Clinical trials
Pain clinical trials
Below are recruiting pain clinical trials, each written for real people, not researchers. We’re tracking 3,263 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05768477Recruiting
Testing different treatments for chronic pain patients
This study looks at different ways to treat long-term (chronic) pain. You may be invited to participate if you’re an adult with chronic pain and can understand the study information.
GhentAges 18 years+ - NCT05819476Recruiting
Testing how open-label placebos affect induced pain
This study tests whether people can feel less pain when they know they are receiving a “placebo” (a treatment with no active pain-relieving medicine). It’s done in healthy adults by triggering short-lasting pain in a controlled way to see how the placebo effect changes pain feelings.
BaselAges 18–65 - NCT05840302Recruiting
Pain education program to increase activity in chronic low back pain
This trial studies whether teaching “pain neuroscience” (how pain works in the body and brain) helps people with long-term low back pain move more. It compares an education program as part of a multidisciplinary rehab to usual care during your planned hospital stay.
Lamalou-les-BainsAges 18 years+ - NCT05851196Recruiting
Personalized exercise for recurrent low back pain
This study looks at how back muscle features can help tailor an exercise program for people with recurring, non-specific low back pain. It may help by matching exercises to your specific back function and symptoms.
DiepenbeekAges 18–60 - NCT05865327Recruiting
Nerve freezing for rib-fracture pain using ultrasound guidance
This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.
Toronto, OntarioAges 18–100 - NCT05877157Recruiting
Study how pain and opioids change after surgery
This study follows adults in the hospital after surgery to understand how pain and opioid (strong pain medicine) use affect them. Your answers on questionnaires help researchers see what happens after different types of anesthesia.
Zagreb, Vinogradska 29Ages 18 years+ - NCT05894772Recruiting
Virtual portal program for youth waiting for chronic pain care
This study tests a virtual “stepped care” portal (a website/app) to help young people manage chronic pain while they’re waiting to start specialized care. It aims to see whether the portal improves support and outcomes during the wait time.
Halifax, Nova ScotiaAges 12–18 - NCT05909709RecruitingPhase 1
Tested injections for chronic facet-related back pain
This Phase 1 study tests the safety of an injection called Alocyte in adults with long-lasting back pain coming from the facet joints. If you qualify, you may be followed closely to check side effects and how you respond over multiple visits.
North Miami, FloridaAges 18 years+ - NCT05961800Recruiting
Study ways to evaluate lumbar back pain blocks
This study looks at how well different methods can evaluate a common procedure used for chronic low back pain (lumbar medial branch blocks). If you have long-lasting, everyday back pain and are having this procedure, you may help researchers compare evaluation approaches.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05963607Recruiting
Weighted blanket trial to reduce chronic pain
This study tests whether using a 15-pound weighted blanket can lower pain and improve sleep for Veterans with long-lasting, non-cancer musculoskeletal pain. It may help by reducing discomfort during rest and sleep.
San Diego, CaliforniaAges 18 years+ - NCT05968664Recruiting
Test whether new spinal cord stimulation settings improve chronic pain
This trial studies whether changing the “stimulation pattern” of spinal cord stimulation can reduce long-lasting pain and improve daily function. You might be a good candidate if you have chronic trunk or leg pain and have already tried multiple pain treatments without enough relief.
Houston, TexasAges 22 years+ - NCT05981261Recruiting
Experimental pain study in Parkinson's and healthy adults
This study looks at how people with Parkinson’s, treated either with levodopa or deep brain stimulation (DBS), and healthy volunteers experience pain. The goal is to understand how Parkinson’s treatments affect pain perception.
AarhusAges Any age - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Birmingham, AlabamaAges 18 years+ - NCT06023225Recruiting
Sex hormones, pain, and opioid use in girls after surgery
This study looks at how sex hormones affect pain and the use of pain medicine after orthopedic surgery in girls. It might help explain why some people need more pain relief than others.
St Louis, MissouriAges 11–16 - NCT06027099RecruitingPhase 3
Testing tizanidine to help reduce opioids after surgery
This study tests whether adding a low-dose muscle relaxant (tizanidine) to your pain plan after surgery can help you safely lower your opioid use. It's for people who have been on long-term opioids and are having surgery at specific hospitals.
Stanford, CaliforniaAges 18–75 - NCT06044584Recruiting
AI tool for tracking pain after injury or nerve pain
This study tests a smartphone-based tool that uses artificial intelligence to track your pain and how it affects your daily life. It may help you and your doctor better understand your pain over time.
Pietra Ligure, SavonaAges 18–80 - NCT06051227RecruitingPhase 3
Pain relief after injury: fentanyl vs. esketamine
This trial compares two strong pain medicines—fentanyl and esketamine—to see which works better for treating pain right after a traumatic injury. You would receive the medicine by spray in your nose or through a vein before going to the hospital.
AmsterdamAges 18 years+ - NCT06052384Recruiting
Better sleep care for chronic pain patients
This study tests whether adding a sleep specialist to your pain care team can help you feel better. If you have chronic pain (lasting over 3 months) and are now seeing a pain doctor for the first time, you may be able to join.
Le Puy-en-VelayAges 18 years+ - NCT06069362Recruiting
Manual Physiotherapy for Neck and Arm Pain
This study tests whether a type of hands-on physical therapy (manual therapy) can help reduce neck and arm pain. It looks at how your body senses touch and pressure to see if that predicts how well you respond.
San Sebastián, GipuzkoaAges 18–80 - NCT06076512Recruiting
Pain clinic safety trial for adults with chronic pain
This trial is testing whether a pain clinic can improve public health safety for adults who have chronic pain and also face social or emotional challenges. It aims to see if this kind of care helps people feel better and avoids opioid-related harms.
Surrey, British ColumbiaAges 20–99 - NCT06094257Recruiting
Study on sensation and satisfaction after mastectomy
This study looks at how people feel after mastectomy, including transgender patients and those having nipple-sparing surgery. It aims to understand sensation and satisfaction to improve future care.
Boston, MassachusettsAges 18 years+ - NCT06102733Recruiting
Pelvic pain study for women and men
This trial is testing treatments for chronic pelvic pain, sacroiliac pain, groin pain, tailbone pain, and piriformis pain. It may help people with persistent pain in these areas find relief.
Surrey, British ColumbiaAges 20–99 - NCT06104384Recruiting
Chronic pain patients with injury claims study
This study looks at injury claims from people with chronic pain to better understand their experiences. It may help improve care for others with similar conditions.
Surrey, British ColumbiaAges 20–99 - NCT06106191Recruiting
Mindfulness program for chronic low back pain
This trial tests a mindfulness-based program designed to help people with long-term low back pain. It aims to see if combining mindfulness with a personalized approach can improve pain management and daily functioning.
Boston, MassachusettsAges 18 years+
Hear when a new Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for pain?
- Yes. Clin2 currently lists 3,263 recruiting pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.