Clinical trials
Liver clinical trials
Below are recruiting liver clinical trials, each written for real people, not researchers. We’re tracking 1,219 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06875128RecruitingPhase 2
Liver-directed chemo with standard chemo for breast cancer
This trial tests if giving a high dose of chemotherapy directly into the liver, followed by standard chemotherapy, is safe and works better than standard chemo alone for people with breast cancer that has spread mostly to the liver.
Tampa, FloridaAges 18 years+ - NCT06863376RecruitingPhase 2
Carbocisteine for fatty liver disease: safety and benefit study
This study tests a medicine called carbocisteine to see if it can help treat nonalcoholic fatty liver disease (NAFLD). If you have a fatty liver and no other liver or kidney conditions, this trial may explore whether this drug is safe and effective for you.
TantaAges 18–65 - NCT06860815RecruitingPhase 2
Cemiplimab with liver radiation for breast cancer that spread to the liver
This trial tests a combination of a drug called cemiplimab (an immunotherapy that helps your immune system fight cancer) and a type of targeted radiation (Y-90 SIR-Spheres) given directly to liver tumors. It is for people with breast cancer that has spread to the liver and who have already had at least one type of chemotherapy.
Duarte, CaliforniaAges 18 years+ - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+ - NCT06856252Recruiting
Studying human liver organoids for a fatty liver disease called NASH
This study takes small samples of liver tissue to grow 3D 'mini livers' (organoids) in the lab. Researchers want to learn how non-alcoholic steatohepatitis (NASH), a serious fatty liver condition, starts and progresses, which could lead to better treatments.
Milan, MilanoAges 18 years+ - NCT06848842RecruitingPhase 2
Ivonescimab and chemotherapy for colorectal cancer that spread only to the liver
This trial tests a new drug called ivonescimab combined with chemotherapy for people whose colorectal cancer has spread only to the liver and cannot be surgically removed right away. The goal is to see if this combination can shrink the tumors enough to allow surgery or other treatments.
BeijingAges 18 years+ - NCT06848465RecruitingPhase 1
Radiation plus chemo-immunotherapy for colon cancer with liver spread
This trial tests a combination of low-dose radiation, chemotherapy, and immunotherapy for people with colorectal cancer that has spread only to the liver. The goal is to see if this approach can shrink tumors and improve outcomes.
Chongqing, Chongqing MunicipalityAges 18–80 - NCT06852820RecruitingPhase 2
PSMA-targeted radioactive therapy for advanced liver cancer
This trial tests a radioactive treatment called 177Lu-PSMA-617 for advanced liver cancer that has not responded to first-line immunotherapy. You need a PSMA-PET scan first to see if your cancer absorbs the treatment.
Cleveland, OhioAges 18 years+ - NCT06836609RecruitingPhase 1/Phase 2
Study of a new drug for fatty liver disease (MASLD/MASH)
This study tests a new drug called ALN-CIDEB for people with fatty liver disease (MASLD or MASH). The goal is to see if it can reduce liver fat and improve liver health. You may qualify if you have a higher BMI and evidence of liver fat on imaging tests.
Chandler, ArizonaAges 18–65 - NCT06838468Enrolling by invitation
Study on liver health in alcohol detox patients
This study is looking at liver health in people staying in a detox unit for alcohol use disorder. Researchers want to see how common liver problems are in this group. Participating involves extra tests like blood work, an ultrasound, and a special liver scan (FibroScan).
Sabadell, BarcelonaAges 18–75 - NCT06832189RecruitingPhase 1
Testing everolimus and epoetin for liver transplant tolerance
This trial is testing whether a combination of two drugs, everolimus and epoetin, can help liver transplant recipients gradually reduce their anti-rejection medicines. If successful, it may lead to long-term transplant tolerance with fewer side effects.
San Francisco, CaliforniaAges 18 years+ - NCT06825559RecruitingPhase 1
Saroglitazar safety in moderate liver impairment from cholestatic disease
This trial tests how the body processes saroglitazar in people with moderate liver impairment caused by cholestatic liver disease. The goal is to ensure the drug is safe and dosed correctly for this group.
