Neurological Diseases or Conditions clinical trials

Test using an app to map eye vision blind spots

This trial tests how well an EyeCTester smartphone app can measure vision blind spots and distorted vision compared with standard eye tests. If you qualify, you’ll do short near-vision and “Amsler grid” style tasks in the clinic to help confirm the app is accurate.

Guided heart stent planning using an inside pressure sensor

This study tests whether using a tiny pressure sensor in heart arteries during a procedure can better guide where to place a stent. It may help doctors choose the safest and most effective stent plan by more accurately measuring artery narrowing.

Collecting health data from NHLBI patients and donors

This study collects information about standard care for people seen by the NHLBI, and also about donors. It helps researchers understand what happens in real-world care, which can improve future treatment decisions.

Theta-burst brain stimulation for younger-onset Alzheimer’s

This trial tests whether a form of brain stimulation (theta-burst stimulation) can improve thinking and memory in people with younger-onset Alzheimer’s. It also compares results with people without dementia who meet similar age and health requirements.

Study for early signs of Parkinson-related brain changes

This study enrolls people with idiopathic REM sleep behavior disorder, a sleep problem that can come before Parkinson’s disease or related conditions. It aims to better understand early (“prodromal”) changes so future treatments can be targeted earlier.

Tracking brain changes in probable Lewy body dementia

This trial follows people with probable Lewy body dementia over several years to see how the brain changes on MRI and on memory/thinking tests. It may help researchers understand disease progression and improve future care for Lewy body dementia.

Long-term study of COPD in adults in China

This study follows people with COPD (chronic lung disease) over many years to better understand the condition. It may help doctors learn what factors predict worsening over time.

Study of mast cell growth in people with mastocytosis

This study looks at what causes mast cells to grow too much in people with mastocytosis. It may help researchers find better ways to diagnose or treat this condition. You can take part in person or by telehealth.

Study of BI 1815368 for diabetic macular edema

This trial tests an experimental medication (BI 1815368) given as an eye injection for people with diabetic macular edema, a condition where fluid builds up in the center of the retina and blurs vision. The study aims to see if this new treatment can reduce swelling and improve vision.

Genetic testing study for people linked to other NIH research

This study collects and sequences (reads) your DNA to help researchers understand health and disease. You may be invited because you are connected to another NIH study, and you must agree to testing, sample storage, and sharing de-identified genetic data for future research.

Test a new esophagus implant to rebuild a short esophagus segment

This Phase 1 study tests the safety and feasibility of a new esophagus implant for people who need only a short (about 6 cm or less) section of their esophagus rebuilt after serious injury or scarring. If it does not work, you must be willing to have a planned “rescue” surgery later.

Study using tonsil tissue to understand infections

This study uses tonsil tissue that is removed during a routine tonsillectomy to grow tiny 'organoids' in the lab. Researchers will study how germs interact with human cells, which could lead to better treatments for infections.

Testing immunotherapy for ctDNA-positive colorectal cancer after treatment

This trial is for people with colorectal cancer whose ctDNA blood test is still positive after surgery and chemotherapy. It tests two immunotherapy drugs (cemiplimab alone or with fianlimab) to see if they can eliminate the remaining cancer cells and prevent the cancer from coming back.

CAR T cells targeting B7-H3 for brain tumors

This trial tests a new type of immune therapy (CAR T cells) that targets a protein called B7-H3 found on some brain tumors. It is for children and young adults with certain brain or spinal cord tumors that have come back after standard treatment, and aims to see if the treatment is safe and effective.

Discontinuation of Disease-modifying Anti-rheumatic Drugs (DMARDs) in Rheumatoid Arthritis Patients Also Using TNF Inhibitors

Study of ManNAc for kidney diseases with proteinuria

This study tests a new drug called ManNAc for people with certain kidney diseases (FSGS, MCD, or MN) that cause protein in the urine. The goal is to see if this drug can help reduce protein loss and improve kidney health.

Studying different forms of childhood brain-wasting disease

This study looks at people with CLN3 and other related forms of NCL (a childhood brain-wasting illness) to better describe symptoms and disease changes over time. You may be followed with regular check-ins, medical records, and sometimes NIH visits or sample collection.

String test for eosinophilic esophagitis in African patients

This study tests a new, less invasive way (the Esophageal String Test) to look for signs of eosinophilic esophagitis—an allergic condition that can make swallowing painful or difficult. It is for people of African descent who have trouble swallowing and are already having an endoscopy.

Study of genes in immune disorders

This research looks at how inherited (genetic) changes may affect the immune system in people with immune problems. It may help by improving understanding of these conditions and, in some cases, guiding faster care for a baby after birth.

Testing a new flu vaccine against H1N1 flu

This study tests an experimental flu vaccine (BPL-1357) in healthy volunteers who will later be exposed to H1N1 flu virus in a controlled setting, to see if the vaccine can prevent or reduce illness.

How HIV prevention drugs affect metabolism in healthy people

This study tests how certain HIV prevention drugs affect the body's metabolism (how it uses energy) in healthy people. It aims to understand side effects before these drugs are used more widely, which could help make future treatments safer.

Study immune system disorders and genetics using lab samples

This study aims to better understand primary immune disorders by collecting genetic and blood (and related) information. It may help researchers identify what causes these conditions and improve future testing and care.

Silevertinib and chemo for a type of glioblastoma

This trial tests a new drug, silevertinib, combined with temozolomide (a chemotherapy) for people with a newly diagnosed glioblastoma that has certain genetic markers. It aims to see if this combination works better than standard treatment for tumors with these specific features.

Gut and brain health study for adults

This study looks at how the bacteria in your gut might affect your thinking and memory as you age. It may help us understand the connection between gut health and brain health.