Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06899932Recruiting
Genutech knee replacement survival study
This study tracks how long Genutech knee replacements last in people with knee arthritis. It is for adults whose arthritis did not improve with non-surgical treatments like physical therapy or medication.
Barcelona, BarcelonaAges 18 years+ - NCT06130956Recruiting
Vegan diet before knee replacement surgery study
This study compares a 2-week vegan diet to a regular diet before knee replacement surgery. It looks at how the diet affects protein turnover in the knee joint.
ArnhemAges 60–80 - NCT06807541Recruiting
Exercise for balance in knee osteoarthritis
This pilot study tests whether a group exercise program can improve balance for people with knee osteoarthritis. You would join supervised exercise classes to see if they help with stability and daily movement.
Chilliwack, British ColumbiaAges Any age - NCT07242170Recruiting
Comparing nerve blocks for pain after knee replacement surgery
This trial tests if adding extra nerve blocks (sciatic, BiFeS, or IPACK) to the usual adductor canal block can reduce pain after total knee replacement. The goal is to find a better way to manage pain and improve recovery.
Erzincan, MerkezAges 18–75 - NCT07245121Recruiting
Sugar water injections for chronic knee arthritis pain
This trial tests whether injecting a sugar-water solution around the nerves of the knee can reduce chronic pain from osteoarthritis. It is for people with long-term knee pain, stiffness, and cracking who have not had recent knee treatments or surgery.
Athens, AtticaAges 38 years+ - NCT07238751Recruiting
Bowen technique and backward walking for knee osteoarthritis
This study tests whether the Bowen technique (a gentle hands-on therapy) combined with walking backward can improve hamstring flexibility and reduce pain in people with knee osteoarthritis. It may help if you have tight hamstrings and mild to moderate knee arthritis.
Islamabad, Punjab ProvinceAges 40–60 - NCT06909851Recruiting
Comparing nerve blocks for pain after knee arthroscopy
This study compares two different types of nerve blocks to see which provides better pain relief after arthroscopic knee surgery. You will receive one of the blocks after your surgery, and your pain levels will be tracked.
IstanbulAges 18–72 - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT07212920Recruiting
Video physiotherapy for recent knee injuries
This study tests whether a video-based physiotherapy assessment works as well as an in-person exam for people with recent knee injuries. If you have a knee injury that started 1 to 12 weeks ago and haven't been treated yet, you may be able to participate from home using your phone or computer.
AlingsåsAges 18 years+ - NCT07214493Recruiting
Study of a prosthetic foot with adjustable heel height
This trial tests a prosthetic foot that lets you adjust the heel height so you can comfortably walk in different shoes or barefoot. It is for people with a leg amputation who already use a certain type of prosthetic foot and want more flexibility in their footwear.
ConcarneauAges 18 years+ - NCT07212777Recruiting
Custom vs standard knee surgery for knee alignment
This study compares a custom 3D-printed surgical guide to the standard technique for a knee realignment surgery called high tibial osteotomy. It is for people with knee arthritis on the inner side of the knee who have not improved with other treatments.
Málaga, MálagaAges 18–70 - NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT06357741Recruiting
Desuzumab for knee osteoarthritis
This study tests a new medicine called Desuzumab for knee osteoarthritis. It looks at whether the medicine can help reduce pain and improve joint function.
Wuhan, HubeiAges 45–75 - NCT05992064Recruiting
Wearable sensors to track recovery after knee replacement
This study uses a small wearable sensor placed on your leg after knee replacement surgery to track your recovery. It helps doctors see how well you are moving and healing, without extra visits to the hospital.
Frederikshavn, North DenmarkAges 18 years+ - NCT07204119Recruiting
Comparing two therapies for knee stiffness after fracture surgery
This trial tests two physical therapy techniques to help people regain knee movement after surgery for a broken leg bone. It may help if you are still having trouble bending or straightening your knee a few weeks after your operation.
Rawalpindi, Punjab ProvinceAges 20–40 - NCT07198555RecruitingPhase 1
Study of BBM-A101 for knee osteoarthritis
This trial tests a new medicine called BBM-A101 for people with moderate knee osteoarthritis. It aims to see if it is safe and helps reduce pain and improve function.
Shenzhen, GuangdongAges 40–75 - NCT07199738Recruiting
Knee replacement study with a new implant option
This study tests a specific knee implant insert (LEGION Medial Stabilized) in people who need a total knee replacement due to arthritis or similar joint disease. It aims to see if the device is safe and works well over time.
Newton, MassachusettsAges 18–80 - NCT06937528RecruitingPhase 1
Extracellular vesicles for severe knee osteoarthritis
This trial tests whether tiny particles called extracellular vesicles can help treat severe knee osteoarthritis. If you have advanced knee arthritis and are otherwise healthy, you may be able to join.
AmmanAges 42–75 - NCT07201597Recruiting
Readiness and knee function after ACL surgery
This study looks at how your mental readiness, knee function, and strength relate after ACL reconstruction using a specific type of tendon graft. It may help you understand if you're ready to return to sports.
Cairo, Cairo GovernorateAges 18–35 - NCT06934421Recruiting
A new approach for knee radiofrequency ablation
This trial tests a revised method for radiofrequency ablation to treat chronic knee pain from severe osteoarthritis (KL grade III or IV). It aims to see if the procedure can help patients who haven't gotten relief from standard treatments like physical therapy, painkillers, and steroid injections.
FaroAges 18 years+ - NCT06748443Recruiting
Injury prevention in youth and adult amateur football players
This trial tests a program to prevent injuries in amateur football players aged 10 and older. It's for teams that practice at least twice a week during the season.
LinköpingAges 10 years+ - NCT06947655Recruiting
Tourniquet types for knee replacement surgery
This study compares different types of tourniquets (tight cuffs) used during knee replacement surgery to see how they affect blood loss and how satisfied surgeons are with them.
Bonn, North Rhine-WestphaliaAges 18 years+ - NCT06251869Recruiting
Electrocautery vs. Scalpel in Joint Replacement Surgery
This trial compares two surgical tools—electrocautery and a cold knife (scalpel)—to see which works better during joint replacement surgery. It aims to find the best way to make incisions, which could mean less bleeding and faster healing.
Cluj-Napoca, ClujAges 18–90
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.