Clinical trials
Knee Arthritis Osteoarthritis clinical trials
Below are recruiting knee arthritis osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 223 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06807541Recruiting
Exercise for balance in knee osteoarthritis
This pilot study tests whether a group exercise program can improve balance for people with knee osteoarthritis. You would join supervised exercise classes to see if they help with stability and daily movement.
Chilliwack, British ColumbiaAges Any age - NCT07637682Recruiting
Percutaneous Neurostimulation for Knee Osteoarthritis Pain
This trial tests a minimally invasive nerve-stimulation treatment for moderate to severe knee osteoarthritis pain in adults who have not found relief with standard treatments. The procedure uses small needles to deliver electrical stimulation near nerves to reduce pain.
TantaAges 18 years+ - NCT06195423Recruiting
Stopping knee arthritis after an ACL tear
This study tests a home exercise program to prevent knee arthritis after an ACL tear. If you had ACL surgery 9 to 36 months ago and still have some knee symptoms, this program may help protect your knee in the long run.
Vancouver, British ColumbiaAges 16–35 - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06836934Enrolling by invitation
Knee brace vs. wedge for osteoarthritis
This study compares two non-surgical options—a soft knee brace vs. a lateral wedge shoe insert—to see which better relieves pain and improves function in people with knee osteoarthritis. If you're between 40 and 60 and have pain on one side of your knee, this study may help you find better relief.
Giza, Giza GovernorateAges 40–60 - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age - NCT04095637Recruiting
Compare two types of partial knee replacement surgeries
This study compares two implant types used for a partial knee replacement (only the inside/medial part) for people with “wear-and-tear” arthritis in that compartment. It looks to see which option leads to better outcomes after surgery and follow-up.
LondonAges 40–80 - NCT06407427Recruiting
Mobile app for recovery after hip, knee, or spine surgery
This study tests whether a mobile app can help with physical therapy after common bone or joint surgeries. You may qualify if you recently had a hip fracture, hip or knee replacement, or spine surgery without paralysis. The app guides your exercises at home.
New Haven, ConnecticutAges 18 years+ - NCT04816773Enrolling by invitation
Long-term follow-up for specific knee replacement parts
This study follows people for up to 10 years after a knee replacement done with specific manufacturer parts. It helps the company and doctors understand how well these knee implants work and whether they cause any long-term problems.
Fremont, CaliforniaAges 21 years+ - NCT06726629Recruiting
Italian Knee Questionnaire Study
This study is testing a new Italian version of a questionnaire that measures how your knee feels and works after knee replacement. The goal is to make sure the questionnaire is accurate for Italian-speaking patients.
BolognaAges 18–85 - NCT06549686RecruitingPhase 3
Knee osteoarthritis treatment study with cell therapy
This trial tests a new cell-based treatment (CLS2901C) for knee osteoarthritis. It combines the treatment with a realignment surgery (proximal tibial osteotomy) to help repair cartilage damage and reduce pain.
Ebina, KanagawaAges 20–79 - NCT07338266RecruitingPhase 1
Study of AVD275 injection for knee osteoarthritis
This trial tests a new injection called AVD275 for people with knee osteoarthritis. It aims to see if the injection is safe and how it works in the body.
Wahroonga, New South WalesAges 20–75 - NCT04472702Recruiting
Ultrasound vs X-ray guidance for knee pain ablation
This trial compares two ways (ultrasound or X-ray guidance) to place a treatment for painful knee arthritis. It aims to see whether one guidance method works as well as the other for reducing knee pain.
Sacramento, CaliforniaAges 35–99 - NCT03286868Recruiting
Tested knee replacement alignment during knee surgery
This study looks at how a specific computer/measurement approach (“Verasense”) helps position the knee during total knee replacement for people with knee arthritis. It may help improve how the new knee fits and aligns as you recover.
Halifax, Nova ScotiaAges 21–80 - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT07464080Recruiting
Brain imaging study for knee replacement patients
This study uses advanced brain scans to understand how pain and recovery change after knee replacement surgery. It may help researchers develop better ways to manage pain after surgery.
Ottawa, OntarioAges 18 years+ - NCT07121556Recruiting
Fat tissue vs fat tissue plus gel for knee osteoarthritis
This trial compares two injections for knee arthritis: one uses your own fat tissue, the other adds a lubricating gel. Researchers want to see if the combination helps pain and function more than fat tissue alone.
BolognaAges 18–75 - NCT04821154Recruiting
Testing outcomes after revision knee replacement with a Persona system
This study looks at how well a specific revision knee replacement system (the Persona system) works after earlier knee problems or surgeries. You may be eligible if you need a revision knee and can follow follow-up care instructions; the trial also checks for certain infection, bone, and health-safety factors.
Fayetteville, ArkansasAges 18 years+ - NCT06488144RecruitingPhase 3
Knee arthritis rehab: helping veterans keep improving
This study tests a program that helps veterans with knee osteoarthritis keep up the gains they make in physical therapy. It uses a Fitbit and a smartphone app to support you and track your activity after your PT sessions end.
Birmingham, AlabamaAges 40–90 - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT06231758RecruitingPhase 3
Metformin for knee osteoarthritis: a phase 3 trial
This study tests whether metformin, a common diabetes medication, can help reduce pain and improve knee function in people with knee osteoarthritis. It may offer a new treatment option for those with moderate knee OA.
Damietta, New DamiettaAges 30–60
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Common questions
- Are there clinical trials for knee arthritis osteoarthritis?
- Yes. Clin2 currently lists 223 recruiting knee arthritis osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee arthritis osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee arthritis osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.