Clinical trials · California
Overweight or Obesity clinical trials in California
We’re tracking 112 recruiting overweight or obesity studies with a site in California — including Phase 1, Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06398509Recruiting
Preventing obesity in Latino babies at checkups
This study tests a program that helps prevent childhood obesity in low-income Latino families. It takes place during your baby's regular checkups and offers extra support for healthy feeding and growth.
San Francisco, CaliforniaAges 1 week–2 months - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Orange, CaliforniaAges 18–99 - NCT07564414RecruitingPhase 3
Weight Loss Study Comparing Two Doses of CagriSema
This study tests whether a new combination medication called CagriSema (in two different doses) helps people with obesity lose weight. You may qualify if you're 18 or older, have a BMI of 35 or higher, and either don't have type 2 diabetes or have it well-controlled.
Escondido, CaliforniaAges 18 years+ - NCT05215886Enrolling by invitation
Bariatric surgery and memory problems in people with obesity
This study looks at how bariatric (weight-loss) surgery may affect memory and thinking in people with obesity who already have memory decline or dementia. It may help doctors understand which patients benefit most and what changes to expect.
Sacramento, CaliforniaAges 18–75 - NCT06544954Recruiting
Grape study for heart and gut health in overweight women
This study tests whether eating California grapes can improve gut health and heart health in overweight or obese women who have been through menopause and may have type 2 diabetes or metabolic syndrome. You would need to eat grapes daily and provide blood and stool samples.
Davis, CaliforniaAges 45–70 - NCT06585462RecruitingPhase 1
Study of AMG 513 for people with obesity
This study tests an experimental medication called AMG 513 to see how safe it is and how the body processes it. It is for people with obesity who may benefit from a new treatment option.
Anaheim, CaliforniaAges 18–65 - NCT07225686RecruitingPhase 3
Maridebart Cafraglutide for sleep apnea in adults on CPAP
This study is testing whether a new medicine, called Maridebart Cafraglutide, can help people with obstructive sleep apnea who are already using a CPAP machine. The medicine may help with weight loss and potentially improve sleep apnea. Participants will either receive the medicine or a placebo (an inactive substance), and the study lasts for several months.
Northridge, CaliforniaAges 18–99 - NCT07225816RecruitingPhase 1
How fasting affects stomach food with GLP-1 drugs
This study looks at how long fasting and temporarily stopping certain diabetes or weight-loss medications (like semaglutide or liraglutide) affects how much food stays in your stomach. It may help understand how these medications work in people who are overweight.
Cypress, CaliforniaAges 18 years+ - NCT06783751Recruiting
New surgical method to reduce acid reflux after weight loss surgery
This trial tests a modified version of sleeve gastrectomy that aims to reduce the risk of acid reflux (GERD) after surgery. It is for people aged 18–65 with a BMI between 35 and 55 who already have some degree of GERD and are planning to have weight loss surgery.
Orange, CaliforniaAges 18–65 - NCT04248127Recruiting
Honey yogurt to improve gut health and mild inflammation
This study tests whether honey-flavored yogurt can improve gut health and “low-grade” inflammation in middle-aged and older women after menopause. You may be asked to follow a yogurt-focused plan and avoid certain foods or supplements to see the effect.
Davis, CaliforniaAges 45–65 - NCT04453072Recruiting
iPhone weight-loss app for teens and young adults after transplant
This study tests whether an iPhone weight-management app can help adolescents and young adults lose weight after a stem cell transplant. If you qualify, you’ll use the app and the team will track changes in weight.
Los Angeles, CaliforniaAges 13–30 - NCT04913064Recruiting
White button mushroom supplement for inflammation in high-risk breast cancer
This trial tests whether a white button mushroom powder supplement can lower inflammation in postmenopausal women who have a high risk of breast cancer. If it helps, it could improve early prevention strategies for people at higher risk.
Duarte, CaliforniaAges 21 years+ - NCT04997473Recruiting
Mobile app weight-loss program for young transplant patients
This trial tests whether a phone app can help young people who previously had a stem cell transplant lose weight. It’s designed for people who are at least 100 days out from transplant and who meet weight criteria.
