Clinical trials · Massachusetts
Obesity clinical trials in Massachusetts
We’re tracking 52 recruiting obesity studies with a site in Massachusetts — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT07776678Recruiting
Body fat and muscle measurement study
This study uses advanced body scans (like MRI and DXA) to better measure body fat and muscle. It may help improve how obesity is diagnosed and treated.
Boston, MassachusettsAges 18 years+ - NCT07598981Recruiting
Obesity Medication Safety and Effectiveness Registry
This registry tracks how well obesity medications work and their safety in real-world use. You'll share your health information and experiences with your obesity medication over time to help doctors understand what works best for different people.
Waltham, MassachusettsAges 18 years+ - NCT07654374RecruitingPhase 3
Study of a new pill for weight loss and diabetes
This study tests a new daily pill (aleniglipron) to help adults with excess weight and type 2 diabetes lose weight and improve blood sugar control. It may be a good fit if you have a BMI of 27 or higher and your diabetes is managed with A1c between 6.5% and 10%.
Methuen, MassachusettsAges 18–79 - NCT07699445RecruitingPhase 4
Lumateperone for weight and mood in bipolar depression
This study tests if lumateperone, a medication for bipolar depression, can also help with weight and aging in people with obesity. You may qualify if you have bipolar I depression and a body mass index (BMI) over 30.
Boston, MassachusettsAges 18–65 - NCT07589608RecruitingPhase 2
Weight Loss Study With Two New Injectable Medications
This study tests two new injectable drugs (macupatide and eloralintide) alone or together to help adults with obesity or excess weight lose weight. The goal is to see if these medications are safe and effective for weight management.
Needham, MassachusettsAges 18–75 - NCT07784270RecruitingPhase 3
Weight loss injection for adults with type 2 diabetes and overweight
This study tests a new injected medicine that may help people with type 2 diabetes and overweight or obesity lose weight. The trial will see how well it works and if it is safe compared to a placebo.
North Dartmouth, MassachusettsAges 18 years+ - NCT07817875RecruitingPhase 3
Tirzepatide for weight loss in children aged 6 to under 12
This study tests a once-weekly medication called tirzepatide to help children aged 6 to under 12 with obesity lose weight. It compares the medication to a placebo (inactive shot) to see if it safely helps with weight loss in this age group.
Boston, MassachusettsAges 6–11 - NCT07496463Enrolling by invitationPhase 2
Setmelanotide for weight loss in pseudohypoparathyroidism type 1a
This study tests an experimental medication called setmelanotide to see if it can help with weight loss in people who have pseudohypoparathyroidism type 1a (PHP1a), a rare genetic condition that often leads to obesity. The goal is to find a new treatment option for weight problems related to PHP1a.
Boston, MassachusettsAges Any age - NCT07467694Recruiting
Postnatal exercise to activate baby's brown fat
This trial tests if exercise after childbirth can activate your baby's brown fat, which helps with metabolism. It may benefit mothers and their healthy, full-term babies.
Boston, MassachusettsAges 18–45 - NCT07226947Recruiting
Exercise to prevent muscle loss with GLP-1 medication
This study looks at whether exercise can help prevent muscle loss in people taking GLP-1 medications (like Wegovy, Ozempic, or Mounjaro) for weight loss. It may help you keep your muscles strong while you lose weight.
Boston, MassachusettsAges 18–99 - NCT07091032Recruiting
Building connections for better health
This study tests if helping people address obesity, cancer screenings, or mental health struggles can improve their overall health. You may qualify if you have obesity, are behind on colon or cervical cancer screening, or have depression or anxiety.
Boston, MassachusettsAges 18–75 - NCT06554717RecruitingPhase 2
Tesamorelin and exercise for physical function in HIV
This study tests whether adding tesamorelin to an exercise program helps older adults with HIV improve their physical function and reduce belly fat. It is designed for people who are mostly sedentary and show early signs of frailty.
