Clinical trials
Obesity clinical trials
Excess body weight that increases the risk of many other health conditions. We’re tracking 1,436 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05414409RecruitingPhase 2
Gut microbiome study in young people with type 1 diabetes
This Phase 2 study looks at the gut microbiome (the bacteria in your intestines) in youth with type 1 diabetes, and how metformin may work differently through the gut. It may help researchers understand mechanisms and future treatment options.
Indianapolis, IndianaAges 11–18 - NCT05394363Recruiting
Victoria children birth-cohort study with parent/guardian consent
This study follows children born in a specific 2-year window and their parents or guardians over time. It helps researchers understand how children and families change as they grow, which can guide future health supports in Victoria.
Parkville, VictoriaAges 1 day+ - NCT05408728Enrolling by invitation
Check how sugar absorption predicts weight loss after endoscopy
This study looks at whether a person’s “sugar absorption” pattern can help predict how much weight they will lose. It involves an endoscopy (a look inside the upper digestive tract) as part of routine care, and then matching the results to future weight change.
Jacksonville, FloridaAges 18 years+ - NCT05320796RecruitingPhase 4
Esomeprazole study after gastric bypass and pouch acid levels
This trial tests how well esomeprazole (a acid-reducing medicine) works after a Roux-en-Y gastric bypass, and how it changes the acidity in the stomach pouch. It may help confirm the best way to control stomach acid after bypass surgery.
Schlieren, SchlierenAges 18 years+ - NCT05316493RecruitingPhase 2/Phase 3
Weight-loss and progesterone treatments for early uterine lining disease
This trial studies a weight-management approach plus a progesterone-releasing IUD (LNG-IUS) and megestrol to treat endometrial atypical hyperplasia, a high-risk precancer of the uterine lining. It may help shrink or control the abnormal cells while supporting fertility or keeping the uterus.
ShanghaiAges 18–45 - NCT05316935RecruitingPhase 2/Phase 3
Hormone therapy for certain early uterine lining cancers without obesity
This trial tests whether adding GnRH medicine and letrozole to standard progestin treatment can better control early, low-risk endometrial cancer or atypical hyperplasia in people who are not obese. It may help some patients avoid progression while keeping the uterus, especially for those wanting future fertility.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT05351476Recruiting
Exercise program for metabolism in postmenopausal women
This trial studies whether a structured exercise program can improve how your body uses fat. It is designed for postmenopausal women with higher weight and prediabetes who are not currently exercising much.
Tallahassee, FloridaAges 50–75 - NCT05305313RecruitingPhase 4
Testing a new propofol dosing method for higher BMI surgeries
This trial studies whether adjusting how propofol (an anesthesia medicine) is dosed based on total body weight improves anesthesia delivery during longer surgeries. It mainly targets people with a higher body mass index having surgery that lasts over an hour.
New Delhi, National Capital Territory of DelhiAges 18–65 - NCT05289310Recruiting
Home low-oxygen nights to study weight and health
This study looks at whether spending 8 hours each night in a low-oxygen tent for 8 weeks affects weight and related health in people with obesity. It also checks safety by monitoring oxygen levels and screening for breathing and heart-related conditions.
Baton Rouge, LouisianaAges 22–65 - NCT05279729Recruiting
Mobile app coaching for people with diabetes
This study tests whether using a smartphone app can help people with type 2 diabetes manage their health. It focuses especially on low-income Hispanic/Latinx adults who regularly check blood sugar.
San Diego, CaliforniaAges 18–64 - NCT05216042Recruiting
Study of genetics and heart/metabolic health in adults
This study looks at how genetic markers (DNA) relate to heart health and “metabolic” health (how your body manages sugar and fat). You may be asked to provide genetic samples and follow study health checks and protocols to help researchers understand who is at higher risk.
Birmingham, AlabamaAges 18 years+ - NCT05234125Recruiting
Lifestyle counseling during pregnancy for African American women
This trial tests a better lifestyle counseling program during pregnancy to help improve health—especially for women who started pregnancy at a higher weight. It may help you learn practical changes for a healthier pregnancy and outcomes.
