Clinical trials
Lidocaine clinical trials
Below are recruiting lidocaine clinical trials, each written for real people, not researchers. We’re tracking 133 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07618676Recruiting
Nitrous Oxide vs Lidocaine for Pain Relief During Needle Procedures
This study compares two pain-relief methods—nitrous oxide gas (laughing gas) and lidocaine numbing cream—to see which works better when doctors need to place a needle in your vein. If you've never used nitrous oxide before and are generally healthy, you may be a good fit.
Belgrade, Savski VenacAges 18–65 - NCT07456826Enrolling by invitationPhase 4
Comparing two eye numbing gels for shots
This trial tests a new eye-numbing gel against the standard numbing method to see which works better for patients getting regular anti-VEGF injections in the eye.
Tyler, TexasAges 18 years+ - NCT06962709Enrolling by invitation
Warmed lidocaine for less pain during eye injections
This trial tests whether warming the numbing medicine (lidocaine) before an eye injection reduces pain. If you're already getting an eye injection for any reason, you may be able to join.
Columbia, MissouriAges Any age - NCT04085913Enrolling by invitationEarly Phase 1
Test shot to reduce opioid use after thyroid or parathyroid surgery
This early-phase study tests whether an injection given during thyroid or parathyroid surgery can lower how much opioid pain medicine you need afterward. It may help some people manage pain with less opioid medication.
Columbia, MissouriAges 18 years+ - NCT07763132Recruiting
Virtual reality for needle pain in children
This study compares using virtual reality goggles, a numbing cream, or standard care to reduce pain and anxiety during blood draws in children aged 3 to 15. It aims to find which method works best to make the experience more comfortable.
Ústí nad Labem, Ústí nad Labem RegionAges 3–15 - NCT07048769RecruitingPhase 4
Pain relief shot for saline ultrasound of the uterus
This trial tests if a numbing injection in the cervix reduces pain during a saline ultrasound that checks the uterus and fallopian tubes. It might help make the procedure more comfortable for you.
Hartsdale, New YorkAges 18–50 - NCT06661967Recruiting
Numbing gel for breathing tube insertion in emergencies
This trial tests if adding a numbing gel to standard care helps doctors insert a breathing tube more quickly on the first try. If you need a breathing tube in the emergency room and are over 18, you may be able to join.
Chon Buri, Changwat Chon BuriAges 18 years+ - NCT07255248RecruitingPhase 4
Knee fat pad pain study for young female athletes
This study tests a treatment for knee fat pad pain in teenage girls who play organized sports. It aims to see if a specific injection helps after physical therapy hasn't worked.
Norwood, MassachusettsAges 12–18 - NCT06121466RecruitingPhase 4
Belly wall injections for abdominal pain study
This study tests whether anesthetic injections into the belly wall can help relieve abdominal pain that feels like it's coming from the muscles or tissues of the belly wall itself. It may be a good option if you have localized pain and haven't tried these injections yet.
Portland, OregonAges 18–100 - NCT07602387Recruiting
Capsaicin cream for chemo-related nerve pain in legs
This study tests whether an 8% capsaicin cream (a chili-pepper derived treatment) can help reduce nerve pain and numbness in the legs caused by cancer chemotherapy drugs (taxanes). The cream is applied directly to affected areas, and the research team will track whether it improves your symptoms and pain levels over time.
Boulogne-Billancourt, HAUTS DE SEINEAges 18 years+ - NCT07374952RecruitingPhase 4
Finding the smallest effective dose for a clavicle nerve block
This study tests how much numbing medicine is needed to block nerves below the collarbone during shoulder surgery. It aims to find the smallest effective dose to reduce side effects.
Montreal, QuebecAges 18–70 - NCT07409896Recruiting
Comparing two numbing shots for painful lower first molars
This study compares two numbing methods for severe tooth pain (pulpitis) in a lower first molar. If you have a tooth that needs a root canal and the pain lingers after cold, this trial may help determine which anesthetic works better for you.
