Clinical trials
Total Neoadjuvant Treatment clinical trials
Below are recruiting total neoadjuvant treatment clinical trials, each written for real people, not researchers. We’re tracking 107 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06758830RecruitingPhase 2/Phase 3
Total neoadjuvant therapy vs surgery for rectal cancer
This trial tests whether a full course of chemotherapy and radiation before any surgery (called total neoadjuvant therapy) can help you avoid surgery and preserve your rectum. It is for people with a specific early stage of rectal cancer that has not spread.
VilniusAges 18 years+ - NCT06940388RecruitingPhase 2
Immunotherapy plus standard treatment for rectal cancer
This trial is testing whether adding the immunotherapy drug tislelizumab to standard total neoadjuvant treatment (chemotherapy and radiation before surgery) can improve outcomes for people with locally advanced rectal cancer. The goal is to see if the combination helps shrink the tumor more than standard treatment alone.
MainzAges 18 years+ - NCT07095439RecruitingPhase 2
Sandwich treatment for stage 2 and 3 rectal cancer
This trial tests a new way of giving radiation and chemotherapy before surgery for rectal cancer that hasn't spread. It aims to see if this 'sandwich' approach is safe and works better than standard treatment.
CairoAges 18–70 - NCT07198165RecruitingPhase 2
Short radiation followed by chemo plus bevacizumab with or without immunotherapy for rectal cancer
This trial tests whether adding an immunotherapy drug (PD-1 inhibitor) to standard chemoradiation and targeted therapy improves outcomes for locally advanced rectal cancer. It is for patients who have not had prior treatment and do not have certain genetic markers (BRAF mutation or MSI-H).
ShanghaiAges 18–75 - NCT06052332Recruiting
Comparing two pre-surgery treatments for older adults with rectal cancer
This study compares two approaches to treating rectal cancer in people age 70 and older who have not yet had surgery. One approach gives chemotherapy and radiation before surgery, and the other adds more chemotherapy after radiation. The goal is to find which plan works better with fewer side effects.
Antwerp, AntwerpenAges 70 years+ - NCT07346248Enrolling by invitation
Complications after pre-surgery treatment for advanced rectal cancer
This study looks at complications that happen after surgery in patients with advanced rectal cancer who got radiation or chemo-radiation before their operation. Researchers want to learn how different pre-surgery treatments affect recovery.
Rozzano, MilanAges 18 years+ - NCT06764355RecruitingPhase 2
Chemo, Immunotherapy, and Chemoradiation Before Surgery for Advanced Esophageal Cancer
This trial tests a combination of chemotherapy, immunotherapy, and chemoradiation before surgery for people with advanced esophageal squamous cell carcinoma. The goal is to see if this approach helps shrink the tumor and improve outcomes.
TaipeiAges 18–75 - NCT05883800Recruiting
Total treatment with tailored radiation for advanced rectal cancer
This study tests a “total neoadjuvant” approach—chemotherapy first, then radiation—using adaptive (tailored) radiation planning for people with locally advanced rectal cancer. It may help improve tumor control while adjusting the radiation based on how your cancer and anatomy respond.
BergenAges 18 years+ - NCT05916040Recruiting
MRI-guided treatment for locally advanced rectal cancer
This trial studies a total “before-surgery” treatment plan for locally advanced rectal cancer, using MRI (a detailed scan) to help guide radiation. It may help patients by aiming to shrink the tumor and improve the chance of successful surgery.
Jette, Brussels CapitalAges 18 years+ - NCT06229041RecruitingPhase 3
Chemo and radiation with or without immunotherapy for high-risk rectal cancer
This trial tests if adding immunotherapy to standard chemotherapy and radiation before surgery helps shrink high-risk rectal cancer and prevent it from coming back. You may be a good fit if you have a specific type of advanced rectal cancer that hasn't spread to other parts of your body.
BeijingAges 18–75 - NCT06835049RecruitingPhase 2
Heating therapy before surgery for high-risk soft tissue sarcoma
This trial tests a new approach for high-risk soft tissue sarcoma of the arm, leg, or trunk. Before surgery, you would receive chemotherapy combined with local hyperthermia (a treatment that gently heats the tumor area) to see if this can improve outcomes.
AarauAges 18 years+ - NCT05563922RecruitingPhase 2
Testing a plan to preserve the anus after rectal chemo-radiation
This Phase 2 study tests a “total neoadjuvant” (chemo plus radiation before the main treatment) plan to see if some people with low rectal cancer can keep their anus. It may help you avoid permanent colostomy if your cancer responds well and you meet the study rules.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07113275RecruitingPhase 3
Short versus long radiation schedule for advanced rectal cancer
This study compares two different schedules of radiation (a short course versus a longer course) followed by standard chemotherapy and immunotherapy for advanced rectal cancer. It aims to see which approach works best to shrink the tumor before surgery.
