Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 205 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07124377Recruiting
Study of hereditary ATTR amyloidosis symptoms
This study looks at how a specific genetic change (Val50Met) affects people with hereditary ATTR amyloidosis. It may help doctors better understand the condition and its symptoms.
Charata, Chaco ProvinceAges 20 years+ - NCT05286710Recruiting
Thrombectomy treatment for new blood clots in the leg
This trial studies a procedure to remove an acute deep vein blood clot in the leg. It may help restore blood flow faster than standard treatment for certain clot locations.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07092579Recruiting
Smart crutch tips for guided weight-bearing after shinbone fracture
This trial tests a smart crutch tip device that helps guide how much weight you put on your leg after a broken shinbone surgery. It aims to make recovery safer and more predictable.
Kyiv, Kyiv OblastAges 18–80 - NCT07093229Enrolling by invitation
Gait analysis for knee arthritis in seniors
This trial studies how walking patterns change in people over 65 with long-term knee osteoarthritis. It aims to understand gait to improve treatment and rehabilitation plans.
CraiovaAges 65–80 - NCT07078201RecruitingPhase 4
Comparing two pain meds in spinal anesthesia for leg surgery
This study compares two medicines (dexmedetomidine and fentanyl) added to a spinal numbing shot for people having planned leg or knee surgery. The goal is to see which one works better to keep your blood pressure stable, and to make the numbing last while keeping you comfortable.
Port SaidAges 20–60 - NCT05425810Recruiting
Smart tool to help check prosthetic socket fit
This study tests an easy-to-use smart system (called ENABLE) that helps assess whether a prosthetic socket fits your leg well. It may help improve comfort and reduce skin problems by making sure the socket fit is assessed in a consistent, affordable way.
Raleigh, North CarolinaAges 18–99 - NCT07075198Recruiting
Testing the Caesar running foot for people with below-knee amputations
This trial tests a new running foot called Caesar for people with below-knee amputations who want to run but don't have a running blade yet. You'll try the foot at home and give feedback on how it works.
Austin, TexasAges 18 years+ - NCT07073586Recruiting
Lymphovenous anastomosis for leg lymphedema
This trial tests if a surgical procedure called lymphovenous anastomosis (LVA) can reduce swelling in the leg caused by lymphedema. It's for people with mild to moderate lymphedema who have been cancer-free for at least one year.
Odense, FynAges 18 years+ - NCT07057817Recruiting
Using Cerament for heel infections to save the leg
This trial tests a special bone filler called Cerament to treat heel bone infections in people with diabetes, aiming to avoid leg amputation. It may help heal the bone after partial heel removal surgery.
GalwayAges 18 years+ - NCT07061522Recruiting
Smoking effects on leg speed and coordination
This study looks at how smoking affects how fast and smoothly you can move your legs. If you are a young adult smoker, your participation helps researchers understand how smoking might slow down your reflexes and coordination.
Istanbul, ÜsküdarAges 18–25 - NCT07047300Recruiting
How a heel lift insole affects walking for healthy adults
This study tests whether wearing a heel lift insole changes how your legs and lower back move while walking. It may help understand if such insoles can benefit people with certain conditions, but right now it only includes healthy volunteers.
Giza, Giza GovernorateAges 18–25 - NCT07040215Recruiting
Robot-assisted walking training after stroke
This study tests whether a robot-assisted walking training program can help people who recently had a stroke improve their walking ability. It is for people in the early recovery phase (1 to 3 months after stroke) who already have moderate balance.
Changhua, TaiwanAges 45–70 - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT07036120Recruiting
How Inserts and Exercises Affect Bunions and Your Legs
This study looks at how wearing special shoe inserts or doing specific exercises can correct bunions and affect your legs. It may help if you have bunions on both feet and are between 18 and 45 years old.
Guangzhou, GuangdongAges 18–45 - NCT07037849Recruiting
Robot suit for leg rehab after stroke
This study is testing whether a wearable robotic leg device can help stroke survivors improve their walking and leg function during rehabilitation. If you have had a stroke and can already stand and walk a little, this robot suit may help you regain more strength and mobility.
Shenzhen, GuangzhouAges 18–75 - NCT07043101Recruiting
Virtual reality for leg rehab with Vector system
This study tests if using a virtual reality headset can help people who are already using a Vector walking system in the hospital. The virtual reality shows goals to aim for while walking, which may make rehab more engaging and effective.
Schenectady, New YorkAges 18 years+ - NCT06998134Recruiting
Exoskeleton walking training for children and young adults
This trial tests whether a robotic leg exoskeleton can help improve walking in children and young adults with certain conditions (like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury) or those with no walking issues. The goal is to find out if the exoskeleton is safe and effective for everyday use, especially in younger people who might lose the ability to walk as they get older.
Bethesda, MarylandAges 5–25 - NCT06810726RecruitingPhase 2
Platelet-rich fibrin gel for diabetic foot ulcers
This trial tests a special gel made from your own blood (platelet-rich fibrin, or PRF) to help heal diabetic foot ulcers that are not getting better with standard care. It may be an option if you have a mild-to-moderate ulcer on the bottom of your foot with good blood flow and no infection.
Corpus Christi, TexasAges 18–80 - NCT06939686Recruiting
Wound matrix study for diabetic foot ulcers
This study tests a new wound dressing made from pig tissue to help heal diabetic foot ulcers. It may help you if you have a foot sore that hasn't healed after 4 weeks of regular care.
Coconut Creek, FloridaAges 18 years+ - NCT06927206Recruiting
Vibration and muscle stimulation for leg function after stroke
This trial tests if adding a gentle vibrator to standard muscle-stimulation therapy can improve leg movement in people recovering from a stroke. It's for those who had a stroke 2 weeks to 3 months ago and have mild to moderate thinking and movement issues.
Lahore, Punjab ProvinceAges 45–60 - NCT06906250Recruiting
European registry for leg vein blood clots
This trial is a registry (a database study) that tracks people with blood clots in the large veins of their legs or abdomen. It does not test any new drug or treatment, but helps doctors learn more about these conditions.
Marseille, FranceAges 18 years+ - NCT06906536Enrolling by invitation
Intermittent low oxygen to improve leg function after spinal injury
This trial tests whether short, controlled sessions of low oxygen (like breathing thin air) can improve leg movement and blood markers in people with spinal cord injuries. It may help with walking or standing.
Boulder, ColoradoAges 18–75 - NCT06899113Recruiting
Comparing a new imaging device to standard blood flow tests
This trial tests a new camera that uses light to check blood flow in your legs. It compares the camera's results to standard tests like ABI and Doppler ultrasound to see if it works as well.
Lake Success, New YorkAges 18 years+ - NCT05300308Recruiting
Studying leg swelling and nighttime urination after pelvic node surgery
This trial looks at why some people develop leg swelling (lymphedema) and frequent nighttime urination (nocturia) after pelvic lymph node surgery for prostate or bladder cancer. It may help doctors better predict and manage these side effects after the operation.
Leuven, FlandersAges 18 years+
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 205 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.