Clinical trials
Metastasis clinical trials
Below are recruiting metastasis clinical trials, each written for real people, not researchers. We’re tracking 342 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04743102Recruiting
Multi-point full-thickness biopsy to confirm complete rectal cancer response
This trial checks whether taking small samples from the full thickness of rectal tissue can accurately confirm that rectal cancer has fully responded to chemotherapy and/or radiation. It may help doctors decide the best next step if no tumor is seen after treatment.
Beijing, Beijing MunicipalityAges 18–80 - NCT04833335Recruiting
MRI scans to tell tumor spread from radiation injury
This trial studies how a special MRI can help doctors tell whether brain lesions after Gamma Knife treatment are growing tumors or radiation injury. It may help you avoid unnecessary treatment if the findings suggest radionecrosis instead of progression.
ParisAges 18 years+ - NCT04858009RecruitingPhase 2
Warm chemotherapy placed in the belly for pancreatic cancer spread
This Phase 2 study tests a treatment that warms chemotherapy and delivers it directly into the abdomen to treat pancreatic cancer that has spread to the lining of the belly (peritoneum). You may be eligible if you completed earlier chemotherapy and your body shows signs the cancer is responding, with limited spread in the abdomen.
Rochester, MinnesotaAges 18–80 - NCT04903678Recruiting
Chemo into spinal fluid for advanced retinoblastoma spread
This trial studies giving chemotherapy directly into the spinal fluid to treat retinoblastoma that has spread to the central nervous system (brain/spinal cord). It may help by targeting tumor cells that are in the fluid around the brain and spinal cord.
ShanghaiAges Any age - NCT07698899RecruitingPhase 1
Study of a new treatment for childhood brain and CNS cancers
This trial tests a radioactive drug (177Lu-DTPA-Omburtamab) given directly into the fluid around the brain for children and teens with certain brain cancers or cancers that have spread to the central nervous system. It aims to see if this treatment is safe and effective for tumors that have come back or not responded to other therapies.
Basking Ridge, New JerseyAges 3–22 - NCT07218380RecruitingPhase 3
Study of Vepugratinib for advanced bladder or urinary tract cancer
This trial tests an experimental drug called Vepugratinib for people with advanced urinary tract cancer that has a specific change in the FGFR3 gene. It may be an option if you haven't had other treatments for advanced cancer and are looking for a new approach.
Huntsville, AlabamaAges 18 years+ - NCT04944030Recruiting
Study collects health data for metastatic lung cancer patients
This study collects medical information and test results from people with lung cancer that has spread (or cannot be cured with local treatment). It does not test a new drug; it helps researchers better understand patients’ health and care needs over time.
AngersAges 18 years+ - NCT04980287Recruiting
Surgery trial for colon cancer spread to stomach-area fat
This trial studies whether a specific surgery that removes the colon’s associated tissue (and part of the nearby stomach-area tissue) improves outcomes for certain colon cancer cases that are at risk of spreading there. If you qualify, your doctors will compare your treatment approach as part of the study to see if it helps.
Wuhan, HubeiAges 18–75 - NCT05023772Recruiting
Laser and targeted radiation for spine metastases
This trial tests a combination treatment that uses a laser and focused radiation to shrink tumors in the spine and help stabilize the area near the spinal cord. It’s meant for adults with certain types of solid cancers that have limited spread in the spine and who are not good candidates for surgery.
Detroit, MichiganAges 18 years+ - NCT05095207RecruitingPhase 1/Phase 2
Abemaciclib and bicalutamide for HER2-negative metastatic breast cancer
This Phase 1/2 trial tests whether combining abemaciclib with bicalutamide can slow or shrink HER2-negative, androgen receptor–positive (AR-positive) metastatic breast cancer. It mainly looks at safety and side effects, and also whether the combination can help patients with this type of breast cancer.
New York, New YorkAges 18–90 - NCT05102747Recruiting
Surgery-like brain radiation for up to 5 metastases
This trial compares two ways of giving focused radiation to the brain for people with a limited number of brain metastases. It aims to see which schedule works best (and is likely best for costs and quality of life).
BordeauxAges 18 years+ - NCT05176665RecruitingPhase 1/Phase 2
EMB-01 for advanced stomach, bile, liver, and colon cancers
This early-phase trial studies EMB-01 in people with advanced or metastatic gastrointestinal cancers to see how well it works and how safe it is. To join, your tumor’s DNA or protein pattern (especially EGFR or cMET) must match specific lab results, and you must have tried standard treatments.
