Clinical trials
Lower Limb Injury clinical trials
Below are recruiting lower limb injury clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06906536Enrolling by invitation
Intermittent low oxygen to improve leg function after spinal injury
This trial tests whether short, controlled sessions of low oxygen (like breathing thin air) can improve leg movement and blood markers in people with spinal cord injuries. It may help with walking or standing.
Boulder, ColoradoAges 18–75 - NCT06293469Recruiting
Speeding up flap surgery for severe leg injuries
This trial tests whether performing flap surgery sooner after a severe leg injury below the knee leads to better outcomes. If you have an open fracture or dislocation that needs a flap, you may be able to join.
Sacramento, CaliforniaAges 18 years+ - NCT06815601Recruiting
Brain stimulation for better limb function after spinal cord injury
This study tests if a non-invasive brain stimulation method can improve arm and hand function in people with spinal cord injury, as well as in healthy individuals. The goal is to find a safe and effective way to boost recovery.
Buffalo, New YorkAges 18–75 - NCT05240014Recruiting
Powered leg braces to help people move more easily
This study tests modular powered leg braces (orthoses) to improve voluntary movement and walking ability in adult participants. It may help you learn whether the braces are safe and useful for your kind of mobility and daily movement.
Ann Arbor, MichiganAges 18–85 - NCT06473740RecruitingPhase 4
Gene therapy plus angioplasty for severe leg blockages
This study tests if adding gene therapy to a standard leg artery-opening procedure (angioplasty or stenting) helps people with severe leg pain or non-healing wounds due to blocked arteries. It may improve blood flow and save the leg from amputation.
Blagoveshchensk, Amur OblastAges 18 years+ - NCT06839885Recruiting
Water Therapy for Swelling in One Leg
This trial tests whether water-based therapy (hydrotherapy) can help reduce swelling in one leg caused by lymphedema. It's for people who have already tried standard lymphedema treatment.
IstanbulAges 18–75 - NCT07768761Recruiting
Electrical stimulation exercise for lower limb paralysis
This trial tests whether a muscle exercise program using electrical stimulation can help people with paralysis in their legs. It may improve muscle strength, blood flow, or other health benefits.
Cleveland, OhioAges 18 years+ - NCT06667492Recruiting
Leg strength measurement in healthy kids
This study measures leg muscle strength in healthy children ages 5 to 16 to better understand normal development. If your child is developing typically and can follow instructions, they may be able to join.
Lamia, PhthiotisAges 5–16 - NCT07323147Enrolling by invitation
Robot-assisted walking therapy for hip fracture recovery
This study tests whether a robot suit can help older adults walk better after hip fracture surgery. If you are 65 or older and had surgery for a broken hip from a minor fall, you may be able to join.
Beijing, Beijing MunicipalityAges 65–100 - NCT06538974Recruiting
Long-term use of an exoskeleton for leg weakness
This trial tests a walking device called an exoskeleton to help people with leg weakness or movement problems. It's designed to see if using the exoskeleton regularly over time can help improve walking or mobility.
ParisAges 18 years+ - NCT07043101Recruiting
Virtual reality for leg rehab with Vector system
This study tests if using a virtual reality headset can help people who are already using a Vector walking system in the hospital. The virtual reality shows goals to aim for while walking, which may make rehab more engaging and effective.
Schenectady, New YorkAges 18 years+ - NCT07155967Enrolling by invitation
Blood flow restriction training for leg strength in older women
This trial tests whether a type of strength training that partly uses blood flow restriction can help older women build leg strength on one side, which may also benefit the other leg. It's for women who are generally healthy and have not had recent leg injuries or surgeries.
Presidente Prudente, São PauloAges 60 years+ - NCT07641621Recruiting
Chiropractic Ankle Treatment and Jump Performance Study
This study tests whether chiropractic ankle manipulation improves how high and powerfully you can jump. Researchers will work with recreationally active adults to see if this treatment affects athletic performance.
Seneca Falls, New YorkAges 18–35 - NCT06780943Recruiting
Study on how people with leg amputations adapt their walking
This study looks at how people with a leg amputation change the way they walk to make up for lost function. It may help improve rehabilitation and prosthetic care.
NîmesAges 18–80 - NCT07440615Recruiting
Leg muscle and heart performance in active adults
This study looks at how leg muscle size relates to heart and muscle performance in healthy men and women. It aims to understand normal differences between sexes.
EskişehirAges 18–30 - NCT06275282Recruiting
Nerve surgery for better leg prosthetic control
This trial tests a new nerve surgery technique to help people with above-knee leg amputations have better control of their prosthetic leg. The goal is to improve how well the prosthesis responds to your movements.
Ann Arbor, MichiganAges 18–75 - NCT06543888Recruiting
Exoskeleton training for walking and daily tasks in older adults
This study tests whether a passive lower-limb exoskeleton can help older adults walk better and do daily activities more easily. You will wear the device during training sessions to see if it improves your movement and independence.
Taoyuan, GuishanAges 60 years+ - NCT07461701Recruiting
Comparing two squat intensities for strength in young women
This study compares two ways of doing bodyweight squats (stopping when you lose 15% vs 30% of your speed) to see which is better for building leg strength and endurance in young women who are not very active. It may help find a simple, safe way to improve fitness at home.
Lahore, Punjab ProvinceAges 18–25 - NCT05859451Recruiting
Heated tobacco product study for surgically treated leg fractures
This study looks at whether a tobacco heating system (instead of cigarettes) affects how well a surgically repaired tibia or femur fracture heals. It mainly targets smokers with a certain smoking history who do not want to join free smoking-cessation seminars.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06492733Recruiting
FastWire device for unblocking leg arteries (FREEFLOW trial)
This trial tests a new wire system to reopen completely blocked leg arteries without surgery. It is for people with severe leg pain or tissue damage caused by blocked arteries, and aims to restore blood flow and improve walking ability.
Wilmington, DelawareAges 18–85 - NCT06927206Recruiting
Vibration and muscle stimulation for leg function after stroke
This trial tests if adding a gentle vibrator to standard muscle-stimulation therapy can improve leg movement in people recovering from a stroke. It's for those who had a stroke 2 weeks to 3 months ago and have mild to moderate thinking and movement issues.
Lahore, Punjab ProvinceAges 45–60 - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT04800276Recruiting
Exercise program for leg artery disease
This trial tests a supervised exercise program for people with leg pain when walking caused by narrowed leg arteries. The goal is to see if exercise can improve walking ability and quality of life.
Le MansAges 18 years+ - NCT06998134Recruiting
Exoskeleton walking training for children and young adults
This trial tests whether a robotic leg exoskeleton can help improve walking in children and young adults with certain conditions (like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury) or those with no walking issues. The goal is to find out if the exoskeleton is safe and effective for everyday use, especially in younger people who might lose the ability to walk as they get older.
Bethesda, MarylandAges 5–25
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Common questions
- Are there clinical trials for lower limb injury?
- Yes. Clin2 currently lists 55 recruiting lower limb injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.