Clinical trials · North Carolina
Pain clinical trials in North Carolina
We’re tracking 72 recruiting pain studies with a site in North Carolina — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06495632RecruitingPhase 4
Scheduled or as-needed pain medicine after surgery?
This study compares taking pain medicine on a fixed schedule versus only when you need it after common outpatient surgeries. It aims to find which approach works better for controlling pain and reducing side effects.
Fayetteville, North CarolinaAges 18–65 - NCT06517056Recruiting
3D Knee Assessment for Active Duty Knee Pain
This trial tests a 3D camera device that measures how your knee moves. It may help find the best way to treat your front-of-knee pain and keep you mission-ready.
Fort Liberty, North CarolinaAges 18–50 - NCT06623669RecruitingPhase 2
Mobile program to reduce pain and improve health in older adults
This trial tests a mobile program to help reduce pain and improve health in older adults with knee or hip arthritis who are not very active. The program involves exercise and may help with weight management.
Winston-Salem, North CarolinaAges 65 years+ - NCT05037968Recruiting
Test bone graft materials for multi-level back fusion surgery
This trial compares two bone-graft materials to help bones heal after back fusion surgery using a rod/screw system. It may help people who have ongoing back or leg pain despite at least 3 months of non-surgical treatments.
Pinehurst, North CarolinaAges 18 years+ - NCT06747871Recruiting
Opioids, low nicotine cigarettes, and chronic pain study
This study tests if using cigarettes with very low nicotine can help people with chronic pain who are on buprenorphine for opioid use disorder. It aims to see if this approach reduces smoking and helps you think about quitting.
Durham, North CarolinaAges 21 years+ - NCT06962306RecruitingPhase 4
Pain relief study for children having cleft palate surgery
This trial tests different ways to manage pain after cleft palate repair in young children. The goal is to find which approach works best to lower pain and improve recovery.
Durham, North CarolinaAges 6 months–4 years - NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Chapel Hill, North CarolinaAges 18 years+ - NCT06983678Recruiting
Quitting smoking and pain sensitivity study
This study looks at how quitting smoking affects pain sensitivity in people who smoke, especially those with chronic low back pain. Researchers will use brain scans and daily surveys to understand these changes.
Durham, North CarolinaAges 21–65 - NCT07245303Recruiting
How Light Affects Pain in Chronic Pain
This study looks at how different kinds of light might change pain levels in people with chronic widespread pain, like fibromyalgia. By using brain scans (MRI), researchers hope to find new ways to manage pain without medication.
Chapel Hill, North CarolinaAges 18 years+ - NCT01719055Recruiting
Long-term follow-up for Boston Scientific pain nerve stimulation
This study looks at how well a Boston Scientific nerve stimulation device works over the long term for pain in everyday care. You may be able to join if you’re already being set up to use one of these approved systems and can reliably report your pain outcomes.
Huntersville, North CarolinaAges 18 years+ - NCT07509671Recruiting
Can a diet help painful diabetic nerve pain?
This study tests whether a special diet can help reduce pain caused by nerve damage from Type 2 diabetes or prediabetes. You may qualify if you have painful diabetic neuropathy and are looking for a non-medication approach.
Hendersonville, North CarolinaAges 18 years+ - NCT06956508Enrolling by invitation
VR therapy to prevent phantom limb pain after amputation
This study tests whether using virtual reality (VR) daily in the hospital after a major amputation can help prevent phantom limb pain. You'll use a VR headset to do simple exercises that may keep your brain from sending pain signals to the missing limb.
Charlotte, North CarolinaAges 13 years+ - NCT06407115Enrolling by invitation
Pain care support for rural patients
This study tests a nurse-led program to help people living in rural areas manage chronic pain. You'll work with a care manager who can support your pain treatment goals.
Winston-Salem, North CarolinaAges 18 years+ - NCT05944354Enrolling by invitation
Wearable system to study spine health for military readiness
This study tests whether a wearable setup can measure spine health during training and daily movement. It may help improve how military members with or without neck or low back pain are monitored and supported.
Seymour-Johnson Air Force Base, North CarolinaAges 18–64 - NCT07210515RecruitingPhase 3
Testing Ambros Therapy for Early CRPS
This trial tests if an intravenous medicine called AMBTX-01 (neridronate) can help people with early-stage Complex Regional Pain Syndrome (CRPS) type 1. It focuses on those whose affected limb feels warm, looks red, and is swollen.
Charlotte, North CarolinaAges 18 years+ - NCT04278404Recruiting
Drug safety study for children already on certain medicines
This study measures how certain medicines move through the body and checks their safety in children. It may help doctors better understand dosing and side effects in kids who are already receiving these treatments, or in some kids who recently tested positive for COVID-19.
Chapel Hill, North CarolinaAges birth–20 years - NCT06884865RecruitingPhase 2
Study of an experimental knee injection for osteoarthritis pain
This study tests a new investigational medicine injected into the knee to see if it is safe and tolerable for people with painful knee osteoarthritis. It may help reduce pain and improve knee function.
Morehead City, North CarolinaAges 45–80 - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Durham, North CarolinaAges 2 months–17 years - NCT03716167Recruiting
Near-infrared laser for healing and pain in leg vein ulcers
This study tests whether a near-infrared laser can improve healing and reduce pain in chronic venous leg ulcers. If you qualify, you may receive laser treatment and will be checked over time for wound healing and pain levels.
Winston-Salem, North CarolinaAges 18 years+ - NCT07721220Recruiting
Nerve gliding moves for strength and endurance in athletes
This study tests whether a gentle nerve-stretching technique (neurodynamics) can improve leg strength and endurance in athletes. If you're 18–30, currently active in sports or intense training, and have no recent leg injury or surgery, you may be able to join.
High Point, North CarolinaAges 18–30 - NCT03427736Recruiting
Studying pain and numbing medicines in children
This trial looks at how well different numbing and pain-relief medicines work in children during routine care. It may help doctors choose safer, better pain control for kids who need these medicines.
Durham, North CarolinaAges birth–17 years - NCT03834818Recruiting
Using a phone app to track pain after orthopedic surgery
This study collects information about pain and recovery after planned (elective) orthopedic surgery. It uses a smartphone to help understand outcomes and pain levels so care may improve.
Durham, North CarolinaAges 18–90 - NCT03876054Recruiting
Tracking outcomes after Abbott neurostimulator implantation
This study follows people long-term after they get an Abbott device implanted to help with chronic pain. It aims to learn how well the therapy works in real-world care over time.
Asheville, North CarolinaAges 18 years+ - NCT04209504Recruiting
Nerve block study for one-sided breathing muscle weakness after shoulder surgery
This trial tests whether a longer-lasting nerve block during shoulder surgery can better manage pain and affect one-sided diaphragm (breathing muscle) weakness. It may help people having planned (first-time) shoulder surgery who are able to follow study pain-checks.
Durham, North CarolinaAges 18–80
Pain trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting pain studies listed above.
- Duke University Medical Center · 3 studies
- Duke North Pavilion · 2 studies
- University of North Carolina at Chapel Hill · 2 studies
- Wake Forest University Health Sciences · 2 studies
- AdventHealth Hendersonville
- Ambros Clinical Trial Site
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist)
- Cape Fear Valley Health System
What taking part in a pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Pain trials in other states
Common questions
- Are there pain clinical trials in North Carolina?
- Yes. We're currently tracking 72 recruiting pain studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a pain study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New pain studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.