Clinical trials · Boston, MA
Pain clinical trials in Boston
We’re tracking 106 recruiting pain studies with a site in or near Boston — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Boston
- NCT04206215Recruiting
Noninvasive brain stimulation for carpal tunnel pain relief
This study tests whether a noninvasive brain stimulation treatment can reduce chronic carpal tunnel (CTS) pain, especially when pain spreads beyond the usual nerve area. If you have long-lasting CTS pain that hasn’t improved with standard treatments, you may be able to try this therapy while being closely monitored for safety.
Charlestown, MassachusettsAges 18–80 - NCT07336537Recruiting
Testing talk-based data collection software for chronic pain
This study tests easy-to-use talk-based software to collect health information from people with chronic pain. It may help researchers learn if tools like these are helpful for managing pain at home or in a lab.
Cambridge, MassachusettsAges 18 years+ - NCT07006675RecruitingPhase 3
NSAIDs for Tibia Fracture Pain and Healing Study
This study tests whether NSAID pain relievers (like ibuprofen) affect bone healing after a broken tibia and if they can help reduce the need for stronger painkillers. If you qualify, you could help doctors learn the safest way to manage pain after this common injury.
Cambridge, MassachusettsAges 18–80 - NCT05188183Recruiting
Remote brain stimulation plus hand training for phantom limb pain
This trial tests whether remote brain stimulation (tDCS) combined with sensory (hand/limb) training can reduce phantom limb pain. It also uses computer prediction (“machine learning”) to estimate who is most likely to benefit.
Cambridge, MassachusettsAges 18 years+ - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Cambridge, MassachusettsAges 18–85 - NCT06515925Recruiting
Virtual group program for managing chronic pain
This study tests a virtual group program that combines medical care with integrative approaches like mindfulness and gentle movement to help adults manage chronic musculoskeletal pain.
Malden, MassachusettsAges 18 years+ - NCT06757075RecruitingPhase 4
Managing pain after children's dental surgery
This study tests different ways to manage pain in young children after dental surgery done under general anesthesia. It aims to find the best method to keep children comfortable and reduce discomfort.
Brighton, MassachusettsAges 4–6 - NCT05726331Recruiting
Tai chi and chiropractic for long-term neck pain
This trial looks at whether a program of tai chi and chiropractic care can improve chronic, non-specific neck pain and daily function. It may help people who have had neck pain for months and want a structured exercise-and-care approach.
Chestnut Hill, MassachusettsAges 18–65 - NCT06976138Recruiting
Using Light or ions to Improve Sleep and Pain After Knee Surgery
This study tests whether a special bright light or negative ion therapy can help older adults sleep better and have less pain after knee replacement surgery. It's for people with knee arthritis who already have trouble sleeping and are scheduled for one knee replacement.
Chestnut Hill, MassachusettsAges 60 years+ - NCT07568015Recruiting
Nerve-targeted treatment for lateral hip pain
This study tests an experimental treatment that targets nerves around the hip to relieve pain on the outside of the hip. It may help people who have tried other treatments without enough relief.
Chestnut Hill, MassachusettsAges 22–80 - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Watertown, MassachusettsAges 18 years+ - NCT03984565RecruitingPhase 2
Study of a new cannabinoid for long-term body pain
This Phase 2 study tests how a new cannabinoid product affects people with ongoing musculoskeletal pain (like arthritis or injuries). It’s meant to see whether the product can improve pain for eligible adults who are not already using CBD regularly.
Belmont, MassachusettsAges 21 years+ - NCT07728695RecruitingPhase 1/Phase 2
Cannabis product for gynecologic pain study
This trial tests a new cannabis-based product to see if it helps with gynecologic pain (like endometriosis). It looks at how the product works and whether it is safe and effective.
Belmont, MassachusettsAges 21 years+ - NCT07353931RecruitingPhase 3
Study of eloralintide for knee osteoarthritis pain in people with overweight or obesity
This trial tests an investigational drug called eloralintide to see if it can reduce knee pain in people with osteoarthritis who also have overweight or obesity. You may be able to join if you have knee osteoarthritis, a BMI of 27 or higher, and have tried to lose weight with diet before.
