Clinical trials
Microbiome clinical trials
Below are recruiting microbiome clinical trials, each written for real people, not researchers. We’re tracking 346 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07699614Recruiting
Lung health and germs in adults in Botswana
This study looks at how the lungs and tiny organisms in the body (microbiome) work together in adults living in Botswana. It may help doctors understand how to keep lungs healthier, especially for people with or without HIV.
GaboroneAges 35 years+ - NCT05878977Recruiting
Testing biomarkers in immunotherapy for advanced melanoma
This trial looks at tissue and scan-related markers (“biomarkers”) to better understand how immunotherapy works in people with advanced melanoma. You may receive standard first-line immunotherapy, and your recent scans and health details will help researchers study why some people respond better than others.
LjubljanaAges 18 years+ - NCT06655233Recruiting
Exploring gut bacteria in pancreatic cancer tumors
This trial studies bacteria found inside pancreatic tumors to see if they can help diagnose or predict the course of the disease. You may be eligible if you have a suspected pancreatic cancer and need a special biopsy (EUS-FNB).
Hunan, HunanAges 18–80 - NCT06051318Recruiting
Diet and gut microbiome effects on blood sugar in healthy adults
This study looks at how your gut bacteria and the foods you eat affect your blood sugar after meals. You'll wear a small sensor to track your blood sugar for 10 days and provide stool samples.
Florianópolis, Santa CatarinaAges 18–60 - NCT07682077Recruiting
Kefir drink to prevent diabetes in pregnancy
This study tests whether a daily probiotic drink (kefir) during pregnancy can help prevent gestational diabetes. It's for pregnant people who are less than 14 weeks along and live near Fredericton, New Brunswick.
Fredericton, New BrunswickAges 19 years+ - NCT07676461Recruiting
Microbiome study in advanced cancer patients starting immunotherapy
This study looks at the bacteria in your mouth, gut, and tumors to see if they affect how well first-line immunotherapy works. It is for people with advanced stomach, colorectal, breast, cervical, or head-and-neck cancer.
Bogotá, Bogota D.C.Ages 18 years+ - NCT07667049RecruitingPhase 1
Gut health study for preterm infants
This study looks at how the gut works in premature babies to better understand digestion and health. It may help improve care for newborns born early.
Baltimore, MarylandAges Up to 4 days - NCT07650149Recruiting
Study of genes, gut bacteria, and lifestyle in obesity
This study looks at how genes, gut bacteria, and lifestyle behaviors relate to weight. Researchers will test a weight-loss medication (tirzepatide) as part of the study to see if it helps people with overweight or obesity.
KrakowAges 18–65 - NCT07636850Recruiting
How almonds affect gut bacteria in children
This study looks at whether eating almonds changes the helpful bacteria in kids' stomachs and intestines. Researchers will give some children almonds to eat and study how it affects their digestive health.
Tallahassee, FloridaAges 6–13 - NCT07635732Recruiting
Urine Bacteria as a Test for Melanoma Treatment Response
This study looks at bacteria naturally found in urine to see if they can help diagnose melanoma and predict how well systemic therapy (medicine that spreads throughout the body) will work. Researchers believe the types of bacteria in your urine may reflect how your immune system is responding to melanoma treatment.
Gratwein, StyriaAges 18 years+ - NCT07623902Recruiting
Tongue test to improve colorectal cancer screening
This study is testing a new, non-invasive tongue test called Gixam. The goal is to see if the test can help detect colorectal cancer or pre-cancerous growths in people whose standard stool tests (FIT) came back negative, potentially improving screening accuracy.
Mobile, AlabamaAges 45–84 - NCT07614542Recruiting
Understanding Gut Health and Hormones in Aging Women
This study explores how your gut bacteria and hormones change as you age. Researchers will collect stool and blood samples and ask about your health to better understand women's aging.
LisbonAges 40–64 - NCT06710574RecruitingPhase 4
Probiotics for sleep problems in Parkinson's disease
This study tests whether taking probiotics can improve REM sleep behavior disorder (RBD) in people with Parkinson's disease. You will receive either a probiotic supplement or a placebo, and researchers will use brain scans to see how it affects your symptoms.
BeijingAges 40–85 - NCT07600008RecruitingEarly Phase 1
Probiotics as a supplement for reflux disease management
This early-stage trial tests whether a probiotic supplement can help support treatment of reflux disease (GERD) in patients already taking a standard reflux medication. Researchers want to see if adding probiotics might improve symptoms or overall digestive health.
OlomoucAges 40–55 - NCT07602920Recruiting
Understanding Gut Leakage in Dengue Fever
This study investigates whether dengue fever causes the intestinal lining to become leaky, allowing harmful substances to enter the bloodstream. Researchers compare blood markers in dengue patients and healthy volunteers to understand how this happens and why it might make dengue worse.
Chittagong, Chattogram DivisionAges 18 years+ - NCT07592975Recruiting
Food with Fiber and B-Vitamins for Gut Health in Older Adults
This study tests whether adding special fibers (prebiotics) and B-vitamins to food can improve your gut bacteria, reduce inflammation, and support mental health. You'll eat fortified foods for several weeks while researchers track changes in your digestion and wellbeing.
Coleraine, County LondonderryAges 50 years+ - NCT07585474Enrolling by invitation
Gut Health During Long Travel for Football Players
This study looks at how long airplane trips affect the gut bacteria in professional male football players. Researchers will track changes in your digestive system during pre-season travel to understand if travel impacts your gut health.
Nashville, TennesseeAges 18–40 - NCT06724133Recruiting
Mouth bacteria and colon polyps study
This study looks at the bacteria in your mouth and how they might be linked to colon polyps. Researchers want to see if certain mouth bacteria affect the body's immune system and increase the risk of polyps.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06614777Recruiting
Darier's disease immune and microbiome study
This study looks at immune markers and gut/skin bacteria in people with Darier's disease. It aims to better understand the condition, which could lead to better treatments in the future.
Toulouse, Centre Hospitalier Universitaire de ToulouseAges 18 years+ - NCT07567794Recruiting
Gut-Brain Connection Study in Parkinson's Disease
This research examines how the gut and brain are connected in Parkinson's disease and aims to better understand the disease. You'd participate in visits and tests over three years, including some involving your digestive system.
Stanford, CaliforniaAges 21–80 - NCT02431845Recruiting
Study of OCD genes, proteins, and gut microbes
This study looks at genes, blood/brain proteins, and gut microbes in people with obsessive-compulsive disorder (OCD). It may help researchers understand what drives OCD and how treatments could be better tailored in the future.
SeoulAges 19–70 - NCT07533890Recruiting
Probiotics and gut health in children with inflammatory bowel disease
This study tests whether a multi-strain probiotic supplement can change the gut bacteria in children and teens with inflammatory bowel disease (IBD). Researchers will collect stool samples to see if the probiotics help restore healthy gut bacteria and potentially improve symptoms.
BernAges 5–18 - NCT03941080Recruiting
Study gut bacteria changes in advanced colorectal cancer
This study looks at how gut bacteria (the microbiome) change during treatment for colorectal cancer that has spread or cannot be removed. Researchers hope the findings may help improve understanding of how treatment works and how to tailor care.
AssenAges 18 years+ - NCT07520461Recruiting
Diet Changes for Ulcerative Colitis Based on Gut Bacteria
This study tests whether a special diet designed to improve your gut bacteria can help control mild ulcerative colitis. You'll receive prepared meals and follow the diet for several weeks to see if it reduces inflammation in your colon.
Minneapolis, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for microbiome?
- Yes. Clin2 currently lists 346 recruiting microbiome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a microbiome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a microbiome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.