Clinical trials
Occlusion clinical trials
Below are recruiting occlusion clinical trials, each written for real people, not researchers. We’re tracking 338 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05560204Enrolling by invitation
Atrial fibrillation treatment using pulsed energy and an appendage closure
This trial tests whether combining a pulsed-field ablation (a targeted heart rhythm treatment) with closing off the left atrial appendage can reduce atrial fibrillation risk. It may help people who need rhythm treatment and also want to lower future stroke risk by blocking a common clot-forming spot.
Hong Kong, ShatinAges 19 years+ - NCT06492733Recruiting
FastWire device for unblocking leg arteries (FREEFLOW trial)
This trial tests a new wire system to reopen completely blocked leg arteries without surgery. It is for people with severe leg pain or tissue damage caused by blocked arteries, and aims to restore blood flow and improve walking ability.
Wilmington, DelawareAges 18–85 - NCT04545502Recruiting
Study of aortic grafts and heart patches after aortic surgery
This study looks at how well certain aortic grafts and cardiovascular patches work after surgery. It may help by improving care for people who need these devices, and by collecting safety and outcome information over time.
Aurora, ColoradoAges 18 years+ - NCT05976685Recruiting
Close the left atrial appendage after stroke despite blood thinners
This study tests whether closing a heart pouch called the left atrial appendage can prevent future strokes in people with atrial fibrillation who had an ischemic stroke even while taking blood thinners. It may help reduce stroke risk by blocking a common place where clotting can start.
BrugesAges 18 years+ - NCT02061436Recruiting
Chronic total occlusion procedure registry
This study collects data from patients who are having a procedure to open a completely blocked coronary artery. It may help improve future treatments for this condition.
Phoenix, ArizonaAges Any age - NCT07253181RecruitingPhase 3
Stroke clot-busting drug before transfer for artery clearing
This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05723926Recruiting
Carotid implants to help prevent stroke repeat in atrial fibrillation
This trial tests whether placing a carotid implant can reduce the chance of having another stroke in people with atrial fibrillation who are already taking blood thinners. It aims to prevent stroke recurrence while you continue prescribed anticoagulation.
Rockford, IllinoisAges 18 years+ - NCT06439082RecruitingPhase 3
Crizanlizumab for sickle cell pain crises
This trial tests whether crizanlizumab can reduce painful sickle cell crises (called vaso-occlusive crises or VOCs) in people with sickle cell disease who have frequent crises. It may be an option for those who still have crises despite current treatments.
Birmingham, AlabamaAges 12–100 - NCT06904911RecruitingPhase 2
Study of tenecteplase into the artery after clot removal for stroke
This study tests a clot-dissolving drug called tenecteplase given directly into the artery after a mechanical thrombectomy (clot removal). The goal is to see if it helps improve blood flow to the small vessels in the brain after the main clot is removed.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04261478Recruiting
Treatment for stroke caused by blocked brain and neck arteries
This trial studies a procedure that opens blocked blood vessels in and behind the brain during a stroke, sometimes after standard clot-thinning medicine. It may help people who have brain tissue that can still be saved and a major blockage in both the neck and brain arteries.
Montreal, QuebecAges 18 years+ - NCT07727395RecruitingPhase 3
Clot-busting drug after successful clot removal for stroke
This trial tests whether giving a clot-busting drug (alteplase) directly into the brain artery after a successful clot removal improves recovery in people with severe stroke. It is for patients who have had a thrombectomy and still have a large blocked artery in the front of the brain.
An GiangAges 18 years+ - NCT06731465Enrolling by invitation
Clear aligners vs braces for crowded lower front teeth
This study compares clear aligners (removable trays) to traditional braces for treating crowded lower front teeth. It aims to see which method works better and is more comfortable for patients.
Sharjah city, Emirate of SharjahAges 16–45 - NCT07135895Recruiting
Artix device for recent leg artery blockages
This study tests a device called Artix to remove blood clots from arteries in the leg that occurred within the last two weeks. It may help restore blood flow and avoid amputation.
San Francisco, CaliforniaAges 18 years+ - NCT07286578Recruiting
Using heart CT scans to guide treatment for blocked arteries
This trial is testing whether a special heart CT scan (coronary CT angiography) can help doctors better understand and treat calcium buildup in your heart arteries. If you have a type of heart disease that might need a stent or other procedure, this study could help decide the best approach.
Boston, MassachusettsAges 18–85 - NCT07072026Recruiting
Opening blocked arteries in the brain long after stroke
This trial looks back at patients who had a procedure to reopen a major artery in the brain that had been blocked for a long time. It will help doctors learn if this treatment is safe and effective for people with chronic blockages in certain key arteries.
EssenAges 18 years+ - NCT07053254Recruiting
Studying vein grafts in older heart bypass patients
This trial looks at how vein grafts work in older adults who need coronary artery bypass surgery. It aims to understand why grafts sometimes fail, so doctors can improve treatment.
SeoulAges 19–100 - NCT06292715Recruiting
Spleen shrinking procedure for severe hypersplenism
This trial tests a procedure that uses heat or cold to shrink part of the spleen and block some of its blood supply, which may improve low blood counts caused by cirrhosis-related hypersplenism. It is for patients whose low white blood cells or platelets have not improved with medicine.
Tianjin, Tianjin MunicipalityAges 18–65 - NCT05490238Recruiting
Wrist vs arm access for complex heart procedures
This study compares using the wrist (radial artery) versus a different access site (conventional radial access approach) during complex, larger “bore” heart procedures to open blocked coronary arteries. It aims to see which approach is safer and works better for challenging cases like chronic blockages or heavily calcified arteries.
ArlonAges 18 years+ - NCT05411445Recruiting
Study blood markers in blocked grafts after bypass surgery
This study looks at small particles in your blood to understand why bypass grafts can become blocked after coronary bypass surgery. It may help doctors better monitor and treat this complication by relating blood markers to what happens after surgery.
Cotignola, RavennaAges 40–80 - NCT04871568Recruiting
Compare two sites for dialysis catheter placement
This trial tests whether placing a dialysis catheter in one location (subclavian/near the collarbone) is as good as placing it in another (jugular/neck) for patients who need a temporary dialysis catheter. It aims to reduce problems like vein narrowing caused by catheter placement.
LundAges 18 years+ - NCT03513770RecruitingEarly Phase 1
Testing how the body controls blood pressure and heart rate
This early research trial looks at how your body’s automatic control system manages blood pressure and heart function. You may be asked to undergo tests to measure these responses, and the study aims to understand control of the circulation (blood flow).
Hershey, PennsylvaniaAges 21–35 - NCT01889459Recruiting
Registry after stent procedure for blocked heart arteries
This study follows people who had a stent placed for a long-standing blockage in a heart artery (called a CTO). It’s mainly a “registry” to understand outcomes after these procedures and help improve care in the future.
KurashikiAges 20 years+ - NCT01484730Recruiting
Imaging study during blocked blood flow
This is a small study testing special camera imaging (including laser-based methods) to see what happens in blood vessels when blood flow is temporarily blocked. It may help researchers improve how they measure and understand blood flow problems.
Irvine, CaliforniaAges 18 years+ - NCT06370182Recruiting
New catheter for clot removal in disabling stroke
This trial tests a new catheter device (ANA Funnel) for removing large blood clots from the brain in people having a disabling stroke. The goal is to see if it safely removes clots better than standard treatment.
Jacksonville, FloridaAges 22–85
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Common questions
- Are there clinical trials for occlusion?
- Yes. Clin2 currently lists 338 recruiting occlusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a occlusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a occlusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.