Clinical trials
Knee Arthritis Osteoarthritis clinical trials
Below are recruiting knee arthritis osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 211 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06773676Recruiting
Home laser device study for knee osteoarthritis relief
This study tests whether using a laser device at home can help reduce knee pain and improve function in people with knee osteoarthritis. You would use the device yourself over several weeks to see if it eases your symptoms.
Ashkelon, Southern DistrictAges 50–90 - NCT07402447Recruiting
Leg strengthening for knee osteoarthritis and walking
This study tests if strengthening your thigh and calf muscles can improve walking in people with knee osteoarthritis. It may help you walk better and feel more stable.
Peshawar, Khyber PakhtunkhwaAges 40–60 - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT06833372Recruiting
Shock wave therapy for knee arthritis
This trial tests if shock wave treatment can reduce knee pain from osteoarthritis. It may help people with moderate knee arthritis who haven't had recent physical therapy or joint injections.
BariAges 45–80 - NCT06755697Recruiting
Comparing injection methods for knee osteoarthritis
This trial compares two ways to give dextrose injections for knee osteoarthritis: one into the joint space and one guided by MRI into the tissues around the knee. It aims to see which approach works better for pain and function.
TaipeiAges 45–80 - NCT06596031Enrolling by invitation
Health coaching for people waiting for hip or knee replacement
This study tests whether health coaching can help people who are waiting for hip or knee replacement surgery. It aims to improve your health and wellbeing while you wait for your operation.
SheffieldAges 18 years+ - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT07329023Recruiting
Acupressure for Knee Arthritis in Older Chinese Adults
This trial tests whether learning self-administered acupressure (a type of massage using fingertips) can help older Chinese adults with knee arthritis manage their pain and stiffness without medication. If you join, you will receive training in a community setting and use a smartphone app to track your progress.
KowloonAges 60 years+ - NCT06074900Recruiting
Waiting for hip or knee replacement study
This study follows people waiting for hip or knee replacement surgery due to osteoarthritis. It helps researchers understand how to better support patients during the wait.
London, OntarioAges 18 years+ - NCT07308834RecruitingPhase 1/Phase 2
Knee injection study for moderate to severe osteoarthritis pain
This study tests a new knee injection called CX-011 to see if it can reduce pain and improve function in people with knee osteoarthritis. It may be a good option if you have tried other treatments without enough relief.
Los Angeles, CaliforniaAges 40–75 - NCT07302204Recruiting
Exercise for knee osteoarthritis pain relief
This study compares two types of exercise — aerobic (like walking or cycling) versus specific therapeutic exercises — to see which one better helps people with knee osteoarthritis who do not get pain relief from exercise. It aims to find an exercise plan that reduces knee pain and improves movement.
São PauloAges 40–75 - NCT06887829Recruiting
A study of low-dose radiation for knee osteoarthritis
This study tests a low-dose radiation treatment for knee osteoarthritis that might reduce pain and improve knee function. If you have been dealing with constant or intermittent knee pain and meet the other criteria, this could be an option for you.
Rochester, MinnesotaAges 50–100 - NCT05100966Recruiting
Exercise program for people waiting for hip or knee replacement
This trial tests a “getting fit” program to help people who are somewhat frail before hip or knee replacement surgery. It aims to improve fitness while you wait for surgery, which may help you feel stronger for recovery.
Calgary, AlbertaAges 60 years+ - NCT07361198Recruiting
Knee artery embolization for arthritis pain
This trial tests a minimally invasive procedure to block small blood vessels in the knee, which may reduce pain from osteoarthritis. It's for people with ongoing knee pain even after standard treatments like medication or physical therapy.
Ústí nad LabemAges 40–80 - NCT05302934Recruiting
Testing a knee-surgery app and sensor after knee replacement
This trial checks whether a data platform that uses a wearable sensor and a phone app works well for people getting a total knee replacement. It may help make follow-up care more organized and easier by capturing recovery information.
Konstanz, Baden-WurttembergAges 18 years+ - NCT07637682Recruiting
Percutaneous Neurostimulation for Knee Osteoarthritis Pain
This trial tests a minimally invasive nerve-stimulation treatment for moderate to severe knee osteoarthritis pain in adults who have not found relief with standard treatments. The procedure uses small needles to deliver electrical stimulation near nerves to reduce pain.
TantaAges 18 years+ - NCT06807541Recruiting
Exercise for balance in knee osteoarthritis
This pilot study tests whether a group exercise program can improve balance for people with knee osteoarthritis. You would join supervised exercise classes to see if they help with stability and daily movement.
Chilliwack, British ColumbiaAges Any age - NCT06681142Recruiting
Pharmacist-physiotherapist team care for early knee osteoarthritis
This study tests a new way to manage early knee osteoarthritis by having a pharmacist and physiotherapist work together. You might get help with pain, stiffness, and movement without needing surgery or strong medications.
Sherwood Park, AlbertaAges 50 years+ - NCT06195423Recruiting
Stopping knee arthritis after an ACL tear
This study tests a home exercise program to prevent knee arthritis after an ACL tear. If you had ACL surgery 9 to 36 months ago and still have some knee symptoms, this program may help protect your knee in the long run.
Vancouver, British ColumbiaAges 16–35 - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT07377669Enrolling by invitation
Partial knee replacement plus ACL repair study
This study tests a combination surgery: repairing the torn ACL at the same time as replacing only the damaged part of your knee. It's designed for active people with arthritis in one knee compartment and a fully torn ACL.
BolognaAges 18–75 - NCT06836934Enrolling by invitation
Knee brace vs. wedge for osteoarthritis
This study compares two non-surgical options—a soft knee brace vs. a lateral wedge shoe insert—to see which better relieves pain and improves function in people with knee osteoarthritis. If you're between 40 and 60 and have pain on one side of your knee, this study may help you find better relief.
Giza, Giza GovernorateAges 40–60
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Common questions
- Are there clinical trials for knee arthritis osteoarthritis?
- Yes. Clin2 currently lists 211 recruiting knee arthritis osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee arthritis osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee arthritis osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.