Clinical trials
Major Depression clinical trials
Below are recruiting major depression clinical trials, each written for real people, not researchers. We’re tracking 453 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06860724Recruiting
Stress and blood vessel health study for adults 18-55
This study looks at how daily stress affects blood vessel function in healthy adults and those with depression. It aims to find links between emotions and physical health.
Newark, DelawareAges 18–55 - NCT06891300RecruitingPhase 2/Phase 3
Ketamine for Suicidal Thoughts in Depression
This study tests if ketamine can help reduce suicidal thoughts in people with major depression. You'll receive ketamine treatment and be monitored closely.
Ottawa, OntarioAges 18–65 - NCT06897670Recruiting
Brain blood flow patterns in mood and memory disorders
This study uses a headband with light sensors (fNIRS) to measure blood flow in the brain while you do thinking tasks. It aims to understand differences in brain activity for people with depression, bipolar disorder, or mild memory loss.
Rochester, MinnesotaAges 18 years+ - NCT06927076Recruiting
DMT with propofol for depression
This study tests whether a combination of DMT (a psychedelic) and propofol (a sedative) can help treat depression. You will receive both medicines in a hospital setting, and the team will monitor your response.
BaselAges 21 years+ - NCT07076342RecruitingPhase 4
Glutamate receptors and cognitive behavioral therapy for insomnia
This study tests how a brain receptor called mGluR5 affects sleep and depression treatment. You may qualify if you have major depression with insomnia and are not currently on antidepressants.
Stony Brook, New YorkAges 18 years+ - NCT07095205RecruitingPhase 4
Nicotine's effect on depression in brain imaging study
This trial uses a special brain scan to see how nicotine might help treat depression. It compares people with depression to healthy volunteers to understand how nicotine affects brain chemistry related to mood.
Stony Brook, New YorkAges 18–65 - NCT07105111RecruitingPhase 4
Valbenazine for tardive dyskinesia after other treatment
This study tests if valbenazine helps adults with tardive dyskinesia whose symptoms continue even after taking or stopping another similar medication. Tardive dyskinesia involves uncontrollable movements from long-term use of certain mental health drugs.
Bryant, ArkansasAges 18 years+ - NCT07111169Recruiting
Brain stimulation and attention in depression study
This study tests whether a non-invasive brain stimulation technique (called iTBS) can improve attention problems in people with major depression. If you have depression and trouble focusing, this trial might help understand a new treatment option.
Chengdu, SichuanAges 18–55 - NCT07113665RecruitingPhase 1
Focused ultrasound brain treatment for severe anorexia
This trial tests if focused ultrasound can help people with severe anorexia nervosa who also have obsessive-compulsive disorder or major depression. It is for those who have not gotten better with other treatments.
Toronto, OntarioAges 18–65 - NCT07115628Recruiting
Accelerated TMS for treatment-resistant depression
This trial tests an accelerated form of transcranial magnetic stimulation (TMS) for people with treatment-resistant depression who have been referred for ECT. It aims to offer a non-invasive, less intensive alternative with fewer side effects.
Jette, Brussels CapitalAges 18–70 - NCT07185815RecruitingPhase 1/Phase 2
Study of a long-acting cariprazine shot for mood and schizophrenia
This trial tests a monthly injection of cariprazine (a medication for mental health conditions) in people who could benefit from it. It aims to see if the shot is safe, tolerable, and effective compared to taking pills every day.
AhmedabadAges 18–64 - NCT07198100Recruiting
Ear stimulation, motivation, and insulin sensitivity in depression
This study explores how a gentle electrical stimulation of the ear might affect mood, motivation, and insulin sensitivity in people with and without depression. It aims to see if this non-invasive technique could offer new ways to help with depression.
BonnAges 18–60 - NCT07219394Recruiting
Peer support for depression in community care
This trial tests if peer-delivered behavioral therapy can help adults with depression symptoms. If you are 18 or older and feel sad or down, this study may teach you practical ways to feel better.
Detroit, MichiganAges 18 years+ - NCT07305701Recruiting
Study on Medical Students' Mental Health
This study follows first-year health students at the University of Orléans to understand their mental health over time. It aims to find ways to support students' well-being during their studies.
Orléans, LoiretAges 18 years+ - NCT07316803Recruiting
Group therapy for romantic relationships in young adults with mental illness
This study tests a group program to help young adults with serious mental health conditions build skills for romantic and social relationships. It may be a good fit if you are single, motivated to work on relationships, and have received mental health care recently.
Épinay-sur-Seine, Île-de-France RegionAges 18 years+ - NCT07329673Recruiting
Testing QbMobile app for ADHD-like symptoms
This trial uses an iPhone app called QbMobile to help tell the difference between ADHD and other conditions like autism, depression, bipolar disorder, or anxiety. It may help people who are not currently being treated for these conditions.
Miami, FloridaAges 6–60 - NCT07362511Recruiting
Imagery rescripting for depression in primary care
This study tests a type of talk therapy called 'imagery rescripting' for people with depression in primary care. In this approach, you learn to change painful mental images into more helpful ones, which may reduce depressive feelings.
Amsterdam, North HollandAges 18–70 - NCT01980147Recruiting
Skills for Wellness program for youth coping with mental health risks
This trial tests a structured skills program to help children and teens (ages 9–21) cope with early mental health warning signs such as anxiety, mood swings, or unusual thoughts. It may help participants build practical coping tools and well-being.
Halifax, Nova ScotiaAges 9–21 - NCT07402356Recruiting
Virtual reality eye test for thinking problems
This study uses virtual reality and eye-tracking (pupillometry) to measure thinking and memory problems in people with Alzheimer's, mild cognitive impairment, or depression. It aims to find better ways to detect and track cognitive changes using a simple, non-invasive procedure.
München, BavariaAges 18–80 - NCT07412132RecruitingPhase 3
Testing lacosamide for hard-to-treat bipolar depression
This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.
São Paulo, São PauloAges 18–65 - NCT07479758Recruiting
Brain scans and vision tests for severe mental illness
This study uses advanced MRI scans and visual perception tests to learn more about severe mental disorders like depression, schizophrenia, and bipolar disorder. It aims to improve diagnosis and treatment outcomes.
Hangzhou, ZhejiangAges 18–45 - NCT07493317RecruitingPhase 2
Tocilizumab for depression with inflammation
This trial tests a medication called tocilizumab, which targets inflammation, to see if it can improve symptoms of major depression in people with signs of inflammation. You may be eligible if you have depression with a high monocyte count and significant loss of interest or pleasure.
New York, New YorkAges 18–70 - NCT07571226Recruiting
Urban Stress and Mental Health Monitoring Study
This study explores how city living and daily stress affect depression, anxiety, and alcohol use disorders by having you wear a monitoring wristband and use a smartphone app to track your physical responses. Researchers hope to better understand the link between environmental stress and mental health symptoms.
BeijingAges 18–60 - NCT07604753Recruiting
Comparing two mental health screening questionnaires
This study compares two different questionnaires that doctors use to diagnose mental health conditions. Researchers want to check if a newer, shorter questionnaire works just as well as the longer standard one.
Hong KongAges 18 years+
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Common questions
- Are there clinical trials for major depression?
- Yes. Clin2 currently lists 453 recruiting major depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.