Clinical trials · California
Overweight or Obesity clinical trials in California
We’re tracking 119 recruiting overweight or obesity studies with a site in California — including Phase 1, Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07817875RecruitingPhase 3
Tirzepatide for weight loss in children aged 6 to under 12
This study tests a once-weekly medication called tirzepatide to help children aged 6 to under 12 with obesity lose weight. It compares the medication to a placebo (inactive shot) to see if it safely helps with weight loss in this age group.
Loma Linda, CaliforniaAges 6–11 - NCT07731139RecruitingPhase 1
Testing a new medicine for people with obesity
This study tests how different amounts of the study medicine PF-08642534 are tolerated and how they work in the body of people with obesity. It aims to find a safe dose for future studies.
Lake Forest, CaliforniaAges 18–70 - NCT05165706Recruiting
Study of how obesity affects insulin resistance over time
This study follows adults over time to understand how weight and body chemistry relate to insulin resistance. It may help researchers learn why insulin resistance happens and what could prevent or improve it.
Stanford, CaliforniaAges 35–65 - NCT07564414RecruitingPhase 3
Weight Loss Study Comparing Two Doses of CagriSema
This study tests whether a new combination medication called CagriSema (in two different doses) helps people with obesity lose weight. You may qualify if you're 18 or older, have a BMI of 35 or higher, and either don't have type 2 diabetes or have it well-controlled.
Escondido, CaliforniaAges 18 years+ - NCT07567001RecruitingPhase 3
Testing NNC0487-0111 for Heart Failure and Obesity
This study tests whether a new medication called NNC0487-0111 can help people with heart failure who also have obesity. Researchers will compare it to a placebo (inactive pill) to see if it improves heart function and overall health.
Alhambra, CaliforniaAges 18 years+ - NCT07291232RecruitingPhase 1
Study of an injected drug for adults with obesity
This study tests an injected medication called ABBV-295 for adults with obesity. The goal is to see how safe it is and how the body processes it. You may join if you have a BMI between 30 and 45 and are generally healthy, and you haven't been on other weight loss treatments recently.
Anaheim, CaliforniaAges 18–65 - NCT05419726Recruiting
Semaglutide study to see how brown fat responds in weight loss
This trial studies how brown fat (a type of body fat) changes after starting semaglutide for weight loss. You may help researchers understand how this medication affects the body’s energy use, which could improve weight-loss treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT07037459RecruitingPhase 3
A study of a new drug for heart failure with obesity
This trial tests a medication called maridebart cafraglutide for people with heart failure (where the heart doesn't pump as well as it should) and obesity. The goal is to see if it can help improve symptoms and outcomes.
Beverly Hills, CaliforniaAges 18–99 - NCT05143697Recruiting
Coaching program to help young children reduce excess weight
This trial tests a family wellness coaching program using motivational interview counseling and referrals. It may help families support healthier habits for children ages 2 to 8 who have weight above a recommended range.
Pasadena, CaliforniaAges 2–8 - NCT06439277RecruitingPhase 3
Tirzepatide for teens with obesity and related health problems
This study tests a medication called tirzepatide (a once-weekly injection) to help teenagers with obesity and related health conditions lose weight. It aims to see if the drug is safe and effective for this age group.
Sacramento, CaliforniaAges 12–17 - NCT06398509Recruiting
Preventing obesity in Latino babies at checkups
This study tests a program that helps prevent childhood obesity in low-income Latino families. It takes place during your baby's regular checkups and offers extra support for healthy feeding and growth.
San Francisco, CaliforniaAges 1 week–2 months - NCT05215886Enrolling by invitation
Bariatric surgery and memory problems in people with obesity
This study looks at how bariatric (weight-loss) surgery may affect memory and thinking in people with obesity who already have memory decline or dementia. It may help doctors understand which patients benefit most and what changes to expect.
Sacramento, CaliforniaAges 18–75 - NCT03022682Recruiting
Study of inflammation and metabolism across diabetes and weight
This is an observational study that follows generally healthy adults to understand how inflammation, diabetes (type 2), and weight/metabolic health relate to each other. It may help researchers figure out why different groups (including different ethnic backgrounds) have different health risks.
