Clinical trials
Neoadjuvant clinical trials
Below are recruiting neoadjuvant clinical trials, each written for real people, not researchers. We’re tracking 905 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05761470RecruitingPhase 2
Test before-surgery cancer treatment for breast tumors with DNA repair gene changes
This trial tests a combination of medications given before surgery (neoadjuvant therapy) for early breast cancer. It is designed for tumors with certain “DNA repair” gene mutations and aims to improve treatment results while shrinking or controlling the cancer.
Guangzhou, GuangdongAges 18–75 - NCT07020247RecruitingPhase 3
Personalized radiation plus chemo with or without immunotherapy for rectal cancer
This trial tests adding immunotherapy to standard radiation and chemotherapy for patients with locally advanced rectal cancer. The goal is to see if a personalized approach improves outcomes while sparing more normal tissue.
Chengdu, SichuanAges 18 years+ - NCT07528066Recruiting
Surgery After Chemotherapy and Immunotherapy for Advanced Lung Cancer
This study follows patients with advanced non-small cell lung cancer (NSCLC) who receive combination chemotherapy and immunotherapy before surgery. Researchers will track how well surgery works after this pre-surgical treatment and compare different surgical approaches.
Fuzhou, FujianAges Any age - NCT07263620Recruiting
Gut bacteria and cancer treatment before surgery
This study looks at the bacteria in your gut to see if they can predict how well chemotherapy or radiation works before surgery for certain cancers. If you have pancreatic, stomach, colon, or esophageal cancer that has spread nearby (but not to distant organs), you may be able to join.
TianjinAges Any age - NCT07044453RecruitingPhase 2/Phase 3
Extra chemo tailored to tumor stage for operated pancreatic cancer
This trial tests whether giving different types of extra chemo (after surgery) based on the stage of your cancer can help prevent it from coming back. It's for people with pancreatic cancer who already had chemo and surgery.
RouenAges 18 years+ - NCT07506876RecruitingPhase 2
Combined hormone and chemo before surgery for HER2+ breast cancer
This trial tests combining hormone therapy with chemotherapy and targeted therapy before surgery for a type of breast cancer that is both hormone-receptor-positive (HR+) and HER2-positive. The goal is to see if this combination works better than standard treatment.
Gresham, OregonAges 18 years+ - NCT04547907RecruitingPhase 3
Testing two HER2 breast cancer medicines before surgery
This trial compares two anti-HER2 medicines given before surgery to shrink HER2-positive early breast cancer. It aims to see which treatment works better as “neoadjuvant” therapy to improve outcomes while keeping you safe.
Zhengzhou, HenanAges 18–70 - NCT05989425RecruitingPhase 2
Surufatinib before surgery for advanced thyroid cancer
This trial tests whether the drug Surufatinib, given before surgery, can shrink locally advanced or metastatic thyroid cancer. It's a targeted therapy that blocks blood vessels that feed tumors, and is given as a pill to see if it makes the cancer easier to remove.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07464756RecruitingPhase 2
Study of SHR-1701 and apatinib with chemo before stomach cancer surgery
This trial tests whether adding SHR-1701 (an immunotherapy) with or without apatinib (a targeted therapy) to standard chemotherapy before surgery can help treat gastric cancer. It is for people with stomach or gastroesophageal junction cancer that has spread to nearby lymph nodes but is still removable.
Nanjing, JiangsuAges 18 years+ - NCT06597227Recruiting
Partial vs total stomach removal for upper stomach cancer after chemo
This trial compares two types of surgery for upper stomach cancer after chemotherapy or radiation. It aims to see if removing only part of the stomach (proximal gastrectomy) works as well as removing the whole stomach (total gastrectomy) to help you recover better.
Wuhan, HubeiAges 18–75 - NCT06693037Recruiting
Choosing next treatment after incomplete response in HER2+ breast cancer
This trial looks at the best next treatment for women with HER2-positive breast cancer who still have leftover cancer after surgery and standard pre-surgery treatment. It helps doctors choose the right therapy for you.
Beijing, Beijing MunicipalityAges Any age - NCT06463262Recruiting
Personalized markers for chordoma before surgery and radiation
This trial tests whether analyzing blood and tumor samples before and after radiation and surgery can help find personalized markers for chordoma. It is for patients with chordoma of the skull base, spine, or sacrum who will receive radiation before surgery.
