Clinical trials · Boston, MA
Obesity clinical trials in Boston
We’re tracking 64 recruiting obesity studies with a site in or near Boston — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT04551482RecruitingPhase 2
Oxytocin to help teens lose weight
This study tests whether the hormone oxytocin can help adolescents with obesity lose weight. You may be asked to stay on your usual diet and routines during the 18-week study to see how well the treatment works.
Boston, MassachusettsAges 10–18 - NCT05725967Enrolling by invitation
Endoscopic and bariatric procedures for obesity
This study looks at people who are having obesity-related procedures, including options done with a scope (endoscopic) and revision after prior bariatric surgery. It may help doctors understand outcomes and improve care for people undergoing these treatments.
Boston, MassachusettsAges 18–80 - NCT01998750Recruiting
Study of genes in severe early childhood obesity
This study looks for genetic (inherited) reasons for severe obesity that starts in very early childhood. It may help doctors better understand the cause of your child’s weight gain and guide future treatment.
Boston, MassachusettsAges Up to 80 years - NCT06138821Recruiting
Endoscopic sleeve gastroplasty for obesity and MASH
This study tests if a procedure called endoscopic sleeve gastroplasty helps people with obesity and a liver condition called MASH lose weight and improve their liver health. It might be an option if you have both obesity and MASH and haven't had weight-loss surgery before.
Boston, MassachusettsAges 18 years+ - NCT06069622Recruiting
How a gene affects weight-loss treatment response
This study looks at how a weight-loss medication affects people with obesity who may have a specific gene difference (caveolin-1). It aims to understand why some people respond differently to GLP-1 treatments like semaglutide.
Boston, MassachusettsAges 18 years+ - NCT05728697Recruiting
Test a liver ultrasound method to measure fat and stiffness
This trial tests a special ultrasound technique during an endoscopy to see how well it can detect changes in the liver from non-alcoholic fatty liver disease. It may help improve non-invasive assessment before or alongside a follow-up liver biopsy.
Boston, MassachusettsAges 18 years+ - NCT07776678Recruiting
Body fat and muscle measurement study
This study uses advanced body scans (like MRI and DXA) to better measure body fat and muscle. It may help improve how obesity is diagnosed and treated.
Boston, MassachusettsAges 18 years+ - NCT06200961Recruiting
Trans-nasal endoscopy for bariatric patients
This study tests a thinner, more comfortable endoscope that goes through the nose instead of the mouth for patients who need an upper GI exam. It may be a gentler option for weight-loss surgery patients.
Boston, MassachusettsAges 18–90 - NCT05711758Recruiting
Endoscopic stomach muscle cut for weight loss
This trial tests whether an endoscopic procedure that cuts a stomach outlet muscle can help with weight loss and be safe. You would be screened to make sure you don’t have certain stomach, heart/lung, or pregnancy-related conditions that could make the procedure unsafe.
Boston, MassachusettsAges 18–70 - NCT06760546RecruitingPhase 3
Testing setmelanotide for weight gain after brain injury
This trial tests a daily injection called setmelanotide to see if it can help people who have gained weight due to a brain injury or condition affecting the hypothalamus. It may help reduce hunger and support weight loss.
Boston, MassachusettsAges 4 years+ - NCT05933499RecruitingPhase 2
Tirzepatide and bimagrumab for body fat and insulin sensitivity
This Phase 2 study tests two medicines to see how they change body fat, insulin sensitivity, and bone health in adults with obesity. It may help people who have tried lifestyle changes to lose weight but have not been able to, though diabetes and several health conditions must be ruled out first.
Boston, MassachusettsAges 18 years+ - NCT07699445RecruitingPhase 4
Lumateperone for weight and mood in bipolar depression
This study tests if lumateperone, a medication for bipolar depression, can also help with weight and aging in people with obesity. You may qualify if you have bipolar I depression and a body mass index (BMI) over 30.
Boston, MassachusettsAges 18–65 - NCT07392190RecruitingPhase 3
Study of eloralintide for people with persistent obesity
This trial tests if adding eloralintide helps people who are still obese or overweight while taking weekly incretin therapy. It aims to support additional weight loss for those who haven't reached their goals.