Wuhan, HubeiAges 18–75 - NCT04280822RecruitingPhase 3
Immunotherapy plus chemo versus chemo alone before surgery
This Phase 3 trial tests whether adding immunotherapy to chemotherapy before surgery works better than chemotherapy alone for resectable esophageal cancer. The goal is to improve outcomes after tumor shrinkage before the operation.
Zhengzhou, HenanAges 18–75 - NCT07176182RecruitingPhase 2
Chemotherapy with alvenor for rectal cancer with high YWHAB
This trial tests adding the drug alvenor to standard chemotherapy before surgery for rectal cancer patients whose tumors have high levels of a protein called YWHAB. The goal is to see if this combination can improve treatment outcomes.
Guangzhou, GuangdongAges 18–75 - NCT06959511RecruitingPhase 2
Zanzalintinib for advanced thyroid cancer before surgery
This trial tests a drug called zanzalintinib for people with advanced thyroid cancer that has spread nearby. The goal is to see if taking this pill before surgery can shrink the tumor and make it easier to remove.
Ann Arbor, MichiganAges 18 years+ - NCT06811870RecruitingPhase 1/Phase 2
Hyperbaric oxygen before surgery for breast cancer
This trial tests adding hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) before standard chemotherapy for breast cancer. The goal is to see if it helps shrink the tumor more effectively before surgery.
Guangzhou, GuangdongAges 18–60 - NCT07033819RecruitingPhase 2
Fuzuloparib and apatinib before surgery for ovarian cancer
This trial tests a combination of two oral drugs—fuzuloparib (a PARP inhibitor) and apatinib (which blocks blood vessel growth to tumors)—given before surgery for advanced ovarian cancer that cannot be removed right away. It is for people whose tumors have a specific genetic marker (HRD positive) and who have not had prior cancer treatment.
Beijing, Beijing MunicipalityAges 18–70 - NCT05412225RecruitingPhase 1
Pre-surgery radiation, then mastectomy and immediate breast reconstruction
This Phase 1 study looks at giving radiation before surgery for people with locally advanced breast cancer, then performing a mastectomy and immediate reconstruction. It aims to see whether this combined approach can shrink the cancer before surgery and safely allow reconstruction afterward.
Basking Ridge, New JerseyAges 18 years+ - NCT07286253RecruitingPhase 2
QL1706 plus chemo before surgery for advanced cervical cancer
This trial is testing whether adding the immunotherapy drug QL1706 to standard chemotherapy before surgery can improve outcomes for women with a certain type and stage of cervical cancer. It is for women whose cancer has not been treated yet and who are healthy enough for the treatment.
Guangzhou, GuangdongAges 18–70 - NCT04842006Recruiting
Personalized treatment plan for rectal cancer before and after surgery
This trial looks at a personalized treatment approach for rectal cancer. It aims to guide the best chemotherapy and (if needed) radiotherapy before and after surgery, based on scans and specific test results.
Helsinki, UusimaaAges 18–100 - NCT06562920RecruitingPhase 2
Immunotherapy plus chemo and SBRT before surgery for limited-stage small cell lung cancer
This trial tests a combination of immunotherapy (adebrelimab), chemotherapy, and targeted radiation (SBRT) before surgery for people with limited-stage small cell lung cancer. The goal is to see if this approach can shrink tumors and improve outcomes before the main treatment.
Hangzhou, ZhejiangAges 18–75 - NCT07371234RecruitingPhase 2
Low-dose radiation and immunotherapy before surgery for head and neck cancer
This trial tests a combination of low-dose radiation and an immunotherapy drug (similar to Keytruda) given before surgery for advanced head and neck cancer. The goal is to see if this approach can shrink tumors and improve outcomes.
GuangdongAges 18–75 - NCT05343325RecruitingPhase 2
Neoadjuvant low-dose radiation with chemo-immunotherapy for head and neck cancer
This Phase 2 study tests whether giving low-dose radiation before surgery—along with chemotherapy and an immunotherapy drug—can work better and be safe for treating locally advanced head and neck squamous cell cancer. It may help shrink tumors before surgery and reduce the chance of the cancer coming back.
Zhuhai, GuangdongAges 18–70
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Common questions
- Are there clinical trials for total neoadjuvant treatment?
- Yes. Clin2 currently lists 107 recruiting total neoadjuvant treatment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total neoadjuvant treatment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total neoadjuvant treatment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.