Chicago, IllinoisAges 18–40 - NCT05199454Recruiting
Study how “fat-like” particles affect blood vessel function
This study looks at whether tiny fat-based particles (“adiposomes”) can affect how well your blood vessels work, especially in people with diabetes and higher body weight. You may be asked to do moderate exercise and other study procedures after passing safety checks.
Chicago, IllinoisAges 18–50 - NCT05147909Recruiting
Testing too much phosphate on exercise and belly fat
This trial studies whether eating extra phosphate changes how well you can exercise and how much visceral (deep belly) fat you have. Because it is a crossover study, you would likely try different phosphate amounts on separate occasions.
Dallas, TexasAges 18–80 - NCT05166447Enrolling by invitation
Check-in study for people from the Inter99 health survey
This study is a long-term follow-up of people who took part in the Inter99 baseline exam. It involves a 3-hour check-in, and it can help researchers learn how people’s health changes over time.
Glostrup MunicipalityAges 50–82 - NCT05173714RecruitingPhase 2
Sit Less and Move More program for people with CKD
This Phase 2 study tests a program to help people with chronic kidney disease (CKD) sit less and move more, plus a medication (semaglutide) for those who qualify. It may help improve health and day-to-day activity while monitoring safety closely.
Stanford, CaliforniaAges 20 years+ - NCT04930029Recruiting
Long-term follow-up after gastric bypass with an omega limb
This study looks at long-term side effects years after gastric bypass surgery done in a specific way. If you had this type of surgery and agree to an endoscopy with small tissue samples at 10 years, you may help doctors understand longer-term outcomes.
LilleAges 18 years+ - NCT05082519RecruitingPhase 2
Calorie restriction and exercise to improve leukemia treatment in young patients
This study tests whether a special diet (calorie restriction) and increased physical activity can make chemotherapy work better for young people with B-ALL. Participants will follow a monitored diet and exercise plan during their first month of treatment.
Los Angeles, CaliforniaAges 7–25 - NCT05071898RecruitingPhase 1
Studying how genetics affect response to GLP-1 weight-loss drugs
This early-stage study looks at how genetic factors may change how people respond to a GLP-1 medicine (semaglutide). The goal is to learn who may benefit most and why, so future treatments can be better matched.
Lancaster, PennsylvaniaAges 18–89 - NCT05067231Recruiting
UAB heart research biobank for adults 18 and older
This study builds a heart-focused research database by enrolling adults who are willing to provide information and/or samples for future cardiovascular research. It may help researchers study heart disease and develop better treatments over time.
Birmingham, AlabamaAges 18 years+ - NCT05051436RecruitingPhase 4
Testing mirabegron and tadalafil to improve sugar control
This study looks at whether mirabegron and tadalafil can improve blood sugar control in people with prediabetes. It may help determine if these medicines can slow the move from prediabetes toward diabetes.
Lexington, KentuckyAges 35–65 - NCT04913064Recruiting
White button mushroom supplement for inflammation in high-risk breast cancer
This trial tests whether a white button mushroom powder supplement can lower inflammation in postmenopausal women who have a high risk of breast cancer. If it helps, it could improve early prevention strategies for people at higher risk.
Duarte, CaliforniaAges 21 years+ - NCT04971720RecruitingPhase 2/Phase 3
Personalized blood pressure timing therapy for some adults
This trial tests whether timing blood pressure medications (based on your natural daily body rhythms) can improve blood pressure control. It’s designed for adults with moderately high blood pressure and focuses on who may benefit from a more precise schedule.
Birmingham, AlabamaAges 18 years+ - NCT04997473Recruiting
Mobile app weight-loss program for young transplant patients
This trial tests whether a phone app can help young people who previously had a stem cell transplant lose weight. It’s designed for people who are at least 100 days out from transplant and who meet weight criteria.
Los Angeles, CaliforniaAges 13–30
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Common questions
- Are there clinical trials for obesity?
- Yes. Clin2 currently lists 1,436 recruiting obesity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a obesity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a obesity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.