Clinical trials
Open Label clinical trials
Below are recruiting open label clinical trials, each written for real people, not researchers. We’re tracking 367 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05217810Recruiting
24-week real-world study of Atectura for asthma
This study follows people with asthma who are starting or using Atectura inhalation capsules to see how they do in everyday practice over 24 weeks. It may help your care team learn whether Atectura works well and safely outside a tightly controlled setting.
Daegu, Dalseo guAges 12–100 - NCT05223816RecruitingPhase 2
Tested drug shots for advanced liver and bile duct cancers
This Phase 2 study tests a drug called VG161 given by injection into liver tumors, either alone or together with nivolumab. It aims to see how well it works and whether it is safe for people with advanced hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC).
Phoenix, ArizonaAges 18 years+ - NCT05296070RecruitingPhase 2
Loncastuximab for relapsed or treatment-resistant marginal zone lymphoma
This Phase 2 study tests loncastuximab tesirine, a medicine that targets lymphoma cells, in people with marginal zone lymphoma that came back or did not respond to prior treatment. It aims to see how well the treatment can control the disease and shrink lymphoma in the body.
Duarte, CaliforniaAges 18 years+ - NCT05340491RecruitingPhase 3
Radiation plus immunotherapy for repeat nasopharyngeal cancer
This trial studies whether adding an anti–PD-1 immunotherapy to standard chemoradiotherapy can control nasopharyngeal cancer that has come back in the local area. It may help patients live longer or have the cancer respond better compared with chemoradiotherapy alone.
Guangzhou, GuangdongAges 18–70 - NCT05366452Recruiting
Early heart pump implant for shock after a heart attack
This trial studies whether putting in a small heart pump early (through the leg) helps people with a heart attack complicated by severe heart weakness (“cardiogenic shock”) compared with standard treatment. It aims to improve survival and recovery by supporting blood flow sooner.
Marseille, Bouche DU RhoneAges 18–80 - NCT05389098Recruiting
Finger foods program to help eating in frail seniors
This study tests whether offering easy “finger foods” can improve eating and independence in older adults living in assisted care. It is looking especially at people who are losing weight, have low muscle strength, and may struggle to chew or swallow.
Château-RenaultAges 75–120 - NCT05457829RecruitingPhase 2
Testing two chemotherapy combinations for relapsed pediatric rhabdomyosarcoma
This trial compares two treatment combinations—liposomal doxorubicin plus irinotecan versus a different chemotherapy plan—in children and teens whose rhabdomyosarcoma came back or did not respond. It aims to see which option works better and is safer for children who have had prior cancer treatment.
GuangzhouAges 6 months–18 years - NCT05483400RecruitingPhase 2
Atezolizumab and tiragolumab study for several solid tumors
This Phase 2 trial tests the cancer medicines atezolizumab and tiragolumab in people with different solid tumors. It aims to see how well these drugs work and what side effects they cause in specific patient groups.
GroningenAges 18 years+ - NCT05491525RecruitingPhase 2/Phase 3
Vibegron for children with nerve bladder using intermittent catheter
This study tests how well and how safely vibegron works long-term in children (ages 2 to under 18) with a nerve-related bladder condition, who regularly use intermittent catheterization. It also tracks how the body processes the medicine and whether it helps bladder control over time.
Little Rock, ArkansasAges 2–17 - NCT05577585Recruiting
Ketamine treatment for obsessive-compulsive disorder symptoms
This study tests whether ketamine can reduce obsessive-compulsive disorder (OCD) symptoms and how it affects stress and thinking. It also compares ketamine to usual care to see if benefits and side effects differ.
Vienna, State of ViennaAges 18 years+ - NCT05576974RecruitingPhase 2
Test a dye used during surgery to find head and neck cancer
This trial tests whether a single dose of an imaging dye (given during surgery) can help doctors find the unknown origin of head and neck cancer and check safety. It may help guide surgery and biopsies when the primary cancer location hasn’t been identified.
Dallas, TexasAges 18–99 - NCT05580211Recruiting
Brain stimulation for schizophrenia with low insight
This trial tests a brain-stimulation approach for people with schizophrenia (or schizoaffective disorder) who don’t always recognize how their illness affects them. It may help improve symptoms and insight while you stay on stable medications during the study.