Rawalpindi, Punjab ProvinceAges 18–55 - NCT07398768Recruiting
Study on a procedure for lines around the mouth and thin lips
This study is looking at a treatment for wrinkles around the mouth and to make the lips fuller. It's for people who already plan to get this treatment at their doctor's office.
Vienna, State of ViennaAges 18 years+ - NCT07322445Recruiting
Study of neck and shoulder pain with special MRI
This study uses special MRI scans to look at muscles and nerves in people with long-term neck or shoulder pain caused by trigger points (tender spots in muscles). The goal is to understand what happens in the body with this type of pain—so doctors can find better ways to treat it.
St Louis, MissouriAges 18–80 - NCT07370129Enrolling by invitation
Numbing injection for pain after tonsil surgery
This study tests a numbing injection near a nerve in your nose to see if it can reduce pain and help you recover faster after tonsillectomy. It is a non-drug approach that may offer an alternative to strong pain medicines.
Ankara, AnkaraAges 12 years+ - NCT07571889Recruiting
Numbing spray to reduce Botox injection pain for chronic migraine
This study tests whether a numbing spray applied inside the nose before Botox injections can reduce injection pain in people with chronic migraine. The goal is to make the treatment more comfortable without affecting how well it works.
East Providence, Rhode IslandAges 18 years+ - NCT06799494RecruitingPhase 4
HPV vaccine: testing a reduced dose schedule
This study tests if giving fewer doses of the HPV vaccine still protects against HPV-related cancers. It may help people who are willing to get a reduced number of shots.
Decatur, GeorgiaAges 18–45 - NCT07419854RecruitingPhase 4
Restoring facial fullness after GLP-1 weight loss with Radiesse
This trial tests whether a facial filler called Radiesse can restore volume lost during weight loss from GLP-1 medications (like Wegovy or Mounjaro). It's for adults just starting GLP-1 therapy who expect to lose 20 pounds or more and want to see if fillers can help their face look fuller.
Pasadena, CaliforniaAges 21–65 - NCT06602349Recruiting
Lidocaine injection for chronic anal/perineal pain
This trial tests whether injecting a numbing medicine (lidocaine) into the painful area helps people with chronic, unexplained pain in the anal or perineal region. It is for patients who have not gotten relief from standard treatments and whose MRI shows no other cause.
Paris, Île-de-France RegionAges 18 years+ - NCT06268704RecruitingPhase 4
Comparing two types of steroid injections for sacroiliac joint pain
This study compares two types of steroid medication used in injections for sacroiliac joint pain. It aims to see if one type works better than the other, helping patients with low back or buttocks pain find relief.
Albuquerque, New MexicoAges 18–99 - NCT07630155Recruiting
Single-use digital scope for kidney cancer surveillance
This trial tests a new, disposable flexible camera (ureteroscope) to safely check for or monitor upper urinary tract cancer in an office setting without putting you to sleep. The goal is to see if patients can tolerate this procedure comfortably while awake.
Ann Arbor, MichiganAges 18 years+ - NCT07601750Enrolling by invitationPhase 4
Local Anesthetic Study for Skin Cancer Surgery
This study tests local anesthetics (numbing medicines) used during Mohs micrographic surgery, a specialized procedure for skin cancer. Researchers want to understand how well these numbing agents work and improve patient comfort during the procedure.
Dallas, TexasAges 18–89 - NCT07268118RecruitingPhase 2
Pain relief for cervical ripening balloon in labor
This study tests if using lidocaine gel on the cervix before placing a ripening balloon can reduce pain for pregnant women at full term. It may help women who want this balloon to start labor feel more comfortable.
Boston, MassachusettsAges 18 years+ - NCT07657897Recruiting
Anesthesia effects on inflammation in liver cancer treatment
This study looks at how different types of anesthesia or sedation affect inflammation in people with early-stage liver cancer who are having a procedure called radiofrequency ablation (RFA). RFA uses heat to destroy small tumors, and researchers want to see if the choice of anesthesia influences the body's immune response, which might help improve recovery.
Cluj-Napoca, ClujAges 18–80
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Common questions
- Are there clinical trials for lidocaine?
- Yes. Clin2 currently lists 133 recruiting lidocaine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lidocaine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lidocaine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.