Clinical trials
Open Label clinical trials
Below are recruiting open label clinical trials, each written for real people, not researchers. We’re tracking 366 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07165769RecruitingPhase 2
ZGR combo for newly diagnosed spleen lymphoma with large cells
This trial tests a combination of three drugs (zanubrutinib, obinutuzumab, and lenalidomide) for people newly diagnosed with splenic B-cell lymphoma that has large cells (prominent nucleoli). The goal is to see if this drug combination is safe and effective.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT06954558RecruitingPhase 1
GK01 for advanced solid tumors that are hard to treat
This trial tests a new drug called GK01 in patients with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug is safe and effective, and may be an option for those who can have a tumor surgically removed.
TianjinAges 18–70 - NCT07162441RecruitingPhase 1
Drug interaction study in healthy volunteers
This trial tests two experimental drugs in healthy adults to see how they interact with each other and to check their safety. It involves taking the drugs in a specific order over multiple days.
Seoul, Gwanak-guAges 19 years+ - NCT07161700Enrolling by invitationPhase 2
Long-term safety study of SPT-300 for major depression
This study is for people who finished the earlier BUOY-1 study of SPT-300 and want to continue treatment. It tests the long-term safety and tolerability of SPT-300 for major depressive disorder, with or without anxious distress.
Chino, CaliforniaAges 18–66 - NCT07141329RecruitingPhase 2
Long-term study of SPN-817 for focal seizures
This study gives SPN-817 to people who completed a prior study of the same drug, to see if it stays safe and works well over a longer time. You may qualify if you already finished that study and have stable seizure medicine.
Port Charlotte, FloridaAges 18 years+ - NCT07120971RecruitingEarly Phase 1
Metformin study for premature babies with lung disease
This study tests whether metformin, a medicine used for diabetes, can help premature babies with chronic lung disease (bronchopulmonary dysplasia, or BPD) breathe better. It may reduce the need for breathing machines.
Milwaukee, WisconsinAges 1 week–6 months - NCT07125066Enrolling by invitationPhase 1
Testing ACER-001 for combined D,L-2 hydroxyglutaric aciduria
This trial tests a drug called ACER-001 in a single patient with a rare metabolic disorder. The goal is to see if the drug helps manage symptoms.
Pittsburgh, PennsylvaniaAges Any age - NCT07117630RecruitingPhase 2
A new drug combo for advanced breast cancer after standard treatment
This trial tests a new drug combination for women with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after standard treatments like CDK4/6 inhibitors and hormone therapy. It aims to see if the combination can help when other options have stopped working.
ShanghaiAges 18 years+ - NCT07123298Recruiting
Program to help older adults feel less alone at home
This study tests a program called CAPABLE Care + Connect that helps older adults who feel lonely or isolated and have trouble with daily activities at home. It connects them with support to feel more capable and less alone.
Baltimore, MarylandAges 50 years+ - NCT07115485RecruitingPhase 2
Study of HLX43 for advanced stomach or junction cancer
This trial tests a new drug called HLX43 (an antibody-drug conjugate targeting PD-L1) for people with advanced stomach or gastroesophageal junction cancer that has progressed after at least one prior treatment. It aims to see if it can shrink tumors and help patients live longer.
BeijingAges 3 weeks–2 months - NCT07106892RecruitingPhase 2
Testing HLX43 for advanced colorectal cancer
This trial tests a new drug, HLX43, that targets a protein called PD-L1 on cancer cells and delivers a chemotherapy-like payload directly to them. It's for people with advanced colorectal cancer that hasn't responded to standard treatments.
BeijingAges 3 weeks–2 months - NCT07112183RecruitingPhase 4
Treprostinil study for Raynaud's attacks
This trial tests a medication called treprostinil to see if it can help people who have frequent Raynaud's attacks. It is for patients with primary or secondary Raynaud's (related to conditions like scleroderma or lupus) who still have attacks despite current treatments.
