Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 205 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07387744Recruiting
Mobility study for people with leg amputation
This study looks at how people with a leg amputation get around both walking and using a wheelchair or scooter. It aims to understand community mobility to help improve care and devices.
Richmond, VirginiaAges 18–85 - NCT07384689Recruiting
Study of leg tissue in non-traumatic amputation patients
This study looks at the tissue environment in the legs of patients who need amputation due to non-traumatic causes, like poor blood flow or infection. Understanding the tissue better might help improve healing for future patients.
Aarhus NAges 18 years+ - NCT06667739Recruiting
Promoting physical activity after leg amputation
This study tests a program to help people who have lost a leg due to diabetes or blood vessel disease become more active. It uses coaching and online modules to support your progress.
Toronto, OntarioAges 18 years+ - NCT06847295Recruiting
Spinal cord stimulation for standing and walking after paralysis
This trial tests if a device that sends mild electrical pulses to the spinal cord, combined with daily therapy, can help people with chronic spinal cord injury regain some ability to stand or walk. It also looks at reducing muscle spasms and improving quality of life.
São Paulo, São PauloAges 18–50 - NCT06283186RecruitingPhase 1
Exercise and pain relief in arms vs. legs: a healthy volunteer study
This trial compares how well exercise reduces pain sensitivity in the arms versus the legs. Healthy participants will do exercise and have their pain response measured to understand how exercise can naturally relieve pain.
MadridAges 18–64 - NCT07317492Recruiting
Hemorrhoids and varicose veins study
This study looks at the connection between hemorrhoids and varicose veins. It may help researchers understand if these conditions are related and how to better treat them.
Aydin, EfelerAges 18 years+ - NCT06873321RecruitingPhase 4
Blood thinners after leg artery surgery to prevent clots
This trial compares two blood-thinning strategies after leg artery surgery or angioplasty to prevent dangerous blood clots. Participants will receive either rivaroxaban plus aspirin or aspirin alone, and researchers will monitor for clots over 30 days.
Pernambuco, PernambucoAges Any age - NCT07312383Recruiting
Skin blood flow study in leg artery disease
This trial uses a special device to measure tiny blood vessels in the skin of patients with severe leg artery disease. It aims to understand how blood flow changes before and after a common treatment to open blocked leg arteries (angioplasty).
OsloAges 18 years+ - NCT07285642Recruiting
Oxygen levels in muscles and brain in COPD patients
This study measures oxygen levels in your brain and leg muscles during exercise to understand how COPD affects them.
IstanbulAges 40–70 - NCT07266077Recruiting
A study of a slope-adapting prosthetic foot for Veterans
This study tests a special prosthetic foot that adapts to slopes (like hills or ramps) to help Veterans with below-knee amputations walk more easily. You would need to visit the Minneapolis VA and use a special foot for a while.
Minneapolis, MinnesotaAges 18–89 - NCT06529874Recruiting
Pain, balance, and strength in children with sickle cell
This study looks at how children (ages 9-14) with sickle cell anemia or who are healthy handle pressure, balance, and strength. It aims to understand pain and movement better to help improve care.
GizaAges 9–14 - NCT07248501Recruiting
Bulgarian exercises for leg function in children
This study tests a type of exercise called Bulgarian exercises to see if they help improve leg function in children. If your child can walk and follow instructions, they may be able to join.
Lahore, Punjab ProvinceAges 8–18 - NCT07221682RecruitingPhase 2/Phase 3
Comparing two nerve block methods for lower leg surgery
This study compares two ways of giving a nerve block (fascia iliaca block) to help with positioning for spinal anesthesia and pain relief after lower leg surgery. The goal is to see which method works better for making patients more comfortable.
Sāhīwāl, Punjab ProvinceAges 30–60 - NCT07204925RecruitingPhase 1
Personalizing a computerized leg for above-knee amputees
This trial tests a new way to personalize a computerized prosthetic leg for people who have lost a leg above the knee. It uses smart learning technology to help the leg adjust to how you walk, which may make walking feel more natural.
Raleigh, North CarolinaAges 18–75 - NCT07206797Recruiting
Ultrasound to measure muscle activity from spinal cord stimulation
This study uses ultrasound to see how muscles respond to two types of electrical stimulation (spinal cord and functional electrical stimulation). It may help researchers better understand how to treat muscle weakness or paralysis.
Raleigh, North CarolinaAges 18–60 - NCT07198698Enrolling by invitation
Sahid method for leg swelling after surgery, infection, or treatment
This study tests a technique called the Sahid method to reduce leg swelling (lymphedema) in women. It might help if you have had swelling in one leg for two years or less due to surgery, infection, cancer, or an injury.
SantiagoAges 30–65 - NCT06621914Recruiting
Blood flow restriction training for military with leg injuries
This trial tests a low-weight exercise program using a special cuff on the leg (blood flow restriction) to see if it helps military personnel recover from leg injuries faster. It could be an option if pain is stopping you from doing normal rehab.
Loughborough, LeicestershireAges 18–55 - NCT07181434Recruiting
Virtual reality for pain relief during leg artery repair
This trial tests whether using a virtual reality headset during a leg artery repair procedure can reduce pain. If you have peripheral artery disease and are having a minimally invasive leg artery surgery under local anesthesia with sedation, you may be able to participate.
PoitiersAges 18 years+ - NCT07175714Recruiting
Study of walking stumbles and slips
This study tests how well different methods can recreate stumbles and slips while walking. It may help people with and without prosthetic legs understand how to prevent falls.
ReykjavikAges 18 years+ - NCT02748226Recruiting
Study of artery procedures for leg artery disease outcomes
This study looks at results of a minimally invasive procedure done inside blood vessels (endovascular therapy) for people with painful or worsening leg artery disease. It uses both past (retrospective) and future (prospective) patient information to better understand outcomes.
SeoulAges 20 years+ - NCT07155967Enrolling by invitation
Blood flow restriction training for leg strength in older women
This trial tests whether a type of strength training that partly uses blood flow restriction can help older women build leg strength on one side, which may also benefit the other leg. It's for women who are generally healthy and have not had recent leg injuries or surgeries.
Presidente Prudente, São PauloAges 60 years+ - NCT07135895Recruiting
Artix device for recent leg artery blockages
This study tests a device called Artix to remove blood clots from arteries in the leg that occurred within the last two weeks. It may help restore blood flow and avoid amputation.
San Francisco, CaliforniaAges 18 years+ - NCT07138066Recruiting
Smart crutch tips for guided weight-bearing after tibia fracture
This trial tests a smart crutch tip that helps guide how much weight you put on your leg while recovering from a broken shin bone. It is for people who have had surgery to fix the fracture and are learning to walk again with crutches.
Kyiv, Kyiv OblastAges 18–80 - NCT07134257Recruiting
Smart crutch tips for leg fracture recovery
This study tests a special crutch tip that helps guide how much weight you put on your leg after shinbone surgery. It may help you recover more safely by giving you feedback on your weight-bearing.
Kyiv, Kyiv OblastAges 18–80
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 205 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.