Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07206797Recruiting
Ultrasound to measure muscle activity from spinal cord stimulation
This study uses ultrasound to see how muscles respond to two types of electrical stimulation (spinal cord and functional electrical stimulation). It may help researchers better understand how to treat muscle weakness or paralysis.
Raleigh, North CarolinaAges 18–60 - NCT07204925RecruitingPhase 1
Personalizing a computerized leg for above-knee amputees
This trial tests a new way to personalize a computerized prosthetic leg for people who have lost a leg above the knee. It uses smart learning technology to help the leg adjust to how you walk, which may make walking feel more natural.
Raleigh, North CarolinaAges 18–75 - NCT07036120Recruiting
How Inserts and Exercises Affect Bunions and Your Legs
This study looks at how wearing special shoe inserts or doing specific exercises can correct bunions and affect your legs. It may help if you have bunions on both feet and are between 18 and 45 years old.
Guangzhou, GuangdongAges 18–45 - NCT07248501Recruiting
Bulgarian exercises for leg function in children
This study tests a type of exercise called Bulgarian exercises to see if they help improve leg function in children. If your child can walk and follow instructions, they may be able to join.
Lahore, Punjab ProvinceAges 8–18 - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Sun City, ArizonaAges 22–80 - NCT06906250Recruiting
European registry for leg vein blood clots
This trial is a registry (a database study) that tracks people with blood clots in the large veins of their legs or abdomen. It does not test any new drug or treatment, but helps doctors learn more about these conditions.
Marseille, FranceAges 18 years+ - NCT07742397Recruiting
Leg strength and balance in adults over 65
This study looks at how differences in strength and function between your left and right legs might affect your risk of falling. If you join, you'll help researchers understand why some older adults fall and others don't, which could lead to better fall prevention.
Milan, MilanAges 65 years+ - NCT07138066Recruiting
Smart crutch tips for guided weight-bearing after tibia fracture
This trial tests a smart crutch tip that helps guide how much weight you put on your leg while recovering from a broken shin bone. It is for people who have had surgery to fix the fracture and are learning to walk again with crutches.
Kyiv, Kyiv OblastAges 18–80 - NCT07266077Recruiting
A study of a slope-adapting prosthetic foot for Veterans
This study tests a special prosthetic foot that adapts to slopes (like hills or ramps) to help Veterans with below-knee amputations walk more easily. You would need to visit the Minneapolis VA and use a special foot for a while.
Minneapolis, MinnesotaAges 18–89 - NCT06596304Recruiting
How blood vessels respond to exercise with and without blood flow restriction
This study looks at how your blood vessels respond to resistance exercise (like weight lifting) with and without a technique called blood flow restriction. It compares younger and older adults to understand how aging affects these responses.
Almada, Monte Da CaparicaAges 18 years+ - NCT06543888Recruiting
Exoskeleton training for walking and daily tasks in older adults
This study tests whether a passive lower-limb exoskeleton can help older adults walk better and do daily activities more easily. You will wear the device during training sessions to see if it improves your movement and independence.
Taoyuan, GuishanAges 60 years+ - NCT07461701Recruiting
Comparing two squat intensities for strength in young women
This study compares two ways of doing bodyweight squats (stopping when you lose 15% vs 30% of your speed) to see which is better for building leg strength and endurance in young women who are not very active. It may help find a simple, safe way to improve fitness at home.
Lahore, Punjab ProvinceAges 18–25 - NCT06471855Recruiting
Rehabilitation support for leg amputation due to diabetes
This study is for people with diabetes or blood vessel disease who are at risk for losing a leg, have already had a lower leg amputation, or use a prosthetic leg. It focuses on a rehabilitation program that helps with both physical and emotional adjustment.
Pavia, PVAges Up to 80 years - NCT06127316Recruiting
Heel lift height and foot pressure with custom braces
This study tests if changing the height of a heel lift in a custom foot brace can improve how weight is distributed on your foot after a serious ankle or hindfoot injury. If you have pain when walking, this could help find better ways to reduce that pain.
Iowa City, IowaAges 18–65 - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT07387744Recruiting
Mobility study for people with leg amputation
This study looks at how people with a leg amputation get around both walking and using a wheelchair or scooter. It aims to understand community mobility to help improve care and devices.
Richmond, VirginiaAges 18–85 - NCT07747727Recruiting
Ultrasound and walking tests for stress incontinence
This study looks at how the pelvic floor changes after menopause and whether simple tests like ultrasound and checking how you walk can help understand stress incontinence. It may help find better ways to diagnose this condition.
Banhā, QalyoubiaAges 50–65 - NCT07057817Recruiting
Using Cerament for heel infections to save the leg
This trial tests a special bone filler called Cerament to treat heel bone infections in people with diabetes, aiming to avoid leg amputation. It may help heal the bone after partial heel removal surgery.
GalwayAges 18 years+ - NCT07708662Recruiting
Boosted compression for long-term leg swelling
This trial tests a stronger compression method for people with long-lasting leg swelling (edema) that is not caused by another medical condition. The goal is to see if it works better than standard care.
Edegem, AntwerpAges 18 years+ - NCT03035747Recruiting
Registry for treatment of varicose veins
This study collects information about people who have varicose veins with abnormal backflow in the leg veins. It’s meant to track how treatments for chronic venous problems are working over time, which can help improve care for others in the future.
Saint PetersburgAges 18 years+ - NCT03409133Recruiting
Neural feedback training for people with leg amputations
This study tests whether a nerve-based “feedback” system can help people with below-knee or above-knee amputations during standing and walking. It focuses on whether the training and device setup are safe and workable for participants over the study period.
Cleveland, OhioAges 18 years+ - NCT03995238Recruiting
Gait training for veterans with leg amputations
This study tests a walking rehabilitation plan to improve how you walk after a lower-leg amputation. It may help if your walking steps are uneven and you have diabetes and/or circulation problems in your legs.
Aurora, ColoradoAges 40–89 - NCT05112705Recruiting
Finding deep vein clots early in ICU patients
This study focuses on diagnosing deep-vein thrombosis (DVT, blood clots in the leg) early in people who are very ill in the ICU. It aims to test an approach to better detect clots sooner, which could help prevent complications.
Riyadh, Riyadh RegionAges 18 years+ - NCT05240014Recruiting
Powered leg braces to help people move more easily
This study tests modular powered leg braces (orthoses) to improve voluntary movement and walking ability in adult participants. It may help you learn whether the braces are safe and useful for your kind of mobility and daily movement.
Ann Arbor, MichiganAges 18–85
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 194 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.