Clinical trials
Major Depression clinical trials
Below are recruiting major depression clinical trials, each written for real people, not researchers. We’re tracking 453 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06860724Recruiting
Stress and blood vessel health study for adults 18-55
This study looks at how daily stress affects blood vessel function in healthy adults and those with depression. It aims to find links between emotions and physical health.
Newark, DelawareAges 18–55 - NCT06854224RecruitingPhase 2
Testing a sleep drug for suicide risk in veterans with depression
This trial tests whether a medication called suvorexant (used for sleep) can help lower suicide risk in veterans who have major depression and have attempted suicide before. The study aims to see if blocking a brain chemical called orexin reduces suicidal thoughts.
The Bronx, New YorkAges 18–70 - NCT06823024Enrolling by invitation
Using speech patterns to predict treatment response in depression, PTSD, or bipolar disorder
This study tests if a computer algorithm can analyze your speech to predict how well you will respond to treatments like TMS or Spravato. It aims to create a simple tool that helps doctors choose the right treatment for you.
Sunnyvale, CaliforniaAges 18–68 - NCT06782724RecruitingPhase 2
Psilocybin therapy for distress in advanced illness
This trial tests whether a single dose of psilocybin (a psychedelic medicine) can help reduce depression and distress in people with advanced lung disease, ALS, multiple sclerosis, or Parkinson's. You would receive preparation, the drug, and follow-up support in a safe, supervised setting.
PragueAges 18 years+ - NCT06788249RecruitingEarly Phase 1
Ketamine for treatment-resistant depression brain study
This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.
Philadelphia, PennsylvaniaAges 25–65 - NCT05973643Recruiting
Metabolomics study during ECT for depression
This study measures changes in your blood and/or body chemistry while you receive electroconvulsive therapy (ECT) for a severe mood episode. The goal is to understand biological signals related to ECT and treatment-resistant depression, which may help improve future care.
BronAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Phoenix, ArizonaAges 18–70 - NCT06749392Recruiting
Depression treatment based on your brain's activity
This study tests a personalized treatment for depression that uses your brain's electrical activity (EEG) to guide therapy. You attend sessions where we monitor your brain's response to help improve your mood.
HaifaAges 18–65 - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Milford, ConnecticutAges Any age - NCT06700902Recruiting
Support program for college students with mental health challenges
This study tests a program called 'Taking Action' to help college students with serious mental illnesses manage their health and daily life. If you're a student with a mental health condition, you may be able to join to learn new coping skills through group education.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06641726Recruiting
Global database linking genetics and health records for mental illness
This trial is building a research database that combines genetic information and long-term health data to improve personalized treatment for serious mental illness. You may be eligible if you have been diagnosed or treated for depression, bipolar disorder, schizophrenia, or dementia.
Oxford, OxfordAges 18–110 - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Phoenix, ArizonaAges 18–85 - NCT06529029RecruitingPhase 2/Phase 3
Comparing new low-pulse ECT to standard ECT for depression
This trial tests a new type of seizure therapy (low amplitude pulse seizure therapy) against the standard ultra-brief right unilateral ECT for people with severe depression, including those with suicidal thoughts. The goal is to see which treatment works better.
Grand Rapids, MichiganAges 18–90 - NCT04296604Recruiting
tDCS brain stimulation to improve thinking and mood
This study tests whether a non-surgical brain stimulation called tDCS can improve “executive function,” which means skills like planning, focus, and decision-making. It is designed for people with several mental health and substance-use conditions, and it may help you if those skills are affected by your diagnosis.
Boston, MassachusettsAges 18–65 - NCT05645575Recruiting
Inpatient TMS for treatment-resistant depression
This study tests an in-hospital brain stimulation treatment (TMS) for people with moderate to severe depression who did not improve after multiple antidepressant treatments. It may help your mood by targeting brain circuits involved in depression, and you would follow an intensive accelerated schedule.
Los Angeles, CaliforniaAges 18–65 - NCT06319378RecruitingPhase 2
Psilocybin for cancer-related depression
This trial tests whether a single dose of psilocybin, a psychedelic medication, can safely and effectively treat major depression in people with cancer. If you have cancer and have been feeling depressed for at least a month, you may qualify.
Gothenburg, GöteborgAges 20–80 - NCT06294119Recruiting
Brain-heart-vessel interaction study in heart surgery patients
This study looks at how your brain, heart, and blood vessels work together during heart surgery. It uses simple tests to measure these connections, which may help doctors better understand your health.
San Donato Milanese, MilanAges 18 years+ - NCT06274112Recruiting
Using brain stimulation to understand social motivation in depression or social anxiety
This study uses transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, to explore how the brain processes social motivation in people with major depressive disorder or social anxiety disorder. Understanding these brain processes could help develop new treatments for social avoidance.
Auburn, AlabamaAges 25–50 - NCT06183359Recruiting
Self-Identification Program for Depression
This study tests a self-identification program for people aged 18 to 70 who are currently in a major depressive episode. It aims to explore whether a simple self-monitoring tool can help you better manage your depression.
MontpellierAges 18–70 - NCT06130371Recruiting
Stress, Inflammation & Brain in Depression vs. Severe PMS
This study looks at how stress and inflammation affect the brain in women with major depression compared to women with severe PMS (PMDD). It could help find better ways to understand and treat these mood disorders.
Tübingen, Baden-WurttembergAges 18–40 - NCT06093906Recruiting
Positive processes and transition to health (PATH) study
This study tests a new therapy that may help people recover after a stressful life event. Over about 6 weeks, you'll work with a coach to retrain your brain's patterns and feel more in control again, as well as reconnect with positive activities.
Newark, DelawareAges 18–65 - NCT05996900Recruiting
Brain stimulation study for adults with epilepsy
This study uses advanced brain monitoring and noninvasive magnetic stimulation to understand how repetitive brain stimulation works in people with epilepsy who are already scheduled for hospital monitoring. It may help develop better treatments for seizures.
Stanford, CaliforniaAges 18–65 - NCT05800925Recruiting
Triage survey to check who can join psychiatry research
This study uses a short questionnaire to figure out who is eligible to join future psychiatry research. It may help people get routed into studies that match their situation and safety needs.
Boston, MassachusettsAges 18 years+ - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+
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Common questions
- Are there clinical trials for major depression?
- Yes. Clin2 currently lists 453 recruiting major depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.