San Francisco, CaliforniaAges 18–75 - NCT07839832Recruiting
Healthy goals study for teens with obesity
This study looks at healthy lifestyle programs for children ages 10-15 who are overweight. You and your child will be involved together in activities to help improve health.
Stanford, CaliforniaAges 10–15 - NCT05197738Recruiting
Study using a sleep health app to improve sleep
This study tests a “sleep health” app (REFRESH) to see how it may help people track and improve sleep. You may be eligible if you’re an adult in the U.S. who can use the app on your own phone.
La Jolla, CaliforniaAges 18 years+ - NCT07815678RecruitingPhase 1/Phase 2
Safety study of an oral medication in people with normal or higher weight
This study tests a new oral medication called ACCG-2671 to see how safe it is and how your body handles it. It's an early-stage trial, so the main focus is on safety and tolerability. The study has different parts: one for people with normal weight and one for people with higher weight who are already taking a GLP-1 injection for weight loss.
Cypress, CaliforniaAges 25–75 - NCT07792837Recruiting
Online intuitive eating program for pregnant women with obesity
This study tests an online program that helps pregnant women with obesity learn to eat intuitively, which means listening to their body's hunger and fullness signals instead of dieting. The goal is to support their well-being during pregnancy.
San Diego, CaliforniaAges 18 years+ - NCT07783802RecruitingPhase 2
Study of clazakizumab for adults with high inflammation and heart risk
This study tests whether clazakizumab can reduce the risk of heart attacks or strokes in people with high levels of inflammation (measured by a blood test called hsCRP) and conditions like heart disease, obesity, diabetes, high blood pressure, or kidney disease. If you qualify, you'll receive either the study drug or a placebo to see if it helps lower your risk.
Glendora, CaliforniaAges 18 years+ - NCT05833217Recruiting
Study for persistent COVID symptoms with insulin resistance
This trial studies people who have ongoing effects after COVID (often called PASC) and may be related to weight and insulin resistance. It may help researchers find better ways to understand the condition and improve treatment.
Palo Alto, CaliforniaAges 18–80 - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Walnut Creek, CaliforniaAges 18 years+ - NCT07478263Recruiting
Healthy eating trial for Latinas to prevent type 2 diabetes
This study tests a behavioral program designed to help Latinas with prediabetes improve their nutrition and eating patterns to prevent type 2 diabetes. It focuses on reducing cravings and building healthy habits.
La Jolla, CaliforniaAges 18–55 - NCT07446439RecruitingPhase 3
Tradipitant for nausea from weight loss injections
This study tests whether the drug tradipitant can help reduce nausea and vomiting caused by weight loss injections like Ozempic or Wegovy. If you have these side effects and are not diabetic, you may be eligible.
Los Angeles, CaliforniaAges 18–65 - NCT07328568Recruiting
Quick sprints for better heart health
This study tests whether short bursts of intense exercise can improve your heart and lung fitness. You might join if you're generally healthy and not already very active.
San Marcos, CaliforniaAges 18–55 - NCT07225816RecruitingPhase 1
How fasting affects stomach food with GLP-1 drugs
This study looks at how long fasting and temporarily stopping certain diabetes or weight-loss medications (like semaglutide or liraglutide) affects how much food stays in your stomach. It may help understand how these medications work in people who are overweight.
Cypress, CaliforniaAges 18 years+
Overweight or Obesity trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting overweight or obesity studies listed above.
- Valley Clinical Trials · 3 studies
- Desert Oasis Healthcare · 2 studies
- Pacific Clinical Studies · 2 studies
- Stanford University · 2 studies
- University of California, Los Angeles (UCLA) · 2 studies
- 310 Clinical Research
- Altasciences Clinical LA, Inc.
- Amicis Research Center
What taking part in a overweight or obesity study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Overweight or Obesity trials in other states
Common questions
- Are there overweight or obesity clinical trials in California?
- Yes. We're currently tracking 119 recruiting overweight or obesity studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a overweight or obesity study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a overweight or obesity trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New overweight or obesity studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.