Overweight or Obesity clinical trials

Lifestyle program for women with obesity

This trial tests a year-long lifestyle program designed to help women with obesity improve their eating, well-being, and health habits. You will meet with a group for support and guidance.

Long-term bivamelagon for hypothalamic obesity

This long-term study tests a new drug, bivamelagon, for people with hypothalamic obesity. It's for those who already completed a similar study and tolerated the drug well.

Weight Loss Drug for Postmenopausal Women With Obesity

This study tests a GLP-1 agonist medication (like Ozempic) to help postmenopausal women lose weight and improve physical and blood vessel health. It focuses on women aged 46–60 with obesity.

Effects of healthy obesity on liver and uric acid risks

This study looks at people who are metabolically healthy but overweight or obese, and how that affects their risk of developing fatty liver disease (MASLD) or high uric acid levels (hyperuricemia). It aims to see if 'healthy' obesity still carries hidden health risks.

Lifestyle medicine study for UAB patients

This study tests a lifestyle program offered in primary care to help patients manage conditions like diabetes, high blood pressure, high cholesterol, or psoriatic arthritis. It aims to see if this approach can improve health and well-being.

Water exercise for knee pain in obese men

This study tests whether a supervised water exercise program (called WATERinMOTION) can reduce knee pain and improve movement in obese men with knee osteoarthritis. It may help if you are looking for a gentle, joint-friendly way to manage your knee pain.

Airway rod for intubation in adults with obesity

This trial tests if a special rod helps place a breathing tube more easily in adults with obesity who are having planned surgery. It could make the procedure safer and more comfortable.

Study of fat cell changes in obesity

This study looks at how fat cells change in people with obesity. It involves a small tissue sample (biopsy) and may help us understand more about weight-related health.

Liver health study for children & young adults with Down syndrome

This study looks at how eating patterns and body composition relate to fatty liver in children and young adults with Trisomy 21 (Down syndrome) or other genetic intellectual disabilities. It may help understand who is at risk and how to prevent liver problems.

Comparing a stent to other endoscopic leak treatments

This trial compares a special stent (the Luso-Cor Stent) to other endoscopic procedures to treat leaks or abnormal connections after certain stomach or esophageal surgeries. It aims to find the best way to fix these complications using a scope.

Childhood obesity prevention study in schools

This study looks at ways to prevent childhood obesity in cities. Researchers will collect information from children ages 6 to 13 in participating schools to understand what helps kids stay healthy.

Obesity classification and brain imaging study

This study looks at how obesity is classified and what brain imaging can show in people with obesity. It may help researchers understand different types of obesity and how they affect the brain.

Coffee and agave drink study for appetite in obesity

This trial tests if a special coffee drink with agave fiber can help control appetite in adults with obesity. You would drink the beverage daily and report how hungry you feel.

Kefir for Childhood Obesity: A Trial

This trial tests whether a probiotic drink called kefir (a fermented milk beverage) can help children and teens with obesity lose weight or improve their health. It's for children who are significantly above a healthy weight and don't have other serious medical conditions or dairy allergies.

Liver imaging study for children with obesity

This study uses MRI scans to look at the livers of children with obesity, to find early signs of liver problems. It may help doctors understand how to protect the liver in children.

Long-term effects of obesity on children's lungs and heart

This study looks at how obesity affects breathing and heart health in children as they get older. Researchers will test kids who were part of a previous study to see how their health has changed after about 6 years.

Turtle Island Tales health program for families

This study tests a program called Turtle Island Tales for caregivers and young children living in certain high-poverty areas. It aims to see if the program helps families be healthier and happier.

Healthy eating and yoga for children with obesity

This study will see if a program of healthy nutrition and yoga helps children who are overweight or obese. It is designed for children without other health problems that cause weight gain.

Bariatric surgery and memory problems in people with obesity

This study looks at how bariatric (weight-loss) surgery may affect memory and thinking in people with obesity who already have memory decline or dementia. It may help doctors understand which patients benefit most and what changes to expect.

Peptide-based diet study for adults on home tube feeding

This study tests whether a special “peptide-based” diet helps people with obesity who rely on home tube feeding after a stroke. It aims to see if this diet is safe and beneficial for weight and overall health while you stay on the nutrition you need.

Healthy Children, Healthy Communities: Effectiveness of a Multilevel Rural Community Engagement Model for Improving Children's Dietary Intake in Family Child Care Homes

Nausea, vomiting, and pain after weight-loss surgery

This study looks at how patients feel after weight-loss surgery, specifically nausea, vomiting, and pain. It uses national registry data to understand these symptoms better, which may help improve care for future patients.

SGLT2 inhibitor for metabolic syndrome and heart health

This study tests whether a diabetes medication called an SGLT2 inhibitor can reduce inflammation in body fat and improve blood vessel function in people with metabolic syndrome. It may help prevent heart disease and other complications.

Vitamin C for gut health in adults with obesity

This trial tests whether taking vitamin C supplements helps improve gut barrier function in adults with obesity. You'll follow a low-fruit-and-vegetable diet for two, two-week periods.