Boston, MassachusettsAges 18 years+ - NCT07351045RecruitingPhase 3
Study of enicepatide for weight loss in obesity or overweight
This study tests a new injectable medication called enicepatide for people with obesity or overweight who have not been able to lose weight through diet and exercise alone. It may help you lose weight and improve health conditions linked to excess weight.
Boston, MassachusettsAges 18 years+ - NCT07226947Recruiting
Exercise to prevent muscle loss with GLP-1 medication
This study looks at whether exercise can help prevent muscle loss in people taking GLP-1 medications (like Wegovy, Ozempic, or Mounjaro) for weight loss. It may help you keep your muscles strong while you lose weight.
Boston, MassachusettsAges 18–99 - NCT04839614Recruiting
Weight-loss surgery plus uterus surgery for certain uterine lining conditions
This trial tests doing weight-loss surgery at the same time as laparoscopic uterus (womb) surgery for people with certain early uterine lining conditions. It may help lower risk from severe obesity while treating the uterine condition.
Boston, MassachusettsAges 18 years+ - NCT07156578Enrolling by invitationPhase 2
Long-term bivamelagon for hypothalamic obesity
This long-term study tests a new drug, bivamelagon, for people with hypothalamic obesity. It's for those who already completed a similar study and tolerated the drug well.
Boston, MassachusettsAges 12 years+ - NCT07794579RecruitingPhase 3
Study of orforglipron for people with overweight at risk of health problems
This trial tests a new medicine, orforglipron, to help people with overweight who are at risk of developing weight-related health issues. It aims to see if the medicine can help with weight management and reduce risks before more serious conditions develop.
Boston, MassachusettsAges 18 years+ - NCT07817875RecruitingPhase 3
Tirzepatide for weight loss in children aged 6 to under 12
This study tests a once-weekly medication called tirzepatide to help children aged 6 to under 12 with obesity lose weight. It compares the medication to a placebo (inactive shot) to see if it safely helps with weight loss in this age group.
Boston, MassachusettsAges 6–11 - NCT04101669Recruiting
Weight-loss liner implant for type 2 diabetes
This study tests an implantable device called the RESET System that may help people with type 2 diabetes lose weight and improve blood sugar control. It is placed in the stomach without surgery and is for adults aged 22 to 65 who are overweight and have not had enough improvement with diabetes medications.
Boston, MassachusettsAges 22–65 - NCT07717658Recruiting
Family weight wellness program for teens and parents
This study tests a weight wellness program that uses food support and group medical visits for teens and their parents. It aims to help families adopt healthier habits together over 12 months.
Boston, MassachusettsAges 12–17 - NCT07496463Enrolling by invitationPhase 2
Setmelanotide for weight loss in pseudohypoparathyroidism type 1a
This study tests an experimental medication called setmelanotide to see if it can help with weight loss in people who have pseudohypoparathyroidism type 1a (PHP1a), a rare genetic condition that often leads to obesity. The goal is to find a new treatment option for weight problems related to PHP1a.
Boston, MassachusettsAges Any age - NCT06554717RecruitingPhase 2
Tesamorelin and exercise for physical function in HIV
This study tests whether adding tesamorelin to an exercise program helps older adults with HIV improve their physical function and reduce belly fat. It is designed for people who are mostly sedentary and show early signs of frailty.
Boston, MassachusettsAges 50–80 - NCT04352244Recruiting
Study of brown fat activity in healthy adults
This study measures how “brown fat” works in the body using planned medical procedures. It looks at healthy adults to understand brown fat activity and what affects it.
Boston, MassachusettsAges 18–75
Hear when a new Obesity trial opens near Boston, MA
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Obesity trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting obesity studies listed above.
- Brigham and Women's Hospital · 9 studies
- Massachusetts General Hospital · 5 studies
- Boston Children's Hospital · 3 studies
- Tufts Medical Center · 2 studies
- Beth Israel Deaconess Medical Center
- Boston Medical Center
- Brigham and Women's Hospital Diabetes Program
- Dana-Farber Cancer Institute
What taking part in a obesity study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting obesity studies in Massachusetts.
Common questions
- Are there obesity clinical trials near Boston?
- Yes. We're currently tracking 64 recruiting obesity studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a obesity study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a obesity trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New obesity studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.