Boston, MassachusettsAges 18 years+ - NCT07105254RecruitingPhase 2
Roflumilast foam study for children with vitiligo
This study tests a medicated foam (Roflumilast) in children with non-segmental vitiligo to see if it can improve skin color on the face and body. It is for patients aged 2 to 17 with small patches and at least some pigmented hair in the face patches.
Dallas, TexasAges 2–18 - NCT07101705RecruitingEarly Phase 1
Testing OriV508 for blood cancers that haven't responded to treatment
This study tests a new treatment called OriV508 for people with blood cancers (multiple myeloma or aggressive B-cell lymphoma) that have not responded to at least two previous therapies. It aims to see if the treatment is safe and helps shrink or control the cancer.
Wuhan, HubeiAges 18–75 - NCT07105709RecruitingPhase 2
Extension study for early Alzheimer's treatment
This study is a follow-up for people who completed a previous trial of an experimental treatment for early Alzheimer's disease. It will continue to test the treatment's safety and effects over a longer period.
Maitland, FloridaAges 50–85 - NCT07097701RecruitingPhase 3
Comparing two forms of mexiletine for non-dystrophic myotonias
This trial compares a new extended-release (PR) form of mexiletine to the immediate-release (IR) form in people with non-dystrophic myotonias. The goal is to see if the longer-acting version works as well or better with fewer side effects.
LeuvenAges 16 years+ - NCT07095465RecruitingPhase 3
Long-term study of ACP-204 for psychosis in Lewy body dementia
This study tests a medication called ACP-204 for psychosis (hallucinations or delusions) in people with Lewy body dementia. It is a long-term extension open to patients who completed a previous ACP-204 study, to see if the drug continues to be helpful and safe.
Irvine, CaliforniaAges 55–84 - NCT07089615Recruiting
Capsule vs colonoscopy for polyp detection
This trial tests a new capsule that you swallow to take pictures of your colon. It may help find polyps (growths that can turn into cancer) as well as a standard colonoscopy does.
Chula Vista, CaliforniaAges 45–75 - NCT07080905RecruitingPhase 3
Gene therapy study for teens with severe hemophilia B
This study tests a one-time gene therapy (CSL222) for teenage boys with severe or moderately severe hemophilia B. It aims to help their bodies produce the clotting factor they need, potentially reducing or eliminating the need for regular factor infusions.
Orange, CaliforniaAges 11.5 years–17.2 years - NCT07078682Recruiting
Study of two supplements for uterine fibroid symptoms
This trial tests two supplements (Elix Cycle Balance and Elix Daily Harmony) to see if they can reduce pain and other symptoms caused by uterine fibroids. It is for women who have regular but painful periods and want to try a non-medicine option.
Las Vegas, NevadaAges 20–45 - NCT06977893RecruitingPhase 3
Chemo and immunotherapy for HR+ breast cancer before surgery
This trial tests whether adding the immunotherapy drug toripalimab to chemotherapy before surgery helps women with a certain type of breast cancer (HR+, HER2-). It aims to see if this combination works better than chemotherapy alone.
HangzhouAges 18–75 - NCT07073547RecruitingPhase 1
Study of AZD0120 for multiple myeloma patients
This trial tests a new drug, AZD0120, in people with multiple myeloma. It aims to find the right dose and see how safe and effective it is. The study includes both newly diagnosed and early relapsed patients.
Phoenix, ArizonaAges 18 years+ - NCT07070323RecruitingPhase 1/Phase 2
Nanobody CD5-CAR T cells for T-cell cancers
This trial tests a new treatment using your own or a donor's immune cells to fight certain T-cell cancers that haven't responded to standard therapies. It may help people who have few other options left.
Beijing, Beijing MunicipalityAges 1–70 - NCT05870800RecruitingPhase 2
Study Immunotherapy and Chemotherapy Before Colon Surgery
This trial tests immunotherapy plus chemotherapy given before surgery for colon cancer that hasn’t spread. It aims to shrink or control the tumor and improve outcomes in people whose tumor has certain immune/biologic features.
Houston, TexasAges 18–80
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Common questions
- Are there clinical trials for open label?
- Yes. Clin2 currently lists 366 recruiting open label studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a open label trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a open label trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.