Clinical trials
Lower Limb clinical trials
Below are recruiting lower limb clinical trials, each written for real people, not researchers. We’re tracking 196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT04953364Recruiting
Tech-based self-management support after a leg amputation
This study tests a technology-based program to help people manage rehabilitation after a lower-limb amputation. It may help by giving structured support for day-to-day care and prosthesis use.
Vancouver, British ColumbiaAges 50 years+ - NCT06194838Recruiting
Mechanical vs. powered knee for above-knee amputees
This study compares a non-powered (mechanical) knee to a powered (battery-assisted) knee for people with above-knee amputations who walk at a moderate level (K2). It will help find out which knee type works better for your daily activities and mobility.
Austin, TexasAges 18 years+ - NCT06419920Recruiting
Prosthetic performance enhancement trial
This study tests whether a new prosthetic foot can help people with a lower-limb amputation walk better. You will use your current foot and the new foot, and we will measure how well you walk.
Las Vegas, NevadaAges 18 years+ - NCT06937242Recruiting
Testing a smarter prosthetic knee for safer walking
This study tests whether a microprocessor-controlled knee can reduce falls in people who walk limited distances. If you use a regular mechanical knee and have a moderate activity level, this trial might help you walk more safely.
Austin, TexasAges 18 years+ - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT07486063RecruitingEarly Phase 1
Motorized leg prosthetics for above-knee amputees
This study tests whether a motorized (powered) prosthetic knee and ankle can help people with above-knee amputations walk better. If you already use a mechanical or microprocessor-controlled leg, you may be able to try a new powered version.
Salt Lake City, UtahAges 18–80 - NCT06415955Recruiting
Walking limits study for people with leg amputation
This study looks at what makes walking harder for people with a lower limb amputation. Participants will walk on a treadmill to help researchers understand these limits and improve rehabilitation.
Nîmes, GardAges 18–80 - NCT06226844Recruiting
Can a vibration device help people with leg artery disease walk further?
This study tests a device called BeatMove to see if it can improve walking distance for people with blocked leg arteries that cause pain when walking. It may help if you have this condition and already take medicines for it.
NîmesAges 18 years+ - NCT07544212Recruiting
Infections after large leg prosthesis implants: tracking outcomes
This study examines infections that occur after people receive a large custom prosthesis (artificial leg) to replace lost bone or tissue. Researchers want to understand who gets infections, why, and how these infections affect long-term health and function.
Bologna, BOAges 14–100 - NCT07721792Recruiting
Study on advanced braces for leg injuries
This study tests a new type of leg brace for people who currently use an ankle-foot orthosis (AFO) to help with walking or daily activities after a lower leg injury. The goal is to see if the new brace works better and is more comfortable.
Tampa, FloridaAges 18–80 - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT06635655Recruiting
Testing a new prosthetic knee for mental ease
This study tests whether a new prosthetic knee system helps reduce mental effort while walking for people with above-knee amputations. If you use a prosthetic leg and are comfortable with a smartphone, you may be able to join.
Multiple LocationsAges 18–84 - NCT07191795Recruiting
Using phantom sensations from socket changes as feedback while walking
This trial tests whether changing how your prosthetic socket fits can create helpful phantom limb sensations that improve your walking. It may help people with major lower-limb amputations walk more naturally.
NancyAges 18 years+ - NCT07447934Recruiting
Vibration therapy for leg muscle stiffness
This trial tests if gentle vibrations can reduce muscle stiffness (spasticity) in the lower leg after a neurologic condition like stroke or brain injury. You may join if you've had spasticity for at least 6 months and can stand with or without help.
New York, New YorkAges 18–85 - NCT05801185Enrolling by invitation
Studying muscle changes after leg unloading in healthy young adults
This trial looks at how human muscle cells change when one leg is not used for a short time. It may help us understand muscle loss and how to prevent it.
Huddinge, Stockholm CountyAges 18–40 - NCT07706452Recruiting
Balance Training for People with a Prosthetic Leg
This study tests a special balance training program for people who use a prosthetic leg after losing a leg due to injury. The program combines balance exercises with a second task (like talking or counting) to improve walking and stability in daily life.
Gaza, Gaza StripAges 18 years+ - NCT04149977Recruiting
Blood flow restriction therapy for knee tendon injuries
This study tests whether blood flow restriction therapy can help healing and recovery after certain knee extensor injuries (like patella or quadriceps tendon rupture). You must be able to take part in the usual physical therapy plan, too.
New York, New YorkAges 18–65 - NCT05347875Recruiting
App training to improve walking aid skills
This trial tests an app-based program meant to help people who already use walking aids learn and practice safer walking aid skills. It may help you move more comfortably if you can use the app and communicate with the study team.
Calgary, AlbertaAges 18–99 - NCT06454734Recruiting
Shock wave therapy for leg lymphedema
This trial tests if shock wave therapy can help reduce leg swelling caused by lymphedema. It is for people with moderate to severe swelling that has affected at least the knee to foot area for 6 months or longer.
BarcelonaAges 18 years+ - NCT06645054Recruiting
Testing a smart hallway system in clinics
This trial tests a smart hallway system that may help monitor walking. It is for people who can walk a short distance on their own, have no major memory or thinking problems, and speak Slovenian.
LjubljanaAges 18 years+ - NCT07579520Recruiting
Music-Based Movement Training After Leg Fracture Recovery
This study tests whether listening to rhythmic music (a technique called rhythmic auditory stimulation) helps young people regain movement and flexibility in their legs after a fracture heals. The goal is to see if music-guided exercises work better than standard rehabilitation.
Lahore, Punjab ProvinceAges 5–18 - NCT07609407Recruiting
Pelvic Stability Training After Stroke for Leg Function
This study tests whether special exercises focused on stabilizing your pelvis (hip area) can help improve leg strength and movement after a stroke. The training is designed for people in the early recovery phase who are learning to stand and walk again.
Faisalabad, Punjab ProvinceAges 40–60 - NCT06975423Recruiting
Walking Sensation Study for older adults
This study is for older adults who walk slowly and have some loss of feeling in their feet. Researchers want to see if a special walking test can help understand this better. You must be generally healthy and free of major medical issues or recent surgeries.
Gainesville, FloridaAges 65–95
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Common questions
- Are there clinical trials for lower limb?
- Yes. Clin2 currently lists 196 recruiting lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.