Clinical trials
Musculoskeletal clinical trials
Below are recruiting musculoskeletal clinical trials, each written for real people, not researchers. We’re tracking 207 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06451588RecruitingPhase 2
Fecal transplant for inflammatory back pain
This study tests whether a fecal microbiota transplant (a procedure that transfers healthy bacteria into your gut) can reduce inflammation and improve symptoms in people with inflammatory back pain (axial spondyloarthritis). It may help if your current treatments are not working well enough.
TromsøAges 18–65 - NCT06398847Recruiting
Virtual reality self-hypnosis for HIV-related pain
This study tests if using a virtual reality (VR) headset for self-hypnosis can help people with HIV manage chronic pain. You would practice at home with a smartphone app, and researchers will track your pain levels over time.
New York, New YorkAges 18 years+ - NCT06368388Recruiting
Personalized phage therapy for hard-to-treat infections
This trial studies using phages (viruses that attack bacteria) to treat infections that have not improved with other treatments. It aims to see if this patient-specific approach works and what it costs.
LeuvenAges Any age - NCT06243848Recruiting
Injection vs. surgery for carpal tunnel syndrome
This trial compares two treatments for carpal tunnel syndrome: an ultrasound-guided injection and a surgery to take pressure off the median nerve. It aims to see which one provides better relief for symptoms like numbness and tingling.
AfyonkarahisarAges 18–75 - NCT06157177RecruitingPhase 4
M640 for acute low back pain study
This trial tests a new treatment (M640) for people with acute low back pain, with or without sciatica. It aims to see if M640 can help reduce pain quickly.
Auburn, AlabamaAges 18–80 - NCT06167928Recruiting
Developing new treatments from donated tissue
This study collects tissue from children having surgery for polydactyly or hip dislocation, so researchers can develop new treatments for muscle and bone problems.
Oswestry, ShropshrieAges Any age - NCT06119698Recruiting
Improving Health for Older Adults With Pain Through Engagement
This study tests a program to help older adults with long-lasting bone, joint, or muscle pain become more active. Participants wear a smartwatch and get support to manage their pain and improve their health.
Boston, MassachusettsAges 55 years+ - NCT06072599Enrolling by invitation
Osteopathic treatment for non-muscle and joint conditions
This trial looks at how osteopathic manipulative treatment can help with health issues that are not related to muscles or joints, like problems with digestion, breathing, or circulation. It aims to see if this type of hands-on care can improve your overall well-being.
Kirksville, MissouriAges 18 years+ - NCT06046859RecruitingPhase 4
Can fluoxetine help recovery after serious injuries?
This study tests whether giving the antidepressant fluoxetine (Prozac) right after a traumatic injury can help improve mental and physical recovery. It is for people who have broken bones or internal injuries from an accident and may be feeling down.
Gainesville, FloridaAges 18–85 - NCT06004804Recruiting
Psychological treatments for chronic pain in veterans
This study compares two group psychological treatments for chronic pain delivered over video conference. It aims to see if these treatments help reduce pain and improve quality of life for veterans.
West Los Angeles, CaliforniaAges 60–95 - NCT05994833Recruiting
Virtual physical therapy for injured runners
This study tests whether virtual physical therapy sessions can help runners with long-lasting injuries like runner's knee or Achilles tendinitis. You would join online therapy for a month instead of in-person visits, and they will check how you improve.
Gainesville, FloridaAges 18–65 - NCT05989230Recruiting
Emotional awareness therapy for pain after orthopedic injury
This trial tests a therapy that helps people understand and express their emotions to manage long-term pain after a serious bone injury. It may help if you have had pain most days for at least three months following surgery for an orthopedic injury.
Baltimore, MarylandAges 18 years+ - NCT05905146Recruiting
Personalized opioid plan to shorten treatment time
This trial tests whether a personalized medication plan can help patients with short-term, non-cancer muscle or joint pain need strong opioid medicine for a shorter time. It’s aimed at improving how long treatment lasts while still managing pain.
LilleAges 18 years+ - NCT05814497Recruiting
Brain scan study of how kids process chronic pain
This study looks at how the brain processes pain sensations in children with certain long-lasting pain conditions. It may help researchers understand what’s happening in the nervous system and guide better treatments.
Cincinnati, OhioAges 10–17 - NCT05738824Recruiting
Study how inflammatory muscle diseases naturally change over time
This study follows people with suspected or confirmed inflammatory muscle disease (and sometimes healthy adults) to better understand how the condition progresses and what changes over time. It may help researchers identify patterns that could guide future treatments.
Bethesda, MarylandAges 2–120 - NCT05742776Recruiting
Ultrasound and sleep quality check in carpal tunnel
This trial studies whether ultrasound exam findings match how well you sleep if you have carpal tunnel syndrome. It may help doctors better understand which ultrasound results go along with worse sleep and symptoms.
Afyonkarahisar, Afyonkarahi̇sarAges 20–80 - NCT05636137Enrolling by invitation
Study links internet habits with pain and body awareness
This study asks high school students about internet use, musculoskeletal pain (pain in muscles and bones), and body awareness (how well you notice your body). It aims to understand whether these things are connected and may help guide future supports for teens.
Muğla, MenteşeAges 15–18 - NCT05567198Recruiting
Testing hormone shots to protect ovaries during lupus chemotherapy
This study looks at whether a monthly/3-month hormone medicine (a “GnRH shot”) can help protect ovaries in people with lupus who are treated with cyclophosphamide. It also compares this to lupus patients who do not receive the ovarian-protecting shot, using questionnaires to track outcomes.
Bethesda, MarylandAges 18–120 - NCT05555576Recruiting
Vitamin C to reduce opioid use after an ER visit
This trial tests whether taking vitamin C after an emergency room visit for a new, short-term muscle or joint pain can lower how many opioid pain pills you use. It may help by reducing opioid consumption while you recover.
Montreal, QuebecAges 18 years+ - NCT05440422RecruitingPhase 2
Anifrolumab for heart health in lupus patients
This study tests whether anifrolumab, a drug that targets the immune system, can improve markers of blood vessel health in people with lupus. It may help reduce the risk of heart problems associated with lupus.
Bethesda, MarylandAges 18–80 - NCT05447299Enrolling by invitation
Muscle and spasticity testing using MRI modeling
This study uses an MRI scan and movement measurements to better understand muscle tightness (spasticity) in children with cerebral palsy. It may help researchers improve how spasticity is evaluated and modeled to support future treatments.
StockholmAges 5–18 - NCT05266976Recruiting
Exercise types and bone markers in healthy older veterans
This study compares different ways of exercising to see how they affect “bone-related” blood markers in older adults. It may help you and researchers understand which exercise patterns support healthy bones.
Aurora, ColoradoAges 60 years+ - NCT05301959Recruiting
Electrolysis treatment for Achilles tendon pain
This trial studies whether percutaneous electrolysis can improve long-lasting Achilles tendon pain. It compares the treatment against a placebo and aims to reduce pain and symptoms in people with MRI-proven tendinopathy.
Buenos Aires, Buenos Aires F.D.Ages 18–65 - NCT05111925Recruiting
Testing after-injury and after-recovery readiness for full duty
This study looks at how well service members are able to return to full physical duty after a low-back or leg injury (or to see readiness in those without an injury). It may help improve return-to-duty planning by measuring changes before and after recovery.
Bethesda, MarylandAges 18–44
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Common questions
- Are there clinical trials for musculoskeletal?
- Yes. Clin2 currently lists 207 recruiting musculoskeletal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a musculoskeletal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a musculoskeletal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.