Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 836 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT06136039Recruiting
Muscle loss and knee replacement recovery in older women
This study looks at how muscle loss (sarcopenia) affects recovery after total knee replacement in older women. If you join, you'll have some simple walking and strength tests to see how your muscles impact your surgical outcome.
SeoulAges 60 years+ - NCT06182059Recruiting
Pain after knee replacement study
This study looks at long-term pain after total knee replacement surgery. It may help understand why some people have persistent pain and find ways to prevent it.
Monza, Monza BrianzaAges 18–85 - NCT06184451Recruiting
TENS with exercise for knee osteoarthritis
This study tests if adding TENS (a pain-relieving electrical stimulation) to a standard exercise program helps people with knee osteoarthritis feel better and move better.
São PauloAges 40–75 - NCT06187038Recruiting
Pain education study for knee osteoarthritis
This trial tests if learning about chronic pain can help people with knee osteoarthritis feel better. You'll join a program that teaches you about pain and how to manage it.
São PauloAges 40–80 - NCT06188806Recruiting
Nerve block location study for knee replacement pain
This study compares two types of nerve blocks (proximal vs. distal adductor canal block) for pain relief after knee replacement surgery. The goal is to see which approach provides better pain control and recovery.
Istanbul, UmraniyeAges 18–85 - NCT06195423Recruiting
Stopping knee arthritis after an ACL tear
This study tests a home exercise program to prevent knee arthritis after an ACL tear. If you had ACL surgery 9 to 36 months ago and still have some knee symptoms, this program may help protect your knee in the long run.
Vancouver, British ColumbiaAges 16–35 - NCT06196567Recruiting
Pulsed magnetic therapy for knee strength before replacement
This study tests whether pulsed electromagnetic field therapy (a non-invasive treatment using magnetic pulses) can improve muscle strength and function in people with severe knee osteoarthritis who are waiting for knee replacement surgery. It may help you feel stronger and move better before your operation.
Hong Kong, NEW TerritoriesAges 50–100 - NCT06245109RecruitingPhase 4
Pain medicine study for knee osteoarthritis
This study tests how well different pain medicines work for knee osteoarthritis and looks at brain patterns to understand why some people get more relief. It may help you find a treatment that works best for you.
Chicago, IllinoisAges 41 years+ - NCT06251167Recruiting
Shoe insoles for knee osteoarthritis
This study tests whether shoe insoles can help people with knee osteoarthritis. You might be eligible if you have had knee pain for at least 6 months, your pain is at least moderate, and you also have pain in the same foot.
Vancouver, British ColumbiaAges 50 years+ - NCT06251869Recruiting
Electrocautery vs. Scalpel in Joint Replacement Surgery
This trial compares two surgical tools—electrocautery and a cold knife (scalpel)—to see which works better during joint replacement surgery. It aims to find the best way to make incisions, which could mean less bleeding and faster healing.
Cluj-Napoca, ClujAges 18–90 - NCT06290336Recruiting
Exercise and education before knee replacement surgery
This study tests if exercise therapy and patient education before total knee replacement can improve recovery. It may help people waiting for their first knee replacement due to osteoarthritis.
Linköping, Östergötland CountyAges 40–85 - NCT07694895Recruiting
AI-assisted education for knee replacement recovery
This trial tests if an AI-powered educational video before you get up and walk after knee replacement surgery can help reduce fear of movement and make you feel more ready to leave the hospital.
Kocaeli, İzmitAges 18–100 - NCT07481461Recruiting
Knee alignment and biology in osteoarthritis
This study looks at how changes in knee alignment affect symptoms and joint biology in people with early knee osteoarthritis. It may help doctors understand how to better treat knee OA.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06357741Recruiting
Desuzumab for knee osteoarthritis
This study tests a new medicine called Desuzumab for knee osteoarthritis. It looks at whether the medicine can help reduce pain and improve joint function.
Wuhan, HubeiAges 45–75 - NCT06383936Recruiting
Knee replacement for active sports lovers
This study tests a new knee replacement designed for active people ages 40 to 65 who used to play sports but had to stop due to knee pain. It aims to see if the implant helps you return to your favorite activities.
BolognaAges 40–65 - NCT06384898Recruiting
Remote Tai Chi for Knee Osteoarthritis
This study tests whether doing Tai Chi (a gentle exercise) remotely from home, twice a week for 12 weeks, can help reduce knee pain and improve function in people with knee osteoarthritis. You would be assigned to either the Tai Chi group or a routine care group that avoids Tai Chi during the study.
Boston, MassachusettsAges 50–100 - NCT06414473RecruitingPhase 1/Phase 2
CBD for knee osteoarthritis pain
This study tests whether a CBD (cannabidiol) product can help reduce pain and improve daily life for people with knee osteoarthritis. If you have moderate to severe knee pain and haven't used cannabis recently, you may be able to join.
Gainesville, FloridaAges 40–75 - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT06462560Recruiting
Live fitness program for knee osteoarthritis
This trial tests a live, interactive strength training program for people recently diagnosed with knee osteoarthritis. It aims to see if this home-based program can help reduce pain and improve daily function.
Murray, UtahAges 55–85 - NCT06462625Recruiting
Knee realignment surgery for arthritis with bowed legs
This study tests how well a realignment surgery (osteotomy) works for people with mild knee arthritis and a bent knee that's at least 3 degrees off center. The surgery may also fix other knee problems like a torn meniscus or ligament at the same time.
BolognaAges 18–70 - NCT06463847RecruitingPhase 1
Stem cell therapy for knee osteoarthritis
This trial tests a new stem cell treatment (UC-MSCs) for knee osteoarthritis. It aims to see if this treatment is safe and can help reduce pain and improve knee function.
Wuhan, HubeiAges 50–70 - NCT06478186RecruitingPhase 4
Knee Osteoarthritis Steroid Injection Study for People with Type 2 Diabetes
This study compares two different steroid knee injections—Zilretta and Kenalog—to see which works better for people with both knee osteoarthritis and type 2 diabetes. It uses a continuous glucose monitor to track blood sugar changes.
Kansas City, KansasAges 40 years+ - NCT06483269Recruiting
Platelet-rich plasma injection for knee arthritis in young athletes
This trial tests using your own platelet-rich plasma (PRP), made from a blood sample, as an injection to treat knee osteoarthritis in active young adults. The goal is to see if it reduces pain and helps you stay active.
BolognaAges 18–40
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 836 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.