Baltimore, MarylandAges 18 years+ - NCT07018947RecruitingPhase 2
Atezolizumab and bevacizumab before and after surgery for liver cancer
This trial tests whether adding two drugs (atezolizumab and bevacizumab) before and after surgery can lower the chance of liver cancer coming back in people with high-risk HCC. You must be eligible for surgical removal of your tumor.
Badalona, BarcelonaAges 18 years+ - NCT07436741RecruitingPhase 3
Study of surufatinib plus chemo before surgery for pancreatic cancer
This trial tests if adding surufatinib to standard chemotherapy before surgery can help people with a certain type of pancreatic cancer. The goal is to see if the combination shrinks the tumor more than chemotherapy alone.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT05991206Recruiting
Atezolizumab with chemo before surgery for lung cancer
This study tests a combination of the immunotherapy drug atezolizumab with standard chemotherapy given before surgery for people with stage II to IIIB non-small cell lung cancer that can be removed. The goal is to see if this approach helps shrink tumors and improve outcomes.
Changsha, HunanAges 18 years+ - NCT06586593Recruiting
Immunotherapy before surgery for advanced melanoma
This study looks at how well immunotherapy works before surgery for melanoma that has spread. If you have stage III or IV melanoma that can be removed, you may be able to join this trial.
AngersAges 18 years+ - NCT07693959RecruitingPhase 3
RC48 plus gemcitabine before bladder cancer surgery
This trial tests a combination of an antibody-drug conjugate (RC48) plus chemotherapy (gemcitabine) given before bladder removal surgery. It is for people with HER2-positive bladder cancer that has grown into the muscle layer.
Hefei, AnhuiAges 18–75 - NCT07402473RecruitingPhase 2
Optimizing treatment before surgery for HER2-positive breast cancer
This trial tests a neoadjuvant (before surgery) treatment plan for people with early-stage HER2-positive breast cancer. The goal is to see if a personalized approach can improve outcomes.
Elizabeth, New JerseyAges 18–90 - NCT07150949RecruitingPhase 2
Comparing two radiation schedules with chemotherapy and immunotherapy for rectal cancer
This study tests two different radiation regimens (long-course vs. short-course) combined with chemotherapy (CAPOX), an immunotherapy drug (PD-1 antibody), and a COX-2 inhibitor for people with MSS locally advanced rectal cancer. The goal is to see which approach works better in shrinking the tumor before surgery.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06908382RecruitingPhase 2
Neoadjuvant QL1706 therapy for esophageal cancer before surgery
This trial tests a new immunotherapy drug, QL1706, given before surgery for esophageal squamous cell cancer. The goal is to see if it helps shrink tumors and improve outcomes for patients who are healthy enough for the treatment.
Jinan, ShandongAges 18–75 - NCT06561308RecruitingPhase 2
Immunotherapy plus chemo for advanced endometrial cancer
This trial tests a combination of a PD-1 inhibitor (a type of immunotherapy) with chemotherapy given before surgery for advanced endometrial cancer. The goal is to see if this approach helps shrink the tumor and improve outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT06550453RecruitingPhase 4
Immunotherapy plus chemo before surgery for RAS-mutated colorectal cancer
This trial tests a combination of immunotherapy (pembrolizumab) plus targeted therapy (bevacizumab) and chemotherapy (CapeOX) given before surgery for a specific type of locally advanced colorectal cancer. It is designed for patients whose tumors have a RAS mutation, are BRAF normal, and are microsatellite stable.
Xi'an, ShaanxiAges 18 years+ - NCT06904014RecruitingPhase 2
Testing a new drug combo before surgery for liver cancer
This trial tests if combining three therapies (sintilimab, lenvatinib, and HAIC) before surgery can help shrink liver tumors that are on the borderline of being removable. It's for people whose cancer has spread into nearby blood vessels but not to other organs.
Jinan, ShandongAges 18–70 - NCT06888102RecruitingEarly Phase 1
Epigenetic therapy before prostate surgery
This trial tests a short course of 'epigenetic therapy' (drugs that change how genes work) given before prostate removal surgery. The goal is to see if it can improve treatment effects and help shrink or control the tumor.
Los Angeles, CaliforniaAges 18 years+
Hear when a new Neoadjuvant trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for neoadjuvant?
- Yes. Clin2 currently lists 905 recruiting neoadjuvant studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a neoadjuvant trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a neoadjuvant trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.