Clinical trials
Oral Infection clinical trials
Below are recruiting oral infection clinical trials, each written for real people, not researchers. We’re tracking 73 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05302531RecruitingPhase 1
Testing high-absorption antibiotics for short-bowel syndrome
This early (Phase 1) study tests how well certain antibiotics get absorbed in the body when you have short-bowel syndrome. It may help doctors choose antibiotics that work better through the mouth for people with this digestion problem.
Vandœuvre-lès-Nancy, LorraineAges 18 years+ - NCT05303337Recruiting
Study of gut and HIV changes after switching to long-acting shots
This trial compares how HIV “reservoirs,” inflammation, and the gut microbiome change when people switch from daily HIV pills to long-acting injectable treatment. It may help you and your team understand what to expect with the switch and how your body responds.
MarseilleAges 18 years+ - NCT06066957RecruitingPhase 2
Oral letermovir to prevent CMV after heart or lung transplant
This trial tests if an oral medication called letermovir can prevent CMV infection in heart or lung transplant recipients who are at risk for CMV. It may offer a convenient option to protect against this virus after transplant.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06488846Enrolling by invitation
Giving HIV injections at home with a helper
This study tests whether having a trained friend or family member give you your HIV injections at home is safe and works as well as getting them at a clinic. You may qualify if you are already on the injectable HIV medication cabotegravir/rilpivirine (Cabenuva) and have a support person willing to help.
San Francisco, CaliforniaAges 18 years+ - NCT07236944RecruitingPhase 4
Testing pivmecillinam pills for E. coli kidney infection
This trial tests if a switch to pivmecillinam pills after IV antibiotics works as well as standard oral antibiotics for E. coli febrile urinary tract infections. It aims to simplify treatment for patients who are already stable.
HaukelandAges 18 years+ - NCT06017817Recruiting
Light therapy for implant gum disease
This study tests a special light-activated treatment (antibacterial photodynamic therapy) to fight infection around dental implants. It may be an option for people with moderate to severe implant-related gum disease who are not smokers and do not have diabetes.
StockholmAges 18–85 - NCT05886816RecruitingPhase 2
Mitoquinone pills to prevent COVID-19 after risky exposure
This trial tests whether an oral medication (mitoquinone/mitoquinol) taken after a high-risk COVID-19 exposure can help prevent you from becoming sick. It is designed for people who currently have no symptoms but had a significant exposure to someone with confirmed COVID-19.
Dallas, TexasAges 18–65 - NCT07139366RecruitingPhase 4
Probiotic plus bismuth combo for stubborn H. pylori
This study tests a combination of a probiotic (Saccharomyces boulardii) plus a standard bismuth-based four-drug treatment for people whose H. pylori infection has not been cured by previous treatments. It aims to see if adding the probiotic helps the treatment work better and cause fewer side effects.
Xi'an, ShaanxiAges 18–75 - NCT07532941RecruitingPhase 4
Stopping antibiotics early versus completing the full course
This study compares two ways of giving antibiotics to children: stopping when symptoms feel better versus finishing all the prescribed doses. Researchers want to see if stopping early is safe and works just as well, which could help reduce unnecessary antibiotic use.
Melbourne, VictoriaAges 1–17 - NCT06076304RecruitingPhase 4
Comparing treatments for acute sinusitis
This trial tests whether nasal steroids, nasal irrigation, or oral antibiotics work best for acute sinusitis. It may help if you have ongoing sinus symptoms or a 'double-sickening' pattern after a cold.
Los Angeles, CaliforniaAges 18–75 - NCT06537609Recruiting
Testing treatments for Gram-negative bloodstream infections
This trial tests different ways to treat infections in the blood caused by Gram-negative bacteria. It looks at whether reducing antibiotics, switching to pills, or managing central lines improves outcomes while keeping you safe.
Kogarah, New South WalesAges birth–130 years - NCT07202546RecruitingPhase 2
New oral HIV drug trial for people new to treatment
This trial tests a new oral HIV medication (VH4524184) in people who have never taken HIV treatment before. It looks at how well the drug controls the virus and how safe it is.