Houston, TexasAges 18 years+ - NCT05184803RecruitingPhase 2
Pre-surgery chemo for advanced stomach cancer with lymph spread
This Phase 2 study tests a combination chemotherapy regimen given before surgery for stomach cancer that cannot be fully removed (unresectable), including spread to lymph nodes. The goal is to shrink the cancer and improve control with a well-known set of medicines given in a specific order.
Seoul, SeoulAges 19 years+ - NCT05257967Recruiting
Testing spinal fluid in EGFR-mutant lung cancer with brain covering spread
This trial looks at spinal fluid (also called CSF) in adults with EGFR-mutant lung cancer that has spread to the lining around the brain/spinal cord. The goal is to better understand the disease and what the spinal fluid tests may show to guide care.
Vancouver, British ColumbiaAges 18 years+ - NCT05304858Recruiting
Study of prostate cancer spread using biopsy and lab tests
This trial studies the “microenvironment” around prostate cancer metastases, using specimens taken during biopsy and other scans. It may help researchers understand what drives prostate cancer spread and improve future treatment choices.
New York, New YorkAges 18 years+ - NCT05314400Recruiting
MRI with contrast for metastatic colon cancer liver lesions
This trial studies an MRI technique using a contrast dye (gadopetate/gadolinium) to better look at liver lesions that may be colon cancer spread. It may help doctors more accurately assess which liver tumors are present and guide next steps.
London, OntarioAges 18 years+ - NCT05338658RecruitingPhase 1
Test drug PAT in adults with solid tumors
This Phase 1 study tests PAT in adults with solid tumor cancers who meet specific immune and health criteria. Because it’s an early safety-and-dosing study, it may help researchers learn whether PAT can be given safely and whether it shows any cancer activity in the right patients.
Minneapolis, MinnesotaAges 18 years+ - NCT05347524Recruiting
Blood test study to detect stomach cancer spread in the belly
This study checks whether a blood liquid biopsy test can detect when stomach cancer has spread to the lining of the abdomen (peritoneal metastasis). It compares people with confirmed belly spread to people whose belly lining tests were negative, using blood samples before/around treatment decisions.
Shanghai, Shanghai MunicipalityAges 18–74 - NCT05352178RecruitingPhase 3
Targeted treatment for few-spread prostate cancer spots
This Phase 3 trial tests whether treating only a small number of prostate cancer metastases can help people with “oligorecurrent” (limited repeat) prostate cancer. It may reduce cancer activity while avoiding broader whole-body treatment for some patients.
LeuvenAges 18 years+ - NCT05386108RecruitingPhase 1/Phase 2
Test abemaciclib plus elacestrant for breast cancer brain spread
This trial studies whether the combination of abemaciclib and elacestrant can slow or shrink ER-positive, HER2-negative breast cancer that has spread to the brain. It is designed for people whose cancer has progressed despite prior hormone (endocrine) treatment.
Fullerton, CaliforniaAges 18 years+ - NCT05394259RecruitingPhase 1
PYLARIFY PET-CT scan to find spread in certain cancers
This early study tests whether a special PET-CT scan called PYLARIFY can detect metastasis (cancer spread) more effectively in pancreatic, liver (HCC), and breast cancers. If the scan results change doctors’ treatment plans, it could help you get the right next therapy sooner.
Houston, TexasAges 18 years+ - NCT05542407RecruitingPhase 1
ONC201 plus atezolizumab for endometrial cancer and obesity
This Phase 1 study tests ONC201 together with atezolizumab in people with metastatic or returning endometrial cancer, especially when obesity may be driving the cancer. It aims to find a safe dose and see whether the combination can slow the cancer’s growth.
Chapel Hill, North CarolinaAges 18 years+ - NCT05554302RecruitingPhase 2
PET scan study for brain metastases after surgery
This trial studies how well a special PET scan tracer (18F-fluciclovine) shows amino-acid changes in brain metastases after they are surgically removed. It may help improve how doctors detect and understand brain metastases and guide follow-up treatment like targeted radiation (SRS).
Miami, FloridaAges 18 years+ - NCT05584267RecruitingPhase 2
Immunotherapy plus targeted brain radiation for lung cancer
This Phase 2 trial studies whether giving immunotherapy along with a precise form of brain radiation can control brain metastases from non-small cell lung cancer. It may help by shrinking or stabilizing spots in the brain while your body’s immune system is also activated.
Changsha, HunanAges 18 years+
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Common questions
- Are there clinical trials for metastasis?
- Yes. Clin2 currently lists 342 recruiting metastasis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a metastasis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a metastasis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.