Quincy, MassachusettsAges 18 years+ - NCT07285018RecruitingPhase 2
Study of a new drug for diabetic nerve pain in legs
This trial tests an investigational drug for people with pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It may help reduce pain in your lower legs if other treatments haven't worked well.
Waltham, MassachusettsAges 18 years+ - NCT07481630RecruitingPhase 3
Testing a new medicine for weight loss and knee pain
This study tests if a new medicine called NNC0487-0111 can help people with extra weight and knee osteoarthritis lose weight and reduce knee pain. If you have knee pain most days and are willing to stop pain relievers for short periods, you may be able to join.
Waltham, MassachusettsAges 18 years+ - NCT07641504RecruitingPhase 2
Testing LY4065967 for chronic low back pain relief
This study tests whether a new medication called LY4065967 can reduce chronic low back pain. Researchers want to see if it works better than current treatments for people who have had lower back pain for at least 3 months.
Waltham, MassachusettsAges 18 years+ - NCT07641517RecruitingPhase 2
Testing LY4065967 for chronic knee osteoarthritis pain
This study tests an experimental drug called LY4065967 to see if it can help reduce pain from osteoarthritis in the knee. You'll be in the trial for several months, with regular check-ins and pain assessments.
Waltham, MassachusettsAges 40 years+ - NCT07266922Enrolling by invitation
Web-based education for runners with knee pain
This study tests if a self-guided online program helps Boston Marathon runners manage patellofemoral pain (pain around or behind the kneecap). It aims to improve your understanding and control of the condition without in-person visits.
Waltham, MassachusettsAges 18–45 - NCT03696199RecruitingPhase 4
Test better pain control after ankle fracture surgery
This trial studies a pain-control approach (a kind of nerve block) to see if it can reduce pain after surgery for certain ankle fractures. It may help you feel more comfortable while your ankle heals after an operation.
Burlington, MassachusettsAges 18–89 - NCT06058624Recruiting
Digital pain management program for veterans
This study tests a new digital program that helps veterans with long-term pain learn to accept and cope with it. You would use a computer at home to complete the program and share your feedback.
Bedford, MassachusettsAges 18 years+ - NCT06128772Recruiting
Acupuncture study for chronic pain
This study tests if battlefield acupuncture, a specific type of ear acupuncture using tiny needles or tacks, can help veterans with chronic pain. It may be a good option if you have a history of substance use disorder and are interested in a non-drug approach to pain relief over 16 weeks.
Bedford, MassachusettsAges 18 years+ - NCT07600203Recruiting
Low-level laser therapy for chronic jaw pain
This study tests whether a special laser device called the Erchonia EVRL can reduce chronic jaw pain caused by TMJ (temporomandibular joint) disorders. You would receive laser treatment and rate your pain over time to see if the laser helps more than a placebo.
Acton, MassachusettsAges 22–75 - NCT06528288Recruiting
Numbing injection for pain relief after back fusion surgery
This study tests whether a special numbing injection (called an erector spinae plane block) given near the spine during surgery can reduce pain after lumbar fusion. If you qualify, you might have less pain and need fewer painkillers after your operation.
Worcester, MassachusettsAges 18 years+
Hear when a new Pain trial opens near Boston, MA
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Pain trials in other cities
Where these studies are running near Boston
Institutions with a site for the recruiting pain studies listed above.
- MedVadis Research Corporation · 3 studies
- Spaulding Rehabilitation Hospital · 3 studies
- Mass General Brigham · 2 studies
- McLean Hospital · 2 studies
- Skylight Health Research · 2 studies
- Acton Dental Associates
- Bay State Clinical Trials
- Bedford VA Healthcare System
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting pain studies in Massachusetts.
Common questions
- Are there pain clinical trials near Boston?
- Yes. We're currently tracking 106 recruiting pain studies with a site near Boston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study near Boston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Boston to take part?
- Not necessarily. These studies have a site near Boston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open near Boston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.