Bakersfield, CaliforniaAges 18 years+ - NCT07179237RecruitingPhase 2
Testing carminal for H. pylori stomach infection
This trial tests a new medicine called carminal for people with stomach inflammation caused by H. pylori bacteria. It aims to see if the drug can help improve symptoms like indigestion and get rid of the infection.
Belgrade, Central SerbiaAges 18 years+ - NCT07184827RecruitingPhase 3
U101 capsules to prevent recurring UTIs in women
This trial tests an oral capsule called U101 to see if it can prevent recurrent urinary tract infections (UTIs) in women who have frequent UTIs. If you've had at least 2 UTIs in the last 6 months or 3 in the last year, you may be able to join.
Kaohsiung CityAges 20–75 - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Indianapolis, IndianaAges 18 years+ - NCT07610395RecruitingPhase 2
Testing an oral drug for cold virus in COPD patients
This trial tests an oral medication (VPV) to see if it can safely treat rhinovirus (a common cold virus) in people with COPD. The goal is to help you recover faster and prevent serious COPD flare-ups.
Mobile, AlabamaAges 40–85 - NCT05219110Recruiting
More fluids for children sick with toxin E. coli
This study looks at whether giving extra (hyper) fluids early helps children with a high-risk E. coli stomach infection. The goal is to improve outcomes by supporting the kidneys during the illness.
Birmingham, AlabamaAges 9 months–21 years - NCT06889701RecruitingPhase 1/Phase 2
Testing TNP-2092 for knee infection after joint replacement
This trial tests a new antibiotic, TNP-2092, given as a shot directly into the knee joint for people with a persistent infection after knee replacement. It is for those whose infection is caused by certain bacteria and who are willing to stay in the hospital for 2 weeks.
Ürümqi, XinjiangAges 18 years+ - NCT07228702Enrolling by invitationPhase 1
Bacteriophage therapy for one patient with lung infection
This is a special program for one patient with a lung infection from Mycobacterium abscessus. The trial uses a treatment with bacteriophages, which are viruses that attack specific bacteria.
Vancouver, British ColumbiaAges Any age - NCT06807736Recruiting
Choosing injectable PrEP for HIV prevention in Cape Town
This study offers three ways to prevent HIV: a shot every two months (injectable PrEP), daily pills, or a vaginal ring. Researchers in Cape Town will help you choose the option that fits your life best.
Cape Town, Western ProvinceAges 15 years+ - NCT07045493Enrolling by invitationPhase 2
Combination therapy for soil-transmitted worms in children aged 2-5
This trial tests whether a combination of medicines works better than a single medicine to treat common intestinal worms (like hookworm and roundworm) in young children in Bangladesh. It is for children who are either stunted (shorter than average for their age) or healthy, and who have a confirmed worm infection.
DhakaAges 2–5 - NCT06650501RecruitingPhase 4
Comparing two blood thinners for staph bloodstream infections
This study compares two types of blood thinners (dabigatran vs. a common Xa inhibitor like apixaban) in people with a staph infection in their blood. The goal is to see which is safer and works better.
Montreal, QuebecAges 18 years+ - NCT05660980RecruitingPhase 1/Phase 2
Oral and monthly shots for HIV control in children
This trial studies whether a child can safely move from HIV medicine taken by mouth to long-acting monthly injections. It looks at keeping HIV levels suppressed (very low) and monitoring side effects and safety over time.
Atlanta, GeorgiaAges 2–11 - NCT06938867RecruitingPhase 1/Phase 2
Study of SNIPR001 for resistant gut bacteria before stem cell transplant
This study tests an experimental oral medicine called SNIPR001. It is designed to reduce resistant E. coli bacteria in the gut before your stem cell transplant, possibly lowering the risk of infection.
Duarte, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for oral infection?
- Yes. Clin2 currently lists 73 recruiting oral infection studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a oral infection trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a oral infection trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.