Los Angeles, CaliforniaAges 13–30 - NCT05082519RecruitingPhase 2
Calorie reduction and activity to help chemo work in B-ALL
This Phase 2 study tests whether eating fewer calories and doing activity safely can make chemotherapy work better for children and young adults with newly diagnosed B-ALL. It aims to reduce chemo resistance, meaning help leukemia respond more strongly to treatment.
Los Angeles, CaliforniaAges 10–25 - NCT05173714RecruitingPhase 2
Sit Less and Move More program for people with CKD
This Phase 2 study tests a program to help people with chronic kidney disease (CKD) sit less and move more, plus a medication (semaglutide) for those who qualify. It may help improve health and day-to-day activity while monitoring safety closely.
Stanford, CaliforniaAges 20 years+ - NCT05197738Recruiting
Study using a sleep health app to improve sleep
This study tests a “sleep health” app (REFRESH) to see how it may help people track and improve sleep. You may be eligible if you’re an adult in the U.S. who can use the app on your own phone.
La Jolla, CaliforniaAges 18 years+ - NCT05228860Recruiting
Nutrition support program for adults with type 2 diabetes
This trial tests whether improving access to healthy food can help adults with type 2 diabetes—especially people dealing with food insecurity. It also includes a family member who helps support healthy eating at home.
Concord, CaliforniaAges 18 years+ - NCT05279729Recruiting
Mobile app coaching for people with diabetes
This study tests whether using a smartphone app can help people with type 2 diabetes manage their health. It focuses especially on low-income Hispanic/Latinx adults who regularly check blood sugar.
San Diego, CaliforniaAges 18–64 - NCT05468437Recruiting
Online nutrition coaching for people with spinal cord injury
This study tests whether telenutrition (nutrition coaching by phone/tablet) can help people with spinal cord injury manage their weight and health. It may be a good fit if you’re mainly using a wheelchair, can use an iPad, and live in California.
San Jose, CaliforniaAges 20 years+ - NCT05514288Recruiting
Endoscopic weight-loss procedures for people with excess weight
This study looks at how well an endoscopic (camera-based) weight-loss procedure helps people lose weight and whether it’s safe. It may be for people who are considering this approach, including some who previously had bariatric surgery but didn’t keep the weight off.
Los Angeles, CaliforniaAges 18–75 - NCT05589155Recruiting
Using a phone app to improve blood sugar and weight
This study looks at whether a mobile phone app can help people with type 2 diabetes improve their health habits, including blood sugar monitoring and weight. You may be able to join if you already check your blood sugar daily and are able to use a smartphone.
San Diego, CaliforniaAges 18–64 - NCT05653258RecruitingPhase 2/Phase 3
Study cells in fat tissue and aging cells in older adults
This study uses a special lab test on tiny samples from body fat to map different cell types and “senescent” (aging) cells. It may help researchers understand how aging and obesity are linked, which could guide future treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05833217Recruiting
Study for persistent COVID symptoms with insulin resistance
This trial studies people who have ongoing effects after COVID (often called PASC) and may be related to weight and insulin resistance. It may help researchers find better ways to understand the condition and improve treatment.
Palo Alto, CaliforniaAges 18–80 - NCT05975580RecruitingPhase 4
Medication plus lifestyle counseling for weight regain after bariatric surgery
This study looks at whether adding medication to lifestyle counseling can help people who have regained weight after sleeve gastrectomy or gastric bypass. It focuses on improving weight control and related health after surgery.
Orange, CaliforniaAges 18–70
Overweight or Obesity trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting overweight or obesity studies listed above.
- University of California, Irvine Medical Center / UC Irvine Health · 3 studies
- Valley Clinical Trials · 3 studies
- San Diego State University · 2 studies
- 310 Clinical Research
- Altasciences Clinical Los Angeles, Inc.
- Cedars-Sinai Medical Center
- CenExel ACT (Anaheim Clinical Trials)
- Children's Hospital Los Angeles
What taking part in a overweight or obesity study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Overweight or Obesity trials in other states
Common questions
- Are there overweight or obesity clinical trials in California?
- Yes. We're currently tracking 112 recruiting overweight or obesity studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a overweight or obesity study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a overweight or obesity trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New overweight or obesity studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.