Clinical trials
Major Depression clinical trials
Below are recruiting major depression clinical trials, each written for real people, not researchers. We’re tracking 453 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05585047Recruiting
Looking for brain and blood markers in major depression
This study looks at treatment response markers (signs in the body) in people with major depressive disorder (MDD). It may help researchers understand who is more likely to benefit from antidepressant treatment.
Changsha, HunanAges 18–60 - NCT05613972Recruiting
Therapy program for suicide risk and past trauma
This trial tests an integrated therapy approach for people who are currently having significant thoughts about suicide and also have a history of childhood trauma. It may help by combining support for trauma experiences with strategies to reduce suicide risk.
Toronto, OntarioAges 18 years+ - NCT05645575Recruiting
Inpatient TMS for treatment-resistant depression
This study tests an in-hospital brain stimulation treatment (TMS) for people with moderate to severe depression who did not improve after multiple antidepressant treatments. It may help your mood by targeting brain circuits involved in depression, and you would follow an intensive accelerated schedule.
Los Angeles, CaliforniaAges 18–65 - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT05800925Recruiting
Triage survey to check who can join psychiatry research
This study uses a short questionnaire to figure out who is eligible to join future psychiatry research. It may help people get routed into studies that match their situation and safety needs.
Boston, MassachusettsAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Phoenix, ArizonaAges 18–70 - NCT05964192Recruiting
Neuro test help after rTMS for treatment-resistant depression
This study checks whether a set of brain and hormone-related blood/marker tests can help predict or improve how well rTMS works for depression. It’s for adults whose depression has not responded to two antidepressants.
Rouffach, AlsaceAges 18–65 - NCT05973643Recruiting
Metabolomics study during ECT for depression
This study measures changes in your blood and/or body chemistry while you receive electroconvulsive therapy (ECT) for a severe mood episode. The goal is to understand biological signals related to ECT and treatment-resistant depression, which may help improve future care.
BronAges 18 years+ - NCT05996900Recruiting
Brain stimulation study for adults with epilepsy
This study uses advanced brain monitoring and noninvasive magnetic stimulation to understand how repetitive brain stimulation works in people with epilepsy who are already scheduled for hospital monitoring. It may help develop better treatments for seizures.
Stanford, CaliforniaAges 18–65 - NCT06045897Recruiting
EEG brain test for young people at risk of psychosis
This study uses a short EEG recording to look at brain activity patterns in young people with early signs of mental health conditions, including those at risk for psychosis, first episode psychosis, depression, or autism. It aims to find brain markers that could help identify people who might benefit from early treatment.
ParisAges 15–30 - NCT06070766Recruiting
At-home ketamine study for chronic conditions
This trial tests a ketamine protocol you can use at home. It may help if you have a long-term health condition.
Bigfork, MontanaAges 18 years+ - NCT06093906Recruiting
Positive processes and transition to health (PATH) study
This study tests a new therapy that may help people recover after a stressful life event. Over about 6 weeks, you'll work with a coach to retrain your brain's patterns and feel more in control again, as well as reconnect with positive activities.
Newark, DelawareAges 18–65 - NCT06183359Recruiting
Self-Identification Program for Depression
This study tests a self-identification program for people aged 18 to 70 who are currently in a major depressive episode. It aims to explore whether a simple self-monitoring tool can help you better manage your depression.
MontpellierAges 18–70 - NCT06236880RecruitingPhase 2
Testing GM-2505 for Moderate to Severe Depression
This trial tests a new oral medication, GM-2505, for people with moderate to severe major depressive disorder (MDD). The goal is to see if it is safe and well-tolerated, either as a stand-alone treatment or alongside a stable SSRI/SNRI antidepressant.
ManchesterAges 18–65 - NCT06274112Recruiting
Using brain stimulation to understand social motivation in depression or social anxiety
This study uses transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, to explore how the brain processes social motivation in people with major depressive disorder or social anxiety disorder. Understanding these brain processes could help develop new treatments for social avoidance.
Auburn, AlabamaAges 25–50 - NCT06294119Recruiting
Brain-heart-vessel interaction study in heart surgery patients
This study looks at how your brain, heart, and blood vessels work together during heart surgery. It uses simple tests to measure these connections, which may help doctors better understand your health.
San Donato Milanese, MilanAges 18 years+ - NCT06319378RecruitingPhase 2
Psilocybin for cancer-related depression
This trial tests whether a single dose of psilocybin, a psychedelic medication, can safely and effectively treat major depression in people with cancer. If you have cancer and have been feeling depressed for at least a month, you may qualify.
Gothenburg, GöteborgAges 20–80 - NCT06385405Recruiting
Brain stimulation for depression using EEG guidance
This trial uses a brain scan technique (EEG) to guide a treatment called repetitive transcranial magnetic stimulation (rTMS) for people with major depressive disorder. It aims to see if personalizing the treatment based on brain activity can help improve depression symptoms.
Shanghai, Shanghai MunicipalityAges 16–65 - NCT06616116Recruiting
Stress Management with Real-Time Body Signal Feedback
This trial tests a stress management program that uses real-time feedback from your body signals (like heart rate). It is for people with mood disorders, such as depression or bipolar disorder, who also feel anxious or stressed. The goal is to help you learn to control your stress better.
Seoul, Jongno-guAges 15–59 - NCT06641726Recruiting
Global database linking genetics and health records for mental illness
This trial is building a research database that combines genetic information and long-term health data to improve personalized treatment for serious mental illness. You may be eligible if you have been diagnosed or treated for depression, bipolar disorder, schizophrenia, or dementia.
Oxford, OxfordAges 18–110 - NCT06700902Recruiting
Support program for college students with mental health challenges
This study tests a program called 'Taking Action' to help college students with serious mental illnesses manage their health and daily life. If you're a student with a mental health condition, you may be able to join to learn new coping skills through group education.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06749392Recruiting
Depression treatment based on your brain's activity
This study tests a personalized treatment for depression that uses your brain's electrical activity (EEG) to guide therapy. You attend sessions where we monitor your brain's response to help improve your mood.
HaifaAges 18–65 - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+ - NCT06854224RecruitingPhase 2
Testing a sleep drug for suicide risk in veterans with depression
This trial tests whether a medication called suvorexant (used for sleep) can help lower suicide risk in veterans who have major depression and have attempted suicide before. The study aims to see if blocking a brain chemical called orexin reduces suicidal thoughts.
The Bronx, New YorkAges 18–70
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Common questions
- Are there clinical trials for major depression?
- Yes. Clin2 currently lists 453 recruiting major depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.