Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05286710Recruiting
Thrombectomy treatment for new blood clots in the leg
This trial studies a procedure to remove an acute deep vein blood clot in the leg. It may help restore blood flow faster than standard treatment for certain clot locations.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05300308Recruiting
Studying leg swelling and nighttime urination after pelvic node surgery
This trial looks at why some people develop leg swelling (lymphedema) and frequent nighttime urination (nocturia) after pelvic lymph node surgery for prostate or bladder cancer. It may help doctors better predict and manage these side effects after the operation.
Leuven, FlandersAges 18 years+ - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT05543785Recruiting
Ketorolac pain block for lower-limb surgery with a tourniquet
This trial looks at whether a ketorolac pain medicine given directly to the leg during surgery can reduce pain after lower-limb orthopedic operations. It may help people who are having one leg operated on with spinal anesthesia and a tourniquet, but it has several safety limits.
Al MansurahAges 19–60 - NCT05793749Recruiting
Prevent leg swelling after gynecologic cancer treatment
This study tests an early approach to help prevent lower-limb lymphedema (chronic leg swelling) after lymph node surgery and radiotherapy for gynecologic cancer. If you’re at risk, it may help your legs stay less swollen and reduce complications.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT05859451Recruiting
Heated tobacco product study for surgically treated leg fractures
This study looks at whether a tobacco heating system (instead of cigarettes) affects how well a surgically repaired tibia or femur fracture heals. It mainly targets smokers with a certain smoking history who do not want to join free smoking-cessation seminars.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06011018Recruiting
Mirror Therapy with Electrical Stimulation or Sound Beats after Stroke
This study tests if combining mirror therapy with either gentle electrical stimulation or special sound beats can help improve leg movement and brain activity after a stroke. It is designed for people who had their first stroke at least 6 months ago and have some movement in their leg.
Kaohsiung CityAges 20–80 - NCT06195956Recruiting
Lower body exercise for shoulder impingement pain
This study tests whether lower body exercises (like walking or leg presses) can help reduce shoulder pain from impingement. It's for people with shoulder pain that has lasted more than 6 weeks and who have not had surgery or a major injury.
GizaAges 20–45 - NCT06283186RecruitingPhase 1
Exercise and pain relief in arms vs. legs: a healthy volunteer study
This trial compares how well exercise reduces pain sensitivity in the arms versus the legs. Healthy participants will do exercise and have their pain response measured to understand how exercise can naturally relieve pain.
MadridAges 18–64 - NCT06296082RecruitingPhase 2/Phase 3
Dry Needling vs Botox for Post-Stroke Leg Stiffness
This study compares two treatments for leg stiffness after a stroke: dry needling (tiny needles placed in trigger points) and Botox injections. It may help you if you've had a first stroke within the past year and have mild to moderate tightness in the calf muscles that limits ankle movement.
Antwerp, FlandersAges 18–75 - NCT06439823Recruiting
Study of arm and leg movement in people with walking problems
This study observes how your arms and legs move as you walk or do other activities. It compares people with conditions that affect movement (like muscle diseases) to healthy volunteers to understand differences.
Liège, LiegeAges 2 years+ - NCT06462625Recruiting
Knee realignment surgery for arthritis with bowed legs
This study tests how well a realignment surgery (osteotomy) works for people with mild knee arthritis and a bent knee that's at least 3 degrees off center. The surgery may also fix other knee problems like a torn meniscus or ligament at the same time.
BolognaAges 18–70 - NCT06476782Recruiting
Motor learning and exercise for stroke recovery
This study tests a combined motor relearning program and aerobic exercise to improve balance and leg function in people recovering from a stroke that happened 1 to 5 months ago. If you qualify, you would receive this therapy to help with your standing stability and walking ability.
Sialkot, Punjab ProvinceAges 50–70 - NCT06492733Recruiting
FastWire device for unblocking leg arteries (FREEFLOW trial)
This trial tests a new wire system to reopen completely blocked leg arteries without surgery. It is for people with severe leg pain or tissue damage caused by blocked arteries, and aims to restore blood flow and improve walking ability.
Wilmington, DelawareAges 18–85 - NCT06517251Recruiting
Arm-hand boost therapy for stroke recovery
This trial tests a special arm and hand therapy program for people who are still in the hospital after a stroke. If you have trouble using your arm or hand, this treatment may help you recover better.
Edegem, AntwerpenAges 18 years+ - NCT06529874Recruiting
Pain, balance, and strength in children with sickle cell
This study looks at how children (ages 9-14) with sickle cell anemia or who are healthy handle pressure, balance, and strength. It aims to understand pain and movement better to help improve care.
GizaAges 9–14 - NCT06538974Recruiting
Long-term use of an exoskeleton for leg weakness
This trial tests a walking device called an exoskeleton to help people with leg weakness or movement problems. It's designed to see if using the exoskeleton regularly over time can help improve walking or mobility.
ParisAges 18 years+ - NCT06621914Recruiting
Blood flow restriction training for military with leg injuries
This trial tests a low-weight exercise program using a special cuff on the leg (blood flow restriction) to see if it helps military personnel recover from leg injuries faster. It could be an option if pain is stopping you from doing normal rehab.
Loughborough, LeicestershireAges 18–55 - NCT06690658Recruiting
Home arm exercises with a robotic trainer
This trial tests whether a robotic trainer can help people do upper body exercises on their own. It may be a good fit if you can sit without back support and follow simple instructions.
Raanana, IsraelAges 18 years+ - NCT06693245Recruiting
Pain during microwave treatment for varicose veins
This study looks at how much pain people feel during a microwave treatment for varicose veins in the leg. It aims to understand what factors affect pain, so the treatment can be more comfortable for future patients.
Chengdu, SichuanAges 18–90 - NCT06711120Recruiting
Comparing two treatments for varicose veins in the lower legs
This study compares two minimally invasive treatments (radiofrequency ablation and microwave ablation) for varicose veins in the small saphenous vein. If your varicose veins cause symptoms like pain, swelling, or heaviness, this trial may help determine which treatment works better.
ChengduAges 18–90 - NCT06713044Recruiting
Quran recitation or music for pain after leg surgery
This trial tests whether listening to Quranic recitation or classical music can reduce pain and inflammation after lower-leg orthopedic surgery. It may help Muslim patients manage pain without extra medication.
Purwokerto, Central JavaAges 18–60 - NCT06729021Recruiting
Predicting leg blood clots after heart or lung surgery
This study tests whether a simple score (Modified Caprini) and a blood test (D-dimer) can help predict and prevent blood clots in the legs after heart or lung surgery. If you are having cardiothoracic surgery and will be in the hospital for a few days, you may be able to join.
BaghdadAges 18 years+ - NCT06731608Recruiting
Fracture prevention study for older adults in rehab
This study tests a system to help prevent another broken bone after a hip, leg, or pelvis fracture. It is for people 65+ who are in a skilled nursing facility for rehab and plan to return home or to assisted living.
Baltimore, MarylandAges 65 years+
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 194 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.