Clinical trials
Major Depression Moderate clinical trials
Below are recruiting major depression moderate clinical trials, each written for real people, not researchers. We’re tracking 167 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Birmingham, AlabamaAges 18–74 - NCT06982820Recruiting
Brain training therapy for depression with loss of interest
This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.
Providence, Rhode IslandAges 22–75 - NCT06633263Enrolling by invitation
Combined therapy for depression and insomnia
This trial tests a combination of two behavioral therapies to improve both depression symptoms and sleep problems. It may help you if you have moderate depression and insomnia and can participate in French-language sessions.
LiègeAges 18–67 - NCT06735885Recruiting
Brain training with feedback app for depression
This trial tests whether a smartphone app combined with brain scanning (fMRI) can help people with depression. You will get real-time feedback on your brain activity to learn how to improve your mood.
Stanford, CaliforniaAges 18–80 - NCT05973851RecruitingPhase 3
Six-week medicine boost for depression after first treatment failure
This study tests a more intensive antidepressant medicine approach for people whose first tried treatment didn’t work well enough. It compares the intensified treatment with usual care, aiming to improve depression symptoms and daily functioning.
InnsbruckAges 18–65 - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT06878859Recruiting
Online program for depression and cannabis use
This study tests a digital (online) program designed to help people who struggle with both depression and cannabis use. If you're feeling down and also using cannabis more than you'd like, this program might help you manage both.
Boston, MassachusettsAges 18 years+ - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT05097586Recruiting
At-home brain stimulation trial for depression during pregnancy
This trial tests whether doing at-home, noninvasive brain stimulation (tDCS) can reduce depression symptoms during pregnancy. It may help people who are in a depressive episode but prefer not to take antidepressant medication right now.
Toronto, OntarioAges 18 years+ - NCT06534684Recruiting
Brain stimulation (iTBS) for depression and thinking changes
This study tests whether a type of brain stimulation called iTBS can improve depression and thinking skills. It uses a magnetic coil over the scalp and is done on multiple days.
TromsøAges 22–65 - NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT07380451Recruiting
Personalized therapy for depression with childhood trauma
This trial tests a flexible, personalized therapy program for adults with depression who also have a history of childhood trauma and personality challenges. It aims to see if this approach helps more than standard care, and you'll receive weekly therapy from a community clinic in Chile.
SantiagoAges 18–65 - NCT06528938Recruiting
Accelerated vs. standard TMS for teen depression
This study tests whether a faster, brain-guided form of TMS (called iTBS) can help treat depression in teenagers better than standard TMS. You may qualify if you're 16–19, have tried an antidepressant that didn't work well, and have no medical reasons to avoid TMS or MRI.
Ottawa, OntarioAges 16–19 - NCT07543328Recruiting
Light therapy added to antidepressants for depression with body symptoms
This study tests whether a special light treatment applied to the scalp (transcranial photobiomodulation) can help people with depression who aren't getting better with antidepressants alone. The light therapy is added to your current medication to see if it reduces both mood symptoms and physical complaints like pain or fatigue.
TaipeiAges 18–65 - NCT06938841Recruiting
Maintenance rTMS for depression
This study tests whether ongoing rTMS treatments can help people who already improved after an initial round of rTMS for depression. It aims to keep the benefits going and prevent relapse.
San Diego, CaliforniaAges 18–80 - NCT06507787Recruiting
Blood test for depression vs. bipolar disorder
This study tests a new blood test (EDIT-B®) to help doctors tell the difference between depression and bipolar disorder. If you have a depressive episode but there is doubt about bipolar disorder, this test might help guide your treatment to improve your health.
ErsteinAges 18–65 - NCT06728774Recruiting
Cognitive rehab for veterans with depression and memory problems
This trial tests a cognitive rehabilitation program for veterans who have depression (MDD) and are experiencing trouble with memory, attention, or thinking. The goal is to see if the program can improve these cognitive issues.
Portland, OregonAges 18 years+ - NCT07749521Recruiting
Treating depressed parents of children with behavioural problems
This study tests a virtual group treatment to help parents with mild to moderate depression improve their own wellbeing and better support their child's emotional and behavioural health. If you are a parent with depression and have a child aged 6-11 who is struggling emotionally or behaviourally, this trial may be for you.
Toronto, OntarioAges 18 years+ - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Phoenix, ArizonaAges 18–75 - NCT07048600Recruiting
Brief trial of ACT-i for adults with chronic insomnia
This trial tests a psychological treatment called ACT-i for people with chronic insomnia (trouble sleeping for a long time). It aims to see if this online therapy can help improve sleep without drugs.
Cluj-NapocaAges 18–59 - NCT06795451RecruitingPhase 1/Phase 2
Spinal stimulation for depression: a clinical trial
This study tests if a non-invasive spinal stimulation device can improve depression symptoms. It is for people currently taking an antidepressant for at least 8 weeks but still experiencing depression.
Mason, OhioAges 18–60 - NCT05295888Recruiting
Temporal Interference treatment for moderate-to-severe depression
This study tests temporal interference (TI), a brain stimulation method, to treat depression. You may be a candidate if you have moderate-to-severe major depression and can follow the study schedule and safety screening.
Toronto, OntarioAges 18–65 - NCT05450432RecruitingPhase 4
Ketamine maintenance to help prevent suicidal thoughts
This Phase 4 study tests whether ongoing treatment with ketamine or esketamine can reduce suicidal thoughts in people with major depression who are at high risk. Because the study focuses on long-term maintenance, you’d receive treatment over time while being closely monitored for safety and mental health changes.
Boston, MassachusettsAges 18–70 - NCT05813093Recruiting
Brain stimulation and brain scans for hard-to-treat depression
This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.
Toronto, OntarioAges 20–65
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Common questions
- Are there clinical trials for major depression moderate?
- Yes. Clin2 currently lists 167 recruiting major depression moderate studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression moderate trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression moderate trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.