Clinical trials
Major Depression Disorder clinical trials
Below are recruiting major depression disorder clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06835855Recruiting
Does mother’s depression affect baby’s attention to emotions?
This study looks at how babies of mothers with depression pay attention to emotional faces. Researchers want to learn if these babies show different patterns of attention to happy or sad cues, which could help understand early development.
Binghamton, New YorkAges 6 months+ - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Phoenix, ArizonaAges 18–65 - NCT06832605Recruiting
Mindfulness classes by video to prevent depression relapse
This trial tests an 8-week mindfulness-based cognitive therapy program delivered via video call to help people with a history of depression prevent future episodes. It may help you learn skills to manage low mood and reduce the chance of relapse.
Elche, AlicanteAges 18 years+ - NCT06823024Enrolling by invitation
Using speech patterns to predict treatment response in depression, PTSD, or bipolar disorder
This study tests if a computer algorithm can analyze your speech to predict how well you will respond to treatments like TMS or Spravato. It aims to create a simple tool that helps doctors choose the right treatment for you.
Sunnyvale, CaliforniaAges 18–68 - NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT06816329Recruiting
Stress and depression risk study for teenage girls
This study looks at how stress affects teenage girls who may be at higher risk for depression due to a parent's history. It involves MRI scans and daily surveys on a cell phone.
Belmont, MassachusettsAges 13–15 - NCT06559826RecruitingPhase 2
Ketamine therapy with or without talk for depression
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
New York, New YorkAges 18–90 - NCT06804525Recruiting
Adapting a mental health survey in Hong Kong
This study adapts a mental health survey for Hong Kong adults. It is open to adults aged 25 and older who live in randomly selected households and can speak Chinese or English.
Hong KongAges 25 years+ - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Birmingham, AlabamaAges 18–85 - NCT06801925Enrolling by invitation
Voice Chatbot for Depression Screening
This trial tests a voice chatbot that uses artificial intelligence to screen for depression. It aims to see if the chatbot is effective and easy to use.
LondonAges 18–65 - NCT06795451RecruitingPhase 1/Phase 2
Spinal stimulation for depression: a clinical trial
This study tests if a non-invasive spinal stimulation device can improve depression symptoms. It is for people currently taking an antidepressant for at least 8 weeks but still experiencing depression.
Mason, OhioAges 18–60 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Little Rock, ArkansasAges 18 years+ - NCT06792175Enrolling by invitation
Using speech to detect mental health conditions
This study uses a computer program to listen to your speech and see if it can help detect mental health or neurodevelopmental conditions. It may help find new ways to diagnose conditions like ADHD, anxiety, depression, and others earlier.
Brookline, MassachusettsAges 13–60 - NCT06773949Recruiting
Exercise before rTMS for hard-to-treat depression
This trial tests if doing exercise before repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms in people who haven't gotten better with standard treatments.
Ottawa, OntarioAges 18–75 - NCT06780917Recruiting
Online cognitive testing for older adults with depression or memory concerns
This study tests whether an online cognitive assessment platform (Creyos) is valid for older adults with major depression or mild cognitive impairment. Participants will complete brain games or puzzles to see how well the online tool measures thinking skills.
Toronto, OntarioAges 60 years+ - NCT06763081Recruiting
SSRI side effects genetics study
This study looks at why some people have behavioral side effects when taking SSRI antidepressants like Prozac or Zoloft. It hopes to find a genetic reason to help doctors choose safer treatments in the future.
Winnipeg, ManitobaAges 6–24 - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT06746155Recruiting
Predictors of relapse in major depression
This study looks at adults with major depressive disorder who have responded to treatment, to find out what might predict a relapse. You will wear a wrist activity monitor and complete questionnaires.
Calgary, AlbertaAges 18–70 - NCT06740331Recruiting
Thinking and memory study for mood disorders
This study looks at how people with bipolar disorder or depression process social situations, memory, and thinking. It compares patients, their relatives, and healthy volunteers to better understand these conditions.
ReimsAges 18–65 - NCT06732284Recruiting
Sleep inertia study in depression
This study looks at sleep inertia (the grogginess you feel after waking up) in people with major depression. It uses a simple reaction-time test to understand how depression affects waking up.
NîmesAges 18–54 - NCT06700902Recruiting
Support program for college students with mental health challenges
This study tests a program called 'Taking Action' to help college students with serious mental illnesses manage their health and daily life. If you're a student with a mental health condition, you may be able to join to learn new coping skills through group education.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06698666RecruitingPhase 3
Can statins help treat depression?
This trial tests if adding a statin (a cholesterol-lowering medicine) to your current depression treatment improves symptoms. It is for adults aged 20 to 45 with mild to moderate depression who are not already taking a statin.
Cairo, Al AbbasiaAges 20–45 - NCT03859297Recruiting
Testing how rumination changes in depressed teens
This study looks at what changes in “rumination” (repetitive worrying/thinking about negative thoughts) in teens with depression, and how those changes relate to recovery. It’s for ages 14–17 who have had major depression and meet specific screening and medical rules.
Columbus, OhioAges 14–17 - NCT06692361Recruiting
Gut bacteria transplant for depression not helped by escitalopram
This trial tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with depression that does not respond well to the antidepressant escitalopram. You will first take escitalopram for 2 weeks, and if it doesn't help enough, you may receive either the real transplant or a placebo capsule.
Wuhu, AnhuiAges 18–65
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Common questions
- Are there clinical trials for major depression disorder?
- Yes. Clin2 currently lists 502 recruiting major depression disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.