Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 832 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06511557Recruiting
Virtual reality vs. leg exercises for knee arthritis
This study compares virtual reality exercises with standard leg-strengthening moves to see which better reduces pain and improves function in people with knee osteoarthritis (OA).
Rawalpindi, Punjab ProvinceAges 50 years+ - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06514703Recruiting
CT vs. X-ray Guided Nerve Ablation for Knee Arthritis
This study compares two different image-guided techniques (CT scan vs. fluoroscopy) to perform a nerve ablation procedure that blocks pain signals from the knee. It aims to find which method works better for reducing pain in people with knee osteoarthritis.
Zagazig, Sharqia ProvinceAges 45–80 - NCT06514755Recruiting
Nerve block before artery treatment for knee pain
This study tests a two-step procedure for long-term knee pain that hasn't improved with other treatments. First, the nerves around the knee are numbed, and then the small arteries feeding the painful area are blocked. The goal is to see if doing the nerve treatment before the artery treatment works better for reducing pain.
ZagazigAges 18–80 - NCT06517056Recruiting
3D Knee Assessment for Active Duty Knee Pain
This trial tests a 3D camera device that measures how your knee moves. It may help find the best way to treat your front-of-knee pain and keep you mission-ready.
Honolulu, HawaiiAges 18–50 - NCT06557018RecruitingPhase 4
Numbing medicine injection for knee replacement pain
This study tests a long-lasting numbing medicine (liposomal bupivacaine) injected around the knee during total knee replacement surgery. It aims to see if this medicine helps control pain and reduce the need for other painkillers after surgery.
Dezhou, ShandongAges 18–80 - NCT06563258Recruiting
Balance training vs vibration therapy for knee arthritis
This study compares two types of exercise therapy—balance training and whole-body vibration—to see which helps knee pain and function better. It is for people with moderate knee osteoarthritis who have not found relief from other treatments.
CairoAges 40–60 - NCT06567301Recruiting
Shockwave vs. special gel for knee osteoarthritis pain
This trial compares two treatments for knee osteoarthritis: a shockwave therapy and a gel containing chitosan nanoparticles (tiny particles) applied with ultrasound. It uses AI to detect changes in knee tissues. The goal is to find which treatment better reduces pain and improves function.
Giza, El DokkiAges 40–60 - NCT06570291RecruitingPhase 3
Stem cell injection for knee osteoarthritis
This trial tests a new treatment using donor stem cells injected into the knee for people with moderate knee osteoarthritis. It aims to see if these cells can reduce pain and improve function.
Shanghai, ChinaAges 40–75 - NCT06571227Recruiting
Understanding knee scores after ACL surgery
This study aims to find what a 'normal' knee score (Lysholm score) means for people after ACL surgery. It will help doctors know if your recovery is on track.
AnkaraAges 18 years+ - NCT06574191Recruiting
Knee osteoarthritis study: pain and health outcomes
This study looks at how knee pain from osteoarthritis affects your daily life and health. You'll use a topical anti-inflammatory gel and answer questions by text or email for two months.
Sacramento, CaliforniaAges 50 years+ - NCT06578182RecruitingPhase 3
Can colchicine reduce knee or hip replacement?
This study tests whether a low-dose medicine called colchicine can lower the chance that people with knee or hip arthritis will need a joint replacement. If you have arthritis in your knee or hip and are not already scheduled for surgery, you may be able to join.
NijmegenAges 45–80 - NCT06580561Recruiting
Exercise and insomnia treatment for knee pain
This study combines a gentle exercise program with a treatment for insomnia to see if it helps older adults with knee osteoarthritis feel less pain and sleep better. You will attend group exercise classes and receive sleep coaching.
Ann Arbor, MichiganAges 50 years+ - NCT06596824Recruiting
Digital training to reduce inflammation after ACL knee surgery
This trial tests a personalized digital training program for people who recently had ACL knee surgery. The goal is to see if correcting movement patterns can lower inflammation and prevent early knee arthritis.
BerlinAges 18–50 - NCT06600958Recruiting
Study of knee arthritis severity and progression
This study looks at how knee osteoarthritis or other types of knee arthritis progress over time, using blood tests and X-rays. It aims to find markers that could predict whether the disease will get worse, which may help guide treatment decisions.
CréteilAges 18 years+ - NCT06603103Recruiting
Comparing two knee implants in total knee replacement
This study compares two types of knee implants (SpheriKA and Origin) used in total knee replacement surgery with a specific alignment technique. The goal is to see which one may lead to better outcomes for patients needing a first knee replacement.
MérignacAges 18 years+ - NCT06627673Recruiting
A new knee implant study for severe arthritis
This study compares a new plastic-and-metal knee implant to a standard metal one for people with severe knee arthritis. If you need a total knee replacement and your knee is not too bent or twisted, you may be a candidate.
Leawood, KansasAges 18 years+ - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT06643845Recruiting
Can medical treatments delay or avoid knee replacement?
This trial tests whether a combination of non-surgical treatments can help people with knee osteoarthritis avoid or delay total knee replacement surgery. It may be an option if you are considering knee replacement but want to explore medical alternatives first.
AmiensAges 18–90 - NCT06650631Recruiting
Heat treatment for knee pain from arthritis
This study tests if a heat treatment device can help reduce knee pain caused by arthritis. It involves people with moderate pain who can walk without help and have a recent knee X-ray.
Gravesano, SwitzerlandAges 19–69 - NCT06658249Recruiting
Core exercises vs foot-ankle strength for knee arthritis
This study compares core strengthening exercises with foot-ankle exercises to see which helps more with knee osteoarthritis symptoms like pain and walking difficulty. It might help you move better and climb stairs more easily.
Lahore, Punjab ProvinceAges 40–65 - NCT06658327Recruiting
Stretching for knee arthritis in postmenopausal women
This study compares two types of stretching to see which better reduces pain and improves movement in postmenopausal women with knee osteoarthritis. It may help you find a simple, drug-free way to manage your symptoms.
Lahore, Punjab ProvinceAges 50–65 - NCT06681142Recruiting
Pharmacist-physiotherapist team care for early knee osteoarthritis
This study tests a new way to manage early knee osteoarthritis by having a pharmacist and physiotherapist work together. You might get help with pain, stiffness, and movement without needing surgery or strong medications.
Sherwood Park, AlbertaAges 50 years+ - NCT06686680Recruiting
Shockwave therapy for knee arthritis after ACL repair
This study tests whether shockwave therapy can help knee pain and function in people who developed knee osteoarthritis after an ACL reconstruction. If you had ACL surgery at least a year ago and still have knee pain, this treatment might offer a new option without surgery.
Cambridge, MassachusettsAges 18–55
Hear when a new Knee trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 832 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.