Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06777134Recruiting
Pelvic floor issues and leg strength in MS patients
This study looks at how pelvic floor problems relate to leg strength and function in people with multiple sclerosis. It may help understand how to better treat these issues.
Istanbul, IstanbulAges 18–65 - NCT06796920Recruiting
Spinal cord stimulation for leg problems in adrenomyeloneuropathy
This trial tests a small device placed near your spinal cord (called epidural spinal cord stimulation) to see if it can help improve leg movement and stiffness in people with adrenomyeloneuropathy (AMN). If you have AMN and trouble walking due to leg stiffness, this study may explore a new option for you.
Beijing, Beijing MunicipalityAges 22–50 - NCT06798766Recruiting
Understanding darker skin tones and vein disease care
This study looks at how people with darker skin tones experience chronic venous insufficiency (a condition that affects blood flow in the legs) and aims to improve how it's diagnosed and treated. It involves two parts: one is sharing your experience through an interview, and the other includes a skin check and photos at the hospital.
London, LondonAges 18 years+ - NCT06806540Recruiting
Peripheral artery disease in patients with deep vein thrombosis in the leg
This study looks at how many people with blood clots in their leg veins also have narrowing in their leg arteries. It uses an ultrasound test to check both conditions.
Bologna, BolognaAges 18 years+ - NCT06810726RecruitingPhase 2
Platelet-rich fibrin gel for diabetic foot ulcers
This trial tests a special gel made from your own blood (platelet-rich fibrin, or PRF) to help heal diabetic foot ulcers that are not getting better with standard care. It may be an option if you have a mild-to-moderate ulcer on the bottom of your foot with good blood flow and no infection.
Corpus Christi, TexasAges 18–80 - NCT06847295Recruiting
Spinal cord stimulation for standing and walking after paralysis
This trial tests if a device that sends mild electrical pulses to the spinal cord, combined with daily therapy, can help people with chronic spinal cord injury regain some ability to stand or walk. It also looks at reducing muscle spasms and improving quality of life.
São Paulo, São PauloAges 18–50 - NCT06873321RecruitingPhase 4
Blood thinners after leg artery surgery to prevent clots
This trial compares two blood-thinning strategies after leg artery surgery or angioplasty to prevent dangerous blood clots. Participants will receive either rivaroxaban plus aspirin or aspirin alone, and researchers will monitor for clots over 30 days.
Pernambuco, PernambucoAges Any age - NCT06899113Recruiting
Comparing a new imaging device to standard blood flow tests
This trial tests a new camera that uses light to check blood flow in your legs. It compares the camera's results to standard tests like ABI and Doppler ultrasound to see if it works as well.
Lake Success, New YorkAges 18 years+ - NCT06927206Recruiting
Vibration and muscle stimulation for leg function after stroke
This trial tests if adding a gentle vibrator to standard muscle-stimulation therapy can improve leg movement in people recovering from a stroke. It's for those who had a stroke 2 weeks to 3 months ago and have mild to moderate thinking and movement issues.
Lahore, Punjab ProvinceAges 45–60 - NCT06939686Recruiting
Wound matrix study for diabetic foot ulcers
This study tests a new wound dressing made from pig tissue to help heal diabetic foot ulcers. It may help you if you have a foot sore that hasn't healed after 4 weeks of regular care.
Coconut Creek, FloridaAges 18 years+ - NCT07037849Recruiting
Robot suit for leg rehab after stroke
This study is testing whether a wearable robotic leg device can help stroke survivors improve their walking and leg function during rehabilitation. If you have had a stroke and can already stand and walk a little, this robot suit may help you regain more strength and mobility.
Shenzhen, GuangzhouAges 18–75 - NCT07040215Recruiting
Robot-assisted walking training after stroke
This study tests whether a robot-assisted walking training program can help people who recently had a stroke improve their walking ability. It is for people in the early recovery phase (1 to 3 months after stroke) who already have moderate balance.
Changhua, TaiwanAges 45–70 - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT07047300Recruiting
How a heel lift insole affects walking for healthy adults
This study tests whether wearing a heel lift insole changes how your legs and lower back move while walking. It may help understand if such insoles can benefit people with certain conditions, but right now it only includes healthy volunteers.
Giza, Giza GovernorateAges 18–25 - NCT07061522Recruiting
Smoking effects on leg speed and coordination
This study looks at how smoking affects how fast and smoothly you can move your legs. If you are a young adult smoker, your participation helps researchers understand how smoking might slow down your reflexes and coordination.
Istanbul, ÜsküdarAges 18–25 - NCT07073586Recruiting
Lymphovenous anastomosis for leg lymphedema
This trial tests if a surgical procedure called lymphovenous anastomosis (LVA) can reduce swelling in the leg caused by lymphedema. It's for people with mild to moderate lymphedema who have been cancer-free for at least one year.
Odense, FynAges 18 years+ - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT07092579Recruiting
Smart crutch tips for guided weight-bearing after shinbone fracture
This trial tests a smart crutch tip device that helps guide how much weight you put on your leg after a broken shinbone surgery. It aims to make recovery safer and more predictable.
Kyiv, Kyiv OblastAges 18–80 - NCT07221682RecruitingPhase 2/Phase 3
Comparing two nerve block methods for lower leg surgery
This study compares two ways of giving a nerve block (fascia iliaca block) to help with positioning for spinal anesthesia and pain relief after lower leg surgery. The goal is to see which method works better for making patients more comfortable.
Sāhīwāl, Punjab ProvinceAges 30–60 - NCT06370273RecruitingPhase 3
Blood thinners for leg casts after injury
This study tests whether taking a blood thinner (anticoagulant) pill can prevent dangerous blood clots in people who have a hard cast or brace on their leg after an injury. It compares two different blood thinners to see which works better.
Carshalton, SurreyAges 16 years+ - NCT07285642Recruiting
Oxygen levels in muscles and brain in COPD patients
This study measures oxygen levels in your brain and leg muscles during exercise to understand how COPD affects them.
IstanbulAges 40–70 - NCT07312383Recruiting
Skin blood flow study in leg artery disease
This trial uses a special device to measure tiny blood vessels in the skin of patients with severe leg artery disease. It aims to understand how blood flow changes before and after a common treatment to open blocked leg arteries (angioplasty).
OsloAges 18 years+ - NCT07317492Recruiting
Hemorrhoids and varicose veins study
This study looks at the connection between hemorrhoids and varicose veins. It may help researchers understand if these conditions are related and how to better treat them.
Aydin, EfelerAges 18 years+ - NCT04800276Recruiting
Exercise program for leg artery disease
This trial tests a supervised exercise program for people with leg pain when walking caused by narrowed leg arteries. The goal is to see if exercise can improve walking ability and quality of life.
Le MansAges 18 years+
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 194 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.