Clinical trials
Osteoarthritis (OA) of the Knee clinical trials
Below are recruiting osteoarthritis (oa) of the knee clinical trials, each written for real people, not researchers. We’re tracking 152 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07464080Recruiting
Brain imaging study for knee replacement patients
This study uses advanced brain scans to understand how pain and recovery change after knee replacement surgery. It may help researchers develop better ways to manage pain after surgery.
Ottawa, OntarioAges 18 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Phoenix, ArizonaAges 18 years+ - NCT07482332Recruiting
Core exercises for knee arthritis in women
This study tests if core stability exercises can reduce pain and improve function in women with knee osteoarthritis. It is designed for those who have not had recent physical therapy and can move their knees and hips freely.
SivasAges 45–65 - NCT07673328Recruiting
Knee brace study for people with knee arthritis
This study tests a motorized knee brace for people with knee osteoarthritis. The brace helps support your knee as you walk, climb stairs, and go up and down ramps.
Ann Arbor, MichiganAges 18–85 - NCT07507175Recruiting
Calf muscle release for women with knee arthritis
This trial tests whether releasing tight calf muscles can help women with knee osteoarthritis feel less pain. It focuses on women who have moderate knee arthritis and a tight spot in their calf muscle.
Giza, Giza GovernorateAges 45–55 - NCT07598474Recruiting
Pregabalin and Movement Therapy for Knee Osteoarthritis Pain
This trial tests whether a nerve pain medication called pregabalin, applied through ultrasound waves to your knee, combined with gentle movement exercises, can reduce pain in advanced knee osteoarthritis. You'll attend 16 treatment sessions over 4 weeks to see if this combination helps.
Faisalābad, Punjab ProvinceAges 40–60 - NCT07603973Recruiting
Smartphone App to Help Manage Knee Osteoarthritis
This study tests whether a smartphone app that provides information and self-management tools helps people with knee osteoarthritis feel better and manage their condition. You would use the app at home to learn exercises, track symptoms, and get support.
Oslo, OsloAges 50 years+ - NCT07637682Recruiting
Percutaneous Neurostimulation for Knee Osteoarthritis Pain
This trial tests a minimally invasive nerve-stimulation treatment for moderate to severe knee osteoarthritis pain in adults who have not found relief with standard treatments. The procedure uses small needles to deliver electrical stimulation near nerves to reduce pain.
TantaAges 18 years+ - NCT07504562Enrolling by invitationPhase 2
Ejiao Paste for Knee Osteoarthritis Pain
This trial tests a traditional Chinese medicine patch called Knee Pain Ejiao Paste for knee osteoarthritis pain. It aims to see if the paste reduces pain and improves function compared to a placebo.
Shanghai, Shanghai MunicipalityAges 40–75 - NCT07478861Enrolling by invitation
Vibration training for seniors with knee arthritis and obesity
This study tests whether whole-body vibration training can help older adults who have both severe knee arthritis and obesity. It aims to improve strength, mobility, and quality of life.
Banī SuwayfAges 60–75 - NCT07351981Enrolling by invitation
Cooled radiofrequency for knee osteoarthritis pain
This study tests a new approach called cooled radiofrequency (TcPRF) to calm knee pain from osteoarthritis. It may be an option if standard treatments haven't worked and you haven't had certain other treatments recently.
AthensAges 45 years+ - NCT07246109Enrolling by invitation
Knee Brace and Muscle Training for Osteoarthritis
This study tests whether wearing a knee brace and doing muscle training exercises can help people with knee osteoarthritis feel better and move more easily. It may be a good option if you have not had knee surgery and are not already in another treatment program.
TaichungAges 55 years+ - NCT07219888Enrolling by invitationPhase 4
Comparing suzetrigine and oxycodone for knee replacement pain
This study compares a new pain medicine called suzetrigine with a commonly used opioid, oxycodone, for pain after a knee replacement. The goal is to see which works better and has fewer side effects.
Louisville, KentuckyAges 21–89 - NCT06946329Enrolling by invitation
Water exercise for knee pain in obese men
This study tests whether a supervised water exercise program (called WATERinMOTION) can reduce knee pain and improve movement in obese men with knee osteoarthritis. It may help if you are looking for a gentle, joint-friendly way to manage your knee pain.
Zahedan, Sistan and BaluchestanAges 45–65 - NCT06444932Enrolling by invitation
Strength training plus joint mobilization for knee osteoarthritis
This study looks at whether adding resistance (strength) exercises to joint mobilization helps people with knee osteoarthritis move better, feel less pain, and get stronger. You'll do standard joint mobilization plus a program of exercises like leg presses and squats.
IslamabadAges 40–70 - NCT06430918Enrolling by invitation
Nerve pain and sleep quality in knee osteoarthritis
This study looks at how nerve pain and sleep quality are related in people with knee osteoarthritis. It aims to help doctors better understand and treat pain.
IzmirAges 18–80 - NCT06211387Enrolling by invitation
Stretching plus resistance exercise for knee osteoarthritis
This study tests whether adding a gentle stretching technique to resistance exercises helps reduce knee pain and improve movement in people with knee osteoarthritis. It may be a good option if you have mild-to-moderate knee arthritis and want to strengthen your knees without surgery.
Islamabad, FederalAges 40–65 - NCT04651673Enrolling by invitation
Knee brace program for adults with knee osteoarthritis pain
This trial looks at using a prescribed knee brace to help relieve knee pain and symptoms from knee osteoarthritis. You may be able to join if your knee braces are being provided through participating clinics and you can consent and complete study questionnaires.
Hässleholm, Skåne CountyAges 18–100 - NCT07542808RecruitingPhase 2/Phase 3
Stem cell treatment vs. hyaluronic acid for knee arthritis
This study tests whether an injection of stem cells (special cells that can help repair tissue) works better than a standard hyaluronic acid injection for knee osteoarthritis pain. Both treatments are injected into the knee to reduce pain and improve function.
Abu DhabiAges 18 years+ - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT05423587Recruiting
Knee artery procedure for long-lasting knee arthritis pain
This study looks at whether blocking small blood vessels in the knee (genicular artery embolisation) can reduce pain from knee osteoarthritis when other non-surgical treatments haven't helped. It also checks safety and whether people can tolerate the imaging tests needed for the procedure.
ReadingAges 45 years+ - NCT05933434RecruitingPhase 1/Phase 2
Stem cell injection trial for chronic knee osteoarthritis
This early-phase study tests an injection of donor stem cells placed into the knee joint to help reduce symptoms of knee osteoarthritis. You may be eligible if you have long-lasting knee pain from mild-to-moderate arthritis and meet safety and imaging requirements.
Aarhus NAges 40–75 - NCT06054633Recruiting
L-arginine for knee osteoarthritis pain
This study tests whether L-arginine, a natural amino acid, can help with knee pain from osteoarthritis. You might be eligible if you are 40–80 years old, have moderate osteoarthritis on X-ray, and have had knee pain for at least 3 months.
Changsha, HunanAges 40–80 - NCT06658327Recruiting
Stretching for knee arthritis in postmenopausal women
This study compares two types of stretching to see which better reduces pain and improves movement in postmenopausal women with knee osteoarthritis. It may help you find a simple, drug-free way to manage your symptoms.
Lahore, Punjab ProvinceAges 50–65
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Common questions
- Are there clinical trials for osteoarthritis (oa) of the knee?
- Yes. Clin2 currently lists 152 recruiting osteoarthritis (oa) of the knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a osteoarthritis (oa) of the knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a osteoarthritis (oa) of the knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.