Overweight or Obesity clinical trials

Healthy Children, Healthy Communities: Effectiveness of a Multilevel Rural Community Engagement Model for Improving Children's Dietary Intake in Family Child Care Homes

Starting semaglutide again after weight-loss surgery in teens

This trial tests if restarting semaglutide (a weekly injection for weight loss) soon after sleeve gastrectomy helps teens with severe obesity keep losing weight. It is for patients who were already taking semaglutide before their surgery.

Testing mirabegron and tadalafil to improve sugar control

This study looks at whether mirabegron and tadalafil can improve blood sugar control in people with prediabetes. It may help determine if these medicines can slow the move from prediabetes toward diabetes.

Exercise, body fat, and hormones in men

This study investigates how exercise affects sex hormones in men with different body types. Participants will engage in a supervised exercise program to see how it interacts with body composition.

Peer support program for obesity and muscle loss awareness in college students

This study tests whether a peer support program (using videos and messages) can help college students become more aware of obesity and muscle loss. It is for students at one university in central Taiwan who are slightly overweight or have higher body fat, and who are otherwise healthy.

Online intuitive eating program for pregnant women with obesity

This study tests an online program that helps pregnant women with obesity learn to eat intuitively, which means listening to their body's hunger and fullness signals instead of dieting. The goal is to support their well-being during pregnancy.

Helping families build healthy routines to prevent early obesity

This study looks at how simple family routines—like mealtime, bedtime, and play—can help prevent obesity in young children. It’s designed for families with low income who want to build healthier habits together.

Heart disease risk study in Black adults

This study looks at how obesity and blood fat (triglyceride) levels affect heart disease risk differently in Black men and women. You may join if you're a healthy Black adult between 18 and 70, without diabetes.

Spinal cord stimulation to reduce stubborn back and leg pain

This trial tests whether spinal cord stimulation (a treatment where a device sends mild signals to the spinal cord) can improve persistent nerve-type back and leg pain. It is mainly for adults who are already planning to try spinal cord stimulation but have not tried it before.

Smartphone weight loss programs for young adult cancer survivors

This study tests two different smartphone-based programs to help young adult cancer survivors lose weight. Participants are randomly assigned to one of two programs and use an app to track their progress.

Quick sprints for better heart health

This study tests whether short bursts of intense exercise can improve your heart and lung fitness. You might join if you're generally healthy and not already very active.

Emotional well-being study for weight loss surgery

This study looks at how weight loss surgery affects patients' feelings and mental health over time. It is for people who qualify for certain weight loss procedures and want to understand the psychological effects.

Calorie restriction and exercise to improve leukemia treatment in young patients

This study tests whether a special diet (calorie restriction) and increased physical activity can make chemotherapy work better for young people with B-ALL. Participants will follow a monitored diet and exercise plan during their first month of treatment.

Study of HS235 in obese patients with pulmonary hypertension and heart failure

This trial tests an investigational drug called HS235 in people who have both obesity (BMI 30-50) and a specific type of heart failure with preserved pumping function, along with high blood pressure in the lungs. The goal is to see if the drug can improve symptoms and quality of life.

Breastfeeding help to prevent childhood obesity

This study offers breastfeeding support to new mothers to help prevent childhood obesity. It is for Hispanic mothers who plan to breastfeed and are eligible for WIC.

Comparing breathing tube devices in people with severe obesity

This trial compares two devices (Airway Scope and GlideScope) used to place a breathing tube during surgery in people with severe obesity. If you qualify, the study will help find which tool works best for patients like you.

Safety and Effectiveness of the Orbera365 Balloon for Weight Loss

This study tests a temporary balloon placed in your stomach to help with weight loss. The balloon stays in place for about a year and is removed at the end of the study. It is for people with a BMI between 30 and 50 who are looking for a non-surgical option.

Fecal transplant for obese women with polyendocrine metabolic ovarian syndrome

This study tests whether a fecal microbiota transplant (a transfer of healthy gut bacteria) can help women with polyendocrine metabolic ovarian syndrome who are also overweight or obese and planning a frozen embryo transfer. It aims to see if this treatment can improve hormone balance and possibly increase the chance of a successful pregnancy.

Digital tool for doctors to prescribe exercise

This trial tests a digital tool that helps doctors create personalized exercise plans for patients with heart disease risk factors. It aims to help you become more active in a safe, supported way.

Understanding a key cell channel in type 2 diabetes

This study looks at how a specific channel in your cells (called the KATP channel) affects blood sugar control in people with and without type 2 diabetes. It aims to understand why some people develop diabetes and how to better treat it.

Phentermine for weight loss in teens

This study tests a medicine called phentermine to help teens ages 12 to 17 with obesity lose weight. It will check if the medicine is safe and works well for teenagers.

Helping with long-term weight loss maintenance support

This study tests an extended care program designed to help people keep weight off after losing it. You would join with a buddy (friend or family member) and attend online sessions via Zoom, along with a few in-person check-ins at the university.

Surgery for stomach cancer and diabetes

This trial tests a surgery for early-stage stomach cancer that also aims to improve type 2 diabetes by changing how your body processes food. It might be an option if you have both conditions and are not using insulin.

Lung opening technique in obese women having gynecologic cancer surgery

This trial tests a lung opening technique (alveolar recruitment) during surgery to improve breathing in obese patients. It may help women with a moderate risk of breathing problems after gynecologic cancer surgery.