surgery: ketamine vs. dexmedetomidine
This trial tests two inhaled medicines given before surgery to see which one works better for pain after nasal surgery. One medicine is ketamine and the other is dexmedetomidine, both given as a mist through a nebulizer.
SohagAges 20–60 - NCT07046611RecruitingPhase 2/Phase 3
Ketamine and Levetiracetam for Seizures in Children
This study tests whether two medicines, ketamine (a sleep medicine) and levetiracetam (a seizure medicine), work better than a standard treatment for stopping long-lasting seizures in children when the first rescue medicine doesn't work.
SohagAges 1–16 - NCT07022821RecruitingPhase 4
Comparing two pain medicines after planned C-section
This study tests two medications, dexmedetomidine and ketamine, to see which one works better for pain after a planned C-section. If you're having a scheduled C-section and are generally healthy, this trial could help find better pain relief options.
Lahore, Punjab ProvinceAges 18–50 - NCT07009158RecruitingPhase 1/Phase 2
Ketamine plus therapy for pain and PTSD
This trial tests if ketamine combined with talk therapy helps people with both chronic pain and PTSD. Participants receive ketamine through an IV in group therapy sessions over several weeks, with the goal of reducing pain and PTSD symptoms.
Kingston, OntarioAges 18–64 - NCT06995690Recruiting
Ketamine to prevent low blood pressure during orthopedic surgery
This study tests if a low dose of ketamine (a pain medicine) given before spinal anesthesia can prevent dangerously low blood pressure during orthopedic surgery. It might help keep your blood pressure steady, making the procedure safer.
CairoAges 18 years+ - NCT06916403Enrolling by invitation
Ketamine infusions for fibromyalgia pain
This study looks at whether ketamine given through an IV can help reduce fibromyalgia pain. It reviews past treatments and also plans new treatments to see how well they work and how safe they are.
Thornhill, OntarioAges 18 years+ - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06891300RecruitingPhase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Ottawa, OntarioAges 18–65 - NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT06788249RecruitingEarly Phase 1
Ketamine for treatment-resistant depression brain study
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
Philadelphia, PennsylvaniaAges 25–65 - NCT06781697RecruitingPhase 3
Ketamine and virtual reality for treatment-resistant depression
This trial tests if adding virtual reality to ketamine treatments can help people with depression that hasn't improved with other treatments. You'll receive IV ketamine as prescribed by your doctor and also use a virtual reality headset during sessions.
Toronto, OntarioAges 18 years+ - NCT06750939Recruiting
Comparing two sedatives for ICU breathing tube placement
This study compares two medicines (propofol and ketamine) used to help you relax and stay stable while a breathing tube is placed. The goal is to see which one is safer for your heart and blood pressure during this procedure in the ICU.
Köseköy, KocaeliAges 18 years+ - NCT06736769Enrolling by invitationPhase 2
Ketamine and learning in eating disorders
This study tests whether a single dose of ketamine can help people with anorexia nervosa learn new ways of thinking about food and body image during recovery. You may be eligible if you are a teenager or young adult currently hospitalized for malnutrition.
San Francisco, CaliforniaAges 16–26 - NCT06713616RecruitingPhase 3
Esketamine vs. ketamine for hard-to-treat depression
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Milford, ConnecticutAges 18 years+ - NCT06668571RecruitingPhase 2
Ketamine for treatment-resistant depression
This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.
Rochester, MinnesotaAges 18–65 - NCT06597695RecruitingPhase 1/Phase 2
Ketamine group therapy for Spanish-speaking adults with depression
This trial tests whether ketamine-assisted group therapy can help Spanish-speaking Latinx adults with major depression. You would receive ketamine in a supportive group setting, with the goal of improving your mood and quality of life.
Chelsea, MassachusettsAges 18–64 - NCT06508710RecruitingPhase 3
Ketamine plus venlafaxine for severe depression
This trial tests whether adding ketamine to the antidepressant venlafaxine helps relieve severe depression faster than venlafaxine alone. If you are hospitalized for a serious depression and you meet safety criteria, you may be eligible.
Le Kremlin-Bicêtre, FranceAges 18–65 - NCT06525584Recruiting
Ketamine to protect the brain during heart surgery in children
This study tests whether giving ketamine during heart surgery helps protect the brain in young children. It is for children aged 1 month to 5 years who are having surgery to fix a hole in the wall between the heart chambers (atrial or ventricular septal defect).
Kemerovo, Please SelectAges 1 month–5 years
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Common questions
- Are there clinical trials for ketamine?
- Yes. Clin2 currently lists 147 recruiting ketamine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ketamine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ketamine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.