Clinical trials
Ketamine clinical trials
Below are recruiting ketamine clinical trials, each written for real people, not researchers. We’re tracking 147 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07230171Recruiting
Short-term S-ketamine for fibromyalgia pain relief
This trial tests if low-dose S-ketamine, given as a short intravenous infusion, can safely improve fibromyalgia pain and other symptoms for people who haven't gotten enough relief from non-drug treatments. S-ketamine is a fast-acting medicine that blocks pain signals and may help reset how the brain processes pain.
BeijingAges 18 years+ - NCT07120477RecruitingPhase 4
Comparing esketamine, crisis planning, and usual care to prevent suicide
This study compares three approaches to help prevent suicide: a new medication called esketamine (a nasal spray), crisis response planning (a personalized safety plan), and enhanced usual care. It aims to see which approach is more effective in reducing suicidal thoughts and behaviors.
Indaiatuba, São PauloAges 14 years+ - NCT07045870Recruiting
Pain relief methods after thyroid surgery
This study compares different ways to manage pain after thyroid removal surgery. It aims to find which method works best for recovery.
SohagAges 18–75 - NCT06994559Recruiting
Music with ketamine for chronic pain
This study tests if listening to music during ketamine infusions helps reduce chronic pain better than ketamine alone. It is for people already getting ketamine infusions for non-cancer pain.
Montreal, QuebecAges 18 years+ - NCT06772753RecruitingPhase 1
Study of Psychedelic Effects in Healthy Adults
This study tests how certain psychoactive substances affect your mind and body. It is looking for healthy volunteers to take part in supervised sessions to explore the effects of these drugs.
Baltimore, MarylandAges 25–55 - NCT06739460Enrolling by invitation
Comparing pain relief: ketamine vs magnesium for hysteroscopy
This study compares two different sedatives, ketamine and magnesium, to see which provides better pain relief for women having a hysteroscopy (a procedure to examine the uterus). It might help you if you are having this procedure and want to be more comfortable during sedation.
Ankara, YenimahalleAges 18–55 - NCT05210764Recruiting
EEG brain activity changes during pediatric surgery under anesthesia
This study looks at how the brain’s electrical activity (measured with a painless EEG sensor) changes in children during planned surgery using common anesthesia medicines. It may help doctors better understand brain effects of anesthesia in healthy children having non–head or non–heart surgery.
BeijingAges 1 minute–18 years - NCT06745388RecruitingPhase 4
Magnesium for cramping during hysteroscopy or D&C
This study tests whether magnesium can reduce cramping during a hysteroscopy or D&C. If you are having one of these procedures and are not on certain medications, you may qualify.
Royal Oak, MichiganAges 18 years+ - NCT06733129RecruitingPhase 3
Which sleeping medicine is best for emergency intubation?
This trial compares different sleeping medicines (ketamine, propofol, and similar drugs) to see which is safest for people who need a breathing tube placed quickly in the operating room. It focuses on those at risk of stomach contents going into the lungs.
AngersAges 18–80 - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Milford, ConnecticutAges Any age - NCT06620276Recruiting
Ketamine and therapy for alcohol use disorder and depression
This trial tests if combining ketamine infusions with weekly therapy can help people who have both alcohol use disorder and hard-to-treat depression. You may qualify if you drink at least moderately, have treatment-resistant depression, and are willing to attend 8 therapy sessions.
Montreal, QuebecAges 18–70 - NCT06608277RecruitingPhase 2
Ketamine and nerve block for headache or PTSD after brain injury
This study tests if ketamine infusions or a stellate ganglion block (a numbing injection near the neck) can help people with long-term headaches or PTSD after a traumatic brain injury. It compares these treatments alone and together.
Chicago, IllinoisAges 18 years+ - NCT06526078Recruiting
Combining brain training with ketamine for depression
This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.
Oakland, CaliforniaAges 18–80 - NCT06511908RecruitingPhase 2
Testing a new ketamine-like drug for hard-to-treat depression
This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.
Bethesda, MarylandAges 18–70 - NCT06462196Recruiting
Study of Depression, Bipolar Disorder & Suicide Risk
This study looks at how depression, bipolar disorder, and suicide risk naturally change over time. It aims to better understand these conditions so doctors can improve treatments.
Bethesda, MarylandAges 18–120 - NCT06402955RecruitingPhase 2
Imaging depression in Parkinson's disease
This study uses brain imaging (PET scans) to understand depression in people with Parkinson's disease. It may also test a depression treatment called ketamine, but the main goal is to see how the brain changes with depression.
New Haven, ConnecticutAges 40–80 - NCT05973851RecruitingPhase 3
Six-week medicine boost for depression after first treatment failure
This study tests a more intensive antidepressant medicine approach for people whose first tried treatment didn’t work well enough. It compares the intensified treatment with usual care, aiming to improve depression symptoms and daily functioning.
InnsbruckAges 18–65 - NCT05962424RecruitingPhase 1
Study of brain activity during thinking using electrode recordings
This Phase 1 study records electrical signals from the brain while you perform thinking tasks. The goal is to better understand how human brain circuits work during cognition, and the study may help future treatments.
Palo Alto, CaliforniaAges 18 years+ - NCT05403086RecruitingPhase 2
Psilocybin for distress in people with serious, life-limiting illness
This Phase 2 study tests whether psilocybin therapy can reduce deep distress (“demoralization”) in people receiving palliative (comfort-focused) care. It may help with mood and well-being, but you must meet safety and medication requirements to join.
Greenbrae, CaliforniaAges 18 years+ - NCT05864053RecruitingPhase 1/Phase 2
Ketamine medicine trial for chronic nerve pain in adults
This Phase 1/2 study tests hydroxynorketamine (a related ketamine-type medicine) to see if it can reduce chronic nerve pain in the arms or legs. You may be able to join if you have nerve pain for more than 3 months and meet safety and health check requirements.
Chicago, IllinoisAges 18–75 - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT05437575RecruitingPhase 3
Testing pain medicine given before arrival to a trauma center
This study tests whether giving pain medicine soon after an injury (before you reach the trauma center) improves comfort and care. You might be eligible if you’re transported to a participating trauma center and meet specific shock and pain levels.
San Diego, CaliforniaAges 18 years+ - NCT05401227RecruitingPhase 1
Brain scan study on glutamate and ketamine in healthy adults
This study uses a special brain scan (MRI) to understand how the brain chemical glutamate works in healthy people. You may be asked to take either an experimental drug or a placebo to see how it affects your brain chemistry.
New York, New YorkAges 18–55 - NCT04480918Recruiting
Registry for people with depression or bipolar to receive psychiatry care
This is a patient registry that enrolls people being evaluated for treatment options from an Interventional Psychiatry Service. It helps track patients with depression, bipolar disorder, or treatment-resistant OCD who are suitable for these psychiatry treatments.
Iowa City, IowaAges 18–99
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Common questions
- Are there clinical trials for ketamine?
- Yes. Clin2 currently lists 147 recruiting ketamine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ketamine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ketamine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.