Boston, MassachusettsAges 50–80 - NCT06988462Recruiting
Bottarga supplement for metabolic health
This study tests a supplement called bottarga, made from fish eggs, to see if it improves cholesterol, blood sugar, or weight in people with metabolic problems like high cholesterol or prediabetes. It is a small pilot study for Massachusetts residents.
Sommerville, MassachusettsAges 18–60 - NCT06557005Recruiting
Helping new mothers with chronic conditions get primary care
This study helps new mothers with chronic health conditions transition smoothly from pregnancy care to regular primary care. If you have high blood pressure, diabetes, severe obesity, depression, or anxiety, you may be able to join a program that coordinates your care after childbirth.
Boston, MassachusettsAges 18 years+ - NCT06511310Recruiting
Exercise, brain health, and weight maintenance after weight loss surgery
This study looks at how exercise affects brain activity and helps people keep weight off after they have regained some weight following bariatric surgery. You may join if you had weight loss surgery, lost weight, and then regained more than 10% of that lost weight within the last 1 to 5 years.
Boston, MassachusettsAges 18–70 - NCT06408961Recruiting
EVs in Obesity and Cardiometabolic Disease
This study looks at tiny particles released by cells (called extracellular vesicles, or EVs) in people with obesity and related heart health issues. Researchers want to see if these particles are different in people with obesity and diabetes, which could help find new ways to treat or prevent heart problems.
Boston, MassachusettsAges 18 years+ - NCT06432790Recruiting
In-person vs online healthy living and asthma program for kids
This study compares two programs for helping children with asthma who are overweight or obese — one that is held in person and another that is offered online. It tests whether learning about healthy habits and asthma management works better when done face-to-face or on a computer.
Boston, MassachusettsAges 4–17 - NCT04551482RecruitingPhase 2
Oxytocin to help teens lose weight
This study tests whether the hormone oxytocin can help adolescents with obesity lose weight. You may be asked to stay on your usual diet and routines during the 18-week study to see how well the treatment works.
Boston, MassachusettsAges 10–18 - NCT06105164Recruiting
Brain's Fullness Circuit Study
This study uses brain imaging and mild magnetic stimulation to explore how a brain circuit helps you feel full after eating. It may help us understand eating behaviors and weight regulation.
Boston, MassachusettsAges 18–65 - NCT06069622Recruiting
How a gene affects weight-loss treatment response
This study looks at how a weight-loss medication affects people with obesity who may have a specific gene difference (caveolin-1). It aims to understand why some people respond differently to GLP-1 treatments like semaglutide.
Boston, MassachusettsAges 18 years+ - NCT05728697Recruiting
Test a liver ultrasound method to measure fat and stiffness
This trial tests a special ultrasound technique during an endoscopy to see how well it can detect changes in the liver from non-alcoholic fatty liver disease. It may help improve non-invasive assessment before or alongside a follow-up liver biopsy.
Boston, MassachusettsAges 18 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Waltham, MassachusettsAges 18 years+ - NCT05464186Recruiting
Whole versus nonfat milk effects on kids’ body composition
This study compares whole milk vs nonfat milk to see how each affects body composition (such as fat and lean mass) in children. It may help families understand whether milk type makes a difference for healthy growth.
Boston, MassachusettsAges 9–12 - NCT07717658Recruiting
Family weight wellness program for teens and parents
This study tests a weight wellness program that uses food support and group medical visits for teens and their parents. It aims to help families adopt healthier habits together over 12 months.
Boston, MassachusettsAges 12–17
Obesity trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting obesity studies listed above.
- Massachusetts General Hospital · 7 studies
- Brigham and Women's Hospital · 3 studies
- Joslin Diabetes Center · 2 studies
- ACCOMPLISH-2 Research Site
- Boston Children's Hospital
- Brigham and Women's Faulkner Hospital
- Cambridge Health Alliance
- CorEvitas, LLC
What taking part in a obesity study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Obesity trials in other states
Common questions
- Are there obesity clinical trials in Massachusetts?
- Yes. We're currently tracking 52 recruiting obesity studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a obesity study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a obesity trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New obesity studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.