Indianapolis, IndianaAges 18–80 - NCT06824974Recruiting
Time-restricted eating for liver disease or cancer
This study tests whether combining time-restricted eating with healthy eating helps people with metabolic liver disease, cirrhosis, or early-stage liver cancer. If you are overweight and currently fast less than 12 hours at night, this diet approach might improve your health.
La Jolla, CaliforniaAges 18 years+ - NCT06814626RecruitingPhase 3
Nutrition therapy for muscle loss in cirrhosis with fluid buildup
This trial tests whether a special nutrition plan can help treat muscle loss in people with liver cirrhosis who also have fluid buildup that doesn't improve with standard treatment. It aims to improve strength and outcomes after a procedure to place a shunt in the liver.
PalermoAges 18–80 - NCT06801665RecruitingPhase 2
Combination therapy for advanced colorectal cancer with liver spread
This trial tests a new combination of treatments for advanced colorectal cancer that has spread to the liver. It aims to see if this combination can shrink tumors and help patients live longer.
ChangzhouAges 18–75 - NCT06794086RecruitingPhase 3
SBRT and immunotherapy for colorectal cancer liver metastases
This trial combines targeted radiation (SBRT) with an immunotherapy drug (PD-1 inhibitor) to treat colorectal cancer that has spread to the liver and can't be removed by surgery. It aims to help shrink or control tumors in patients whose cancer has a normal DNA repair system (pMMR/MSS).
Guangzhou, GuangdongAges 18–75 - NCT03844399Recruiting
3D ultrasound imaging during liver or kidney procedures
This study uses a new 3D ultrasound scan while you get standard care for a liver or kidney biopsy or ablation. The goal is to see whether the imaging is clear and useful during these procedures.
London, OntarioAges 18 years+ - NCT06787183RecruitingPhase 2
Short-course radiation with chemoimmunotherapy for rectal cancer that has spread to the liver
This trial tests whether combining short-course radiation with a chemotherapy regimen (CAPOX) and an immunotherapy drug (QL1706) can help treat rectal cancer that has spread to the liver. It is designed for patients who have not had any prior cancer treatment.
Fuzhou, FujianAges 18–75 - NCT04837885RecruitingPhase 2
Liver-targeted radioactive drug for GI or pancreas NET liver spread
This study tests a way to deliver a radioactive “somatostatin-type” medicine directly into the liver artery to treat liver-dominant spread of neuroendocrine tumors (NETs). It may help shrink or control liver metastases after standard treatment has not worked enough.
BordeauxAges 18 years+ - NCT06681818Recruiting
New method to measure liver regrowth after surgery
This study tests a new way to measure how well your liver grows back and heals after part of it is removed. The goal is to predict and prevent complications after surgery.
Englewood, New JerseyAges 18 years+ - NCT03789383Recruiting
Living donor liver transplant and biliary complication outcomes study
This study looks at what factors lead to “biliary complications” (problems involving the bile ducts that help move bile from the liver) after an adult living-donor liver transplant. It’s aimed at people who had this specific type of transplant at the study hospital in Egypt.
AsyutAges 18–65 - NCT06777485Recruiting
China liver cancer patient registry study
This study is creating a database of people with liver cancer (including hepatocellular carcinoma and other types). It aims to collect health information and samples over time to better understand the disease and improve future care. If you join, you will be asked to provide blood and leftover tissue from surgery or biopsy, and to follow up with the research team.
Anqing, AnhuiAges 18 years+ - NCT06774144Enrolling by invitationPhase 3
Rezafungin to prevent fungal infections in liver transplant patients
This trial tests whether a medicine called rezafungin can help prevent serious fungal infections in people who have received a liver transplant. If you have certain risk factors, this study may offer extra protection against infections.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05439226Recruiting
Diet plan targeting liver fat for type 2 diabetes
This study tests whether a Chinese medical nutrition therapy diet can reduce liver fat and help manage type 2 diabetes in people who also have fatty liver. You may be asked to follow a specific eating plan and keep your diabetes care stable during the study.
Yichang, HubeiAges 18–75
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Common questions
- Are there clinical trials for liver?
- Yes. Clin2 currently lists 1,219 recruiting liver studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a liver trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a liver trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.