Toronto, OntarioAges 18 years+ - NCT05607329Recruiting
Surgery plus chemo versus chemo alone for ovarian cancer relapse
This trial tests whether doing additional surgery to remove visible tumor (“secondary cytoreduction”) before chemotherapy helps compared with chemotherapy alone. It’s for ovarian (or related) cancer that came back after prior PARP inhibitor maintenance and platinum chemotherapy.
Hangzhou, ZhejiangAges 18–70 - NCT05645575Recruiting
Inpatient TMS for treatment-resistant depression
This study tests an in-hospital brain stimulation treatment (TMS) for people with moderate to severe depression who did not improve after multiple antidepressant treatments. It may help your mood by targeting brain circuits involved in depression, and you would follow an intensive accelerated schedule.
Los Angeles, CaliforniaAges 18–65 - NCT05648591RecruitingPhase 4
Iloperidone study for teens with schizophrenia or bipolar I
This Phase 4 study checks how safe and well-tolerated iloperidone is when used in a typical, open-label way for teenagers. It may help doctors better understand side effects and safety in teens with schizophrenia or bipolar I disorder.
Little Rock, ArkansasAges 12–17 - NCT05660642RecruitingPhase 2
Safety and tolerability study for BPL-003 in hard-to-treat depression
This Phase 2 study tests BPL-003 in people with treatment-resistant depression to learn about its safety and how it affects the body and brain. Because it is open-label, everyone knows they are getting the study treatment, and you’ll also need to stop your current antidepressant during the study.
LiverpoolAges 18–75 - NCT05735080RecruitingPhase 1/Phase 2
INX-315 for advanced cancers with a specific gene change
This trial studies an experimental medicine (INX-315) given in an “open-label” way to people with advanced cancer that has not responded to prior treatment. It mainly looks at safety and side effects first, and also checks how well it works in cancers with a specific gene amplification.
Orlando, FloridaAges 18 years+ - NCT05746897RecruitingPhase 1
First-in-human test of an anti-PVRIG drug for advanced cancers
This early-phase study tests NM1F (an anti-PVRIG antibody) in people with advanced solid tumors to see if it’s safe and whether it may work. It also includes pembrolizumab (a PD-1 “checkpoint” medicine), aiming to boost the immune system against the cancer.
Dallas, TexasAges 18 years+ - NCT05757141RecruitingPhase 1/Phase 2
Study of fosigotifator for vanishing white matter disease
This early-phase study tests fosigotifator in people with vanishing white matter disease (VWM). The goal is to see whether the treatment is safe and could affect how the disease works in the body and brain.
Boston, MassachusettsAges 6 months+ - NCT05789056RecruitingPhase 2/Phase 3
Study lotion for Netherton syndrome safety and symptom improvement
This trial tests a prescription lotion (QRX003) to see if it is safe and helpful for people with Netherton syndrome. Because the study checks skin symptoms on certain body areas and closely controls other treatments, it may be best for patients who can keep their current regimen stable.
San Diego, CaliforniaAges 14 years+ - NCT05791864RecruitingPhase 1/Phase 2
Gene therapy for vision loss in CLN2, tested for safety
This early-phase trial studies a gene therapy medicine called TTX-381 to see if it is safe and tolerable in people with CLN2 disease that affects the eyes. The study also looks at how well the treatment fits into existing eye enzyme therapy care.
HamburgAges 1–7 - NCT05819476Recruiting
Testing how open-label placebos affect induced pain
This study tests whether people can feel less pain when they know they are receiving a “placebo” (a treatment with no active pain-relieving medicine). It’s done in healthy adults by triggering short-lasting pain in a controlled way to see how the placebo effect changes pain feelings.
BaselAges 18–65 - NCT05836259RecruitingPhase 1/Phase 2
TN-201 for heart symptoms from MYBPC3 heart disease
This early trial tests TN-201 to see how safe it is and how well it works to reduce symptoms in adults with MYBPC3-related hypertrophic cardiomyopathy. It’s designed to learn safe dosing, and you may be eligible if you have specific genetic heart changes and ongoing symptoms.
La Jolla, CaliforniaAges 18–75 - NCT05856643RecruitingEarly Phase 1
Study drug for ovarian cancer after prior treatment failure
This early-phase study tests SZ011 in people with ovarian epithelial cancer that has come back or did not respond to standard first treatment. You may qualify if your tumor shows a specific marker (mesothelin) and your health tests are strong enough to safely receive the study drug.
Shantou, GuangdongAges 18–80
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Common questions
- Are there clinical trials for open label?
- Yes. Clin2 currently lists 367 recruiting open label studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a open label trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a open label trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.