Clinical trials
Mitochondrial Diseases clinical trials
Below are recruiting mitochondrial diseases clinical trials, each written for real people, not researchers. We’re tracking 45 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01780168Recruiting
Study of metabolism, infection, and immunity in mitochondrial disease
This study looks at how metabolism, infections, and the immune system work together in people with mitochondrial disease. It aims to learn more about the condition and may help guide future treatments.
Bethesda, MarylandAges 4 weeks–115 years - NCT01532791Recruiting
Study of mitochondrial mutation m.3243A>G in families
This study looks at the natural course of a specific inherited mitochondrial DNA change (m.3243A>G) over time. It may help doctors better understand how this mutation affects health and outcomes, even if no treatment is given.
New York, New YorkAges 4 years+ - NCT04113447Recruiting
Mitochondrial donation study for parents of confirmed mtDNA mutation
This study follows families using mitochondrial donation to reduce the risk from a confirmed mitochondrial DNA (mtDNA) mutation. It aims to learn outcomes over about 18 months of the child’s life and whether the treatment works well and safely for families like yours.
Newcastle upon Tyne, Tyne & WearAges Any age - NCT04322734Recruiting
Blood tests study immune and metabolism markers in neurodevelopment
This study looks for biological “signals” in blood—related to the immune system and metabolism—to better understand conditions like autism and other brain or development-related disorders. It may help researchers find markers that could guide future diagnosis or treatment.
Phoenix, ArizonaAges Up to 18 years - NCT05958706Recruiting
Testing how heart cells use fuel in heart failure
This study looks at how the heart uses energy fuel in people with heart failure, including those with type 2 diabetes. It may help researchers understand what’s going on inside the heart and how it could be treated in the future.
DüsseldorfAges 20–85 - NCT07680816Recruiting
Study of gamma delta T cells in critically ill patients
This study looks at a type of immune cell called gamma delta T cells in patients who are very sick in the ICU, including those with and without sepsis. The goal is to understand how these cells work differently in these patients, which could help find better treatments.
Wuhan, Outside of the USAges 18–80 - NCT06017869RecruitingPhase 2
Mitochondria therapy for Pearson Syndrome in children
This trial tests a one-time infusion of your own blood cells mixed with donated mitochondria to see if it can help children with Pearson Syndrome grow better and improve their health. It is a new approach that aims to provide the energy your cells need.
Ramat Gan, IsraelAges 1–18 - NCT05241262RecruitingPhase 1
N-acetylcysteine for people with m.3243A>G and low brain glutathione
This trial tests whether the supplement N-acetylcysteine (NAC) can help people who have the m.3243A>G mitochondrial genetic change and low levels of a brain chemical called glutathione. The study aims to see if raising glutathione in the brain is safe and potentially beneficial for these patients.
New York, New YorkAges 18–80 - NCT05305287RecruitingPhase 4
Measuring liver energy use in people with diabetes and fatty liver disease
This study looks at how the liver uses energy (mitochondria) in people with type 2 diabetes and fatty liver disease. By understanding this, researchers may find better ways to treat liver problems.
San Antonio, TexasAges 18–80 - NCT07775872Recruiting
Study of polg-related disease over time
This study follows people of all ages with a confirmed POLG-related disease to learn how the condition changes over time. The information collected may help design better care and future treatments.
San Diego, CaliforniaAges Any age - NCT06631820Recruiting
A study of epicatechin for muscle health in advanced kidney disease
This trial tests whether a natural supplement called epicatechin can improve muscle health in people with advanced chronic kidney disease (CKD). You may be able to join if you have low kidney function and are not planning to start dialysis or have a kidney transplant in the next 4 months.
Huddinge, Stockholm CountyAges 60 years+ - NCT05422534RecruitingPhase 3
CoQ10 plus exercise for people with advanced kidney disease
This trial tests whether a supplement called CoQ10, along with supervised exercise, can improve how the body uses energy in people on chronic dialysis. It may help with muscle function and overall health if your heart and dialysis situation are stable enough.
Sacramento, CaliforniaAges 18–75 - NCT06938542Enrolling by invitation
Palliative care needs for kids with rare diseases
This study asks children with rare diseases and their families about what kind of palliative care (comfort and support) they need. It aims to understand how to better help families through their child's illness.
Washington D.C., District of ColumbiaAges 1–99 - NCT06559878Enrolling by invitation
Liver Mitochondria Study in Fatty Liver Disease
This study looks at how the liver's mitochondria (the energy powerhouses of cells) work in people with fatty liver disease. Participants will have an MRI scan and receive a small amount of fat solution through an IV to see how the liver processes fat.
Helsinki, UusimaaAges 18–75 - NCT04984226RecruitingPhase 2
Sodium bicarbonate for kidney disease energy and acidity
This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.
Sacramento, CaliforniaAges 21–85 - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT06880406Recruiting
Study of cell energy in Alzheimer's and other dementias
This study looks at how energy production in cells (mitochondria) differs in people with Alzheimer's or other dementias compared to healthy volunteers. It involves a one-time spinal tap to collect fluid for analysis.
Nice, PACAAges 18 years+ - NCT06813443Recruiting
Studying cardiomyopathy to find who needs a heart transplant
This study is looking at people with cardiomyopathy to understand which patients are most in need of a heart transplant. By joining, you will help doctors learn more about critical cases and improve care for heart muscle disease.
Bologna, Emilia-Romagna/BolognaAges 12 years+ - NCT07244809Recruiting
Study on stress history and blood vessel health in young adults
This study tests whether early-life stress affects blood vessel function in young adults by looking at a type of cell stress called oxidative stress. It involves measuring how well your blood vessels work and may help understand why some people have higher heart risks.
Iowa City, IowaAges 18–29 - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT07699380RecruitingPhase 2
Metabolic therapy to improve insulin sensitivity in type 1 diabetes
This trial tests a drug that may help your body use insulin better and improve how your cells produce energy. It might lead to better blood sugar control and less insulin needed.
Seattle, WashingtonAges 18–69
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Common questions
- Are there clinical trials for mitochondrial diseases?
- Yes. Clin2 currently lists 45 recruiting mitochondrial diseases studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitochondrial diseases trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitochondrial diseases trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.