Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 205 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07629674Recruiting
Video Therapy to Help Leg Movement Recovery After Stroke
This study tests whether watching specially designed videos can help improve leg strength and walking ability in people recovering from stroke. You'll receive this video therapy alongside your regular rehabilitation care.
Saint-EtienneAges 18–80 - NCT07625020Recruiting
Nerve Hydrodissection for Diabetic Nerve Entrapment Pain
This trial tests a minimally invasive ultrasound-guided procedure that uses fluid injection to free trapped nerves in the lower legs of people with diabetes. The goal is to relieve pain, numbness, and weakness when standard medications haven't worked well enough.
Chongqing, Chongqing MunicipalityAges 18–85 - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT06711120Recruiting
Comparing two treatments for varicose veins in the lower legs
This study compares two minimally invasive treatments (radiofrequency ablation and microwave ablation) for varicose veins in the small saphenous vein. If your varicose veins cause symptoms like pain, swelling, or heaviness, this trial may help determine which treatment works better.
ChengduAges 18–90 - NCT06713044Recruiting
Quran recitation or music for pain after leg surgery
This trial tests whether listening to Quranic recitation or classical music can reduce pain and inflammation after lower-leg orthopedic surgery. It may help Muslim patients manage pain without extra medication.
Purwokerto, Central JavaAges 18–60 - NCT07592325Recruiting
Testing a New Flexible Prosthetic Socket for Below-Knee Amputees
This trial compares a new flexible prosthetic socket design to the rigid socket you currently wear. The goal is to see if the new socket is more comfortable, easier to put on, and improves how well your prosthetic leg works for daily activities.
ClamartAges 18 years+ - NCT07578753Enrolling by invitation
Robot-assisted walking therapy for burn and fracture recovery
This study tests whether a robotic device that helps you walk can improve movement and function after you've had a severe burn and broken bone in your leg. The robot guides your leg through walking motions while you're healing, and researchers want to see if it helps you regain strength and independence faster.
SeoulAges 18–70 - NCT05859451Recruiting
Heated tobacco product study for surgically treated leg fractures
This study looks at whether a tobacco heating system (instead of cigarettes) affects how well a surgically repaired tibia or femur fracture heals. It mainly targets smokers with a certain smoking history who do not want to join free smoking-cessation seminars.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Sun City, ArizonaAges 22–80 - NCT07561320RecruitingPhase 4
Two ways to treat enlarged veins in your leg
This study compares two minimally invasive procedures to treat enlarged great saphenous veins (a vein in your thigh that can cause swelling, pain, or skin changes). Both procedures seal off the problematic vein by either using heat and mechanical motion or injecting a foaming substance.
São Paulo, São PauloAges 18 years+ - NCT07558317Recruiting
Resistance Exercise for Lower Leg Swelling
This study tests whether strength-training exercises can help reduce swelling in the lower leg caused by lymphedema. You'll wear compression garments as usual and add supervised resistance exercises to see if they improve your symptoms and quality of life.
HerlevAges 18 years+ - NCT07554443Recruiting
Wearable Device to Improve Balance and Walking in Older Adults
This study tests a wearable device called Walkasins that uses gentle vibrations on your foot to help improve balance and walking ability. It's designed for older adults with nerve damage in their feet who have difficulty with balance.
Jacksonville, FloridaAges 60 years+ - NCT07520487Recruiting
Ketamine Plus Spinal Anesthesia for Older Adults Undergoing Leg Surgery
This study tests whether adding ketamine (a type of anesthetic medication) to spinal anesthesia—numbing medication injected near the spine—can make the numbness last longer for older adults having leg surgery. The goal is to see if this combination improves pain control after surgery.
Cairo, Giza GovernorateAges 65 years+ - NCT07515144Enrolling by invitation
Nerve Stretching for Muscle Strength in Older Adults
This study tests whether a gentle nerve-stretching technique in the leg can help older adults with age-related muscle loss regain strength and muscle size. You'll attend sessions where a therapist guides your leg through specific movements designed to mobilize nerves and improve muscle function.
Seremban, Negeri SembilanAges 60 years+ - NCT07472543Recruiting
Virtual reality exercises for leg lymphedema after cancer surgery
This trial tests whether virtual reality-based exercises can help reduce leg swelling caused by lymphedema after gynecological or other cancer surgery. It may be a good option if you have lymphedema in one leg and can commit to daily sessions for a month.
AnkaraAges 18–65 - NCT07469020Recruiting
Cle-pad study: Checking leg artery health in spine surgery patients
This study is looking at how common blockages in leg arteries (peripheral artery disease, or PAD) are in people who are having surgery for lumbar spinal stenosis or had surgery less than 3 months ago. If you qualify, it may help doctors better understand and treat this condition.
LilleAges 18 years+ - NCT07466823Recruiting
Spasticity Patterns and Quality of Life in MS
This study looks at patterns of muscle stiffness (spasticity) in people with multiple sclerosis and how these patterns affect daily life and well-being. It aims to better understand the link between spasticity and quality of life.
IstanbulAges 18 years+ - NCT07461701Recruiting
Comparing two squat intensities for strength in young women
This study compares two ways of doing bodyweight squats (stopping when you lose 15% vs 30% of your speed) to see which is better for building leg strength and endurance in young women who are not very active. It may help find a simple, safe way to improve fitness at home.
Lahore, Punjab ProvinceAges 18–25 - NCT06796920Recruiting
Spinal cord stimulation for leg problems in adrenomyeloneuropathy
This trial tests a small device placed near your spinal cord (called epidural spinal cord stimulation) to see if it can help improve leg movement and stiffness in people with adrenomyeloneuropathy (AMN). If you have AMN and trouble walking due to leg stiffness, this study may explore a new option for you.
Beijing, Beijing MunicipalityAges 22–50 - NCT07440615Recruiting
Leg muscle and heart performance in active adults
This study looks at how leg muscle size relates to heart and muscle performance in healthy men and women. It aims to understand normal differences between sexes.
EskişehirAges 18–30 - NCT06806540Recruiting
Peripheral artery disease in patients with deep vein thrombosis in the leg
This study looks at how many people with blood clots in their leg veins also have narrowing in their leg arteries. It uses an ultrasound test to check both conditions.
Bologna, BolognaAges 18 years+ - NCT06439823Recruiting
Study of arm and leg movement in people with walking problems
This study observes how your arms and legs move as you walk or do other activities. It compares people with conditions that affect movement (like muscle diseases) to healthy volunteers to understand differences.
Liège, LiegeAges 2 years+ - NCT07397468RecruitingPhase 1/Phase 2
Study of JUV-161 for leg immobilization recovery
This trial tests a drug called JUV-161 to see if it can help protect muscle from loss when a leg is immobilized (in a cast or boot). It is for healthy adults who are willing to undergo a leg immobilization period and muscle biopsy.
AucklandAges 45–65 - NCT07397390Enrolling by invitation
Study of a new scoring balloon for leg artery blockages with heavy calcium buildup
This study tests a new balloon device that scores the artery walls to treat leg artery blockages with heavy calcium deposits. It aims to see if the device helps prepare the vessel safely and effectively before placing a stent.
Dalian, LiaoningAges 18–85
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 205 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.