Clinical trials
Major Depressive Disorder clinical trials
Below are recruiting major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 502 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06907654Recruiting
Couples study for depression and relationship wellbeing
This study looks at how partners can support each other while coping with depression. Couples will use a mental health app for a short time to see if it helps improve mood and relationships.
Madison, WisconsinAges 18 years+ - NCT05973643Recruiting
Metabolomics study during ECT for depression
This study measures changes in your blood and/or body chemistry while you receive electroconvulsive therapy (ECT) for a severe mood episode. The goal is to understand biological signals related to ECT and treatment-resistant depression, which may help improve future care.
BronAges 18 years+ - NCT06142955Recruiting
TMS therapy for depression in autism spectrum disorder
This study tests whether transcranial magnetic stimulation (TMS), a noninvasive brain stimulation technique, can help treat depression in people with autism spectrum disorder. It may help if you are between 18 and 40, have autism and depression, and are not taking medications that could interfere.
New Haven, ConnecticutAges 18–40 - NCT03678194Recruiting
Smartphone app tool for doctors managing daily depression
This trial tests a smartphone app that helps doctors manage depression in everyday life. It may help improve how care is tracked and adjusted soon after starting antidepressant treatment.
BordeauxAges 18–65 - NCT04436081RecruitingPhase 2
CBD oil without THC for agitation in Alzheimer’s dementia
This trial studies whether a THC-free CBD oil softgel can reduce agitation in people with Alzheimer’s-related dementia. It compares CBD to a control to see if it improves difficult behaviors and is safe over the study period.
Norfolk, VirginiaAges 50–90 - NCT07852728RecruitingPhase 2
Oxygen therapy for first responders after head injuries
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and overall well-being in first responders who have had a traumatic brain injury and still have symptoms. If you are a first responder dealing with ongoing brain injury symptoms, this study could help you find new ways to feel better.
Boise, IdahoAges 18–75 - NCT07280416Recruiting
Sleep changes in first year after cancer diagnosis
This study follows people who are newly diagnosed with cancer to see how their sleep changes during the first year. It looks at whether treatments like chemo or immunotherapy affect insomnia.
Le Puy-en-VelayAges 18–80 - NCT07219264Recruiting
Mental health first aid training for cancer survivors
This study offers a free training program called Mental Health CPR for cancer survivors and their supporters. It is designed to help Latino/Hispanic communities in southern Puerto Rico learn how to provide emotional first aid and mental health support to people affected by cancer.
Ponce, Puerto RicoAges 21–99 - NCT07198542Enrolling by invitation
Vagus nerve stimulation for somatic symptom disorder
This trial tests if gentle electrical stimulation on the vagus nerve in the ear or neck can help reduce physical symptoms that are closely linked to stress. It is for adults with somatic symptom disorder who are on stable medications.
Douliu, YunlinAges 18–65 - NCT07237009Recruiting
Personalized reminiscence therapy for memory loss
This trial tests a digital app that uses personal photos and memories to help people with early memory problems feel less depressed or apathetic. It's designed for seniors who have mild cognitive impairment or early dementia.
AngersAges 60 years+ - NCT05453513Recruiting
Study how depression and cannabis affect the brain in young adults with HIV
This study looks at brain activity to understand how depression and cannabis use may be linked in young adults living with HIV. It mainly involves questionnaires, mental health screening, and brain scans, which may help researchers better understand risk factors and brain “underpinnings.”
Miami, FloridaAges 18–59 - NCT06784908Recruiting
Stress and pain study for people living with HIV
This study looks at how stress affects pain in people with HIV. It may help find better ways to manage pain in this group.
New Haven, ConnecticutAges 18–68 - NCT07149428Recruiting
Deep study of smell loss causes using brain scans
This study uses brain imaging and electrical recordings to understand the brain's role in smell loss from any cause—like COVID, sinus problems, or chemotherapy. You may be eligible if you have any degree of smell loss lasting under a year.
Bethesda, MarylandAges 18–99 - NCT06187090Recruiting
Supplement therapy for adults with autism
This trial tests whether a specific supplement can help adults with Level 1 autism. It is open only to Italian-speaking participants aged 18–35 who do not have other major mental health or brain conditions.
Udine, UDAges 18–35 - NCT07223736Recruiting
AI education for new mothers after birth
This study tests an AI-based education tool for first-time mothers to help with recovery and reduce loneliness after childbirth. You participate from home using your smartphone for 2-6 weeks after delivery.
La Jolla, CaliforniaAges 18 years+ - NCT05867849RecruitingPhase 3
Cannabidiol treatment for bipolar depression symptoms
This trial tests whether cannabidiol (CBD) can reduce symptoms of bipolar depression. You may be eligible if you have bipolar I or II and a current depressive episode while staying on approved mood-stabilizing or antipsychotic medication.
Vancouver, British ColumbiaAges 19–70 - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06175104Recruiting
HeartGPS: Support for parents after a prenatal heart diagnosis
This study tests a counseling program for parents whose unborn baby has a serious heart condition called single ventricle. The program aims to help parents manage stress and support their baby's development before and after birth.
Los Angeles, CaliforniaAges 18 years+ - NCT07060066Recruiting
TMS for depression in schizophrenia
This study tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation) can help with depression in people who have schizophrenia. You would receive TMS sessions targeting areas of the brain linked to mood, and the goal is to see if this improves depression symptoms.
Houston, TexasAges 18–60 - NCT04289142RecruitingPhase 4
Testing memory effects of dexmedetomidine during heart surgery
This study looks at how a sleep medicine called dexmedetomidine affects thinking and memory after heart surgery. It compares cognitive outcomes over time to see if this sedation choice changes long-term brain function.
Vancouver, British ColumbiaAges 60 years+ - NCT06212219Recruiting
EEG brain training to help arm recovery after stroke
This study tests whether a brain-training technique called neurofeedback can improve arm movement in people who recently had a stroke. It uses an EEG cap to measure your brain activity while you do arm exercises, helping you relearn how to move your affected arm.
ToulouseAges 18–99 - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for major depressive disorder?
- Yes. Clin2 currently lists 502 recruiting major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.