Clinical trials
Mitral Valve Insufficiency clinical trials
Below are recruiting mitral valve insufficiency clinical trials, each written for real people, not researchers. We’re tracking 42 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06552689Recruiting
Testing Sutra Hemi-valve for leaky mitral valve
This trial tests a new, less invasive heart valve (Sutra Hemi-valve) for people with a leaky mitral valve who cannot have standard surgery. The valve is delivered through a vein in your leg, so you avoid open-heart surgery.
HamiltonAges 18 years+ - NCT06608823Recruiting
Comparing surgery vs. the Trilogy valve for aortic regurgitation
This trial compares a new less-invasive valve replacement (Trilogy TAVR) with standard open-heart surgery for people with significant aortic regurgitation. It aims to see which treatment works better for patients who are eligible for both procedures.
Burlingame, CaliforniaAges Any age - NCT05655897Recruiting
Clips for leaky mitral valve in high-surgery-risk heart patients
This trial studies whether a device called GeminiOne can safely and effectively repair a leaky mitral valve using a catheter-based “clip” technique. It may help patients who have moderate-to-severe or severe valve leakage but are considered too high-risk for open surgery.
Suzhou, JiangsuAges 18 years+ - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT04436653Recruiting
New valve procedure for severe right-sided leakage
This trial tests whether a new minimally invasive valve replacement device (put through a catheter) can improve health in people with severe right-sided tricuspid valve leaking. It’s for patients who are considered too high-risk for standard open-heart tricuspid surgery.
Beijing, Beijing MunicipalityAges 50 years+ - NCT07370467Recruiting
MRI study for mitral & tricuspid valve repair
This study uses MRI scans to take detailed pictures of the heart before and after a valve repair procedure. It helps doctors better understand how these new, less invasive treatments affect heart function.
Milan, MilanAges 18 years+ - NCT07691307Recruiting
TruGamma tricuspid valve replacement study
This trial tests a new device called TruGamma to replace the tricuspid valve without open-heart surgery. It is for older adults with severe tricuspid regurgitation who cannot have surgery and still have symptoms despite medication.
Beijing, Beijing MunicipalityAges 65 years+ - NCT05913908Recruiting
Valve procedure study for severe tricuspid leakage
This trial tests how well a new catheter-based valve system works for people with severe (or worse) tricuspid valve leaking who still have symptoms despite medicines. It aims to improve outcomes by treating the leaking valve without open-heart surgery, if your heart structure and overall health fit the study.
Phoenix, ArizonaAges 18 years+ - NCT05610566Recruiting
HighLife valve replacement for severe leaking mitral valve
This trial studies a new catheter-based valve replacement system for people with moderate to severe, or severe, mitral valve regurgitation (a leaky mitral valve). It aims to check whether the procedure is safe and can improve heart function compared with expected care.
Suzhou, JiangsuAges 18 years+ - NCT04097145Recruiting
Heart valve repair for severe leaking tricuspid valve
This trial tests a catheter-based procedure (done through the blood vessels) to repair a severely leaky tricuspid valve. It may help people with symptoms or past hospitalizations from tricuspid valve leakage who are higher-risk for standard surgery.
Phoenix, ArizonaAges 18 years+ - NCT06467110Enrolling by invitation
Study of SQ-Kyrin TMVr System for leaky mitral valve
This trial tests a new device called the SQ-Kyrin TMVr System to treat severe mitral regurgitation (a leaky heart valve) in people who are not good candidates for traditional open-heart surgery. The goal is to repair the valve without major surgery, using a catheter-based approach.
Shenyang, LiaoningAges 18 years+ - NCT03728049Recruiting
Blood test during TAVI to improve heart valve procedure outcomes
This study checks whether a quick bedside blood test helps guide care during a minimally invasive TAVI procedure (a new valve put in without open-heart surgery). It may improve safety and outcomes by helping the team manage bleeding-related decisions in real time.
Clermont-FerrandAges 18 years+ - NCT03958773Enrolling by invitation
Transcatheter treatment for severe leaking mitral valve
This study tests a new catheter-based system to treat severe mitral valve leaking when open-heart surgery is considered high risk. It may help improve blood flow and symptoms by repairing the valve without open surgery, using ultrasound guidance and follow-up visits to track safety and results.
KaunasAges 18 years+ - NCT07019935Recruiting
Predicting outcomes after mitral valve repair
This study looks at how well a newer, less invasive heart valve repair works for people with leaky mitral valves. It aims to create a tool to predict who will get the best results.
Guangzhou, GuangdongAges 18 years+ - NCT07662655RecruitingEarly Phase 1
PADN for pulmonary hypertension after mitral valve repair
This study tests a new procedure called pulmonary artery denervation (PADN) to lower high blood pressure in the lungs that persists after a mitral valve repair. It aims to see if this extra treatment improves symptoms and outcomes for people with this condition.
Xiamen, FujianAges 18–80 - NCT06964035Enrolling by invitation
How original valve problem affects new valve's long-term health
This study looks at how the original problem with your aortic valve (narrowing, leaking, or both) might affect how long the replacement valve stays healthy. If you had both your aortic and mitral valves replaced, doctors want to track how well the new valve works over time.
Maastricht, MaastrichtAges 18 years+ - NCT05040074Recruiting
Transcatheter repair for leaking mitral valve in high-risk patients
This trial studies a minimally invasive device meant to fix a badly leaking mitral valve (mitral regurgitation) without open-heart surgery. It may be an option if you’re considered too high-risk for standard surgery and your heart anatomy fits the device.
Shenyang, LiaoningAges 18 years+ - NCT07086534Recruiting
GeminiOne Clip for Severe Mitral Regurgitation
This trial tests a new device called GeminiOne that clips together part of your leaky mitral valve to reduce backward blood flow. It is for people with severe mitral regurgitation who are not candidates for open-heart surgery.
Thousand Oaks, CaliforniaAges 18 years+
Hear when a new Mitral Valve Insufficiency trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for mitral valve insufficiency?
- Yes. Clin2 currently lists 42 recruiting mitral valve insufficiency studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mitral valve insufficiency trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mitral valve insufficiency trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.