Clinical trials
Lower Limb Injury clinical trials
Below are recruiting lower limb injury clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07028723Recruiting
Proprioception and ligament injury risk in pivoting sports
This study tests whether your sense of body position and movement affects your risk of knee or ankle ligament injuries while playing sports like rugby, soccer, or handball. Participating could help identify ways to prevent these injuries.
MontpellierAges 14–25 - NCT07721792Recruiting
Study on advanced braces for leg injuries
This study tests a new type of leg brace for people who currently use an ankle-foot orthosis (AFO) to help with walking or daily activities after a lower leg injury. The goal is to see if the new brace works better and is more comfortable.
Tampa, FloridaAges 18–80 - NCT04149977Recruiting
Blood flow restriction therapy for knee tendon injuries
This study tests whether blood flow restriction therapy can help healing and recovery after certain knee extensor injuries (like patella or quadriceps tendon rupture). You must be able to take part in the usual physical therapy plan, too.
New York, New YorkAges 18–65 - NCT04953364Recruiting
Tech-based self-management support after a leg amputation
This study tests a technology-based program to help people manage rehabilitation after a lower-limb amputation. It may help by giving structured support for day-to-day care and prosthesis use.
Vancouver, British ColumbiaAges 50 years+ - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06419920Recruiting
Prosthetic performance enhancement trial
This study tests whether a new prosthetic foot can help people with a lower-limb amputation walk better. You will use your current foot and the new foot, and we will measure how well you walk.
Las Vegas, NevadaAges 18 years+ - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT06685094Recruiting
Pain, movement, and quality of life study for Albanian speakers
This study is translating health questionnaires into Albanian to better understand pain, movement, mood, and quality of life. It aims to help people with muscle, joint, or back pain.
Murcia, MurciaAges 18–80 - NCT06923293Recruiting
Motorized Leg Brace to Improve Walking After Injury
This study tests a custom motorized leg brace (called an AFO) to help people walk better after a past leg injury. If you have had a leg injury for over a year and can stand for 30 minutes, this device might help improve your walking.
West Orange, New JerseyAges 18–80 - NCT06937242Recruiting
Testing a smarter prosthetic knee for safer walking
This study tests whether a microprocessor-controlled knee can reduce falls in people who walk limited distances. If you use a regular mechanical knee and have a moderate activity level, this trial might help you walk more safely.
Austin, TexasAges 18 years+ - NCT07191795Recruiting
Using phantom sensations from socket changes as feedback while walking
This trial tests whether changing how your prosthetic socket fits can create helpful phantom limb sensations that improve your walking. It may help people with major lower-limb amputations walk more naturally.
NancyAges 18 years+ - NCT07579520Recruiting
Music-Based Movement Training After Leg Fracture Recovery
This study tests whether listening to rhythmic music (a technique called rhythmic auditory stimulation) helps young people regain movement and flexibility in their legs after a fracture heals. The goal is to see if music-guided exercises work better than standard rehabilitation.
Lahore, Punjab ProvinceAges 5–18 - NCT05124652Recruiting
Testing a prosthetic socket that adjusts automatically
This trial is testing a prosthetic socket that can automatically adjust to help fit better and feel more comfortable. It may help people with below-knee (transtibial) amputations who currently struggle with socket fit or comfort.
Seattle, WashingtonAges 18 years+ - NCT06975423Recruiting
Walking Sensation Study for older adults
This study is for older adults who walk slowly and have some loss of feeling in their feet. Researchers want to see if a special walking test can help understand this better. You must be generally healthy and free of major medical issues or recent surgeries.
Gainesville, FloridaAges 65–95 - NCT07432685Enrolling by invitation
Can movement predict chronic pain after combat limb injuries?
This study is looking for people with combat-related arm or leg injuries to see if how they move can predict long-term pain. Researchers hope to better understand who might develop chronic pain and help improve treatment.
LvivAges 18–50 - NCT06127316Recruiting
Heel lift height and foot pressure with custom braces
This study tests if changing the height of a heel lift in a custom foot brace can improve how weight is distributed on your foot after a serious ankle or hindfoot injury. If you have pain when walking, this could help find better ways to reduce that pain.
Iowa City, IowaAges 18–65 - NCT06621914Recruiting
Blood flow restriction training for military with leg injuries
This trial tests a low-weight exercise program using a special cuff on the leg (blood flow restriction) to see if it helps military personnel recover from leg injuries faster. It could be an option if pain is stopping you from doing normal rehab.
Loughborough, LeicestershireAges 18–55 - NCT06847295Recruiting
Spinal cord stimulation for standing and walking after paralysis
This trial tests if a device that sends mild electrical pulses to the spinal cord, combined with daily therapy, can help people with chronic spinal cord injury regain some ability to stand or walk. It also looks at reducing muscle spasms and improving quality of life.
São Paulo, São PauloAges 18–50 - NCT06370273RecruitingPhase 3
Blood thinners for leg casts after injury
This study tests whether taking a blood thinner (anticoagulant) pill can prevent dangerous blood clots in people who have a hard cast or brace on their leg after an injury. It compares two different blood thinners to see which works better.
Carshalton, SurreyAges 16 years+ - NCT03622879Recruiting
Mirror therapy plus mild skin stimulation for leg movement after stroke
This trial tests whether using a mirror together with mild electrical stimulation on the skin can improve lower-limb movement after stroke. You may be eligible if you can already lift your ankle a bit and walk independently, and if certain thinking, vision, and skin issues are not present.
Hong KongAges 55–85 - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT06452186Recruiting
Study of a new leg prosthetic controller for improved balance
This study tests a new prosthetic leg controller that helps people with below-knee amputations walk more steadily and with better balance. You may be eligible if you have used a prosthetic leg for at least a year and are comfortable walking in the community.
Raleigh, North CarolinaAges 18–99
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Common questions
- Are there clinical trials for lower limb injury?
- Yes. Clin2 currently lists 55 recruiting lower limb injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.